* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Thursday, September 18, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    REO to return for UI homecoming – The News-Gazette

    REO Gears Up to Ignite the Stage at UI Homecoming Celebration!

    Gen V Season 2: What is The Odessa Project? – yahoo.com

    Gen V Season 2: Unlocking the Secrets of The Odessa Project

    PENN Entertainment stock rating reiterated at Market Outperform by JMP – Investing.com

    PENN Entertainment Stock Rated a Market Outperformer by Experts

    Here’s how NJ’s once-vibrant nightclub scene was born and why it died – Bergen Record

    The Rise and Fall of New Jersey’s Once-Vibrant Nightclub Scene: What Happened?

    The Emmys are back: Viewership soars to highest numbers in 4 years – yahoo.com

    The Emmys Return with a Bang: Viewership Hits a 4-Year High

    From Spinal Tap II to Ed Sheeran : your complete entertainment guide to the week ahead – The Guardian

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Bucking the Odds: Why Technology Companies Should Embrace Software Patents Today – Crowell & Moring LLP

    Bucking the Odds: Why Technology Companies Should Embrace Software Patents Today – Crowell & Moring LLP

    City IT presented Best of North Carolina Technology Award – RaleighNC.gov

    City IT Honored with Best of North Carolina Technology Award

    LELO Releases 2025 Futurist Report: Intergenerational Views on Relationships, Sex, and Technology – PR Newswire

    Exploring the Future: How Different Generations View Relationships, Sex, and Technology in 2025

    Will New Big Technology Engagements Reshape Innodata’s Growth Path? – Yahoo Finance

    Could New Major Tech Partnerships Propel Innodata to Unprecedented Growth?

    Unlocking AI Success: How People, Process, and Technology Form the Ultimate Triangle

    Billion-dollar coffins? New technology could make oceans transparent and Aukus submarines vulnerable – The Guardian

    Billion-Dollar Coffins? How New Technology Could Make Oceans Transparent and Expose Submarines

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    REO to return for UI homecoming – The News-Gazette

    REO Gears Up to Ignite the Stage at UI Homecoming Celebration!

    Gen V Season 2: What is The Odessa Project? – yahoo.com

    Gen V Season 2: Unlocking the Secrets of The Odessa Project

    PENN Entertainment stock rating reiterated at Market Outperform by JMP – Investing.com

    PENN Entertainment Stock Rated a Market Outperformer by Experts

    Here’s how NJ’s once-vibrant nightclub scene was born and why it died – Bergen Record

    The Rise and Fall of New Jersey’s Once-Vibrant Nightclub Scene: What Happened?

    The Emmys are back: Viewership soars to highest numbers in 4 years – yahoo.com

    The Emmys Return with a Bang: Viewership Hits a 4-Year High

    From Spinal Tap II to Ed Sheeran : your complete entertainment guide to the week ahead – The Guardian

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Bucking the Odds: Why Technology Companies Should Embrace Software Patents Today – Crowell & Moring LLP

    Bucking the Odds: Why Technology Companies Should Embrace Software Patents Today – Crowell & Moring LLP

    City IT presented Best of North Carolina Technology Award – RaleighNC.gov

    City IT Honored with Best of North Carolina Technology Award

    LELO Releases 2025 Futurist Report: Intergenerational Views on Relationships, Sex, and Technology – PR Newswire

    Exploring the Future: How Different Generations View Relationships, Sex, and Technology in 2025

    Will New Big Technology Engagements Reshape Innodata’s Growth Path? – Yahoo Finance

    Could New Major Tech Partnerships Propel Innodata to Unprecedented Growth?

    Unlocking AI Success: How People, Process, and Technology Form the Ultimate Triangle

    Billion-dollar coffins? New technology could make oceans transparent and Aukus submarines vulnerable – The Guardian

    Billion-Dollar Coffins? How New Technology Could Make Oceans Transparent and Expose Submarines

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

‘Minimal’ Benefit Seen With Antibiotics for Acute Sinusitis in Kids

July 25, 2023
in Health
‘Minimal’ Benefit Seen With Antibiotics for Acute Sinusitis in Kids
Share on FacebookShare on Twitter

Antibiotic treatment provided “minimal” benefit for children with acute sinusitis and was accompanied by more cases of clinically significant diarrhea, researchers reported.

In a randomized trial of kids ages 2 to 11 years, mean symptom scores during the first 10 days were significantly lower in those who received amoxicillin and clavulanate compared with a placebo group (9.04 vs 10.60 on the Pediatric Rhinosinusitis Symptom Score).

That difference translated to a significant between-group difference of -1.69 (95% CI -2.07 to -1.31) on the 40-point scale, according to researchers led by Nader Shaikh, MD, MPH, of UPMC Children’s Hospital of Pittsburgh, and colleagues.

In addition, the length of time to symptom resolution was significantly lower for children in the antibiotic group (7 days) versus the placebo group (9 days; P=0.003), they wrote in JAMA.

Although small, the differences were probably noticeable to the children and to their parents, Shaikh and team said. “A between-group difference of 2 points in the mean symptom scores would be seen when comparing a hypothetical child with ‘an extreme amount’ of irritability from day 2-11 versus a child with ‘some’ irritability,” they wrote.

Of note, antibiotics provided more benefit to those with nasopharyngeal pathogens detected compared with those without pathogens detected, with between-group differences in mean symptom scores of -1.95 (95% CI -2.40 to -1.51) and -0.88 (95% CI -1.63 to -0.10), respectively.

Efficacy did not significantly differ whether colored nasal discharge was present or not (between-group difference -1.62 for colored nasal discharge vs -1.70 for clear nasal discharge; P=0.52 for the interaction between treatment group and the presence of colored nasal discharge).

As for secondary outcomes, children in the antibiotic group were significantly less likely to experience treatment failure, develop acute otitis media, or receive additional systemic antibiotics compared with those in the placebo group.

The study provides some key context for therapeutic decision making, but it isn’t practice-changing, wrote Aaron M. Milstone, MD, MHS, of Johns Hopkins University School of Medicine in Baltimore, and colleagues in an accompanying editorial, noting that because nasopharyngeal swabs were cultured for all of the patients, the results might not be applicable to most therapeutic settings.

Although the study “offers interesting nuances related to 3 of the 4 moments of antibiotic decision making, it does not seem to be a game changer in the understanding of acute bacterial sinusitis,” they added.

“Overall, the current study suggests that antibiotics may provide mild relief in symptom burden in children with acute bacterial sinusitis, especially in those with common respiratory bacteria,” they concluded. “However, given the limitations of nasopharyngeal bacterial pathogen testing, widespread adoption of a test-based treatment approach is not there yet.”

Universal, or at least more frequent, testing would greatly improve antibiotic stewardship, Shaikh and team said. If antibiotic use was limited to those with culture-proven bacterial infections, it would have reduced use by 28%.

In an exploratory analysis, Shaikh and team determined that the highest clinical benefit with antibiotics was seen in patients infected with Streptococcus pneumoniae or Haemophilus influenzae. There was no significant interaction between treatment and the presence of Moraxella catarrhalis.

“If antibiotic use was limited to children with H. influenzae or S. pneumoniae in their nasopharynx at the time of diagnosis, antibiotic use would decrease by 53%,” they pointed out.

In a second accompanying editorial published in JAMA Otolaryngology–Head & Neck Surgery, Sophie G. Shay, MD, of the Medical College of Wisconsin in Milwaukee, and Jennifer J. Shin, MD, SM, of Brigham and Women’s Hospital and Harvard Medical School in Boston, noted that “[d]evelopment of a … practical point-of-care test option for acute bacterial rhinosinusitis could invoke a paradigm shift for ambulatory care professionals assessing patients whose presentation raises uncertainty in the diagnosis of viral or bacterial acute rhinosinusitis.”

“Point-of-care multiplex polymerase chain reaction testing with same-day results could potentially be leveraged to reduce antibiotic prescriptions,” they wrote. “While this approach requires nasopharyngeal swabs, which have traditionally been viewed as invasive by patients and families, as the authors note, in the setting and needs of the COVID-19 pandemic, such swabs have become more frequently accepted. In this setting, swabbing amid acute rhinosinusitis could be a more feasible proposition.”

Study Details

All of the children included in the study had to meet the American Academy of Pediatrics’ diagnostic criteria for acute sinusitis: persistent illness, which the study defined as symptoms for 11-13 days without improvement; worsening or new onset of nasal discharge, daytime cough, or fever after initial improvement; or severe onset with concurrent fever and purulent (yellow or green) nasal discharge for at least 3 consecutive days.

Of the 510 children included, 64% were ages 2 to 5 years, 54% were boys, and 52% were white.

The children were divided into two groups based on the presence or absence of purulent nasal discharge (67% had colored nasal discharge present). They were randomized to a 10-day course of oral amoxicillin (90 mg/kg per day) and clavulanate (6.4 mg/kg per day) or matching placebo.

At enrollment, nasopharyngeal specimens for culture to identify S. pneumoniae (26-30% of patients), H. influenzae (29-31%), and M. catarrhalis (44-53%) were obtained.

The primary outcome was measured by the 40-point Pediatric Rhinosinusitis Symptom Score during the first 10 days after diagnosis.

There were no serious adverse events associated with treatment. Children who received antibiotics were no more likely to have a treatment-resistant pathogen at follow-up than those who received placebo (13% vs 12%). However, more than twice as many developed clinically significant diarrhea (11.4% vs 4.7%; P=0.005). Rash was also twice as common, but the difference was not statistically significant.

Disclosures

This research was supported by a grant from the National Institute of Allergy and Infectious Diseases.

Shaikh reported owning stock in and serving as a consultant for Kaizen Bioscience. A co-author reported having patents for a pediatric oral suspension formulation of amoxicillin-clavulanate potassium and the method for use that are licensed to Kaizen Bioscience. Other co-authors reported relationships with Merck Sharp and Dohme, Merck, and GlaxoSmithKline.

Milstone and co-authors reported no conflicts of interest.

Shin reported book royalties from Springer Publishing and Plural Publishing and funding from the American Academy of Otolaryngology-Head and Neck Surgery Foundation, the Brigham Care Redesign Incubator and Startup Program Award, the Schlager Family Innovation Fund Award, and the Master Clinician Award. Shay reported no conflicts of interest.

Primary Source

JAMA

Source Reference: Shaikh N, et al “Identifying children likely to benefit from antibiotics for acute sinusitis: a randomized clinical trial” JAMA 2023; DOI: 10.1001/jama.2023.10854.

Secondary Source

JAMA

Source Reference: Caballero TM, et al “Acute bacterial sinusitis: limitations of test-based treatment” JAMA 2023; DOI: 10.1001/jama.2023.11365.

Additional Source

JAMA Otolaryngology–Head & Neck Surgery

Source Reference: Shay SG, Shin JJ “Time for acute bacterial rhinosinusitis point-of-care testing — snot or not” JAMA Otolaryngol Head Neck Surg 2023; DOI: 10.1001/jamaoto.2023.2612.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/pediatrics/generalpediatrics/105612

Tags: BenefithealthMinimal'
Previous Post

Many Postpartum Check-Ups Omit Discussion of Mom’s Heart Health

Next Post

Proteins Predict Dementia; Brain Function in Long COVID; Pregabalin Plus Opioids

Trump Designates Antifa ‘Terror Organisation’ Days After Charlie Kirk Murder – NDTV

Trump Designates Antifa ‘Terror Organisation’ Days After Charlie Kirk Murder – NDTV

September 18, 2025
Study: UIS contributes nearly $1 billion to the Illinois economy – NPR Illinois

Study: UIS contributes nearly $1 billion to the Illinois economy – NPR Illinois

September 18, 2025
REO to return for UI homecoming – The News-Gazette

REO Gears Up to Ignite the Stage at UI Homecoming Celebration!

September 18, 2025
WATCH: Former CDC doctor says U.S. is on track to see uptick in preventable diseases under Kennedy – PBS

WATCH: Former CDC Doctor Warns of Rising Preventable Diseases in the U.S

September 18, 2025
Local politicians, judges, officials face increased threats, new data shows – WDSU

Local politicians, judges, officials face increased threats, new data shows – WDSU

September 18, 2025
Washington State Honors Hanford Team for Protecting Native Habitat – Department of Energy (.gov)

Washington State Celebrates Hanford Team’s Success in Protecting Native Habitat

September 17, 2025
Kent State University unveils poetry inspired by science despite federal funding cut – Ideastream

Kent State University Unveils Science-Inspired Poetry Amid Federal Funding Cuts

September 17, 2025
Fired CDC director warns of backslide in US vaccine science under RFK Jr – Al Jazeera

Fired CDC director warns of backslide in US vaccine science under RFK Jr – Al Jazeera

September 17, 2025
Melting Pot Brings Back Its Most ‘Luxurious’ Fondue for a Limited Time – yahoo.com

Melting Pot Brings Back Its Most ‘Luxurious’ Fondue for a Limited Time – yahoo.com

September 17, 2025
Bucking the Odds: Why Technology Companies Should Embrace Software Patents Today – Crowell & Moring LLP

Bucking the Odds: Why Technology Companies Should Embrace Software Patents Today – Crowell & Moring LLP

September 17, 2025

Categories

Archives

September 2025
MTWTFSS
1234567
891011121314
15161718192021
22232425262728
2930 
« Aug    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (824)
  • Economy (844)
  • Entertainment (21,723)
  • General (17,097)
  • Health (9,889)
  • Lifestyle (858)
  • News (22,149)
  • People (848)
  • Politics (854)
  • Science (16,055)
  • Sports (21,344)
  • Technology (15,826)
  • World (828)

Recent News

Trump Designates Antifa ‘Terror Organisation’ Days After Charlie Kirk Murder – NDTV

Trump Designates Antifa ‘Terror Organisation’ Days After Charlie Kirk Murder – NDTV

September 18, 2025
Study: UIS contributes nearly $1 billion to the Illinois economy – NPR Illinois

Study: UIS contributes nearly $1 billion to the Illinois economy – NPR Illinois

September 18, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version