* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Saturday, October 4, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Al Roker Gives Olivia Dean an Unexpected ‘New Job’ on the ‘Today’ Show – Yahoo

    Al Roker Shocks Olivia Dean with an Exciting New Role on the ‘Today’ Show

    Books about the arts and some haunts for a Denton October – Denton Record-Chronicle

    Uncover Artistic Treasures and Spooky Adventures to Experience in Denton This October

    Taylor Swift Releases New Album The Life of a Showgirl : Listen and Read the Full Credits – Yahoo

    Taylor Swift Releases New Album The Life of a Showgirl : Listen and Read the Full Credits – Yahoo

    Toni Braxton Is Turning Her Biggest Hits Into Lifetime Movies – Yahoo

    Toni Braxton Is Turning Her Biggest Hits Into Lifetime Movies – Yahoo

    Major airline to offer new in-flight entertainment options for passengers – PennLive.com

    Major airline to offer new in-flight entertainment options for passengers – PennLive.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    A Tech Expo Shows What China Can Make, but Not Who’ll Buy It All – The New York Times

    Inside China’s Tech Expo: Cutting-Edge Innovations Face Uncertain Demand

    Steampunk Metal Oval Technology Sense Sunglasses Personality Handmade Chain Multicolor Sunglasses UV400 – The San Joaquin Valley Sun

    Steampunk Metal Oval Sunglasses with Handmade Multicolor Chain – Bold UV400 Protection and Unique Style

    STELLA Automotive AI Appoints Fred Seidelman as Chief Technology Officer – Yahoo Finance

    STELLA Automotive AI Appoints Fred Seidelman as New Chief Technology Officer

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Al Roker Gives Olivia Dean an Unexpected ‘New Job’ on the ‘Today’ Show – Yahoo

    Al Roker Shocks Olivia Dean with an Exciting New Role on the ‘Today’ Show

    Books about the arts and some haunts for a Denton October – Denton Record-Chronicle

    Uncover Artistic Treasures and Spooky Adventures to Experience in Denton This October

    Taylor Swift Releases New Album The Life of a Showgirl : Listen and Read the Full Credits – Yahoo

    Taylor Swift Releases New Album The Life of a Showgirl : Listen and Read the Full Credits – Yahoo

    Toni Braxton Is Turning Her Biggest Hits Into Lifetime Movies – Yahoo

    Toni Braxton Is Turning Her Biggest Hits Into Lifetime Movies – Yahoo

    Major airline to offer new in-flight entertainment options for passengers – PennLive.com

    Major airline to offer new in-flight entertainment options for passengers – PennLive.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    A Tech Expo Shows What China Can Make, but Not Who’ll Buy It All – The New York Times

    Inside China’s Tech Expo: Cutting-Edge Innovations Face Uncertain Demand

    Steampunk Metal Oval Technology Sense Sunglasses Personality Handmade Chain Multicolor Sunglasses UV400 – The San Joaquin Valley Sun

    Steampunk Metal Oval Sunglasses with Handmade Multicolor Chain – Bold UV400 Protection and Unique Style

    STELLA Automotive AI Appoints Fred Seidelman as Chief Technology Officer – Yahoo Finance

    STELLA Automotive AI Appoints Fred Seidelman as New Chief Technology Officer

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

New biomarker shows potential to evaluate treatment response for metastatic colorectal cancer

July 15, 2024
in Health
New biomarker shows potential to evaluate treatment response for metastatic colorectal cancer
Share on FacebookShare on Twitter

A new biomarker shows potential to evaluate treatment response for metastatic colorectal cancer

Graphical abstract. Credit: Biomedicine & Pharmacotherapy (2024). DOI: 10.1016/j.biopha.2024.116857

Colorectal cancer is the second leading cause of cancer deaths worldwide and the third most diagnosed cancer, affecting over a million people annually. The problem worsens if the tumor is metastatic, meaning it moves from the original organ to other parts of the body. In this scenario, the five-year survival rate drops from 70–90% to just 10%.

While some subgroups of colorectal cancer patients are beginning to have new therapeutic options, the vast majority of metastatic patients still follow conventional treatments, typically involving chemotherapy with biological agents. Initially effective, these treatments often encounter resistance over time, leading to inevitable disease progression.

Proteins with potential to measure treatment response

Researchers at the Can Ruti Campus, collaborating through the CARE and ProCURE programs of IGTP and Institut Català d’Oncologia (ICO) respectively, have been searching for reliable biomarkers for years to select the best therapeutic option for each patient. Their research has led them to study chemokines, small proteins secreted by tumor cells that attract other cells from the immune system.

They focused on the CXC family, which plays an important role in pathological processes in cancer by modifying the tumor microenvironment. Previous results in cell models indicate that high secretion of these proteins is associated with resistance to oxaliplatin, one of the most used chemotherapies in this neoplasm.

Thus, the authors of the study published in Biomedicine & Pharmacotherapy analyzed the blood of 104 patients with metastatic colorectal cancer undergoing oxaliplatin-based treatment. They collected serum samples before treatment, during response evaluation, and at disease progression or the last follow-up visit, and analyzed possible changes and their relationship with treatment response and prognosis.

This approach with blood samples is more comprehensive than other methods that only analyze part of a lesion. Additionally, it is a non-invasive and time-specific sample extraction method.

The chemokine CXCL13 shows promising results

The study examined 11 CXC chemokines. The researchers observed that first-line oxaliplatin-based treatment causes changes in the levels of these proteins. One of them, CXCL13, stands out because it shows a different behavior: increasing levels are associated with a positive treatment response and improved survival, while a decrease is associated with non-response and poorer prognosis.

Dr. Eva Martínez Balibrea, leader of the Resistance, Chemotherapy, and Predictive Biomarkers (RCPB) group at IGTP and ICO, explains the significance of this finding, “CXCL13 is an opportunity to measure the response to oxaliplatin chemotherapy in a minimally invasive way using simple techniques that can be used by any clinical laboratory.”

She adds, “This is the first study to show a correlation between serum CXCL13 and prognosis in patients with colorectal cancer treated with oxaliplatin.” It is important to note that oxaliplatin is quite toxic, often causing patients to abandon treatment:

“Having a tool that allows us to choose the treatment will also help avoid unnecessary toxicities and improve the quality of life for patients.”

The authors obtained comparable results using computational data from a similar patient group. In this other analysis, they also observed the correlation between CXCL13, the presence of tertiary lymphoid structures—aggregates of immune cells formed in chronic inflammation sites, including tumors—and the correlation of both with prognosis.

Martínez-Balibrea is cautious considering it is a study in a specific cohort of patients, but she is optimistic about the future and says, “We are making progress in the search for predictive and prognostic markers. Finding a potential biomarker with non-invasively extracted samples is great news. We will continue this line of research in future studies.”

More information:
Sara Cabrero-de las Heras et al, Changes In Serum CXCL13 Levels Are Associated With Outcomes of Colorectal Cancer Patients Undergoing First-Line Oxaliplatin-Based Treatment, Biomedicine & Pharmacotherapy (2024). DOI: 10.1016/j.biopha.2024.116857

Provided by
Germans Trias i Pujol Research Institute

Citation:
New biomarker shows potential to evaluate treatment response for metastatic colorectal cancer (2024, July 15)
retrieved 15 July 2024
from https://medicalxpress.com/news/2024-07-biomarker-potential-treatment-response-metastatic.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2024-07-biomarker-potential-treatment-response-metastatic.html

Tags: Biomarkerhealthshows
Previous Post

Atomic force microscopy in the characterization and clinical evaluation of neurological disorders

Next Post

Exploring the pathogenesis of autoimmune liver diseases from the heterogeneity of target cells

How the gathering of Israel is accelerating around the world – Church News

The Global Gathering of Israel: How It’s Accelerating Like Never Before

October 4, 2025
United States Economic Forecast Q3 2025 – Deloitte

United States Economic Forecast Q3 2025 – Deloitte

October 4, 2025
Al Roker Gives Olivia Dean an Unexpected ‘New Job’ on the ‘Today’ Show – Yahoo

Al Roker Shocks Olivia Dean with an Exciting New Role on the ‘Today’ Show

October 4, 2025
Holding Commercial Health Insurers Accountable – American Hospital Association

Holding Commercial Health Insurers Accountable – American Hospital Association

October 4, 2025
Inside Iowa Politics: Ian Roberts deceived Des Moines School Board, chair says – KTIV

Inside Iowa Politics: Ian Roberts deceived Des Moines School Board, chair says – KTIV

October 4, 2025
‘This is unprecedented:’ Ecology restricts surface water use in the Yakima River Basin – Yakima Herald-Republic

Unprecedented Move: Ecology Imposes New Restrictions on Yakima River Basin Surface Water Use

October 4, 2025
Roane State, TCAT Knoxville mark milestone at new health science campus – Oakridger

Roane State and TCAT Knoxville Celebrate Major Milestone at New Health Science Campus

October 4, 2025
Science Hill blanks Morristown East – Johnson City Press

Science Hill Cruises to a Commanding Shutout Over Morristown East

October 4, 2025
Favorite Halloween candies in Missouri, Oklahoma, Kansas, Arkansas – Yahoo

Discover the Most Beloved Halloween Candies in Missouri, Oklahoma, Kansas, and Arkansas!

October 4, 2025
MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

October 4, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (850)
  • Economy (871)
  • Entertainment (21,745)
  • General (17,402)
  • Health (9,914)
  • Lifestyle (883)
  • News (22,149)
  • People (872)
  • Politics (882)
  • Science (16,081)
  • Sports (21,371)
  • Technology (15,853)
  • World (854)

Recent News

How the gathering of Israel is accelerating around the world – Church News

The Global Gathering of Israel: How It’s Accelerating Like Never Before

October 4, 2025
United States Economic Forecast Q3 2025 – Deloitte

United States Economic Forecast Q3 2025 – Deloitte

October 4, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version