PHILADELPHIA — Dropping aspirin from the antithrombotic regimen after HeartMate 3 left ventricular assist device (LVAD) implantation appeared safer than the usual combination approach in the ARIES-HM3 trial.
Atop warfarin or other vitamin K antagonist therapy, placebo was noninferior to low-dose aspirin for the primary composite endpoint of survival free of stroke, pump thrombosis, major nonsurgical bleeding, and arterial peripheral thromboembolism over 24 months (68% vs 74%, P
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