* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Saturday, September 27, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Cardi B Adds More Dates to Little Miss Drama Tour: ‘Y’all Making Me Work’ – Yahoo

    Cardi B Extends Little Miss Drama Tour: “Y’all Making Me Work

    ‘Today’: Sheinelle Jones Thanks Katie Couric for Support After Husband’s Death – CBS 19 News

    Sheinelle Jones Expresses Heartfelt Thanks to Katie Couric for Support After Husband’s Passing

    Sate your hunger at DBA’s Taste of Downtown – Bakersfield.com

    Indulge Your Cravings at DBA’s Taste of Downtown!

    Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

    Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

    Why Hilaria Baldwin Has Found the ‘DWTS’ Process ‘Embarrassing’ At Times – WFXG

    Hilaria Baldwin Opens Up About the Embarrassing Moments on Her ‘DWTS’ Journey

    Harvest Fest 2025 – yadkinripple.com

    Celebrate the Bounty: Harvest Fest 2025 is Coming!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Aurora police hope to add facial recognition technology to crime-fighting tools – CBS News

    Aurora Police Aim to Boost Crime-Fighting with New Facial Recognition Technology

    Autonomous Solutions shows off cutting-edge technology for the public – Cache Valley Daily

    Autonomous Solutions Unveils Cutting-Edge Technology for the Public

    Amazon to Pay $2.5 Billion in Prime Membership Settlement – The New York Times

    Amazon to Pay $2.5 Billion in Prime Membership Settlement – The New York Times

    What are we really gaining from technology? – Fast Company

    What Are We Really Gaining from Technology?

    TOMI Environmental Solutions, Inc. Expands SteraMist iHP Technology Services in Healthcare Sector with New Provider Partnership – Quiver Quantitative

    TOMI Environmental Solutions Accelerates SteraMist iHP Technology Expansion in Healthcare with New Provider Partnership

    Indiana County Technology Center’s Joint Operating Committee looks to the future as program plans began to take shape – Indiana Gazette Online

    Indiana County Technology Center’s Joint Operating Committee Charts an Exciting Path Forward as New Program Plans Take Shape

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Cardi B Adds More Dates to Little Miss Drama Tour: ‘Y’all Making Me Work’ – Yahoo

    Cardi B Extends Little Miss Drama Tour: “Y’all Making Me Work

    ‘Today’: Sheinelle Jones Thanks Katie Couric for Support After Husband’s Death – CBS 19 News

    Sheinelle Jones Expresses Heartfelt Thanks to Katie Couric for Support After Husband’s Passing

    Sate your hunger at DBA’s Taste of Downtown – Bakersfield.com

    Indulge Your Cravings at DBA’s Taste of Downtown!

    Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

    Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

    Why Hilaria Baldwin Has Found the ‘DWTS’ Process ‘Embarrassing’ At Times – WFXG

    Hilaria Baldwin Opens Up About the Embarrassing Moments on Her ‘DWTS’ Journey

    Harvest Fest 2025 – yadkinripple.com

    Celebrate the Bounty: Harvest Fest 2025 is Coming!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Aurora police hope to add facial recognition technology to crime-fighting tools – CBS News

    Aurora Police Aim to Boost Crime-Fighting with New Facial Recognition Technology

    Autonomous Solutions shows off cutting-edge technology for the public – Cache Valley Daily

    Autonomous Solutions Unveils Cutting-Edge Technology for the Public

    Amazon to Pay $2.5 Billion in Prime Membership Settlement – The New York Times

    Amazon to Pay $2.5 Billion in Prime Membership Settlement – The New York Times

    What are we really gaining from technology? – Fast Company

    What Are We Really Gaining from Technology?

    TOMI Environmental Solutions, Inc. Expands SteraMist iHP Technology Services in Healthcare Sector with New Provider Partnership – Quiver Quantitative

    TOMI Environmental Solutions Accelerates SteraMist iHP Technology Expansion in Healthcare with New Provider Partnership

    Indiana County Technology Center’s Joint Operating Committee looks to the future as program plans began to take shape – Indiana Gazette Online

    Indiana County Technology Center’s Joint Operating Committee Charts an Exciting Path Forward as New Program Plans Take Shape

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Psychostimulant No Help in Relieving Cancer-Related Fatigue

May 23, 2024
in Health
Psychostimulant No Help in Relieving Cancer-Related Fatigue
Share on FacebookShare on Twitter

Six weeks of treatment with methylphenidate did no better than placebo for improving cancer-related fatigue (CRF).The results continued a pattern of inconsistency in outcomes of studies investigating psychostimulants for CRF.Changes in trial design and a focus on specific subpopulations might make additional studies worthwhile.

The psychostimulant methylphenidate proved no better than placebo for relieving cancer-related fatigue (CRF) in a randomized trial.

After 6 weeks of treatment in palliative care patients with advanced cancer, those allocated to methylphenidate had a 2-point greater improvement fatigue score as compared with placebo, a nonsignificant difference. After 10 weeks, the methylphenidate group still had only a nonsignificant improvement versus placebo.

Scores on quality-of-life (QoL) and symptom outcomes also did not differ between groups at 6 weeks, with the exception of a modest improvement in depression in the methylphenidate arm, reported Patrick Charles Stone, MD, of University College London, and coauthors in the Journal of Clinical Oncology.

“On the basis of our findings, we do not recommend the use (or further trials) of methylphenidate for fatigue in patients with advanced cancer receiving palliative care,” the authors concluded. “However, given the absence of major AEs [adverse events], it would be safe to continue to explore its use in future clinical trials for other symptoms (e.g., low mood or opioid-related drowsiness), in combination with other interventions (e.g., exercise or psychological therapies) or in different populations (e.g., post-treatment fatigue).”

The authors of an accompanying editorial agreed that the negative results should not close the door to future studies of methylphenidate or other psychostimulants.

“We believe there remains room for further trials in this area, particularly in subpopulations that have demonstrated promise, using measures that are sensitive to the specific aspect of fatigue that is most likely to demonstrate a benefit,” wrote Camilla Zimmerman, MD, PhD, of the University of Texas MD Anderson Cancer Center in Houston, and coauthors. “Considering the multifactorial nature of CRF, combination therapies of methylphenidate with other CRF treatments such as physical activity or cognitive behavioral therapy should also be considered.”

The study’s negative outcome continued a pattern of inconsistency with clinical trials of psychostimulants such as methylphenidate in patients with cancer or AIDS, owing in large part to challenges in trial design, William Breitbart, MD, of Memorial Sloan Kettering Cancer Center in New York City, told MedPage Today via email.

“Thus, we’ve seen several trials that show benefit and multiple trials that show no benefit,” said Breitbart, a member of the National Comprehensive Cancer Network (NCCN) Guidelines Panel for Cancer-Related Fatigue.

Challenges of such trials include:

Choosing a sufficiently severe fatigue threshold to allow adequate room for improvement in fatigue; the current study used>3 on a scale of 10Screening out patients with clinical depression to ensure the study assesses the effects of methylphenidate on cancer-related fatigue and not fatigue associated with depressionA study should focus on a homogeneous population (e.g., patients with prostate cancer treated with hormonal therapy); patients with advanced cancer have multiple potential causes of fatigue which might respond differently to methylphenidateThe placebo effect for a subjective symptom such as fatigue can be quite prolonged, and active drug and placebo may not separate for 4-6 weeks or more, so longer trials are necessaryAssessing fatigue with scales that focus only on subjective report — without studying cognitive effects and physical endurance effects, as well — reduces a multi-dimensional symptom to only one dimension, which may be insufficient to draw conclusions

“The NCCN Guidelines support the use of psychostimulants is not simply based on the published trials, but also on clinical judgment and expertise,” said Breitbart. “Clinicians utilize methylphenidate in clinical practice and often see benefits in fatigue. Treatment effects are often improved further if the underlying causes of fatigue can be simultaneously treated (e.g., anemia). However, a consensus of clinicians treating clinical fatigue in patients who are fatigued from cancer treatments of other etiologies find methylphenidate to be useful.”

Stone and colleagues noted that the NCCN “advises that methylphenidate can be considered in selected patients, but should be used cautiously and not until treatment and disease-specific morbidities have been characterized and excluded.” The guideline points out that optimal dosing and schedule have yet to be determined. Meanwhile, the European Society for Medical Oncology guideline on cancer-related fatigue “is noncommittal about the issue,” they wrote.

Given the ongoing uncertainty about methylphenidate’s effectiveness, the authors performed a placebo-controlled trial of individually titrated doses of the drug in patients with advanced cancer. The primary objective was fatigue scores after 6 weeks of treatment. Secondary outcomes included QoL, AEs, activities of daily living, appetite, patient satisfaction, survival, and need for other medications. Fatigue was assessed by means of the FACIT-F questionnaire, and significant baseline fatigue was defined as>3.

Data analysis included 159 patients (76 men, 83 women) who had a mean age of 63.7. The most common cancers in both groups were breast, lung, prostate, and lower gastrointestinal. Other baseline characteristics were balanced between the methylphenidate and placebo arms.

AEs had no discernible patterns to suggest greater harm from methylphenidate than placebo. A total of 25 serious AEs occurred in each arm.

After 6 weeks, the FACIT-F score in the methylphenidate group exceeded that of the placebo group by 1.97 (95% CI -0.95 to 4.90, P=0.186). A sensitivity analysis resulted in a difference of 2.05 in favor of methylphenidate, also nonsignificant. A threshold analysis produced a difference of 3.15 in favor of methylphenidate, still less than a minimally clinically important difference (MCID) of 5.

An analysis at 10 weeks showed a difference of 2.20 in favor of methylphenidate, still less than the MCID.

Mortality was similar in the two groups.

author['full_name']

Charles Bankhead is senior editor for oncology and also covers urology, dermatology, and ophthalmology. He joined MedPage Today in 2007. Follow

Disclosures

The study was supported by the UK National Institute for Health Research.

Stone had no relevant financial disclosures. Co-author Nick Freemantle disclosed relationships with Sanofi/Aventis, AstraZeneca, Thea, ALK, and Bloomsbury Therapeutixs.

Zimmermann is an associate editor of the Journal of Clinical Oncology. She disclosed a relationship with Pfizer.

Breitbart disclosed a relationship with Novartis.

Primary Source

Journal of Clinical Oncology

Source Reference: Stone PC, et al “Methylphenidate versus placebo for treating fatigue in patients with advanced cancer: Randomized, double-blind, multicenter, placebo-controlled trial” J Clin Oncol 2024; DOI: 10.1200/JCO.23.02639.

Secondary Source

Journal of Clinical Oncology

Source Reference: Chin-Yee N, et al “Putting methylphenidate for cancer-related fatigue to rest?” J Clin Oncol 2024; DOI: 10.1200/JCO.24.00707.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/hematologyoncology/othercancers/110281

Tags: healthPsychostimulantrelieving
Previous Post

The Morning Routine Jennifer Garner Swears By to Feel and Look Her Best at 52

Next Post

Nutrition Experts Call on Congress to Advance ‘Food Is Medicine’ Movement

City Parks Initiative Launches Ecological Tracker for Bond Projects – Citizen Portal AI

Revolutionary Ecological Tracker Unveiled to Transform Monitoring of City Parks Bond Projects

September 27, 2025
Award-winning science writer leads student discussions at Eckerd – theonlinecurrent.com

Award-Winning Science Writer Inspires Student Discussions at Eckerd College

September 27, 2025
Human Head Transplants: Where the Science Stands, and Why the Ethics Are So Complicated – Discover Magazine

Human Head Transplants: The Science Behind the Procedure and the Complex Ethical Debate

September 27, 2025
New lifestyle brand TENŌRE set to open flagship store in Waikīkī – KITV

New lifestyle brand TENŌRE set to open flagship store in Waikīkī – KITV

September 27, 2025
Aurora police hope to add facial recognition technology to crime-fighting tools – CBS News

Aurora Police Aim to Boost Crime-Fighting with New Facial Recognition Technology

September 27, 2025
Hawaii women’s volleyball team prepares to get creative for Big West play – Spectrum News NY1

Hawaii women’s volleyball team prepares to get creative for Big West play – Spectrum News NY1

September 27, 2025
Hypertension – World Health Organization (WHO)

Hypertension – World Health Organization (WHO)

September 26, 2025
In Kansas City, Secretary Rollins Speaks on State of Farm Economy, Announces Suite of Actions to Support American Farmers – USDA (.gov)

Secretary Rollins Launches Bold New Initiatives to Boost Kansas City’s Farm Economy and Empower American Farmers

September 26, 2025
Cardi B Adds More Dates to Little Miss Drama Tour: ‘Y’all Making Me Work’ – Yahoo

Cardi B Extends Little Miss Drama Tour: “Y’all Making Me Work

September 26, 2025
Vandalia Health Mon Stonewall Jackson Memorial Hospital to host blood drive Sept. 29 – Mon Health

Vandalia Health Mon Stonewall Jackson Memorial Hospital to Host Life-Saving Blood Drive on September 29

September 26, 2025

Categories

Archives

September 2025
M T W T F S S
1234567
891011121314
15161718192021
22232425262728
2930  
« Aug    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (839)
  • Economy (859)
  • Entertainment (21,734)
  • General (17,265)
  • Health (9,902)
  • Lifestyle (872)
  • News (22,149)
  • People (861)
  • Politics (869)
  • Science (16,069)
  • Sports (21,359)
  • Technology (15,842)
  • World (842)

Recent News

City Parks Initiative Launches Ecological Tracker for Bond Projects – Citizen Portal AI

Revolutionary Ecological Tracker Unveiled to Transform Monitoring of City Parks Bond Projects

September 27, 2025
Award-winning science writer leads student discussions at Eckerd – theonlinecurrent.com

Award-Winning Science Writer Inspires Student Discussions at Eckerd College

September 27, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version