* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Sunday, June 8, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Ceramic Dalmatian Entertainment is WLAF’s Business of the Week – WLAF

    Spotlight on Success: Ceramic Dalmatian Entertainment Shines as This Week’s Featured Business!

    Brass Lion Entertainment unveils co-op action RPG Wu-Tang: Rise of the Deceiver – VentureBeat

    Unleash Your Inner Warrior: Discover the Co-Op Action RPG Wu-Tang: Rise of the Deceiver!

    Entertainment lineup released for 2025 Mississippi State Fair – WAPT

    Exciting Entertainment Lineup Unveiled for the 2025 Mississippi State Fair!

    After Denzel Washington Said He Would Be In Black Panther 3, Ryan Coogler Explained Why He’s ‘Fine’ With That Information Being Revealed So Early – Yahoo

    Ryan Coogler Shares Why He’s Cool with Denzel Washington’s Black Panther 3 Reveal!

    Traveling Tacos and Tequila Festival to stop at Florence Yall’s stadium this October – Cincinnati Enquirer

    Get Ready for a Flavor Fiesta: Traveling Tacos and Tequila Festival Hits Florence Y’all’s Stadium This October!

    9 things to do this weekend in Lake County plus a look ahead – Leesburg Daily Commercial

    Discover 9 Exciting Weekend Adventures in Lake County and What’s Coming Up!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Drag racer survives frightening airborne crash at World Wide Technology Raceway – FOX 2

    Drag racer survives frightening airborne crash at World Wide Technology Raceway – FOX 2

    Apple Watch and the future of wearable technology in healthcare – MSN

    Revolutionizing Healthcare: The Future of Wearable Technology with Apple Watch

    ECS Professor Pankaj K. Jha Receives NSF Grant to Develop Quantum Technology – Syracuse University News

    Unlocking the Future: ECS Professor Pankaj K. Jha Secures NSF Grant for Groundbreaking Quantum Technology Development

    Fire Tech Brief: 5 Fire Apparatus Technology Upgrades – firehouse.com

    Revving Up Safety: 5 Innovative Upgrades for Fire Apparatus Technology

    U.S. FDA Grants Platform Technology Designation to the Viral Vector Used in SRP-9003, Sarepta’s Investigational Gene Therapy for the Treatment of Limb Girdle Muscular Dystrophy Type 2E/R4 – Sarepta Therapeutics

    Breakthrough for Gene Therapy: FDA Designates Viral Vector in Sarepta’s SRP-9003 for Limb Girdle Muscular Dystrophy Treatment

    Waunakee Fifth-Graders Dive into the Future at Exciting Tech Day!

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Ceramic Dalmatian Entertainment is WLAF’s Business of the Week – WLAF

    Spotlight on Success: Ceramic Dalmatian Entertainment Shines as This Week’s Featured Business!

    Brass Lion Entertainment unveils co-op action RPG Wu-Tang: Rise of the Deceiver – VentureBeat

    Unleash Your Inner Warrior: Discover the Co-Op Action RPG Wu-Tang: Rise of the Deceiver!

    Entertainment lineup released for 2025 Mississippi State Fair – WAPT

    Exciting Entertainment Lineup Unveiled for the 2025 Mississippi State Fair!

    After Denzel Washington Said He Would Be In Black Panther 3, Ryan Coogler Explained Why He’s ‘Fine’ With That Information Being Revealed So Early – Yahoo

    Ryan Coogler Shares Why He’s Cool with Denzel Washington’s Black Panther 3 Reveal!

    Traveling Tacos and Tequila Festival to stop at Florence Yall’s stadium this October – Cincinnati Enquirer

    Get Ready for a Flavor Fiesta: Traveling Tacos and Tequila Festival Hits Florence Y’all’s Stadium This October!

    9 things to do this weekend in Lake County plus a look ahead – Leesburg Daily Commercial

    Discover 9 Exciting Weekend Adventures in Lake County and What’s Coming Up!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Drag racer survives frightening airborne crash at World Wide Technology Raceway – FOX 2

    Drag racer survives frightening airborne crash at World Wide Technology Raceway – FOX 2

    Apple Watch and the future of wearable technology in healthcare – MSN

    Revolutionizing Healthcare: The Future of Wearable Technology with Apple Watch

    ECS Professor Pankaj K. Jha Receives NSF Grant to Develop Quantum Technology – Syracuse University News

    Unlocking the Future: ECS Professor Pankaj K. Jha Secures NSF Grant for Groundbreaking Quantum Technology Development

    Fire Tech Brief: 5 Fire Apparatus Technology Upgrades – firehouse.com

    Revving Up Safety: 5 Innovative Upgrades for Fire Apparatus Technology

    U.S. FDA Grants Platform Technology Designation to the Viral Vector Used in SRP-9003, Sarepta’s Investigational Gene Therapy for the Treatment of Limb Girdle Muscular Dystrophy Type 2E/R4 – Sarepta Therapeutics

    Breakthrough for Gene Therapy: FDA Designates Viral Vector in Sarepta’s SRP-9003 for Limb Girdle Muscular Dystrophy Treatment

    Waunakee Fifth-Graders Dive into the Future at Exciting Tech Day!

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

New computer tools can reconstruct 3D brain from biobank photos

December 12, 2023
in Health
New computer tools can reconstruct 3D brain from biobank photos
Share on FacebookShare on Twitter

New computer tools can reconstruct 3D brain from biobank photos

Examples of inputs and outputs from the MADRC dataset. Credit: (2023). DOI: 10.7554/eLife.91398.1

Researchers have developed a suite of free tools for analyzing vast amounts of brain dissection photographs at brain banks worldwide to enhance understanding of neurodegenerative diseases.

The study, published today as a Reviewed Preprint in eLife, is described by the editors as providing a valuable open-source tool for researchers in the neuropathology and neuroimaging field, supported by convincing evidence from experiments using both real and synthetic data.

Measuring the volume of different brain regions is an important way to understand aging and neurodegenerative diseases and is usually carried out either by using a magnetic resonance imaging (MRI) scan in people while they are alive or by studying sections of brain tissue donated to brain banks after death.

Being able to link the results of microscopic tissue analysis with large-scale macroscopic data from MRI scans is invaluable, but MRI scans are usually obtained from patients many years before they die, making it difficult to link what is seen on the scan with what is later seen under a microscope.

An alternative to this is to take an MRI scan of the brain following post-mortem and before tissue sections are taken for microscopic analysis. However, few biobank centers have the equipment or expertise to do this. Instead, quantitative measurements such as cortical thickness and atrophy of specific regions are often estimated qualitatively by researchers looking at brain slices.

“We set out to propose a solution to this problem by leveraging routinely acquired dissection photographs of brain slices before microscopic analysis,” explains lead author Harshvardhan Gazula, Postdoctoral Research Associate at the Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital (MGH), Massachusetts, US.

“These vast collections of dissection photographs present an invaluable and currently under-used information resource, which holds the promise of advancing our understanding of various brain functions and disorders.”

Harshvardhan and colleagues have developed a suite of computational tools that will allow other researchers to use these dissection photographs to reconstruct a 3D picture of the brain. The suite is freely available and has three modules: the first corrects for different perspectives and pixel sizes in the original images; the second builds a 3D reconstruction of the brain from the photos, using a 3D brain surface scan or generic brain atlas as a reference point; and the third module then segments the brain reconstruction into different brain regions—such as the hippocampus, thalamus, and cortex.

The structure and volumes of these regions can then be compared with other MRI scans and used alongside the microscopic data to learn more about changes that occur in neurodegenerative disease.

To assess the accuracy of the tools, the team carried out three validation steps. First, they used their tool to analyze dissection photographs from 21 post-mortem confirmed Alzheimer’s disease cases and 12 age-matched control brains. This showed that the model captured well-known patterns of Alzheimer’s disease, such as shrinkage (atrophy) in the hippocampus and enlargement of the brain ventricle.

Next, they compared the accuracy of the new tool with the current gold-standard analysis method, which employs a different technique for the segmentation step. This showed that the new tool outperformed the older version in several ways: for example, it was more effective at filling in missing information between brain slices.

Finally, the team evaluated how robust the algorithms are at reconstructing the brain across a large, variable set of data simulated from MRI scans from a further 500 participants. This showed that the method was reasonably robust even when there was more spacing between brain slice images, but it also showed that consistency in the thickness of brain slices is important for accuracy.

This study comes with a few limitations, including the fact that the method can only segment the whole cortex and is currently unable to subdivide it into regions—a task known as ‘cortical parcellation.’

Accurate cortical parcellation would be of interest because the morphometrics of individual regions—specifically, measurements of their thickness—are more predictive of neuropathology. The authors say they are now looking to extend the toolset to allow for cortical parcellation in the future.

“Leveraging the vast amounts of dissection photographs available at brain banks worldwide to perform morphometry is a promising avenue for enhancing our understanding of various neurodegenerative diseases,” concludes senior author Juan Eugenio Iglesias, Associate Professor of Radiology at the Athinoula A. Martinos Center for Biomedical Imaging at MGH.

“Our publicly available tools are easy to use by anyone with little or no training and enable a cost-effective and time-saving link between morphometric phenotypes and neuropathological diagnosis. We expect these tools to play a crucial role in the discovery of new imaging markers to study neurodegenerative diseases.”

More information:
Harshvardhan Gazula et al, Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology, eLife (2023). DOI: 10.7554/eLife.91398.1

Journal information:
eLife

Citation:
New computer tools can reconstruct 3D brain from biobank photos (2023, December 12)
retrieved 12 December 2023
from https://medicalxpress.com/news/2023-12-tools-reconstruct-3d-brain-biobank.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2023-12-tools-reconstruct-3d-brain-biobank.html

Tags: Computerhealthtools
Previous Post

Problem Gambling Tied to Risk for Long-Term Work Disability

Next Post

Researchers identify distinct mechanisms underlying reading errors in stroke survivors

designing for ‘abundance,’ with ecological landscaper kelly norris – A Way To Garden

Embracing Abundance: Insights from Ecological Landscaper Kelly Norris

June 8, 2025
How to take photos on your phone via remote control – Popular Science

How to take photos on your phone via remote control – Popular Science

June 8, 2025
Opinion | RFK Jr.’s Deadly War on Science – Common Dreams

RFK Jr.’s Dangerous Assault on Science: A Call to Action

June 8, 2025
The Worst Bonne Maman Preserves Flavor Leaves A Lot To Be Desired – Yahoo

The Worst Bonne Maman Preserves Flavor Leaves A Lot To Be Desired – Yahoo

June 8, 2025
D.C. Hosts WorldPride Parade in the Shadow of Trump – The New York Times

Celebrating Love and Unity: D.C. Lights Up for WorldPride Parade Amidst Political Tensions

June 8, 2025
This New England state has the best economy in the country, according to WalletHub – Boston.com

Discover the New England State Boasting the Strongest Economy in the Nation!

June 8, 2025
Ceramic Dalmatian Entertainment is WLAF’s Business of the Week – WLAF

Spotlight on Success: Ceramic Dalmatian Entertainment Shines as This Week’s Featured Business!

June 8, 2025
Billy Joel jokes about aging, cremation after brain disorder diagnosis – Fox News

Billy Joel Shares Hilarious Takes on Aging and Life After a Health Scare

June 8, 2025
Supreme Court restores DOGE’s access to sensitive Social Security data and says it doesn’t have to turn over documents – CNN

Supreme Court Grants DOGE Access to Sensitive Social Security Data, Protects Confidential Documents!

June 8, 2025
Drag racer survives frightening airborne crash at World Wide Technology Raceway – FOX 2

Drag racer survives frightening airborne crash at World Wide Technology Raceway – FOX 2

June 8, 2025

Categories

Archives

June 2025
MTWTFSS
 1
2345678
9101112131415
16171819202122
23242526272829
30 
« May    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (676)
  • Economy (689)
  • Entertainment (21,595)
  • General (15,271)
  • Health (9,731)
  • Lifestyle (693)
  • News (22,149)
  • People (690)
  • Politics (697)
  • Science (15,908)
  • Sports (21,192)
  • Technology (15,675)
  • World (674)

Recent News

designing for ‘abundance,’ with ecological landscaper kelly norris – A Way To Garden

Embracing Abundance: Insights from Ecological Landscaper Kelly Norris

June 8, 2025
How to take photos on your phone via remote control – Popular Science

How to take photos on your phone via remote control – Popular Science

June 8, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version