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Risk for autism increased for children born to those with infertility

November 21, 2023
in Health
Risk for autism increased for children born to those with infertility
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Risk for autism increased for children born to those with infertility

Children born to individuals with infertility have a slightly higher risk for autism spectrum disorder (ASD), according to a study published online Nov. 20 in JAMA Network Open.

Maria P. Velez, M.D., Ph.D., from Queen’s University in Kingston, Ontario, Canada, and colleagues examined the association between infertility and its treatments on the risk for ASD in a population-based cohort study in Ontario.

The exposure was mode of conception: unassisted conception; infertility without fertility treatment (subfertility); ovulation induction (OI) or intrauterine insemination (IUI); or in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). Diagnosis of ASD at age 18 months or older was assessed as the study outcome.

Data were included for 1,370,152 children: 86.5, 10.3, 1.5, and 1.7 percent with unassisted conception, parental subfertility, OI or IUI, and IVF or ICSI, respectively. The researchers found that among children in the unassisted conception group, the incidence rate of ASD was 1.93 per 1,000 person-years.

Relative to the unassisted conception group, the adjusted hazard ratios for ASD were 1.20, 1.21, and 1.16 in the subfertility group, the OI or IUI group, and the IVF or ICSI group, respectively. A sizeable proportion of the association between mode of conception and ASD risk was mediated by obstetrical and neonatal factors.

“Efforts to decrease multifetal pregnancy following OI or IUI and IVF should continue to be reinforced, alongside the development of focused care pregnancy plans both for individuals with subfertility and those receiving fertility treatment,” the authors write.

More information:
Maria P. Velez et al, Infertility and Risk of Autism Spectrum Disorder in Children, JAMA Network Open (2023). DOI: 10.1001/jamanetworkopen.2023.43954

Copyright © 2023 HealthDay. All rights reserved.

Citation:
Risk for autism increased for children born to those with infertility (2023, November 21)
retrieved 21 November 2023
from https://medicalxpress.com/news/2023-11-autism-children-born-infertility.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

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Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2023-11-autism-children-born-infertility.html

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