* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Wednesday, June 4, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

    Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

    Salem’s Harborwalk Garden Cultivates Community with Entertainment, Food, and Events – 105.7 WROR

    Discover the Vibrant Community Spirit at Salem’s Harborwalk Garden: A Hub for Entertainment, Food, and Fun!

    Entertainment-Focused Narrative and Culture Change Practice – New America

    Transforming Culture Through Engaging Entertainment Narratives

    Rising stars: Young classical musicians surging on social media – Yahoo

    Meet the Next Generation of Classical Music Sensations Making Waves on Social Media!

    Devin Harjes Dies: ‘Manifest’ & ‘Boardwalk Empire’ Actor Was 41 – WyomingNews.com

    Tragic Loss: Devin Harjes, Star of ‘Manifest’ and ‘Boardwalk Empire,’ Passes Away at 41

    Why Starz Entertainment Stock Soared Today – The Motley Fool

    Unpacking the Surge: What Fueled Starz Entertainment’s Stock Explosion Today!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Finland Set to Lead EU Quantum Technology Defense Project – IoT World Today

    Finland Set to Lead EU Quantum Technology Defense Project – IoT World Today

    AI for lawyers: Win back your time using technology – nationaljurist.com

    Reclaim Your Time: How AI is Transforming the Legal Profession

    Prosecutors accuse men of exporting U.S. military technology to China – Milwaukee Journal Sentinel

    Men Charged with Illegally Exporting U.S. Military Technology to China

    ROLAND’S NEW WIRELESS TRIGGER TECHNOLOGY, PORTER & DAVIES ON TOUR, NEW 64 AUDIO ASPIRE UNIVERSAL IEM MODELS, WAVES FREE PLUGIN PACK – Modern Drummer Magazine

    ROLAND’S NEW WIRELESS TRIGGER TECHNOLOGY, PORTER & DAVIES ON TOUR, NEW 64 AUDIO ASPIRE UNIVERSAL IEM MODELS, WAVES FREE PLUGIN PACK – Modern Drummer Magazine

    This giant microwave may change the future of war – MIT Technology Review

    Revolutionizing Warfare: The Impact of a Game-Changing Giant Microwave

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

    Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

    Salem’s Harborwalk Garden Cultivates Community with Entertainment, Food, and Events – 105.7 WROR

    Discover the Vibrant Community Spirit at Salem’s Harborwalk Garden: A Hub for Entertainment, Food, and Fun!

    Entertainment-Focused Narrative and Culture Change Practice – New America

    Transforming Culture Through Engaging Entertainment Narratives

    Rising stars: Young classical musicians surging on social media – Yahoo

    Meet the Next Generation of Classical Music Sensations Making Waves on Social Media!

    Devin Harjes Dies: ‘Manifest’ & ‘Boardwalk Empire’ Actor Was 41 – WyomingNews.com

    Tragic Loss: Devin Harjes, Star of ‘Manifest’ and ‘Boardwalk Empire,’ Passes Away at 41

    Why Starz Entertainment Stock Soared Today – The Motley Fool

    Unpacking the Surge: What Fueled Starz Entertainment’s Stock Explosion Today!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Finland Set to Lead EU Quantum Technology Defense Project – IoT World Today

    Finland Set to Lead EU Quantum Technology Defense Project – IoT World Today

    AI for lawyers: Win back your time using technology – nationaljurist.com

    Reclaim Your Time: How AI is Transforming the Legal Profession

    Prosecutors accuse men of exporting U.S. military technology to China – Milwaukee Journal Sentinel

    Men Charged with Illegally Exporting U.S. Military Technology to China

    ROLAND’S NEW WIRELESS TRIGGER TECHNOLOGY, PORTER & DAVIES ON TOUR, NEW 64 AUDIO ASPIRE UNIVERSAL IEM MODELS, WAVES FREE PLUGIN PACK – Modern Drummer Magazine

    ROLAND’S NEW WIRELESS TRIGGER TECHNOLOGY, PORTER & DAVIES ON TOUR, NEW 64 AUDIO ASPIRE UNIVERSAL IEM MODELS, WAVES FREE PLUGIN PACK – Modern Drummer Magazine

    This giant microwave may change the future of war – MIT Technology Review

    Revolutionizing Warfare: The Impact of a Game-Changing Giant Microwave

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Researchers reverse chemotherapy-related fertility loss using cell-based therapy

July 21, 2023
in Health
Researchers reverse chemotherapy-related fertility loss using cell-based therapy
Share on FacebookShare on Twitter

stem cell

Credit: CC0 Public Domain

A new study in a preclinical model, by investigators from Brigham and Women’s Hospital, demonstrates the potential for restoring fertility when the ovaries have stopped working. The researchers found that adult stem cells could restore healthy hormone levels after chemotherapy and lead to natural conception resulting in the birth of live mice. Techniques based on the study could revolutionize fertility options for women with premature ovarian failure. The results are published today in the journal eBioMedicine.

The preclinical study showed that injecting ovarian tissue-derived differentiated induced pluripotent stem cells can restore hormone production and fertility in mice with premature ovarian failure related to genetic diseases and cancer treatment.

“This proof-of-principle study shows that you can take non-reproductive cells and make them into functional eggs that can develop into multiple generations of live animals,” said corresponding author Raymond Manohar Anchan, MD, Ph.D., director of the stem cell biology and regenerative medicine research laboratory in the Brigham’s Center for Infertility and Reproductive Surgery. “The study is exciting because it gives hope to patients with ovarian failure that they may be able to have biological children and make reproductive hormones.”

Studies like this one show the promise of cell therapy for treating incurable conditions. Mass General Brigham’s Gene and Cell Therapy Institute is helping to translate scientific discoveries made by researchers into first-in-human clinical trials, and ultimately, life-changing treatments for patients. The Institute’s multidisciplinary approach sets it apart from others in the space, helping researchers to rapidly advance new therapies and pushing the technological and clinical boundaries of this new frontier.

About 5% of women have premature ovarian failure from cancer treatment or genetic issues. As cancer rates among younger adults continue to rise, chemotherapy-related infertility rates are expected to rise as well. Once a person’s ovaries fail, hormone levels fall, and they lose the ability to create eggs and conceive children. There are currently no therapies to get their fertility back after ovarian failure. To have kids, people with ovarian failure need to use donor or frozen eggs or embryos.

Ovarian failure can also cause other health issues related to low hormone levels. People with ovarian failure may lose bone mass and have sexual and heart health issues. Synthetic hormone replacement therapy can help, but there are limited data on its long-term use in teens and young people.

Previous studies have shown that cells from the mouse ovary, called granulosa cells, can be used to create induced pluripotent stem cells. These stem cells can become any kind of cell in the body. The researchers turned them into ovarian cells and showed in the lab that the cells make reproductive hormones like estrogen and progesterone and can become cells that turn into eggs.

The researchers saw that the injected stem cells restored the mouse hormone levels and fertility, including the ability to conceive and give birth to live mouse pups naturally. Interestingly, they also saw that the injection of stem cells into one ovary appeared to heal the other ovary, restarting its egg production.

“I think that was the most exciting finding. We were able to get some of the animals’ autologous eggs to come resume development in both ovaries, not just the ovary we injected,” Anchan said. “The stem cells must be secreting a factor promoting this healing process. We’re now looking at what the factor or factors might be. Identifying such a factor or factors would be doubly exciting because perhaps we can treat some patients with this factor without having to inject any cells.”

Limitations of the study include that it was done in mice. There’s no proof this would work in humans. There may be ethical issues in using induced stem cells to conceive new humans. The researchers don’t know if the pups born from these stem cell-derived eggs are healthy and normal beyond surviving birth and being able to breed. Longer-term studies of the offspring from these experiments are happening now.

More information:
Elias, K., Ng, N et al. Fertility restoration in mice with chemotherapy induced ovarian failure using differentiated iPSCs, eBioMedicine (2023). DOI: 10.1016/j.ebiom.2023.104715

Citation:
Researchers reverse chemotherapy-related fertility loss using cell-based therapy (2023, July 21)
retrieved 21 July 2023
from https://medicalxpress.com/news/2023-07-reverse-chemotherapy-related-fertility-loss-cell-based.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2023-07-reverse-chemotherapy-related-fertility-loss-cell-based.html

Tags: ‘ReversehealthResearchers
Previous Post

Study: Gastric bypass surgery associated with non-alcohol substance use disorder

Next Post

Finger-Prick Blood Test Promising for Alzheimer’s Diagnosis

Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

June 4, 2025
Kehoe calls special session on storm damage, KC sports teams – FOX 2

Kehoe Announces Special Session to Address Storm Damage and Support KC Sports Teams

June 3, 2025
From Eggs To Fingerlings, Wyoming Students Dive Into The World Of Fish Conservation – KGAB

From Eggs to Fingerlings: Wyoming Students Make Waves in Fish Conservation!

June 3, 2025
‘Sport Science’ founder, host John Brenkus dies at 54 – USA Today

Remembering John Brenkus: The Visionary Behind ‘Sport Science’ Passes Away at 54

June 3, 2025
Champion for Science Education Begins Term as 2025–2026 President of the National Science Teaching Association – FinancialContent

New Era for Science Education: Meet the 2025–2026 President of the National Science Teaching Association!

June 3, 2025
What is the 6-6-6 walking workout that’s going viral? Know its health benefits – financialexpress.com

Discover the Viral 6-6-6 Walking Workout: Unlock Its Amazing Health Benefits!

June 3, 2025

Rediscovered After 185 Years: Meet the Adorable Asian Small-Clawed Otter, the World’s Tiniest Otter Species!

June 3, 2025
USD/JPY climbs a full cent as the US economy keeps on rolling – TradingView

USD/JPY Soars as US Economic Momentum Continues!

June 3, 2025
Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

June 3, 2025
Entry list: Henry Ford Health 200 at Michigan International Speedway – arcaracing.com

Get Ready for the Henry Ford Health 200: Exciting Entry List Revealed for Michigan International Speedway!

June 3, 2025

Categories

Archives

June 2025
MTWTFSS
 1
2345678
9101112131415
16171819202122
23242526272829
30 
« May    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (663)
  • Economy (677)
  • Entertainment (21,583)
  • General (15,260)
  • Health (9,720)
  • Lifestyle (680)
  • News (22,149)
  • People (678)
  • Politics (686)
  • Science (15,898)
  • Sports (21,182)
  • Technology (15,664)
  • World (665)

Recent News

Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

June 4, 2025
Kehoe calls special session on storm damage, KC sports teams – FOX 2

Kehoe Announces Special Session to Address Storm Damage and Support KC Sports Teams

June 3, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version