* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Monday, September 15, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Fall’s Hottest Ski Films Are Going on Tour—Here’s the List – yahoo.com

    Experience the Thrill: Fall’s Hottest Ski Films Hit the Road-Don’t Miss the Tour!

    Ryan Reynolds reveals he called a journalist who said mean things about John Candy – yahoo.com

    Ryan Reynolds Reveals the Moment He Stood Up to a Journalist Who Insulted John Candy

    Entertainment Community Fund Launches Program Supporting Entrepreneurs – Playbill

    Entertainment Community Fund Unveils Exciting New Program to Empower Entrepreneurs

    Behind the turntables: DJ Johnny Kage’s story of perseverance – yahoo.com

    Behind the Turntables: DJ Johnny Kage’s Inspiring Journey of Perseverance

    The other WWE star James Gunn wanted for Peacemaker instead of John Cena – yahoo.com

    The WWE Star James Gunn Originally Wanted for Peacemaker Instead of John Cena

    Quinta Brunson, John Stamos Join Entertainment and Technology Summit – Variety

    Quinta Brunson and John Stamos to Headline Thrilling Entertainment and Technology Summit

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology

    Unlocking AI Success: How People, Process, and Technology Form the Ultimate Triangle

    Billion-dollar coffins? New technology could make oceans transparent and Aukus submarines vulnerable – The Guardian

    Billion-Dollar Coffins? How New Technology Could Make Oceans Transparent and Expose Submarines

    What if artificial intelligence is just a “normal” technology? – The Economist

    What if artificial intelligence is just a “normal” technology? – The Economist

    Lincoln Trail College Receives $100,000 Grant from Marathon Petroleum Corporation for Technology Center – wwbl.com

    Lincoln Trail College Lands $100,000 Grant from Marathon Petroleum to Elevate Technology Center

    Aston Martin to integrate Pirelli’s cyber tyre technology in future models – Just Auto

    Aston Martin to Revolutionize Future Models with Pirelli’s Cutting-Edge Cyber Tyre Technology

    Figure Technology’s stock sizzles after IPO, as investors stay hungry for crypto deals – MarketWatch

    Figure Technology’s Stock Skyrockets After IPO Amid Surging Crypto Investor Excitement

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Fall’s Hottest Ski Films Are Going on Tour—Here’s the List – yahoo.com

    Experience the Thrill: Fall’s Hottest Ski Films Hit the Road-Don’t Miss the Tour!

    Ryan Reynolds reveals he called a journalist who said mean things about John Candy – yahoo.com

    Ryan Reynolds Reveals the Moment He Stood Up to a Journalist Who Insulted John Candy

    Entertainment Community Fund Launches Program Supporting Entrepreneurs – Playbill

    Entertainment Community Fund Unveils Exciting New Program to Empower Entrepreneurs

    Behind the turntables: DJ Johnny Kage’s story of perseverance – yahoo.com

    Behind the Turntables: DJ Johnny Kage’s Inspiring Journey of Perseverance

    The other WWE star James Gunn wanted for Peacemaker instead of John Cena – yahoo.com

    The WWE Star James Gunn Originally Wanted for Peacemaker Instead of John Cena

    Quinta Brunson, John Stamos Join Entertainment and Technology Summit – Variety

    Quinta Brunson and John Stamos to Headline Thrilling Entertainment and Technology Summit

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology

    Unlocking AI Success: How People, Process, and Technology Form the Ultimate Triangle

    Billion-dollar coffins? New technology could make oceans transparent and Aukus submarines vulnerable – The Guardian

    Billion-Dollar Coffins? How New Technology Could Make Oceans Transparent and Expose Submarines

    What if artificial intelligence is just a “normal” technology? – The Economist

    What if artificial intelligence is just a “normal” technology? – The Economist

    Lincoln Trail College Receives $100,000 Grant from Marathon Petroleum Corporation for Technology Center – wwbl.com

    Lincoln Trail College Lands $100,000 Grant from Marathon Petroleum to Elevate Technology Center

    Aston Martin to integrate Pirelli’s cyber tyre technology in future models – Just Auto

    Aston Martin to Revolutionize Future Models with Pirelli’s Cutting-Edge Cyber Tyre Technology

    Figure Technology’s stock sizzles after IPO, as investors stay hungry for crypto deals – MarketWatch

    Figure Technology’s Stock Skyrockets After IPO Amid Surging Crypto Investor Excitement

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Proteins Predict Signs of Alzheimer’s Disease

November 21, 2023
in Health
Proteins Predict Signs of Alzheimer’s Disease
Share on FacebookShare on Twitter

Protein indicators of subclinical peripheral heath in plasma were linked with markers of Alzheimer’s disease and neurodegeneration, cross-sectional proteomic analyses showed.

Greater protein-based risk for cardiovascular disease, heart failure mortality, and kidney disease was associated with plasma biomarkers of amyloid-beta, phosphorylated tau181 (p-tau181), neurofilament light (NfL, a measure of neuronal injury), and glial fibrillary acidic protein (GFAP, a measure of astrogliosis), even in people without cardiovascular or kidney disease, reported Keenan Walker, PhD, of the National Institute on Aging in Baltimore, and co-authors.

Proteomic indicators of body fat percentage, lean body mass, and visceral fat also were tied to p-tau181, NfL, and GFAP, Walker and colleagues wrote in the Annals of Neurology.

The study aimed to assess the possible effects of health traits, disease, and disease risk on blood-based biomarkers of Alzheimer’s and neurodegeneration, Walker noted.

“Plasma biomarkers of Alzheimer’s disease and neurodegeneration are now commonly used in research and increasingly used in the clinical setting, so it is important to understand how person-specific factors can affect these biomarkers,” he told MedPage Today.

Previous work by Walker and colleagues identified 38 proteins significantly associated with incident dementia within 5 years, with two proteins (SVEP1 and angiostatin) causally implicated in Alzheimer’s disease through Mendelian randomization.

In the current study, Walker and colleagues looked at 14 protein-based health indicators derived from plasma samples, plus plasma and PET measures of Alzheimer’s and neurodegeneration, in the Baltimore Longitudinal Study of Aging (BLSA). They also used data from the Atherosclerosis Risk in Communities (ARIC) study to see whether proteomic indicators that were correlated with Alzheimer’s biomarkers also predicted 25-year dementia risk.

A total of 706 BLSA participants were included in the primary analyses; all were cognitively unimpaired at the time of biomarker measurement. Mean age was about 68, 54% were women, and 67% were white.

Overall, BLSA participants had lower prevalence of heart ischemic disease and chronic kidney disease than Americans 65 and older, the researchers noted. The prevalence of heart failure was on par with the general population.

Higher kidney disease, secondary (but not primary) cardiovascular disease risk, and heart failure prognosis risk (preserved and reduced ejection fraction) were consistently linked to levels of plasma biomarkers indicative of greater Alzheimer’s pathology and neurodegenerative burden, after adjusting for age, sex, race, and education.

“Notably, the kidney disease risk associations and cardiovascular disease risk and heart failure prognosis associations remained largely similar when participants with evidence of kidney dysfunction (estimated glomerular filtration rate under 60) and cardiovascular disease (i.e., heart ischemic disease, congestive heart failure, or stroke) were excluded,” Walker and co-authors wrote.

Higher body fat percentage and visceral fat were associated with lower p-tau181, NfL, and GFAP. Greater lean body mass was associated with higher p-tau181 and lower NfL and GFAP. Among participants with positive amyloid PET, poor heart failure prognosis was positively correlated with higher cortical amyloid beta, after adjusting for demographics.

In the ARIC study of 11,285 people, a total of 2,063 (18.3%) had incident dementia over a median follow-up of 21.1 years. Increased dementia risk was associated with higher primary and secondary cardiovascular risk, as well as poorer heart failure prognosis, after adjustments for age, sex, race, study site, education, and APOE4 status.

“Importantly, these associations remained similar after excluding participants with coronary heart disease, stroke, and suspected heart failure (based on the use of heart failure medications) at the time of protein measurement,” Walker and co-authors observed.

The study had several limitations, the researchers acknowledged. The proteomic health indicators were constructed and validated in cohorts that consisted primarily of white participants, and it’s unclear whether they were optimal for the sizable subset of non-white participants in BLSA and ARIC. Some null results in the PET analyses were due to small sample sizes.

In addition, the primary analyses were cross-sectional and could not shed light on how changing peripheral health might influence Alzheimer’s biomarker progression.

Judy George covers neurology and neuroscience news for MedPage Today, writing about brain aging, Alzheimer’s, dementia, MS, rare diseases, epilepsy, autism, headache, stroke, Parkinson’s, ALS, concussion, CTE, sleep, pain, and more. Follow

Disclosures

This study was supported by the intramural research program of the National Institute on Aging.

Walker reported no conflicts of interest. Some co-authors are employees of SomaLogic, which developed the protein-based health indicators used in the study and has a commercial interest in the results.

Primary Source

Annals of Neurology

Source Reference: Dark HE, et al “Proteomic indicators of health predict Alzheimer’s disease biomarker levels and dementia risk” Ann Neurol 2023; DOI: 10.1002/ana.26817.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/neurology/dementia/107467

Tags: healthpredictproteins
Previous Post

Alteplase Not Harmful in NOAC Users, Even in a More Bleeding-Prone Cohort

Next Post

Apixaban Prophylaxis Fails to Reduce Clots in Pediatric ALL

Washington takes on flawed federal climate report – NewsRadio 560 KPQ

Washington Challenges Key Flaws in Federal Climate Report

September 14, 2025
James Webb telescope’s ‘starlit mountaintop’ could be the observatory’s best image yet — Space photo of the week – Live Science

James Webb Telescope Unveils Stunning ‘Starlit Mountaintop’ – Perhaps Its Most Breathtaking Image Yet

September 14, 2025

Colby College Announces Exciting New $150 Million Science Facility Funded by Anonymous Donor

September 14, 2025
Maine Coon Cat’s Sweet Love Story With Tiny Sphynx Kitty Is Touching Hearts – yahoo.com

Adorable Maine Coon and Tiny Sphynx Share a Heartwarming Love Story

September 14, 2025

Unlocking AI Success: How People, Process, and Technology Form the Ultimate Triangle

September 14, 2025
Transgender student who challenged Idaho sports ban drops lawsuit – KTVB

Transgender student who challenged Idaho sports ban drops lawsuit – KTVB

September 14, 2025
Ricky Hatton, former world boxing champion, found dead in his home at age 46 – cbsnews.com

Heartbreaking News: Former World Boxing Champion Ricky Hatton Dies at 46

September 14, 2025
US, Chinese officials hold talks in Spain on trade irritants, TikTok deadline – Reuters

US and Chinese Officials Convene in Spain to Resolve Trade Disputes and Address TikTok Deadline

September 14, 2025
Fall’s Hottest Ski Films Are Going on Tour—Here’s the List – yahoo.com

Experience the Thrill: Fall’s Hottest Ski Films Hit the Road-Don’t Miss the Tour!

September 14, 2025
What’s Happening in Health: Kids & Mental Health Town Hall – WKRC

Inside the Kids & Mental Health Town Hall: Key Insights You Can’t Miss

September 14, 2025

Categories

Archives

September 2025
MTWTFSS
1234567
891011121314
15161718192021
22232425262728
2930 
« Aug    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (820)
  • Economy (839)
  • Entertainment (21,717)
  • General (17,037)
  • Health (9,883)
  • Lifestyle (855)
  • News (22,149)
  • People (843)
  • Politics (848)
  • Science (16,050)
  • Sports (21,340)
  • Technology (15,822)
  • World (822)

Recent News

Washington takes on flawed federal climate report – NewsRadio 560 KPQ

Washington Challenges Key Flaws in Federal Climate Report

September 14, 2025
James Webb telescope’s ‘starlit mountaintop’ could be the observatory’s best image yet — Space photo of the week – Live Science

James Webb Telescope Unveils Stunning ‘Starlit Mountaintop’ – Perhaps Its Most Breathtaking Image Yet

September 14, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version