* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Tuesday, September 23, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Why Hilaria Baldwin Has Found the ‘DWTS’ Process ‘Embarrassing’ At Times – WFXG

    Hilaria Baldwin Opens Up About the Embarrassing Moments on Her ‘DWTS’ Journey

    Harvest Fest 2025 – yadkinripple.com

    Celebrate the Bounty: Harvest Fest 2025 is Coming!

    Fox News Entertainment Newsletter: Kate Middleton stuns during Trump state visit, Brett James dead at 57 – Fox News

    Kate Middleton Stuns During Trump State Visit; Remembering Brett James at 57

    Lara Beitz to headline Oshkosh show with top comedians at Time Community Theater Sept. 27 – Yahoo

    Lara Beitz to Headline Star-Studded Oshkosh Comedy Night on September 27

    Shakespeare (with a twist) in Grand Junction – Yahoo

    Experience Shakespeare Like Never Before in Grand Junction

    Congress Bill Spotlight: Make Entertainment Great Again (MEGA) Act, Renaming Kennedy Center to Trump Center – The Fulcrum

    Congress Proposes MEGA Act to Rename Kennedy Center as Trump Center and Revitalize Entertainment

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Agentic AI and the future of work: navigating technological promise and the risk of increased automation – Equal Times

    Agentic AI and the Future of Work: Embracing Innovation While Navigating Automation Challenges

    Technology alliance introduces system for stable recycling quality – RECYCLING magazine

    Innovative Technology Alliance Unveils Breakthrough System for Consistent Recycling Quality

    Pepper Pike council considers upgrading technology for streaming meetings, remote meeting participation – Cleveland.com

    Pepper Pike Council Explores Upgrading Technology for Enhanced Streaming and Remote Participation

    How Michelin Uses Technology to Rethink Tire Manufacturing: Interview – Motor1.com

    How Michelin’s Tech-Driven Revolution Is Transforming Tire Manufacturing

    Analysts Offer Insights on Technology Companies: Avnet (AVT), Nvidia (NVDA) and Atlassian (TEAM) – The Globe and Mail

    Experts Share Key Insights on Avnet, Nvidia, and Atlassian’s Future Prospects

    Top Technology Executives Recognized at the 2025 Carolina CIO ORBIE Awards – Yahoo Finance

    Celebrating Excellence: Top Technology Executives Honored at the 2025 Carolina CIO ORBIE Awards

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Why Hilaria Baldwin Has Found the ‘DWTS’ Process ‘Embarrassing’ At Times – WFXG

    Hilaria Baldwin Opens Up About the Embarrassing Moments on Her ‘DWTS’ Journey

    Harvest Fest 2025 – yadkinripple.com

    Celebrate the Bounty: Harvest Fest 2025 is Coming!

    Fox News Entertainment Newsletter: Kate Middleton stuns during Trump state visit, Brett James dead at 57 – Fox News

    Kate Middleton Stuns During Trump State Visit; Remembering Brett James at 57

    Lara Beitz to headline Oshkosh show with top comedians at Time Community Theater Sept. 27 – Yahoo

    Lara Beitz to Headline Star-Studded Oshkosh Comedy Night on September 27

    Shakespeare (with a twist) in Grand Junction – Yahoo

    Experience Shakespeare Like Never Before in Grand Junction

    Congress Bill Spotlight: Make Entertainment Great Again (MEGA) Act, Renaming Kennedy Center to Trump Center – The Fulcrum

    Congress Proposes MEGA Act to Rename Kennedy Center as Trump Center and Revitalize Entertainment

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Agentic AI and the future of work: navigating technological promise and the risk of increased automation – Equal Times

    Agentic AI and the Future of Work: Embracing Innovation While Navigating Automation Challenges

    Technology alliance introduces system for stable recycling quality – RECYCLING magazine

    Innovative Technology Alliance Unveils Breakthrough System for Consistent Recycling Quality

    Pepper Pike council considers upgrading technology for streaming meetings, remote meeting participation – Cleveland.com

    Pepper Pike Council Explores Upgrading Technology for Enhanced Streaming and Remote Participation

    How Michelin Uses Technology to Rethink Tire Manufacturing: Interview – Motor1.com

    How Michelin’s Tech-Driven Revolution Is Transforming Tire Manufacturing

    Analysts Offer Insights on Technology Companies: Avnet (AVT), Nvidia (NVDA) and Atlassian (TEAM) – The Globe and Mail

    Experts Share Key Insights on Avnet, Nvidia, and Atlassian’s Future Prospects

    Top Technology Executives Recognized at the 2025 Carolina CIO ORBIE Awards – Yahoo Finance

    Celebrating Excellence: Top Technology Executives Honored at the 2025 Carolina CIO ORBIE Awards

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

New gene therapy could significantly reduce seizures in severe childhood epilepsy

December 15, 2023
in Health
New gene therapy could significantly reduce seizures in severe childhood epilepsy
Share on FacebookShare on Twitter

New gene therapy could significantly reduce seizures in severe childhood epilepsy

CAMK2A-EKC therapy reduces seizure frequency. A. Timeline. B. Heatmap displaying seizure occurrence in each animal injected with either CAMK2A-GFP (gray) or CAMK2A-EKC virus (purple) before and after the treatment (virus injection on day 0). Crosses correspond to days where data acquisition was incomplete. C. Graph displaying the change in number of seizures in animals treated with CAMK2A-EKC normalized to the average change in CAMK2A-GFP treated animals (one sample Wilcoxon test vs 0). D. Cumulative seizures normalized to baseline (CAMK2A-GFP n=11 mice, CAMK2A-EKC n=13 mice, repeated measures 2-way ANOVA followed by Bonferroni multiple comparison test). E. Graph showing the percentage of seizure-free days (unpaired Student’s t test). Credit: Brain (2023). DOI: 10.1093/brain/awad387

UCL researchers have developed a new gene therapy to cure a devastating form of childhood epilepsy, which a new study shows can significantly reduce seizures in mice.

The study, published in Brain, sought to find an alternative to surgery for children with focal cortical dysplasia.

Focal cortical dysplasia is caused by areas of the brain that have developed abnormally and is among the most common causes of drug-resistant epilepsy in children. It frequently occurs in the frontal lobes, which are important for planning and decision-making. Epilepsy in focal cortical dysplasia is associated with comorbidities, including learning disabilities.

Although surgery to remove the affected brain malformation is effective, its use is severely limited by the risk of permanent neurological deficit and does not always result in seizure freedom.

Consequently, researchers at the UCL Queen Square Institute of Neurology evaluated a gene therapy based on the overexpression of a potassium channel that regulates neuronal excitability in a mouse model of focal cortical dysplasia in the frontal lobe.

Potassium channels control the movement of potassium ions in and out of cells. When there is an overexpression of a potassium channel, it means that there is greater regulation, resulting in the decrease of the activity of cells and, in turn, stopping seizures.

Co-corresponding author Professor Gabriele Lignani (UCL Queen Square Institute of Neurology), said, “It is very exciting to see that this new gene therapy could potentially be used as an effective alternative to surgery in patients with focal cortical dysplasia.”

Gene therapies have previously been shown to work in another form of epilepsy where seizures arise in the temporal lobes but have not been tested in focal cortical dysplasia.

In this case, the researchers introduced an engineered potassium channel gene called EKC into the affected frontal lobe of the epileptic mice. For added safety, they used a virus that is unable to replicate in order to carry the potassium channel gene.

Before giving the treatment, researchers monitored the mice’s brain activity for 15 days. They then injected either the virus carrying the EKC gene or a control virus into the affected brain area. The team then monitored the mice’s brain activity for another 15 days.

The researchers found that gene therapy reduced seizures by an average of 87% when compared with the control group, without affecting the mouse’s memory or behavior.

Lead author Dr. Vincent Magloire (UCL Queen Square Institute of Neurology) said, “Following the successful study in mice, we believe the treatment is suitable for clinical translation, and, taking into account the size of the unmet need, it could be deployed to thousands of children who are currently severely affected by uncontrolled seizures.”

Co-corresponding author Professor Dimitri Kullmann (UCL Queen Square Institute of Neurology) added, “Plans for a first in human clinical trial are underway and are planned in the next five years.”

More information:
Amanda Almacellas-Barbanoj et al, Anti-seizure Gene Therapy for Focal Cortical Dysplasia, Brain (2023). DOI: 10.1093/brain/awad387

Journal information:
Brain

Citation:
New gene therapy could significantly reduce seizures in severe childhood epilepsy (2023, December 14)
retrieved 15 December 2023
from https://medicalxpress.com/news/2023-12-gene-therapy-significantly-seizures-severe.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2023-12-gene-therapy-significantly-seizures-severe.html

Tags: healthsignificantlyTherapy
Previous Post

‘Long flu’ has emerged as a consequence similar to long COVID

Next Post

Risk of death decreases after COVID-19 vaccine but protection wanes after six months, finds study

FOCUS | SCIO holds press conference on promoting high-quality development through high-level ecological & environmental protection – Xinhua

FOCUS | SCIO holds press conference on promoting high-quality development through high-level ecological & environmental protection – Xinhua

September 23, 2025
Researcher on Tylenol-Autism Connection: Not the Best Science – Managed Healthcare Executive

Researcher Questions the Science Behind Tylenol-Autism Link

September 23, 2025
Da Vinci’s Genetic Secrets May Soon Be Revealed by Ambitious DNA Project – ScienceAlert

Unlocking Da Vinci’s Genetic Mysteries: The Ambitious DNA Project Set to Reveal All

September 23, 2025
Eco-Chic Home & Lifestyle Design Market Is Booming Worldwide | Major Giants The Joinery, Emeco, Greenington – openPR.com

Eco-Chic Home & Lifestyle Design Market Is Booming Worldwide | Major Giants The Joinery, Emeco, Greenington – openPR.com

September 23, 2025
Agentic AI and the future of work: navigating technological promise and the risk of increased automation – Equal Times

Agentic AI and the Future of Work: Embracing Innovation While Navigating Automation Challenges

September 23, 2025
Viking Sports Weekly September 22 – csuvikings.com

Viking Sports Weekly September 22 – csuvikings.com

September 23, 2025
Dynamic Pricing is Fair Play for the 2026 FIFA World Cup – Cato Institute

How Dynamic Pricing Will Revolutionize the 2026 FIFA World Cup Experience

September 22, 2025
White House Touts Rising Confidence In U.S. Economy Under Trump’s Second Term – Yahoo

White House Celebrates Rising Optimism in U.S. Economy Amid Trump’s Second Term

September 22, 2025
Why Hilaria Baldwin Has Found the ‘DWTS’ Process ‘Embarrassing’ At Times – WFXG

Hilaria Baldwin Opens Up About the Embarrassing Moments on Her ‘DWTS’ Journey

September 22, 2025
New Tech Ally Ready to Fight Against Chronic Health Conditions – Sutter Health

Revolutionary Tech Partner Set to Transform the Fight Against Chronic Health Conditions

September 22, 2025

Categories

Archives

September 2025
MTWTFSS
1234567
891011121314
15161718192021
22232425262728
2930 
« Aug    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (832)
  • Economy (852)
  • Entertainment (21,730)
  • General (17,189)
  • Health (9,895)
  • Lifestyle (865)
  • News (22,149)
  • People (855)
  • Politics (862)
  • Science (16,063)
  • Sports (21,352)
  • Technology (15,835)
  • World (836)

Recent News

FOCUS | SCIO holds press conference on promoting high-quality development through high-level ecological & environmental protection – Xinhua

FOCUS | SCIO holds press conference on promoting high-quality development through high-level ecological & environmental protection – Xinhua

September 23, 2025
Researcher on Tylenol-Autism Connection: Not the Best Science – Managed Healthcare Executive

Researcher Questions the Science Behind Tylenol-Autism Link

September 23, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version