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Researchers find an epigenetic key that unlocks common deadly cancers

July 28, 2023
in Health
Researchers find an epigenetic key that unlocks common deadly cancers
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Researchers find an epigenetic key that unlocks common deadly cancers

Lesions (in green) akin to basal cell carcinoma that were induced by SOX9 in the epidermis. Abnormal differentiation is shown in red, and blue marks cell nuclei. Credit: Yihao Yang, Fuchs Lab

Early on, every stem cell faces a fateful choice. During skin development, for instance, the embryonic epidermis begins as a single layer of epidermal progenitor cells. Their choice is to become a mature epidermal cell or switch to becoming a hair follicle cell. This so-called fate switch is governed by the transcription factor SOX9. If the progenitor cell expresses SOX9, hair follicle cells develop. If it doesn’t, epidermal cells do.

But there is a dark side to SOX9, as it’s implicated in many of the deadliest cancers worldwide, including lung, skin, head and neck, and bone cancer. In skin, some aberrant adult epidermal stem cells later turn on SOX9 despite their chosen path—and never turn it off, kickstarting a process that ultimately activates cancer genes.

Scientists have never fully understood how this doomed outcome ensues at a molecular level. But now Rockefeller researchers have revealed the mechanisms behind this malignant turn of events. SOX9, it turns out, belongs to a special class of proteins that govern the transfer of genetic information from DNA to mRNA. That means it has the ability to pry open sealed pockets of genetic material, bind to previously silent genes within, and activate them. They published their results in Nature Cell Biology.

“Our discovery provides new insights into how cancer derails a stem cell’s carefully tuned decision-making process, thereafter making it impossible for it to make normal tissue,” says Elaine Fuchs, head of the Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development. “It also illuminates new SOX9-activated genes as potential therapeutic targets.”

Rare keys to gene expression

Our genome is not an open book. In fact, it’s more like a library filled with a few billion books that are mostly under lock-and-key—the majority of genetic material actually lies silent within non-coding and tightly bound packets of DNA cordoned off by histone proteins in a closed state. Together the DNA and histones form what’s called closed chromatin. The genes that are packaged into this cloistered material is inaccessible to the transcription proteins, or factors, that would help it to express the genes within.

But there are a few rare keys that aren’t simply transcription factors. These “pioneer factors” can unlock those genetic packets. They possess the superpower to peer inside the closed chromatin and recognize binding sites within. They then recruit other transcription factors to help them pry open the closed chromatin and bind to receptor sites on the nucleosome, which reprograms the chromatin and activates new genes.

This normally happens during early stages of development, when a stem cell’s fate is yet to be determined. In adult skin, SOX9 is normally associated with maintaining the identity of adult hair follicle stem cells. It’s normally suppressed in adult epidermal stem cells. But that’s not the case when it comes to basal cell and squamous cell carcinomas.

“In the disease context, SOX9 gets reactivated in adult epidermal stem cells,” says Yihao Yang, first author of the study.

How this process might unfold step by step has been unknown, Yang says. “Reprogramming in vitro happens really fast—within 48 hours. With such a short time window, it’s hard to get a good resolution on the sequence of events.”

The SOX9 swap

To find out, the researchers engineered mice that contained a copy of SOX9 that could be activated in their adult epidermal stem cells when the mice were fed doxycycline, a drug that induced the transgenic SOX9.

“In adult tissues, choices that were easily made in embryogenesis are tightly suppressed so that adult stem cells stick to their dedicated task,” explains Fuchs.

Unleashing SOX9, however, turned out to be a potent influencer, progressively reprogramming the epidermal stem cells to new fates. “By only expressing this single SOX9 transcription factor,” Yang says, “we were able to induce basal cell carcinoma-like structures by week six. By week 12, we started to see lesions that resembled human basal cell carcinoma.”

Simultaneously, they tracked the epigenetic process going on behind the scenes. In the first two weeks, SOX9 turned off the epidermal stem cell genes. Reversing their normal state, they began to turn on hair follicle stem cell genes.

Seeking the mechanism, the researchers discovered that to achieve this fate switch, SOX9 hijacked the nuclear machinery from the active epidermal genes and brought this stolen equipment to the silent hair follicle genes. It then enlisted other transcription factors to pry open the closed chromatin bind to the silent genes within, turning them on.

“When SOX9 could not be regulated, the stem cells failed to make hair but instead just kept proliferating and activating several new transcription factors, eventually leading to a basal cell carcinoma state,” Fuchs says.

This complicated, identity-shifting back-and-forth was only possible because SOX9 is a pioneer factor, Yang says. “Only a pioneer factor has the ability to access closed chromatin,” he points out.

Because SOX9 is overly active in many of the deadliest cancers worldwide, the researchers aim to look for ways to intervene in its role in proliferating these cells. “By identifying how SOX9’s interacting proteins and its target genes change during malignancy, we hope to make inroads into unearthing new drug targets for these cancers,” Fuchs says.

More information:
Yihao Yang et al, The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates, Nature Cell Biology (2023). DOI: 10.1038/s41556-023-01184-y

Citation:
Researchers find an epigenetic key that unlocks common deadly cancers (2023, July 28)
retrieved 28 July 2023
from https://medicalxpress.com/news/2023-07-epigenetic-key-common-deadly-cancers.html

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