* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Monday, June 2, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Rising stars: Young classical musicians surging on social media – Yahoo

    Meet the Next Generation of Classical Music Sensations Making Waves on Social Media!

    Devin Harjes Dies: ‘Manifest’ & ‘Boardwalk Empire’ Actor Was 41 – WyomingNews.com

    Tragic Loss: Devin Harjes, Star of ‘Manifest’ and ‘Boardwalk Empire,’ Passes Away at 41

    Why Starz Entertainment Stock Soared Today – The Motley Fool

    Unpacking the Surge: What Fueled Starz Entertainment’s Stock Explosion Today!

    Unveiling the Enigmatic: First Looks at Destruction and Puck in ‘The Sandman

    Jackie Chan Reveals This Family Member ‘Never Watched’ The Whole Of Any Of His Movies – Yahoo

    Jackie Chan Reveals This Family Member ‘Never Watched’ The Whole Of Any Of His Movies – Yahoo

    Mavs CEO holds firm on new arena, entertainment district in Dallas – Dallas News

    Mavs CEO Stands Strong on Vision for New Arena and Entertainment District in Dallas

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    ROLAND’S NEW WIRELESS TRIGGER TECHNOLOGY, PORTER & DAVIES ON TOUR, NEW 64 AUDIO ASPIRE UNIVERSAL IEM MODELS, WAVES FREE PLUGIN PACK – Modern Drummer Magazine

    ROLAND’S NEW WIRELESS TRIGGER TECHNOLOGY, PORTER & DAVIES ON TOUR, NEW 64 AUDIO ASPIRE UNIVERSAL IEM MODELS, WAVES FREE PLUGIN PACK – Modern Drummer Magazine

    This giant microwave may change the future of war – MIT Technology Review

    Revolutionizing Warfare: The Impact of a Game-Changing Giant Microwave

    Bajeed Pattan Joins Forbes Technology Council as Innovation Leader – PRWeb

    Bajeed Pattan Takes the Helm as Innovation Leader at Forbes Technology Council!

    Lafayette Regional Technology Council – Tech Leadership That’s Homegrown and Future-Focused – Discover Lafayette

    Lafayette Regional Technology Council – Tech Leadership That’s Homegrown and Future-Focused – Discover Lafayette

    Drone technology demo in Cambria County showcases future of lifesaving medical deliveries – local21news.com

    Revolutionizing Healthcare: Drone Technology Takes Flight for Lifesaving Medical Deliveries in Cambria County

    Revolutionary Harvesting Technology Promises to Slash CAR-T Manufacturing Costs!

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Rising stars: Young classical musicians surging on social media – Yahoo

    Meet the Next Generation of Classical Music Sensations Making Waves on Social Media!

    Devin Harjes Dies: ‘Manifest’ & ‘Boardwalk Empire’ Actor Was 41 – WyomingNews.com

    Tragic Loss: Devin Harjes, Star of ‘Manifest’ and ‘Boardwalk Empire,’ Passes Away at 41

    Why Starz Entertainment Stock Soared Today – The Motley Fool

    Unpacking the Surge: What Fueled Starz Entertainment’s Stock Explosion Today!

    Unveiling the Enigmatic: First Looks at Destruction and Puck in ‘The Sandman

    Jackie Chan Reveals This Family Member ‘Never Watched’ The Whole Of Any Of His Movies – Yahoo

    Jackie Chan Reveals This Family Member ‘Never Watched’ The Whole Of Any Of His Movies – Yahoo

    Mavs CEO holds firm on new arena, entertainment district in Dallas – Dallas News

    Mavs CEO Stands Strong on Vision for New Arena and Entertainment District in Dallas

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    ROLAND’S NEW WIRELESS TRIGGER TECHNOLOGY, PORTER & DAVIES ON TOUR, NEW 64 AUDIO ASPIRE UNIVERSAL IEM MODELS, WAVES FREE PLUGIN PACK – Modern Drummer Magazine

    ROLAND’S NEW WIRELESS TRIGGER TECHNOLOGY, PORTER & DAVIES ON TOUR, NEW 64 AUDIO ASPIRE UNIVERSAL IEM MODELS, WAVES FREE PLUGIN PACK – Modern Drummer Magazine

    This giant microwave may change the future of war – MIT Technology Review

    Revolutionizing Warfare: The Impact of a Game-Changing Giant Microwave

    Bajeed Pattan Joins Forbes Technology Council as Innovation Leader – PRWeb

    Bajeed Pattan Takes the Helm as Innovation Leader at Forbes Technology Council!

    Lafayette Regional Technology Council – Tech Leadership That’s Homegrown and Future-Focused – Discover Lafayette

    Lafayette Regional Technology Council – Tech Leadership That’s Homegrown and Future-Focused – Discover Lafayette

    Drone technology demo in Cambria County showcases future of lifesaving medical deliveries – local21news.com

    Revolutionizing Healthcare: Drone Technology Takes Flight for Lifesaving Medical Deliveries in Cambria County

    Revolutionary Harvesting Technology Promises to Slash CAR-T Manufacturing Costs!

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Multi-generational toxicant exposures show cumulative, inherited health effects

January 23, 2024
in Health
Multi-generational toxicant exposures show cumulative, inherited health effects
Share on FacebookShare on Twitter

Multi-generational toxicant exposures show cumulative, inherited health effects

DMR identification. The number of DMRs found using different P-value cutoff thresholds. The All-Window column shows all DMRs. The Multiple Window column shows the number of DMRs containing at least two nearby significant windows (1 kb each). The number of DMRs with the number of significant windows (1 kb per window) at a P-value threshold of P Environmental Epigenetics (2023). DOI: 10.1093/eep/dvad006

While exposure to a single substance like DDT has been shown to create inherited disease susceptibility, a recent study in animals found exposure to multiple different toxicants across generations can amplify those health problems.

In the study, published in the journal Environmental Epigenetics, an initial generation of pregnant rats was exposed to a common fungicide, then their progeny to jet fuel and the following generation to DDT. When those rats were then bred out to a fifth unexposed generation, the incidence of obesity as well as kidney and prostate diseases in those animals were compounded, rising by as much as 70%.

Researchers also found that their epigenetics, molecular processes independent of DNA that influence gene expression, were also greatly altered.

“We looked at multiple-generation exposures because these types of things are going on routinely, and previous research has only looked at single exposures,” said Michael Skinner, a WSU biology professor and the study’s corresponding author. “We found that if multiple generations get different exposures, then eventually there’s an amplification or compounded effect on some diseases.”

The study did show that for other diseases, those associated with the ovaries and the testes, the incidence rose in the first generation of progeny but appeared to plateau with the additional generational exposures.

Skinner and his colleagues also conducted epigenetic analysis of each generation of the animals, finding that the toxicant exposures shifted their entire epigenetics dramatically. Along with changes to genes themselves, inherited epigenetics which influence gene expression, are considered to have a significant impact on evolution.

“When we made the comparisons with different generations, we did not find a lot of overlap in epigenetics. In other words, every time each generation had a new exposure, it appeared to reprogram the whole epigenome,” Skinner said.

While the study does not exactly mimic what may have happened to human generations, people in the U.S. have potentially been exposed to these particular toxicants at different times. The authors note a likely sequential exposure over human generations might involve an exposure to DDT which was widely used in the 1950s, then plastics in the 1970s, followed by many modern herbicides still in use today.

The study provides evidence that multiple toxicant exposures of past human generations likely had a compounded impact on grandchildren and great-grandchildren. Knowing about these possible impacts can help people and doctors address potential diseases before they develop, Skinner said.

Researchers including Skinner’s lab at WSU have been working to identify epigenetic biomarkers for inherited health conditions in humans including for obesity, autism and pre-term birth.

“We need to know to what degree our past generations activities that have affected us,” Skinner said. “We cannot necessarily fix this problem, but it’s important to know that it happened so that we can try to better treat potential health problems through preventative medicine.”

More information:
Eric E Nilsson et al, Multiple generation distinct toxicant exposures induce epigenetic transgenerational inheritance of enhanced pathology and obesity, Environmental Epigenetics (2023). DOI: 10.1093/eep/dvad006

Citation:
Multi-generational toxicant exposures show cumulative, inherited health effects (2024, January 23)
retrieved 23 January 2024
from https://medicalxpress.com/news/2024-01-multi-generational-toxicant-exposures-cumulative.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2024-01-multi-generational-toxicant-exposures-cumulative.html

Tags: healthMulti-generationaltoxicant
Previous Post

2009 update to WIC cost-effective for reducing childhood obesity

Next Post

Detention fails to help young lawbreakers avoid further offenses, report shows

Frans and Liu receive outstanding paper in landscape ecology award – Michigan State University

Frans and Liu receive outstanding paper in landscape ecology award – Michigan State University

June 2, 2025
‘Amazing Worlds of Science Fiction and Science Fact’ Review: An Education in Exoplanets – WSJ

Exploring the Fascinating Realms of Science Fiction and Fact: A Journey Through Exoplanets

June 2, 2025
2-Year-Old Prodigy Joins ‘High IQ’ Club Mensa as Youngest Member Ever – ScienceAlert

Meet the 2-Year-Old Prodigy Who Just Became Mensa’s Youngest Member Ever!

June 2, 2025
Labubu Fever Ignites a Global Craze for Lifestyle and Investment – iChongqing

Labubu Fever Ignites a Global Craze for Lifestyle and Investment – iChongqing

June 2, 2025
Erin Hills ‘dominates’ Nelly Korda at U.S. Women’s Open, where she finished second – Golfweek

Nelly Korda Falls Short at U.S. Women’s Open as Erin Hills Takes Center Stage

June 2, 2025
Economy Shrank Less Than Previously Thought in First Quarter – Investopedia

Economy Shrank Less Than Previously Thought in First Quarter – Investopedia

June 2, 2025
Rising stars: Young classical musicians surging on social media – Yahoo

Meet the Next Generation of Classical Music Sensations Making Waves on Social Media!

June 2, 2025
Medicaid work rules could leave a million Californians with no health insurance – CalMatters

California’s Medicaid Work Rules: A Million Residents at Risk of Losing Health Coverage!

June 2, 2025
Texas Democrat Beto O’Rourke returns to Houston area for another town hall – Houston Public Media

Beto O’Rourke Makes a Comeback: Join Him for an Engaging Town Hall in Houston!

June 2, 2025
In Indore, Alstom’s advanced metro train and CBTC signalling technology transform urban mobility as revenue service commences – Alstom

Revolutionizing Urban Mobility: Alstom Launches Advanced Metro Train and Cutting-Edge Signalling Technology in Indore

June 2, 2025

Categories

Archives

June 2025
MTWTFSS
 1
2345678
9101112131415
16171819202122
23242526272829
30 
« May    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (659)
  • Economy (673)
  • Entertainment (21,580)
  • General (15,256)
  • Health (9,716)
  • Lifestyle (676)
  • News (22,149)
  • People (675)
  • Politics (682)
  • Science (15,894)
  • Sports (21,178)
  • Technology (15,660)
  • World (661)

Recent News

Frans and Liu receive outstanding paper in landscape ecology award – Michigan State University

Frans and Liu receive outstanding paper in landscape ecology award – Michigan State University

June 2, 2025
‘Amazing Worlds of Science Fiction and Science Fact’ Review: An Education in Exoplanets – WSJ

Exploring the Fascinating Realms of Science Fiction and Fact: A Journey Through Exoplanets

June 2, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version