* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Tuesday, October 7, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Charlie Hunnam Reflects on Playing a Serial Killer in Monster: The Ed Gein Story – Yahoo

    Charlie Hunnam Reveals the Dark Challenges of Playing a Serial Killer in Monster: The Ed Gein Story

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    Why Taylor Swift Name-Dropped Elizabeth Taylor in Her New Album – Yahoo

    Here’s Why Taylor Swift Dropped Elizabeth Taylor’s Name in Her New Album

    Al Roker Gives Olivia Dean an Unexpected ‘New Job’ on the ‘Today’ Show – Yahoo

    Al Roker Shocks Olivia Dean with an Exciting New Role on the ‘Today’ Show

    Books about the arts and some haunts for a Denton October – Denton Record-Chronicle

    Uncover Artistic Treasures and Spooky Adventures to Experience in Denton This October

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    ARM Institute opens technology project call to speed submarine manufacturing – The Robot Report

    ARM Institute Unveils Cutting-Edge Technology Project to Revolutionize Submarine Manufacturing

    Forget Cowbells. Cows Wear High-Tech Collars Now. – The New York Times

    Ditch the Cowbells: Discover the High-Tech Collars Transforming Cattle Care

    What the Recent Price Surge Means for Figure Technology Solutions After SEC Settlement – Yahoo Finance

    What the Recent Price Surge Reveals About Figure Technology Solutions Following SEC Settlement

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    A Tech Expo Shows What China Can Make, but Not Who’ll Buy It All – The New York Times

    Inside China’s Tech Expo: Cutting-Edge Innovations Face Uncertain Demand

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Charlie Hunnam Reflects on Playing a Serial Killer in Monster: The Ed Gein Story – Yahoo

    Charlie Hunnam Reveals the Dark Challenges of Playing a Serial Killer in Monster: The Ed Gein Story

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    Why Taylor Swift Name-Dropped Elizabeth Taylor in Her New Album – Yahoo

    Here’s Why Taylor Swift Dropped Elizabeth Taylor’s Name in Her New Album

    Al Roker Gives Olivia Dean an Unexpected ‘New Job’ on the ‘Today’ Show – Yahoo

    Al Roker Shocks Olivia Dean with an Exciting New Role on the ‘Today’ Show

    Books about the arts and some haunts for a Denton October – Denton Record-Chronicle

    Uncover Artistic Treasures and Spooky Adventures to Experience in Denton This October

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    ARM Institute opens technology project call to speed submarine manufacturing – The Robot Report

    ARM Institute Unveils Cutting-Edge Technology Project to Revolutionize Submarine Manufacturing

    Forget Cowbells. Cows Wear High-Tech Collars Now. – The New York Times

    Ditch the Cowbells: Discover the High-Tech Collars Transforming Cattle Care

    What the Recent Price Surge Means for Figure Technology Solutions After SEC Settlement – Yahoo Finance

    What the Recent Price Surge Reveals About Figure Technology Solutions Following SEC Settlement

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    A Tech Expo Shows What China Can Make, but Not Who’ll Buy It All – The New York Times

    Inside China’s Tech Expo: Cutting-Edge Innovations Face Uncertain Demand

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Published Data Show Why GSK Bailed on Its Maternal RSV Vaccine

March 14, 2024
in Health
Published Data Show Why GSK Bailed on Its Maternal RSV Vaccine
Share on FacebookShare on Twitter

GSK’s abandoned maternal respiratory syncytial virus (RSV) vaccine protected infants from severe RSV, final results of a phase III trial indicated, but those positive outcomes came at the expense of an unexplained higher risk for preterm birth.

For newborns up to 6 months of age, efficacy with the RSV prefusion F protein-based vaccine (RSVPreF3-Mat) during pregnancy arrived at 65.5% (95% credible interval [CrI] 37.5-82.0) and 69% (95% CrI 33.0-87.6), respectively, against either any or severe RSV-associated lower respiratory tract disease, according to Philip Dormitzer, MD, PhD, of GSK in Waltham, Massachusetts, and colleagues.

But a 37% increased risk of preterm birth in the vaccination arm led the company to halt the trial in February 2022 and cease further development of the maternal vaccine, the researchers reported in the New England Journal of Medicine.

In total, 6.8% of infants in the vaccination arm were born preterm, as compared with 4.9% of those in the placebo group (RR 1.37, 95% CI 1.08-1.74). For every 54 infants born to women who received the vaccine, one additional preterm birth occurred.

“No other safety signal has been observed among infant or maternal participants in any trial of RSVPreF3-Mat,” the study authors wrote, adding that a previous phase II trial and unpublished data from a phase III trial found no association between the vaccine and preterm births.

Dormitzer and investigators also considered potential effects of additional vaccines received during pregnancy — such as vaccines for COVID, the flu, tetanus, and tetanus-diphtheria, none of which have been linked to an increased risk for preterm birth. Receipt of additional vaccines during pregnancy was associated with a lower incidence of preterm birth in both the vaccine and placebo groups, but the reduction in risk was greater in the placebo group.

RSV is the leading cause of hospitalization among infants in the U.S., with 2% to 3% of infants younger than 6 months of age hospitalized for RSV infection annually, noted Sonja Rasmussen, MD, of Johns Hopkins University School of Medicine in Baltimore, and Denise Jamieson, MD, MPH, of the University of Iowa Carver College of Medicine in Iowa City, in an accompanying editorial.

“Whether the safety signal in the RSVPreF3-Mat trial is real or occurred by chance is unknown,” they wrote.

Currently, only Pfizer’s bivalent RSV vaccine (Abrysvo) is approved and recommended for use during pregnancy to protect newborns from serious RSV-related outcomes. However, concerned with a possible risk for preterm birth, the FDA restricted its use to between weeks 32 and 36 of gestation. (The monoclonal antibody nirsevimab [Beyfortus] is also recommended for use in newborns entering their first RSV season, provided the mother did not receive an RSV vaccine during pregnancy.)

With more maternal vaccines in development, the editorialists said that “continued focus on balancing the benefits with the potential risks of maternal vaccination will be essential as we move forward to protect infants from the severe effects of infectious diseases.”

The current study, GRACE or RSV MAT-009, was a phase III double-blind trial that enrolled 5,328 pregnant women ages 18-49 across 24 countries. Women were randomized 2:1 to receive the RSV vaccine or placebo between 24 and 34 weeks of gestation.

Most of the women (80%) were between the ages of 18 and 34 years, with 17% ages 35 to 39 and the remaining over 40. When it came to race and ethnicity, 47% were white, 33% were Hispanic or Latino, and 14% were Black. About half were of low to middle income.

At day 43 after birth, data were available for 3,494 infants in the vaccine group and 1,739 in the placebo group. Of infants in the vaccine group, 237 were born prematurely (
>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/infectiousdisease/vaccines/109161

Tags: bailedhealthPublished
Previous Post

Space Flights Provoke Tension Headaches, Migraine

Next Post

Novel CAR-T for Glioblastoma Induced ‘Dramatic’ Responses in Early Trial

Jason Anderson Signs for Suzuki for 2026 SMX World Championship – Monster Energy AMA Supercross

Jason Anderson Signs for Suzuki for 2026 SMX World Championship – Monster Energy AMA Supercross

October 7, 2025
Downtown St. Paul’s economy showing new life after state employees mandated to return to office – 5 EYEWITNESS NEWS

Downtown St. Paul Thrives Again as State Employees Return to the Office

October 7, 2025
No, Anthony Boyle Didn’t Use a Prosthetic in His House of Guinness Bath Scene – Yahoo

Anthony Boyle Opens Up About the Shocking Truth Behind His House of Gucci Bath Scene

October 7, 2025
Ozzy Osbourne documentary reveals agonizing health struggles of his final years – USA Today

Inside Ozzy Osbourne’s Heartbreaking Battle with Health in His Final Years

October 7, 2025
Latino leaders explore the role community organizing can play in national politics – OSV News

Latino Leaders Unite to Amplify Community Power and Drive National Change

October 7, 2025
Ecology blazing the trail for more clean energy projects – Washington State Department of Ecology (.gov)

How Ecology is Powering the Shift to a Greener Energy Future

October 7, 2025
Penn State Brandywine Earth sciences professor earns two national awards – Penn State University

Penn State Brandywine Earth sciences professor earns two national awards – Penn State University

October 7, 2025
UNESCO and CODATA launch resources on open science for crisis response – unesco.org

UNESCO and CODATA Launch Innovative Open Science Tools to Enhance Crisis Response

October 7, 2025
New Engen Report Identifies Key Trends and Winning Strategies for Active Lifestyle Brands in 2025 and Beyond – Fitt Insider

New Engen Report Identifies Key Trends and Winning Strategies for Active Lifestyle Brands in 2025 and Beyond – Fitt Insider

October 7, 2025
ARM Institute opens technology project call to speed submarine manufacturing – The Robot Report

ARM Institute Unveils Cutting-Edge Technology Project to Revolutionize Submarine Manufacturing

October 7, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (855)
  • Economy (876)
  • Entertainment (21,749)
  • General (17,457)
  • Health (9,918)
  • Lifestyle (888)
  • News (22,149)
  • People (877)
  • Politics (887)
  • Science (16,086)
  • Sports (21,376)
  • Technology (15,856)
  • World (859)

Recent News

Jason Anderson Signs for Suzuki for 2026 SMX World Championship – Monster Energy AMA Supercross

Jason Anderson Signs for Suzuki for 2026 SMX World Championship – Monster Energy AMA Supercross

October 7, 2025
Downtown St. Paul’s economy showing new life after state employees mandated to return to office – 5 EYEWITNESS NEWS

Downtown St. Paul Thrives Again as State Employees Return to the Office

October 7, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version