* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Thursday, October 23, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Reba McEntire Details Personal Relationship With Late Stepson Brandon Blackstock – KNDU

    Reba McEntire Shares Emotional Tribute to Her Late Stepson Brandon Blackstock

    Sacramento city leaders approve adding 2 entertainment zones in midtown – CBS News

    Sacramento City Leaders Approve Two Thrilling New Entertainment Zones in Midtown

    AMC brings first new Dolby Experience to Gwinnett since 2017 – Wyoming News Now

    AMC Launches First New Dolby Experience in Gwinnett Since 2017

    Hetzel Design: blending architecture and entertainment – Blooloop

    Hetzel Design: Where Architecture and Entertainment Unite in Perfect Harmony

    Country music legend rushed to hospital year after heart surgery. Here’s what we know – PennLive.com

    Country Music Legend Rushed to Hospital One Year After Heart Surgery – What’s Happening Now?

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Rydberg Technologies Inc. Announces Launch of Rydberg Photonics in Berlin – The Quantum Insider

    Rydberg Technologies Launches Exciting New Photonics Division in Berlin

    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 Technology Stocks to Buy Now – Yahoo Finance

    3 Must-Buy Tech Stocks You Can’t Afford to Miss Right Now

    ‘New frontier’: Austin leaders start discussions on air taxi technology – KXAN Austin

    Austin Leaders Ignite Exciting Conversations on the Future of Air Taxi Technology

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Reba McEntire Details Personal Relationship With Late Stepson Brandon Blackstock – KNDU

    Reba McEntire Shares Emotional Tribute to Her Late Stepson Brandon Blackstock

    Sacramento city leaders approve adding 2 entertainment zones in midtown – CBS News

    Sacramento City Leaders Approve Two Thrilling New Entertainment Zones in Midtown

    AMC brings first new Dolby Experience to Gwinnett since 2017 – Wyoming News Now

    AMC Launches First New Dolby Experience in Gwinnett Since 2017

    Hetzel Design: blending architecture and entertainment – Blooloop

    Hetzel Design: Where Architecture and Entertainment Unite in Perfect Harmony

    Country music legend rushed to hospital year after heart surgery. Here’s what we know – PennLive.com

    Country Music Legend Rushed to Hospital One Year After Heart Surgery – What’s Happening Now?

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

    Strictly Come Dancing results: Chris Robshaw is eliminated while drag queen La Voix escapes dance-off – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Rydberg Technologies Inc. Announces Launch of Rydberg Photonics in Berlin – The Quantum Insider

    Rydberg Technologies Launches Exciting New Photonics Division in Berlin

    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    A look into new technology at Columbia University that could help prevent a dangerous pregnancy complication – ABC7 New York

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    Office Technology: Dealers’ Managed IT Revenue up Nearly 30% – The Cannata Report –

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 E Network Technology Group Limited Closes $1.5 Million Convertible Promissory Note Offering – Quiver Quantitative

    3 Technology Stocks to Buy Now – Yahoo Finance

    3 Must-Buy Tech Stocks You Can’t Afford to Miss Right Now

    ‘New frontier’: Austin leaders start discussions on air taxi technology – KXAN Austin

    Austin Leaders Ignite Exciting Conversations on the Future of Air Taxi Technology

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Researchers develop preclinical vaccine to regulate immune responses to prevent kidney and heart transplant rejection

November 16, 2023
in Health
Researchers develop preclinical vaccine to regulate immune responses to prevent kidney and heart transplant rejection
Share on FacebookShare on Twitter

vaccine

Credit: CC0 Public Domain

A subtype of CD8 T cells, which are classically known to promote immune system responses, may be in fact regulating the immune system by suppressing immune cells causing self-destructive responses leading to autoimmune disorders and organ graft rejection. A team led by researchers from the Department of Medicine and the Transplant Research Center at Brigham and Women’s Hospital, in collaboration with researchers from the Dana-Farber Cancer Institute, has developed a vaccine in preclinical models to promote immune regulation.

The work is published in the Journal of Clinical Investigation.

The vaccine utilizes synthetically modified natural peptides to stimulate CD8 T regulatory cells. Using a mouse model, the researchers discovered that those self-peptides, presented by a specific class of major histocompatibility complexes, flag harmful immune cells for the body’s own regulatory CD8 Tregs to attack and eliminate. The vaccine stimulated and promoted those regulatory T cells that in turn kept the harmful cells under check.

These cells are crucial for maintaining immune responses and preventing inflammation. The researchers found that the developed vaccine prolongs allograft survival in mice and tested anti-allograft immunity on mismatched kidney transplants. An analogous pathway in humans was also identified, implying that this research could protect those with autoimmune disorders or organ transplant patients.

“This new vaccine promotes immune regulation that treats autoimmunity and prolongs kidney allograft survival in mice. Our research identifies an analogous pathway in humans that we hope to target soon,” said co-corresponding author Jamil R. Azzi, MD, Ph.D., of the Brigham’s Transplant Research Center. “Identification of human T cell receptors homologous to the mouse model tested may form the basis of a novel and effective treatment for disorders that reflect excessive or dysregulated immune responses.”

This work was done in collaboration with co-corresponding author Harvey Cantor MD, of the Dana-Farber Cancer Institute.

More information:
Hye-Jung Kim et al, A narrow T cell receptor repertoire instructs thymic differentiation of MHC class Ib-restricted CD8+ regulatory T-cells, Journal of Clinical Investigation (2023). DOI: 10.1172/JCI170512

Citation:
Researchers develop preclinical vaccine to regulate immune responses to prevent kidney and heart transplant rejection (2023, November 15)
retrieved 15 November 2023
from https://medicalxpress.com/news/2023-11-preclinical-vaccine-immune-responses-kidney.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2023-11-preclinical-vaccine-immune-responses-kidney.html

Tags: develophealthResearchers
Previous Post

Senators Discuss Making Medicare’s Relaxed Telehealth Rules Permanent

Next Post

FTC warns food industry trade groups and influencers about disclosures on paid social media posts

UIPM 2025 Obstacle World Championships (OCR): All you need to know – Union Internationale de Pentathlon Moderne (UIPM)

Your Ultimate Guide to the 2025 Obstacle World Championships

October 23, 2025
PPPs in Bolivia: The future of our economy? – Dentons

Could PPPs Unlock Bolivia’s Path to Economic Prosperity?

October 23, 2025
Reba McEntire Details Personal Relationship With Late Stepson Brandon Blackstock – KNDU

Reba McEntire Shares Emotional Tribute to Her Late Stepson Brandon Blackstock

October 23, 2025
Mark Peterson receives inaugural APSA Career Achievement Award in Health Politics and Policy – UCLA

Mark Peterson receives inaugural APSA Career Achievement Award in Health Politics and Policy – UCLA

October 23, 2025
GOP senator accuses Dems of playing politics with people’s lives: ‘This is a crime’ – Fox Business

GOP Senator Slams Democrats for Playing Politics with People’s Lives: ‘This Is a Crime

October 23, 2025
Forest cover enhances pest control by birds and bats independently of vineyard management intensity – besjournals

Forest cover enhances pest control by birds and bats independently of vineyard management intensity – besjournals

October 22, 2025
November Family Consumer Science Program – Alachua County

November Family Consumer Science Program – Alachua County

October 22, 2025
Correction: Anti-Science Movement story – The News-Gazette

Unraveling the Truth Behind the Anti-Science Movement: A Closer Look

October 22, 2025
Best Burgers 2025: 9 cult-favorite burgers off the beaten path – Yahoo

Best Burgers 2025: 9 cult-favorite burgers off the beaten path – Yahoo

October 22, 2025
Rydberg Technologies Inc. Announces Launch of Rydberg Photonics in Berlin – The Quantum Insider

Rydberg Technologies Launches Exciting New Photonics Division in Berlin

October 22, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (881)
  • Economy (903)
  • Entertainment (21,774)
  • General (17,751)
  • Health (9,944)
  • Lifestyle (915)
  • News (22,149)
  • People (903)
  • Politics (913)
  • Science (16,113)
  • Sports (21,402)
  • Technology (15,882)
  • World (886)

Recent News

UIPM 2025 Obstacle World Championships (OCR): All you need to know – Union Internationale de Pentathlon Moderne (UIPM)

Your Ultimate Guide to the 2025 Obstacle World Championships

October 23, 2025
PPPs in Bolivia: The future of our economy? – Dentons

Could PPPs Unlock Bolivia’s Path to Economic Prosperity?

October 23, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version