* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Saturday, July 26, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Cote de Pablo reveals how Michael Weatherly used his soap opera roots to put her at ease in “NCIS” love scene – yahoo.com

    Cote de Pablo Reveals How Michael Weatherly’s Soap Opera Background Made Their “NCIS” Love Scene Easier

    City of Pelham announces entertainment district plans for former Oak Mountain Amphitheatre site – WVTM

    Pelham Unveils Exciting New Entertainment District Plans for Former Oak Mountain Amphitheatre Site

    Black Box Players presents ‘The Three Musketeers’ – CBS 19 News

    Experience the Adventure: Black Box Players Bring ‘The Three Musketeers’ to Life!

    AP Entertainment SummaryBrief at 1:51 p.m. EDT – Channel 3000

    Entertainment Highlights: Key Updates You Can’t Miss

    ‘Devil Wears Prada 2’ casts Anne Hathaway’s love interest replacing Adrian Grenier’s Nate – Entertainment Weekly

    Devil Wears Prada 2′ Casts New Love Interest for Anne Hathaway, Replacing Adrian Grenier’s Nate

    12 ‘Late Show’ Moments Proving Stephen Colbert Can’t Be Replaced – The Mountaineer

    12 Unforgettable ‘Late Show’ Moments That Prove Stephen Colbert Is Truly One of a Kind

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Validea’s Top Information Technology Stocks Based On Peter Lynch – 7/25/2025 – Nasdaq

    Validea’s Top Information Technology Stocks Based On Peter Lynch – 7/25/2025 – Nasdaq

    WhoFi: New surveillance technology can track people by how they disrupt Wi-Fi signals – Tech Xplore

    WhoFi: New surveillance technology can track people by how they disrupt Wi-Fi signals – Tech Xplore

    Google Cloud Announced as a Key Technology Partner for Odoo Connect 2025 in San Francisco – GlobeNewswire

    Google Cloud Announced as a Key Technology Partner for Odoo Connect 2025 in San Francisco – GlobeNewswire

    Behind the Screens: The Impact of Technology on Real Estate – TRREB

    Behind the Screens: How Technology is Transforming the Future of Real Estate

    Sustainserv and Palau Announce Technology Partnership to Leverage Innovative AI Platform to Advance Sustainability Reporting – Business Wire

    Sustainserv and Palau Team Up to Transform Sustainability Reporting with Breakthrough AI Technology

    Morgan Adamski Joins PwC in Newly Created Cyber, Data & Technology Risk Division – HSToday

    Morgan Adamski Leads the Charge in PwC’s Cutting-Edge Cyber, Data & Technology Risk Division

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Cote de Pablo reveals how Michael Weatherly used his soap opera roots to put her at ease in “NCIS” love scene – yahoo.com

    Cote de Pablo Reveals How Michael Weatherly’s Soap Opera Background Made Their “NCIS” Love Scene Easier

    City of Pelham announces entertainment district plans for former Oak Mountain Amphitheatre site – WVTM

    Pelham Unveils Exciting New Entertainment District Plans for Former Oak Mountain Amphitheatre Site

    Black Box Players presents ‘The Three Musketeers’ – CBS 19 News

    Experience the Adventure: Black Box Players Bring ‘The Three Musketeers’ to Life!

    AP Entertainment SummaryBrief at 1:51 p.m. EDT – Channel 3000

    Entertainment Highlights: Key Updates You Can’t Miss

    ‘Devil Wears Prada 2’ casts Anne Hathaway’s love interest replacing Adrian Grenier’s Nate – Entertainment Weekly

    Devil Wears Prada 2′ Casts New Love Interest for Anne Hathaway, Replacing Adrian Grenier’s Nate

    12 ‘Late Show’ Moments Proving Stephen Colbert Can’t Be Replaced – The Mountaineer

    12 Unforgettable ‘Late Show’ Moments That Prove Stephen Colbert Is Truly One of a Kind

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Validea’s Top Information Technology Stocks Based On Peter Lynch – 7/25/2025 – Nasdaq

    Validea’s Top Information Technology Stocks Based On Peter Lynch – 7/25/2025 – Nasdaq

    WhoFi: New surveillance technology can track people by how they disrupt Wi-Fi signals – Tech Xplore

    WhoFi: New surveillance technology can track people by how they disrupt Wi-Fi signals – Tech Xplore

    Google Cloud Announced as a Key Technology Partner for Odoo Connect 2025 in San Francisco – GlobeNewswire

    Google Cloud Announced as a Key Technology Partner for Odoo Connect 2025 in San Francisco – GlobeNewswire

    Behind the Screens: The Impact of Technology on Real Estate – TRREB

    Behind the Screens: How Technology is Transforming the Future of Real Estate

    Sustainserv and Palau Announce Technology Partnership to Leverage Innovative AI Platform to Advance Sustainability Reporting – Business Wire

    Sustainserv and Palau Team Up to Transform Sustainability Reporting with Breakthrough AI Technology

    Morgan Adamski Joins PwC in Newly Created Cyber, Data & Technology Risk Division – HSToday

    Morgan Adamski Leads the Charge in PwC’s Cutting-Edge Cyber, Data & Technology Risk Division

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Results of trial will help guide treatment of malignant bowel obstruction in patients with advanced cancer

August 1, 2023
in Health
Results of trial will help guide treatment of malignant bowel obstruction in patients with advanced cancer
Share on FacebookShare on Twitter

patient

Credit: CC0 Public Domain

Findings from the first-ever prospective trial including a randomized pathway comparing surgery to non-surgical treatment of malignant bowel obstruction (MBO) provide important evidence to help inform clinical decision-making in managing this frequent complication in patients with advanced cancer.

Results include data on clinical outcomes and patient quality of life and are being reported in The Lancet Gastroenterology & Hepatology.

The S1316 study, a hybrid design trial that included a randomized component, was led by the SWOG Cancer Research Network, a clinical trials group. The principal investigator was Robert S. Krouse, MD, professor of surgery at the Perelman School of Medicine at the University of Pennsylvania and chief of surgery at the Corporal Michael J. Crescenz Veterans Affairs Medical Center in Philadelphia.

“We knew enrolling patients in the hospital with this acute issue and advanced cancer would be difficult, but the questions are of great importance to clinicians, patients, and families,” Krouse said. “Based on the results, we believe surgically eligible patients with MBO should be offered an operation earlier in their hospital stay to improve their symptoms, even though these results suggest it will not increase their number of days alive and out of the hospital.”

Partial or complete blockage of the bowel, most often the small intestine, is a common problem for patients with advanced abdominal tumors—particularly for those with ovarian or colorectal cancers. Bowel obstruction can be caused directly by tumors or by adhesions or other complications resulting from surgery or radiation treatment.

In addition to being potentially life-threatening, obstruction can cause considerable suffering, including vomiting, pain, and constipation, and can seriously reduce a patient’s quality of life. Patients with MBO typically are facing end-stage cancer, and their care at this point is primarily palliative, intended to improve their quality of life and reduce symptoms and pain.

Doctors treating MBO in these patients have two primary options—surgical management or non-surgical medical management. But evidence that can help them determine which approach should be preferred has been limited. The S1316 clinical trial was designed to generate such evidence.

Conducted at institutions across the United States within the NCI National Clinical Trials Network, including NCI Community Oncology Research Program (NCORP) sites, as well as at sites in Mexico, Peru, and Colombia, S1316 enrolled 221 patients with MBO, all of whom were considered candidates for surgery. Of these, 199 met the criteria for inclusion in the trial analysis.

At registration, patients were offered the opportunity to be assigned at random to surgery or non-surgical management. About one-quarter of patients selected randomization. Patients who chose not to be randomized instead decided with their physician whether to undergo surgery or to have their MBO treated non-surgically. About 40% in this patient-choice group opted for surgery.

The primary outcome assessed was a measure the researchers termed “good days,” defined as days a patient was alive and out of the hospital. The team tracked the number of good days each patient had during their first three months (91 days) following registration to the trial. They found that the count of good days in those three months did not vary significantly between the two approaches to treating MBO. Additionally, patients’ ability to eat at week five also did not differ between the two treatment approaches.

Other secondary measures, however, suggest that surgery resulted in improvements in MBO-related symptoms. Patients who underwent surgery had, on average, better symptom severity scores for vomiting, constipation, nausea, and pain at week four than patients who were treated non-surgically. Overall, among patients hospitalized for their MBO, those who underwent surgery also reported fewer MBO-related symptoms after leaving the hospital.

“We are continuing to analyze the data to allow us to make recommendations to clinicians regarding the optimal operations and other quality of life factors that may be impacted by the type of treatment received,” Krouse added. “Our network of institutions and investigators will allow us to examine other important question in this population of cancer survivors.”

More information:
Krouse RS, Surgical versus non-surgical management for patients with malignant bowel obstruction (S1316): a pragmatic comparative effectiveness trial, The Lancet Gastroenterology & Hepatology (2023). DOI: 10.1016/S2468-1253(23)00191-7

Provided by
SWOG Cancer Research Network

Citation:
Results of trial will help guide treatment of malignant bowel obstruction in patients with advanced cancer (2023, August 1)
retrieved 1 August 2023
from https://medicalxpress.com/news/2023-08-results-trial-treatment-malignant-bowel.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2023-08-results-trial-treatment-malignant-bowel.html

Tags: healthresultstrial
Previous Post

New research shines light on how COVID-19 vaccination reduces severity and mortality after breakthrough infections

Next Post

Early-stage cancer diagnoses decreased sharply in the US during first year of COVID-19 pandemic

Foraging activity by an ecosystem engineer, the superb lyrebird, ‘farms’ its invertebrate prey – besjournals

How the Superb Lyrebird Cleverly ‘Farms’ Its Invertebrate Prey While Foraging

July 26, 2025
AI turns immune cells into precision cancer killers—in just weeks – ScienceDaily

AI turns immune cells into precision cancer killers—in just weeks – ScienceDaily

July 26, 2025
Our new book on ideological threats to science – Why Evolution Is True

Unveiling the Hidden Ideological Threats Challenging Evolutionary Science

July 26, 2025

When Veganism Goes to Extremes: Inside the Rise of an Intense Lifestyle

July 26, 2025
The Semi-Fictional Book That Transformed the Culinary World – The New Yorker

The Semi-Fictional Book That Transformed the Culinary World – The New Yorker

July 26, 2025
The economy is continuing to grow, Jack Ablin says – Fox Business

The Economy Keeps Expanding, Says Jack Ablin

July 26, 2025
Cote de Pablo reveals how Michael Weatherly used his soap opera roots to put her at ease in “NCIS” love scene – yahoo.com

Cote de Pablo Reveals How Michael Weatherly’s Soap Opera Background Made Their “NCIS” Love Scene Easier

July 26, 2025
Wellpoint-IBIS Health Clinical Trial – Mass Retirees Association

Wellpoint-IBIS Health Clinical Trial Empowers Mass Retirees for Better Care

July 26, 2025
Disgraced former US Rep. George Santos reports to NJ federal prison to serve 7-year fraud sentence – CNN

Disgraced Former Rep. George Santos Starts 7-Year Prison Sentence in New Jersey

July 26, 2025
Validea’s Top Information Technology Stocks Based On Peter Lynch – 7/25/2025 – Nasdaq

Validea’s Top Information Technology Stocks Based On Peter Lynch – 7/25/2025 – Nasdaq

July 25, 2025

Categories

Archives

July 2025
MTWTFSS
 123456
78910111213
14151617181920
21222324252627
28293031 
« Jun    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (739)
  • Economy (763)
  • Entertainment (21,644)
  • General (16,111)
  • Health (9,801)
  • Lifestyle (771)
  • News (22,149)
  • People (765)
  • Politics (772)
  • Science (15,978)
  • Sports (21,260)
  • Technology (15,745)
  • World (746)

Recent News

Foraging activity by an ecosystem engineer, the superb lyrebird, ‘farms’ its invertebrate prey – besjournals

How the Superb Lyrebird Cleverly ‘Farms’ Its Invertebrate Prey While Foraging

July 26, 2025
AI turns immune cells into precision cancer killers—in just weeks – ScienceDaily

AI turns immune cells into precision cancer killers—in just weeks – ScienceDaily

July 26, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version