* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Friday, June 13, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Op-Ed: Data Storage and Protection in Today’s Media & Entertainment Industry – Sports Video Group

    How Data Storage and Protection Are Transforming the Media & Entertainment Industry

    The Analyst Verdict: PENN Entertainment In The Eyes Of 7 Experts – Nasdaq

    7 Experts Reveal the Ultimate Verdict on PENN Entertainment

    3 Arts Entertainment Expands Into News With Acquisition of OManagement (Exclusive) – The Hollywood Reporter

    3 Arts Entertainment Expands Into News With Acquisition of OManagement (Exclusive) – The Hollywood Reporter

    Leading Proxy Advisory Firm Glass Lewis Recommends Shareholders Vote “FOR” Both of PENN Entertainment’s Director Nominees on the WHITE Proxy Card – Business Wire

    Glass Lewis Urges Shareholders to Support All PENN Entertainment Director Nominees on the WHITE Proxy Card

    Cisco Partners with Monumental Sports & Entertainment to Power New D.C. Arena – Cisco Newsroom

    Cisco Teams Up with Monumental Sports & Entertainment to Revolutionize the New D.C. Arena Experience

    Middle Eastern Entertainment Headlines at 5:49 a.m. GMT – Yahoo

    Exciting Updates from the Middle Eastern Entertainment Scene!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Rimac Technology Powers the Bugatti Tourbillon with Cutting-Edge Battery and Powertrain Tech – Rimac Newsroom

    Rimac Technology Drives the Bugatti Tourbillon with Revolutionary Battery and Powertrain Innovation

    “Co-creation” boosts commercial technology for dual-use defense applications – Breaking Defense

    “Co-creation” boosts commercial technology for dual-use defense applications – Breaking Defense

    MSI Viking and Mahr Host Technology Day – WSPA 7NEWS

    Step Inside the Thrilling World of MSI Viking and Mahr Technology Day!

    6.12pm is the new 8pm – Go Technology – cgastrategy.com

    6.12pm is the new 8pm – Go Technology – cgastrategy.com

    Russian Scientists Develop Sub-Ångström Technology for Next-Gen Quantum Processors – The Quantum Insider

    Russian Scientists Pioneer Sub-Ångström Technology to Revolutionize Next-Gen Quantum Processors

    Study uncovers SiPore Technology’s capacity to regulate blood glucose levels – Nutraceutical Business Review

    Study uncovers SiPore Technology’s capacity to regulate blood glucose levels – Nutraceutical Business Review

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Op-Ed: Data Storage and Protection in Today’s Media & Entertainment Industry – Sports Video Group

    How Data Storage and Protection Are Transforming the Media & Entertainment Industry

    The Analyst Verdict: PENN Entertainment In The Eyes Of 7 Experts – Nasdaq

    7 Experts Reveal the Ultimate Verdict on PENN Entertainment

    3 Arts Entertainment Expands Into News With Acquisition of OManagement (Exclusive) – The Hollywood Reporter

    3 Arts Entertainment Expands Into News With Acquisition of OManagement (Exclusive) – The Hollywood Reporter

    Leading Proxy Advisory Firm Glass Lewis Recommends Shareholders Vote “FOR” Both of PENN Entertainment’s Director Nominees on the WHITE Proxy Card – Business Wire

    Glass Lewis Urges Shareholders to Support All PENN Entertainment Director Nominees on the WHITE Proxy Card

    Cisco Partners with Monumental Sports & Entertainment to Power New D.C. Arena – Cisco Newsroom

    Cisco Teams Up with Monumental Sports & Entertainment to Revolutionize the New D.C. Arena Experience

    Middle Eastern Entertainment Headlines at 5:49 a.m. GMT – Yahoo

    Exciting Updates from the Middle Eastern Entertainment Scene!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Rimac Technology Powers the Bugatti Tourbillon with Cutting-Edge Battery and Powertrain Tech – Rimac Newsroom

    Rimac Technology Drives the Bugatti Tourbillon with Revolutionary Battery and Powertrain Innovation

    “Co-creation” boosts commercial technology for dual-use defense applications – Breaking Defense

    “Co-creation” boosts commercial technology for dual-use defense applications – Breaking Defense

    MSI Viking and Mahr Host Technology Day – WSPA 7NEWS

    Step Inside the Thrilling World of MSI Viking and Mahr Technology Day!

    6.12pm is the new 8pm – Go Technology – cgastrategy.com

    6.12pm is the new 8pm – Go Technology – cgastrategy.com

    Russian Scientists Develop Sub-Ångström Technology for Next-Gen Quantum Processors – The Quantum Insider

    Russian Scientists Pioneer Sub-Ångström Technology to Revolutionize Next-Gen Quantum Processors

    Study uncovers SiPore Technology’s capacity to regulate blood glucose levels – Nutraceutical Business Review

    Study uncovers SiPore Technology’s capacity to regulate blood glucose levels – Nutraceutical Business Review

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Neoadjuvant Chemo-IO Promising in Borderline Resectable Pancreatic Cancer

April 11, 2024
in Health
Neoadjuvant Chemo-IO Promising in Borderline Resectable Pancreatic Cancer
Share on FacebookShare on Twitter

SAN DIEGO — A preoperative combination of chemotherapy and immunotherapy (IO) appeared safe and effective for borderline resectable pancreatic cancer in a small pilot study, a researcher reported here.

In the phase I/II trial, neoadjuvant treatment with modified FOLFIRINOX (5-fluorouracil with leucovorin, irinotecan, and oxaliplatin) plus nivolumab (Opdivo) was associated with favorable rates of R0 resection, along with a median progression-free survival of 21.9 months and median overall survival (OS) of 34.6 months, with longer survival for those who successfully went on to surgery, according to Zev Wainberg, MD, of the University of California Los Angeles School of Medicine.

Prior studies of chemotherapy/IO in the metastatic setting have largely failed, he noted, but the current results support ongoing investigations in less-advanced disease.

“Instead of exclusively studying it in metastatic disease, we need to be studying these drugs earlier on in both borderline and locally advanced disease to understand the impact of these drugs on tumor biology,” said Wainberg at the annual meeting of the American Association for Cancer Research (AACR).

The 28 patients in this study received modified FOLFIRINOX plus the PD-1 checkpoint inhibitor nivolumab for 3 to 6 months. If, after 3 months, patients were downstaged to resectable disease, they were eligible for an attempt at R0 resection. If not, they continued treatment for another 3 months.

Of the 28 patients, 22 underwent surgery (79%) — 21 achieving R0 resections and one achieving an R1. Surgery resulted in two pathologic complete responses, two near complete responses, and 15 partial responses.

Patients with borderline resectable cancer account for about 20% of pancreatic cancer patients. These are patients with tumors that are considered to be resectable — with or without vascular reconstruction — but are at high risk for positive margins. Achieving an R0 (negative margin) resection, rather than an R1 resection (where microscopically margins still demonstrate the presence of tumor), is critical as that is associated with longer survival, Wainberg noted.

“The quick time for an R0 resection is very important for this disease because that has been associated with prognosis, but part of the challenge is how to introduce these drugs in the neoadjuvant space, because adjuvant chemo and adjuvant treatment — generally speaking — for pancreatic cancer is very difficult,” he said. “Trying to move drugs up front is what we are getting at, and in that respect we were very pleased with the progression-free and overall survival outcomes.”

AACR session moderator Alice Ho, MD, of Duke University Medical Center in Durham, North Carolina, said the 79% resection rate “sounds pretty stunning.”

Wainberg noted that the Alliance A021501 study suggested R0 resection rates of about 70-75% with chemotherapy, but added that what he and his team were trying to accomplish in the current study was to use neoadjuvant therapy to reduce recurrences as well.

Study participants in the phase I/II trial had a median age of 67.5 years, and 57% were male. Baseline ECOG Performance Status score was 0 in 61% of people (indicating full activity) and 1 in the remaining 39% (restricted in physically strenuous activity but otherwise ambulatory). Patients completed a median 5.5 cycles of treatment, and median follow-up for survival outcomes was 25.6 months.

The primary endpoint was safety and secondary endpoints included resection rates and survival endpoints.

Survival was longer for those who had surgery, with Kaplan-Meier estimates of 27.3 months for progression-free survival and 44 months for OS. Overall, the 12- and 18-month OS rates were 82% and 77%, respectively, “higher than historical controls,” Wainberg observed.

The Alliance trial, which established preoperative modified FOLFIRINOX (without radiation) as the reference regimen for the current study, had an 18-month OS rate of 66.7% and a median OS of 29.8 months.

Regarding safety, half of the patients in the study had grade ≥3 adverse events, all which were exclusively attributed to chemotherapy. Importantly, he added that there were no grade 2 postoperative fistulas — a concern after pancreatic cancer resection — and no postoperative complications.

author['full_name']

Mike Bassett is a staff writer focusing on oncology and hematology. He is based in Massachusetts.

Disclosures

Wainberg reported relationships with Bristol Myers Squibb, Amgen, AstraZeneca, Arcus, Merck, Daiichi Sankyo, Astellas, Novartis, Pfizer, Eli Lilly, and Seagen.

Primary Source

American Association for Cancer Research

Source Reference: Wainberg Z, et al “A pilot clinical trial of neoadjuvant modified FOLFIRINOX plus nivolumab in borderline resectable pancreas cancer” AACR 2024; Abstract CT031.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/meetingcoverage/aacr/109610

Tags: Chemo-IOhealthNeoadjuvant
Previous Post

Study Assuages Thyroid Cancer Fears With GLP-1 Receptor Agonists

Next Post

Cypago Announces New Automation Support for AI Security and Governance

How madagascar’s lizards became the island’s last hope for reforestation – ScienceDaily

How Madagascar’s Lizards Became the Island’s Unexpected Heroes of Reforestation

June 13, 2025
This is the science behind protecting Minnesota’s native orchids – Detroit Lakes Tribune

The Science Behind Protecting Minnesota’s Rare Native Orchids

June 13, 2025
IBM plans to build first-of-its-kind quantum computer by 2029 after ‘solving key bottleneck’ – Live Science

IBM plans to build first-of-its-kind quantum computer by 2029 after ‘solving key bottleneck’ – Live Science

June 13, 2025
Aging: Healthy habits could offset stroke, dementia, depression risk – Medical News Today

Aging Gracefully: How Healthy Habits Can Reduce Your Risk of Stroke, Dementia, and Depression

June 13, 2025
With the 2026 World Cup one year away, the USMNT can’t seem to win a game – CNN

With the 2026 World Cup Just a Year Away, USMNT Struggles to Secure a Win

June 13, 2025
German economy to grow 0.3% in 2025, DIW Berlin raises forecast – Investing.com

German economy to grow 0.3% in 2025, DIW Berlin raises forecast – Investing.com

June 13, 2025

Texas Public Health Departments Brace for Challenges Amid $119 Million Federal Funding Cut

June 13, 2025
Trump didn’t want Israel to strike. They did it anyway. – CNN

Trump didn’t want Israel to strike. They did it anyway. – CNN

June 13, 2025
Rimac Technology Powers the Bugatti Tourbillon with Cutting-Edge Battery and Powertrain Tech – Rimac Newsroom

Rimac Technology Drives the Bugatti Tourbillon with Revolutionary Battery and Powertrain Innovation

June 13, 2025
CWS 2025: Sports on 6 goes 1-on-1 with ESPN’s Kyle Peterson ahead of CWS – WOWT

CWS 2025: Sports on 6 goes 1-on-1 with ESPN’s Kyle Peterson ahead of CWS – WOWT

June 13, 2025

Categories

Archives

June 2025
MTWTFSS
 1
2345678
9101112131415
16171819202122
23242526272829
30 
« May    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (684)
  • Economy (699)
  • Entertainment (21,601)
  • General (15,364)
  • Health (9,740)
  • Lifestyle (703)
  • News (22,149)
  • People (700)
  • Politics (706)
  • Science (15,916)
  • Sports (21,200)
  • Technology (15,685)
  • World (682)

Recent News

How madagascar’s lizards became the island’s last hope for reforestation – ScienceDaily

How Madagascar’s Lizards Became the Island’s Unexpected Heroes of Reforestation

June 13, 2025
This is the science behind protecting Minnesota’s native orchids – Detroit Lakes Tribune

The Science Behind Protecting Minnesota’s Rare Native Orchids

June 13, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version