* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Tuesday, September 23, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

    Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

    Why Hilaria Baldwin Has Found the ‘DWTS’ Process ‘Embarrassing’ At Times – WFXG

    Hilaria Baldwin Opens Up About the Embarrassing Moments on Her ‘DWTS’ Journey

    Harvest Fest 2025 – yadkinripple.com

    Celebrate the Bounty: Harvest Fest 2025 is Coming!

    Fox News Entertainment Newsletter: Kate Middleton stuns during Trump state visit, Brett James dead at 57 – Fox News

    Kate Middleton Stuns During Trump State Visit; Remembering Brett James at 57

    Lara Beitz to headline Oshkosh show with top comedians at Time Community Theater Sept. 27 – Yahoo

    Lara Beitz to Headline Star-Studded Oshkosh Comedy Night on September 27

    Shakespeare (with a twist) in Grand Junction – Yahoo

    Experience Shakespeare Like Never Before in Grand Junction

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Meta to expand Montgomery data hub, pushing total investment to $1.5 billion – Alabama Department of Commerce

    Meta to Supercharge Montgomery Data Hub with $1.5 Billion Investment

    Agentic AI and the future of work: navigating technological promise and the risk of increased automation – Equal Times

    Agentic AI and the Future of Work: Embracing Innovation While Navigating Automation Challenges

    Technology alliance introduces system for stable recycling quality – RECYCLING magazine

    Innovative Technology Alliance Unveils Breakthrough System for Consistent Recycling Quality

    Pepper Pike council considers upgrading technology for streaming meetings, remote meeting participation – Cleveland.com

    Pepper Pike Council Explores Upgrading Technology for Enhanced Streaming and Remote Participation

    How Michelin Uses Technology to Rethink Tire Manufacturing: Interview – Motor1.com

    How Michelin’s Tech-Driven Revolution Is Transforming Tire Manufacturing

    Analysts Offer Insights on Technology Companies: Avnet (AVT), Nvidia (NVDA) and Atlassian (TEAM) – The Globe and Mail

    Experts Share Key Insights on Avnet, Nvidia, and Atlassian’s Future Prospects

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

    Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

    Why Hilaria Baldwin Has Found the ‘DWTS’ Process ‘Embarrassing’ At Times – WFXG

    Hilaria Baldwin Opens Up About the Embarrassing Moments on Her ‘DWTS’ Journey

    Harvest Fest 2025 – yadkinripple.com

    Celebrate the Bounty: Harvest Fest 2025 is Coming!

    Fox News Entertainment Newsletter: Kate Middleton stuns during Trump state visit, Brett James dead at 57 – Fox News

    Kate Middleton Stuns During Trump State Visit; Remembering Brett James at 57

    Lara Beitz to headline Oshkosh show with top comedians at Time Community Theater Sept. 27 – Yahoo

    Lara Beitz to Headline Star-Studded Oshkosh Comedy Night on September 27

    Shakespeare (with a twist) in Grand Junction – Yahoo

    Experience Shakespeare Like Never Before in Grand Junction

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Meta to expand Montgomery data hub, pushing total investment to $1.5 billion – Alabama Department of Commerce

    Meta to Supercharge Montgomery Data Hub with $1.5 Billion Investment

    Agentic AI and the future of work: navigating technological promise and the risk of increased automation – Equal Times

    Agentic AI and the Future of Work: Embracing Innovation While Navigating Automation Challenges

    Technology alliance introduces system for stable recycling quality – RECYCLING magazine

    Innovative Technology Alliance Unveils Breakthrough System for Consistent Recycling Quality

    Pepper Pike council considers upgrading technology for streaming meetings, remote meeting participation – Cleveland.com

    Pepper Pike Council Explores Upgrading Technology for Enhanced Streaming and Remote Participation

    How Michelin Uses Technology to Rethink Tire Manufacturing: Interview – Motor1.com

    How Michelin’s Tech-Driven Revolution Is Transforming Tire Manufacturing

    Analysts Offer Insights on Technology Companies: Avnet (AVT), Nvidia (NVDA) and Atlassian (TEAM) – The Globe and Mail

    Experts Share Key Insights on Avnet, Nvidia, and Atlassian’s Future Prospects

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Scientists find cancer-like features in atherosclerosis, spurring opportunity for new treatment approaches

April 30, 2024
in Health
Scientists find cancer-like features in atherosclerosis, spurring opportunity for new treatment approaches
Share on FacebookShare on Twitter

Atherosclerosis

Atherosclerosis is a condition affecting the cardiovascular system. If atherosclerosis occurs in the coronary arteries (which supply the heart) the result may be angina pectoris, or in worse cases a heart attack. Credit: Wikipedia/CC BY 3.0

Researchers have discovered that the smooth muscle cells that line the arteries of people with atherosclerosis can change into new cell types and develop traits similar to cancer that worsen the disease. The study has been published in Circulation.

Atherosclerosis is characterized by a narrowing of arterial walls and can increase risk of coronary artery disease, stroke, peripheral artery disease, or kidney disorders. The findings, supported by the National Institutes of Health (NIH), could pave the way for the use of anti-cancer drugs to counteract the tumor-like mechanisms driving the buildup of plaque in the arteries, the major cause of cardiovascular disease.

“This discovery opens up a whole new dimension for our understanding about therapeutic strategies for the prevention and treatment of atherosclerosis,” said Ahmed Hasan, M.D., Ph.D., program director in the Division of Cardiovascular Sciences at the National Heart, Lung, and Blood Institute, part of NIH.

“Previous research has suggested that atherosclerosis and cancer may share some similarities, but this association has not been fully described until now.”

Using a combination of molecular techniques in mouse models and tissue samples taken from patients with atherosclerosis, the researchers characterized the molecular mechanisms that drive the smooth muscle cells to transition into cancer-like cell types.

The researchers found increased rates of DNA damage and genomic instability—two hallmarks of cancer—in the converted smooth muscle cells of atherosclerotic plaque when compared to healthy tissue. Genomic instability is the increased tendency for DNA mutations and other genetic changes to occur during cell division.

Probing further, they also found that cancer-associated genes became more active as the smooth muscle cells were being reprogrammed into the cells that made up the plaque. Using a mouse model expressing a known cancer mutation accelerated the reprogramming and worsened atherosclerosis. Finally, treating atherosclerotic mice with the anti-cancer drug niraparib, which targets DNA damage, showed potential for preventing and treating atherosclerosis.

“In fact, we saw that niraparib actually shrinks the atherosclerotic plaques in mice,” said Huize Pan, Ph.D., assistant professor of medicine at Vanderbilt University Medical Center, Nashville, Tennessee, and first author of the study.

Muredach Reilly, M.D., professor of Medicine at Columbia University, New York City, and senior author on the study, explained that understanding the molecular mechanisms that are driving the transition of smooth muscle cells can provide opportunities to disrupt tumor-like pathways and change how the cell behaves, in turn preventing or slowing progression of atherosclerosis.

More information:
Pan H, Ho SE, Xue C, et al. Atherosclerosis is a smooth muscle cell-driven tumor-like disease Circulation (2024). DOI: 10.1161/CIRCULATIONAHA.123.067587

Citation:
Scientists find cancer-like features in atherosclerosis, spurring opportunity for new treatment approaches (2024, April 30)
retrieved 30 April 2024
from https://medicalxpress.com/news/2024-04-scientists-cancer-features-atherosclerosis-spurring.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2024-04-scientists-cancer-features-atherosclerosis-spurring.html

Tags: cancer-likehealthScientists
Previous Post

Microbiome researchers challenge the state of the art in colon cancer biomarker discovery

Next Post

Baidu and Tesla Sign FSD Mapping Partnership

Meta to expand Montgomery data hub, pushing total investment to $1.5 billion – Alabama Department of Commerce

Meta to Supercharge Montgomery Data Hub with $1.5 Billion Investment

September 23, 2025
Packers’ Josh Jacobs dealing with a super concerning rushing stat – Yahoo Sports

Packers’ Josh Jacobs dealing with a super concerning rushing stat – Yahoo Sports

September 23, 2025
U.S. and Israel against the world as Palestine dominates UN week – Axios

U.S. and Israel against the world as Palestine dominates UN week – Axios

September 23, 2025
Global economic outlook weakens as policy uncertainty weighs on demand – OECD

Global economic outlook weakens as policy uncertainty weighs on demand – OECD

September 23, 2025
Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

September 23, 2025
AI Tool Predicts Health Problems in Patients 20 Years Before They Emerge – eWeek

AI Tool Detects Health Issues Two Decades Before Symptoms Appear

September 23, 2025
Germany’s €80B Rearmament Plan Sidelines US Weapons – politicstoday.org

Germany’s €80B Rearmament Plan Sidelines US Weapons – politicstoday.org

September 23, 2025
FOCUS | SCIO holds press conference on promoting high-quality development through high-level ecological & environmental protection – Xinhua

FOCUS | SCIO holds press conference on promoting high-quality development through high-level ecological & environmental protection – Xinhua

September 23, 2025
Researcher on Tylenol-Autism Connection: Not the Best Science – Managed Healthcare Executive

Researcher Questions the Science Behind Tylenol-Autism Link

September 23, 2025
Da Vinci’s Genetic Secrets May Soon Be Revealed by Ambitious DNA Project – ScienceAlert

Unlocking Da Vinci’s Genetic Mysteries: The Ambitious DNA Project Set to Reveal All

September 23, 2025

Categories

Archives

September 2025
MTWTFSS
1234567
891011121314
15161718192021
22232425262728
2930 
« Aug    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (832)
  • Economy (853)
  • Entertainment (21,731)
  • General (17,196)
  • Health (9,896)
  • Lifestyle (865)
  • News (22,149)
  • People (855)
  • Politics (863)
  • Science (16,063)
  • Sports (21,353)
  • Technology (15,836)
  • World (837)

Recent News

Meta to expand Montgomery data hub, pushing total investment to $1.5 billion – Alabama Department of Commerce

Meta to Supercharge Montgomery Data Hub with $1.5 Billion Investment

September 23, 2025
Packers’ Josh Jacobs dealing with a super concerning rushing stat – Yahoo Sports

Packers’ Josh Jacobs dealing with a super concerning rushing stat – Yahoo Sports

September 23, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version