* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Wednesday, October 22, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Sacramento city leaders approve adding 2 entertainment zones in midtown – CBS News

    Sacramento City Leaders Approve Two Thrilling New Entertainment Zones in Midtown

    AMC brings first new Dolby Experience to Gwinnett since 2017 – Wyoming News Now

    AMC Launches First New Dolby Experience in Gwinnett Since 2017

    Hetzel Design: blending architecture and entertainment – Blooloop

    Hetzel Design: Where Architecture and Entertainment Unite in Perfect Harmony

    Country music legend rushed to hospital year after heart surgery. Here’s what we know – PennLive.com

    Country Music Legend Rushed to Hospital One Year After Heart Surgery – What’s Happening Now?

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Placer County town of Loomis considers entertainment zone for downtown – CBS News

    Loomis Unveils Thrilling New Entertainment Zone to Revitalize Downtown

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 Technology Stocks to Buy Now – Yahoo Finance

    3 Must-Buy Tech Stocks You Can’t Afford to Miss Right Now

    ‘New frontier’: Austin leaders start discussions on air taxi technology – KXAN Austin

    Austin Leaders Ignite Exciting Conversations on the Future of Air Taxi Technology

    How a Gemma model helped discover a new potential cancer therapy pathway – blog.google

    How a Gemma Model Revealed a Breakthrough Pathway for Cancer Treatment

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Sacramento city leaders approve adding 2 entertainment zones in midtown – CBS News

    Sacramento City Leaders Approve Two Thrilling New Entertainment Zones in Midtown

    AMC brings first new Dolby Experience to Gwinnett since 2017 – Wyoming News Now

    AMC Launches First New Dolby Experience in Gwinnett Since 2017

    Hetzel Design: blending architecture and entertainment – Blooloop

    Hetzel Design: Where Architecture and Entertainment Unite in Perfect Harmony

    Country music legend rushed to hospital year after heart surgery. Here’s what we know – PennLive.com

    Country Music Legend Rushed to Hospital One Year After Heart Surgery – What’s Happening Now?

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Placer County town of Loomis considers entertainment zone for downtown – CBS News

    Loomis Unveils Thrilling New Entertainment Zone to Revitalize Downtown

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 Technology Stocks to Buy Now – Yahoo Finance

    3 Must-Buy Tech Stocks You Can’t Afford to Miss Right Now

    ‘New frontier’: Austin leaders start discussions on air taxi technology – KXAN Austin

    Austin Leaders Ignite Exciting Conversations on the Future of Air Taxi Technology

    How a Gemma model helped discover a new potential cancer therapy pathway – blog.google

    How a Gemma Model Revealed a Breakthrough Pathway for Cancer Treatment

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

New ‘atherosclerosis atlas’ sheds light on heart attacks, strokes

December 12, 2023
in Health
New ‘atherosclerosis atlas’ sheds light on heart attacks, strokes
Share on FacebookShare on Twitter

New 'atherosclerosis atlas' sheds light on heart attacks, strokes

Graphical Abstract. Credit: Cell Reports (2023). DOI: 10.1016/j.celrep.2023.113380

University of Virginia School of Medicine researchers have created an “atlas of atherosclerosis” that reveals, at the level of individual cells, critical processes responsible for forming the harmful plaque buildup that causes heart attacks, strokes, and coronary artery disease.

Atherosclerosis, or hardening of the arteries, affects half of Americans between ages 45 and 84, and many don’t even know it, the National Institutes of Health reports. Over time, fatty plaques build up inside the arteries, where they can slow blood flow. When they break loose, they can be deadly, triggering strokes and heart attacks.

Doctors and scientists have been eager to better understand the complex factors that influence the formation and stability of the plaques, and UVA’s new work offers unprecedented insights that will facilitate the development of new ways to treat atherosclerosis, battle coronary artery disease (CAD), and help prevent plaque formation.

“To begin to develop effective treatments targeting specific disease processes in the vessel wall, we need to characterize gene expression programs at single-cell resolution,” said researcher Clint L. Miller, Ph.D., of the University of Virginia School of Medicine’s Center for Public Health Genomics, as well as its Departments of Biochemistry and Molecular Genetics and Public Health Sciences.

“By establishing this map, we can inform strategies to reprogram dysregulated cell states in order to prevent or reverse the disease or identify biomarkers to assess a patient’s risk of having clinical events.”

Understanding atherosclerosis

The formation of atherosclerotic plaques involves multiple types of cells, including immune cells, smooth muscle cells, and endothelial cells that line the arteries. Many of these cells transition into other types of cells during plaque formation, making it a huge challenge for scientists to determine the composition and origin of the plaque itself.

Miller and his collaborators, led by graduate student Jose Verdezoto Mosquera, have built a “comprehensive single-cell map of human atherosclerosis” encompassing almost 120,000 cells from atherosclerotic coronary and carotid arteries. In addition to charting broad cell lineages, the researchers leveraged this resource to dissect more granular and rare cell subtypes within atherosclerotic plaques.

The study also reveals new insights on the changes smooth muscle cells go through during disease progression, some of which contribute to the “calcification,” or hardening, of the coronary arteries. This led to the finding that two genes, LTBP1 and CRTAC1, can serve as measures for the progression of atherosclerosis.

“Beyond characterizing cell diversity, integrating this newly built atherosclerosis single-cell reference with large-scale human genetic data was critical to start identifying disease-causing cell types and subtypes,” Mosquera said. “For example, we identified the contribution of smooth muscle cell subtypes, such as fibroblast-like and lipid-rich smooth muscle cells, as well as the genes associated with these phenotypes.”

The UVA researchers say their new atlas represents a “critical step” toward developing better, more targeted interventions to battle atherosclerosis and CAD, as well as identify candidate biomarkers to prevent heart attacks and strokes and improve patient outcomes.

“We plan to extend this single-cell atlas with future iterations to include additional datasets from defined disease stages and patients from diverse backgrounds,” Miller said. “By integrating the corpus of single-cell data generated in the scientific community, we can mitigate sampling bias and establish more robust candidate disease mechanisms and potential interventions.”

The researchers have published their findings in the journal Cell Reports.

More information:
Jose Verdezoto Mosquera et al, Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis, Cell Reports (2023). DOI: 10.1016/j.celrep.2023.113380

Citation:
New ‘atherosclerosis atlas’ sheds light on heart attacks, strokes (2023, December 12)
retrieved 12 December 2023
from https://medicalxpress.com/news/2023-12-atherosclerosis-atlas-heart.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2023-12-atherosclerosis-atlas-heart.html

Tags: 'atherosclerosisATLAShealth
Previous Post

Caring for LGBTQ+ nursing home residents in culturally appropriate and inclusive ways

Next Post

How to watch BBC iPlayer from the U.S. and abroad on iPhone, iPad, or Mac

Forbes Unveils First-Ever “Most Powerful Women In Sports” List, Featuring 25 Of The Trailblazers Transforming The Industry, Including Gayle Benson, Caitlin Clark, Michele Kang, Serena Williams And More – Forbes

Meet the 25 Trailblazing Women Revolutionizing the World of Sports, Featuring Gayle Benson, Caitlin Clark, Michele Kang, Serena Williams and More

October 22, 2025
Grandmaster Daniel Naroditsky remembered for his impact on the chess world – NPR

Grandmaster Daniel Naroditsky: Honoring a Timeless Chess Legacy

October 22, 2025
Seattle’s Creative Economy: Building Talent, Culture, and Community – GeekWire

Seattle’s Creative Economy: How Talent, Culture, and Community Are Shaping the Future

October 22, 2025
Sacramento city leaders approve adding 2 entertainment zones in midtown – CBS News

Sacramento City Leaders Approve Two Thrilling New Entertainment Zones in Midtown

October 22, 2025
Self-efficacy mediates the effect of hope on health promotion intention in Chinese stroke patients – Nature

How Hope Boosts Health Motivation in Chinese Stroke Patients Through Self-Efficacy

October 22, 2025
Arizona AG sues to force House Speaker Johnson to seat Democrat Adelita Grijalva – NBC News

Arizona AG sues to force House Speaker Johnson to seat Democrat Adelita Grijalva – NBC News

October 22, 2025
Historic achievement: Governor Ferguson, Ecology celebrate nuclear waste officially being turned into glass at Hanford Site | Governor Bob Ferguson – Governor Ferguson (.gov)

Historic Breakthrough: Governor Ferguson and Ecology Celebrate Nuclear Waste Transformed into Glass at Hanford Site

October 22, 2025
Transcript: Mission to Mars — Bad science fiction – Financial Times

Mission to Mars: When Science Fiction Takes a Dark Turn

October 22, 2025
Science Hill, South Greene volleyball win TSSAA state tournament openers – WCYB

Science Hill and South Greene Dominate Opening Matches in TSSAA State Volleyball Tournament

October 22, 2025
GCC Influencer Market Jumps 75% As Lifestyle Creators Lead Growth – Net Influencer

GCC Influencer Market Soars 75% Fueled by Lifestyle Creators Leading the Boom

October 22, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (880)
  • Economy (902)
  • Entertainment (21,773)
  • General (17,741)
  • Health (9,943)
  • Lifestyle (914)
  • News (22,149)
  • People (902)
  • Politics (912)
  • Science (16,112)
  • Sports (21,402)
  • Technology (15,881)
  • World (885)

Recent News

Forbes Unveils First-Ever “Most Powerful Women In Sports” List, Featuring 25 Of The Trailblazers Transforming The Industry, Including Gayle Benson, Caitlin Clark, Michele Kang, Serena Williams And More – Forbes

Meet the 25 Trailblazing Women Revolutionizing the World of Sports, Featuring Gayle Benson, Caitlin Clark, Michele Kang, Serena Williams and More

October 22, 2025
Grandmaster Daniel Naroditsky remembered for his impact on the chess world – NPR

Grandmaster Daniel Naroditsky: Honoring a Timeless Chess Legacy

October 22, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version