* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Thursday, June 12, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    The Analyst Verdict: PENN Entertainment In The Eyes Of 7 Experts – Nasdaq

    7 Experts Reveal the Ultimate Verdict on PENN Entertainment

    3 Arts Entertainment Expands Into News With Acquisition of OManagement (Exclusive) – The Hollywood Reporter

    3 Arts Entertainment Expands Into News With Acquisition of OManagement (Exclusive) – The Hollywood Reporter

    Leading Proxy Advisory Firm Glass Lewis Recommends Shareholders Vote “FOR” Both of PENN Entertainment’s Director Nominees on the WHITE Proxy Card – Business Wire

    Glass Lewis Urges Shareholders to Support All PENN Entertainment Director Nominees on the WHITE Proxy Card

    Cisco Partners with Monumental Sports & Entertainment to Power New D.C. Arena – Cisco Newsroom

    Cisco Teams Up with Monumental Sports & Entertainment to Revolutionize the New D.C. Arena Experience

    Middle Eastern Entertainment Headlines at 5:49 a.m. GMT – Yahoo

    Exciting Updates from the Middle Eastern Entertainment Scene!

    Ceramic Dalmatian Entertainment is WLAF’s Business of the Week – WLAF

    Spotlight on Success: Ceramic Dalmatian Entertainment Shines as This Week’s Featured Business!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    MSI Viking and Mahr Host Technology Day – WSPA 7NEWS

    Step Inside the Thrilling World of MSI Viking and Mahr Technology Day!

    6.12pm is the new 8pm – Go Technology – cgastrategy.com

    6.12pm is the new 8pm – Go Technology – cgastrategy.com

    Russian Scientists Develop Sub-Ångström Technology for Next-Gen Quantum Processors – The Quantum Insider

    Russian Scientists Pioneer Sub-Ångström Technology to Revolutionize Next-Gen Quantum Processors

    Study uncovers SiPore Technology’s capacity to regulate blood glucose levels – Nutraceutical Business Review

    Study uncovers SiPore Technology’s capacity to regulate blood glucose levels – Nutraceutical Business Review

    SunHydrogen Unveils Large Hydrogen Reactor in Houston – Fuel Cells Works

    SunHydrogen Launches Groundbreaking Large-Scale Hydrogen Reactor in Houston

    Technology, Labor Rights, and Political Power in Kenya and Across Africa – Tech Policy Press

    How Technology is Shaping Labor Rights and Political Power Across Africa

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    The Analyst Verdict: PENN Entertainment In The Eyes Of 7 Experts – Nasdaq

    7 Experts Reveal the Ultimate Verdict on PENN Entertainment

    3 Arts Entertainment Expands Into News With Acquisition of OManagement (Exclusive) – The Hollywood Reporter

    3 Arts Entertainment Expands Into News With Acquisition of OManagement (Exclusive) – The Hollywood Reporter

    Leading Proxy Advisory Firm Glass Lewis Recommends Shareholders Vote “FOR” Both of PENN Entertainment’s Director Nominees on the WHITE Proxy Card – Business Wire

    Glass Lewis Urges Shareholders to Support All PENN Entertainment Director Nominees on the WHITE Proxy Card

    Cisco Partners with Monumental Sports & Entertainment to Power New D.C. Arena – Cisco Newsroom

    Cisco Teams Up with Monumental Sports & Entertainment to Revolutionize the New D.C. Arena Experience

    Middle Eastern Entertainment Headlines at 5:49 a.m. GMT – Yahoo

    Exciting Updates from the Middle Eastern Entertainment Scene!

    Ceramic Dalmatian Entertainment is WLAF’s Business of the Week – WLAF

    Spotlight on Success: Ceramic Dalmatian Entertainment Shines as This Week’s Featured Business!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    MSI Viking and Mahr Host Technology Day – WSPA 7NEWS

    Step Inside the Thrilling World of MSI Viking and Mahr Technology Day!

    6.12pm is the new 8pm – Go Technology – cgastrategy.com

    6.12pm is the new 8pm – Go Technology – cgastrategy.com

    Russian Scientists Develop Sub-Ångström Technology for Next-Gen Quantum Processors – The Quantum Insider

    Russian Scientists Pioneer Sub-Ångström Technology to Revolutionize Next-Gen Quantum Processors

    Study uncovers SiPore Technology’s capacity to regulate blood glucose levels – Nutraceutical Business Review

    Study uncovers SiPore Technology’s capacity to regulate blood glucose levels – Nutraceutical Business Review

    SunHydrogen Unveils Large Hydrogen Reactor in Houston – Fuel Cells Works

    SunHydrogen Launches Groundbreaking Large-Scale Hydrogen Reactor in Houston

    Technology, Labor Rights, and Political Power in Kenya and Across Africa – Tech Policy Press

    How Technology is Shaping Labor Rights and Political Power Across Africa

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Progression Independent of Relapse Activity in Pediatric-Onset MS

November 30, 2023
in Health
Progression Independent of Relapse Activity in Pediatric-Onset MS
Share on FacebookShare on Twitter

Pediatric-onset multiple sclerosis (MS) patients showed progression independent of relapse activity (PIRA) even when they were relatively young, a prospective cohort study found.

Confirmed PIRA events within 48 weeks of baseline occurred in 40.4% of pediatric-onset MS patients and were more frequent in older-onset groups, reported Maria Pia Amato, MD, of the University of Florence in Italy, and co-authors in JAMA Neurology.

For a subgroup of MS patients with at least one Expanded Disability Status Scale (EDSS) evaluation every 6 months, the incidence of PIRA was 1.3% at age 20 but rapidly increased to 9% from ages 21 through 30, then nearly doubled with each additional age decade from ages 40 to 70. Cumulative relapse-associated worsening (RAW) followed a similar trend from ages 20 to 60.

While MS patients younger than 18 have a lower rate of disability, pediatric age itself is not protective, Amato and colleagues observed. “In other words, the time of injury itself is not protective against disability; rather, while the subject has a youthful immune system and a more resilient brain, less disability is manifest,” they wrote.

PIRA, especially when it develops early in MS, is a dominant driver of disability accumulation over time. Prior research suggested that age may be a main risk factor for PIRA because of its prominence in older patients, but information about the relative contributions of PIRA and RAW to disability accrual in pediatric-onset MS is scarce.

“We … hypothesized that, in this young population, the main driver of disability accumulation had to be RAW,” Amato wrote in an email to MedPage Today, but “our hypothesis was only partially met.”

“Early and accurate diagnosis and early treatment are essential in pediatric-onset MS patients, as they are at risk of irreversible disability accrual while they are still very young,” she added.

The findings provide “further confirmation that risk of disease progression in pediatric-onset MS is high, and that earlier treatment and anti-inflammatory therapy confers long term benefits in this population, including benefits related to progression,” noted Ann Yeh, MD, of the Hospital for Sick Children in Toronto, who wasn’t involved with the study.

“Importantly, progression may occur at a relatively young age even in the absence of clinical relapses,” Yeh told MedPage Today.

Amato and colleagues used data from the Italian MS Register from 2000 to 2021. They included 16,130 MS patients with clinically isolated syndrome and relapsing-remitting course at first neurologic evaluation who subsequently had three or more EDSS evaluations and 5 years or more of follow-up. Patients with a primary or secondary progressive course at first evaluation and those enrolled in clinical trials were excluded.

Three age groups of MS patients were evaluated: pediatric-onset (age 18 or younger when diagnosed), adult-onset (ages 19-50), and late-onset patients (older than 50). The overall cohort had a median age of 28.7 at disease onset and was 68.3% female. The pediatric-onset group had a median age of 15.8 at onset and also was 68.3% female.

Baseline was defined as the first EDSS evaluation, and follow-up time was the time between the first and last available EDSS entry. Confirmed disability accrual (CDA) was a confirmed disability increase of a number of points (depending on baseline score) on the EDSS 48 weeks or more from baseline.

RAW was defined as a CDA event in which the increase in disability happened either 90 days or earlier after a relapse, or 30 days or earlier before relapse. PIRA was defined as a CDA event occurring more than 90 days after a relapse, or more than 30 days before relapse.

A first 48-week CDA event occurred in 55.2% of patients. PIRA accounted for 74.4% of CDA events that occurred in pediatric-onset MS, 80.8% of those occurring in adult-onset MS, and 90.5% of those seen in late-onset MS.

Overall, 94.2% of participants received moderate-efficacy disease-modifying therapy (DMT) and 5.8% received high-efficacy DMT. Older age at onset (adult-onset MS vs pediatric-onset HR 1.42; late-onset MS vs pediatric-onset HR 2.98), longer disease duration (HR 1.04), and shorter exposure to DMT (HR 0.69) were associated with PIRA (all P
>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/neurology/multiplesclerosis/107591

Tags: healthindependentProgression
Previous Post

Experts’ Hopes for the Future of dMMR Uterine Cancer Treatment

Next Post

Coronary Heart Disease by Age 45 Linked With Later Dementia

MSI Viking and Mahr Host Technology Day – WSPA 7NEWS

Step Inside the Thrilling World of MSI Viking and Mahr Technology Day!

June 12, 2025
Connections: Sports Edition hints for June 11, 2025, puzzle No. 261 – The New York Times

Connections: Sports Edition hints for June 11, 2025, puzzle No. 261 – The New York Times

June 12, 2025
Washington Department of Ecology Proposes New Permitting Program for Projects that Alter or ‎Impact Waters of the State – JD Supra

Washington Department of Ecology Unveils New Permitting Program for Projects Affecting State Waters

June 11, 2025
Ssss-ummer fun at Cook Museum of Natural Science – WHNT.com

Ssss-ummer fun at Cook Museum of Natural Science – WHNT.com

June 11, 2025
Researchers create AI-based tool that restores age-damaged artworks in hours – The Guardian

Revolutionary AI Tool Restores Age-Damaged Artworks in Just Hours

June 11, 2025
Summer-Ready Blue Lifestyle Sneakers – Trend Hunter

Step Into Summer with Stylish Blue Lifestyle Sneakers

June 11, 2025
USU supported $1.4 billion to the state economy in 2023, says new study – KSLTV.com

USU supported $1.4 billion to the state economy in 2023, says new study – KSLTV.com

June 11, 2025
SAG-AFTRA Suspends Strike Against Video Game Companies, Paving Way for Return to Work – Yahoo

SAG-AFTRA Ends Video Game Strike, Clearing the Path for Actors to Return to Work

June 11, 2025
Deion Sanders provides update amid speculation about his health: ‘I can assure you all that everything is OK’ – CBS Sports

Deion Sanders Sets the Record Straight: “I Can Assure You All That Everything Is OK

June 11, 2025
Trump plans to phase out FEMA, shift disaster management to states – Scripps News

Trump Calls for Phasing Out FEMA, Empowering States to Lead Disaster Management

June 11, 2025

Categories

Archives

June 2025
MTWTFSS
 1
2345678
9101112131415
16171819202122
23242526272829
30 
« May    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (682)
  • Economy (696)
  • Entertainment (21,600)
  • General (15,335)
  • Health (9,737)
  • Lifestyle (700)
  • News (22,149)
  • People (697)
  • Politics (703)
  • Science (15,913)
  • Sports (21,198)
  • Technology (15,683)
  • World (680)

Recent News

MSI Viking and Mahr Host Technology Day – WSPA 7NEWS

Step Inside the Thrilling World of MSI Viking and Mahr Technology Day!

June 12, 2025
Connections: Sports Edition hints for June 11, 2025, puzzle No. 261 – The New York Times

Connections: Sports Edition hints for June 11, 2025, puzzle No. 261 – The New York Times

June 12, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version