* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Saturday, June 7, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Brass Lion Entertainment unveils co-op action RPG Wu-Tang: Rise of the Deceiver – VentureBeat

    Unleash Your Inner Warrior: Discover the Co-Op Action RPG Wu-Tang: Rise of the Deceiver!

    Entertainment lineup released for 2025 Mississippi State Fair – WAPT

    Exciting Entertainment Lineup Unveiled for the 2025 Mississippi State Fair!

    After Denzel Washington Said He Would Be In Black Panther 3, Ryan Coogler Explained Why He’s ‘Fine’ With That Information Being Revealed So Early – Yahoo

    Ryan Coogler Shares Why He’s Cool with Denzel Washington’s Black Panther 3 Reveal!

    Traveling Tacos and Tequila Festival to stop at Florence Yall’s stadium this October – Cincinnati Enquirer

    Get Ready for a Flavor Fiesta: Traveling Tacos and Tequila Festival Hits Florence Y’all’s Stadium This October!

    9 things to do this weekend in Lake County plus a look ahead – Leesburg Daily Commercial

    Discover 9 Exciting Weekend Adventures in Lake County and What’s Coming Up!

    Shows to Watch – The Advocate

    Must-See Shows You Can’t Miss!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    ECS Professor Pankaj K. Jha Receives NSF Grant to Develop Quantum Technology – Syracuse University News

    Unlocking the Future: ECS Professor Pankaj K. Jha Secures NSF Grant for Groundbreaking Quantum Technology Development

    Fire Tech Brief: 5 Fire Apparatus Technology Upgrades – firehouse.com

    Revving Up Safety: 5 Innovative Upgrades for Fire Apparatus Technology

    U.S. FDA Grants Platform Technology Designation to the Viral Vector Used in SRP-9003, Sarepta’s Investigational Gene Therapy for the Treatment of Limb Girdle Muscular Dystrophy Type 2E/R4 – Sarepta Therapeutics

    Breakthrough for Gene Therapy: FDA Designates Viral Vector in Sarepta’s SRP-9003 for Limb Girdle Muscular Dystrophy Treatment

    Waunakee Fifth-Graders Dive into the Future at Exciting Tech Day!

    Property Technology Magazine Unveils “PropTech Top 50 Index” and the “2025 PropTech Trends Report – The Great Rebuild.” – Business Wire

    Property Technology Magazine Unveils “PropTech Top 50 Index” and the “2025 PropTech Trends Report – The Great Rebuild.” – Business Wire

    Micron Technology (NASDAQ:MU) Stock Price Expected to Rise, UBS Group Analyst Says – MarketBeat

    UBS Analyst Predicts Surge in Micron Technology Stock Price!

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Brass Lion Entertainment unveils co-op action RPG Wu-Tang: Rise of the Deceiver – VentureBeat

    Unleash Your Inner Warrior: Discover the Co-Op Action RPG Wu-Tang: Rise of the Deceiver!

    Entertainment lineup released for 2025 Mississippi State Fair – WAPT

    Exciting Entertainment Lineup Unveiled for the 2025 Mississippi State Fair!

    After Denzel Washington Said He Would Be In Black Panther 3, Ryan Coogler Explained Why He’s ‘Fine’ With That Information Being Revealed So Early – Yahoo

    Ryan Coogler Shares Why He’s Cool with Denzel Washington’s Black Panther 3 Reveal!

    Traveling Tacos and Tequila Festival to stop at Florence Yall’s stadium this October – Cincinnati Enquirer

    Get Ready for a Flavor Fiesta: Traveling Tacos and Tequila Festival Hits Florence Y’all’s Stadium This October!

    9 things to do this weekend in Lake County plus a look ahead – Leesburg Daily Commercial

    Discover 9 Exciting Weekend Adventures in Lake County and What’s Coming Up!

    Shows to Watch – The Advocate

    Must-See Shows You Can’t Miss!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    ECS Professor Pankaj K. Jha Receives NSF Grant to Develop Quantum Technology – Syracuse University News

    Unlocking the Future: ECS Professor Pankaj K. Jha Secures NSF Grant for Groundbreaking Quantum Technology Development

    Fire Tech Brief: 5 Fire Apparatus Technology Upgrades – firehouse.com

    Revving Up Safety: 5 Innovative Upgrades for Fire Apparatus Technology

    U.S. FDA Grants Platform Technology Designation to the Viral Vector Used in SRP-9003, Sarepta’s Investigational Gene Therapy for the Treatment of Limb Girdle Muscular Dystrophy Type 2E/R4 – Sarepta Therapeutics

    Breakthrough for Gene Therapy: FDA Designates Viral Vector in Sarepta’s SRP-9003 for Limb Girdle Muscular Dystrophy Treatment

    Waunakee Fifth-Graders Dive into the Future at Exciting Tech Day!

    Property Technology Magazine Unveils “PropTech Top 50 Index” and the “2025 PropTech Trends Report – The Great Rebuild.” – Business Wire

    Property Technology Magazine Unveils “PropTech Top 50 Index” and the “2025 PropTech Trends Report – The Great Rebuild.” – Business Wire

    Micron Technology (NASDAQ:MU) Stock Price Expected to Rise, UBS Group Analyst Says – MarketBeat

    UBS Analyst Predicts Surge in Micron Technology Stock Price!

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Scientists uncover 95 regions of the genome linked to PTSD

April 18, 2024
in Health
Scientists uncover 95 regions of the genome linked to PTSD
Share on FacebookShare on Twitter

gene editing

Credit: Unsplash/CC0 Public Domain

In post-traumatic stress disorder (PTSD), intrusive thoughts, changes in mood, and other symptoms after exposure to trauma can greatly impact a person’s quality of life. About 6% of people who experience trauma develop the disorder, but scientists don’t yet understand the neurobiology underlying PTSD.

Now, a new genetic study of more than 1.2 million people has pinpointed 95 loci, or locations in the genome, that are associated with risk of developing PTSD, including 80 that had not been previously identified. The study, from the PTSD working group within the Psychiatric Genomics Consortium (PGC—PTSD) together with Cohen Veterans Bioscience, is the largest and most diverse of its kind, and also identified 43 genes that appear to have a role in causing PTSD. The work appears in Nature Genetics.

“This discovery firmly validates that heritability is a central feature of PTSD based on the largest PTSD genetics study conducted to date and reinforces there is a genetic component that contributes to the complexity of PTSD,” said Caroline Nievergelt, co-first and corresponding author on the study and a professor in the Department of Psychiatry at the University of California, San Diego. Adam Maihofer, a genetic epidemiologist in Nievergelt’s lab, was a co-first author as well.

The findings both confirm previously discovered genetic underpinnings of PTSD and provide many novel targets for future investigation that could lead to new prevention and treatment strategies.

“It’s exciting that we see the exponential increase in loci with increases in sample size we see for other disorders,” said Karestan Koenen, senior author on the study, an institute member of the Broad Institute of MIT and Harvard, and an investigator with the Stanley Center for Psychiatric Research at Broad. Koenen leads the Stanley Center’s Biology of Trauma Initiative and the Global Neuropsychiatric Genomics Initiative, and is a professor of psychiatric epidemiology at the Harvard T. H. Chan School of Public Health. “This is a milestone for PTSD genetics.”

Genetic roots

Previous twin and genetic studies, including an investigation by the same team in 2017 and an expanded study in 2019, showed that PTSD has a genetic component, and that many genes contribute to the condition.

But these analyses pointed to different genetic loci across datasets, and many studies struggled to distinguish loci that were specific to PTSD risk from those that were also linked to conditions such as depression and cardiovascular disease. Genetic datasets have also historically focused on people of European ancestry, even though there is a disproportionately high burden of trauma and PTSD among people of African, Native American, and Latin American ancestry in the United States and globally.

In the new study, Nievergelt, Koenen, and other researchers from the PGC compiled data from 88 different genome-wide association studies, which use genetic data from large groups of people to look for associations between regions of the genome and the chance of developing a condition or trait.

In all, the dataset contained information about the risk of developing PTSD from more than 1.2 million individuals of European ancestry (including about 140,000 with PTSD), about 50,000 with African ancestry (including about 12,000 with PTSD), and about 7,000 with Native American ancestry (about 2,000 with PTSD).

Meta-analysis of the data revealed 95 loci strongly associated with PTSD, including 80 that had not been identified previously. Forty three genes appeared to play a role in causing PTSD, including some that affect brain cells called neurons, brain chemicals called neurotransmitters, ion channels (which allow ions to pass in and out of cells), connections between neurons called synapses, and the endocrine and immune systems. The researchers found that PTSD shared many genetic features with depression, as well as several PTSD-specific loci.

Although previous studies found a higher prevalence of PTSD in females than males, the researchers did not find evidence for this in their data. They examined the X chromosome, which earlier studies did not do, and found five loci linked with PTSD. But they add that these changes on the X chromosome would have similar effects in males and females.

To more deeply probe how PTSD genetics affect the brain, the team studied gene expression data and found that the cerebellum, the brain region that controls movement and balance, may be involved in the disorder in addition to regions scientists have previously connected with PTSD, such as the cortex and amygdala.

In particular, the research team found that interneurons, which connect motor and sensory neurons, were involved in PTSD risk. Future studies could help determine how key genes in these tissues and cells affect PTSD symptoms and behaviors.

“For the first time, we are approaching a genetic architecture for PTSD, which both validates prior understanding of some of the critical biology underlying trauma-related disorders, while also pointing towards exciting and novel new targets and mechanisms,” said Kerry Ressler, a co-leader of the PGC—PTSD working group, chief scientific officer at McLean Hospital, and Professor of Psychiatry at Harvard Medical School. “These data are an important first step in next generation approaches to novel interventions for PTSD.”

In line with previous findings, Nievergelt, Koenen, and their colleagues also found that polygenic scores—a calculation of a person’s genetic chance of developing a certain condition based on millions of single-letter changes in their DNA—for PTSD risk are not readily translatable across populations. The researchers say this disparity highlights the importance of continuing to expand the depth and diversity of populations included in future studies of PTSD.

“We know that trauma and PTSD disproportionately affects under-resourced populations globally, particularly African ancestry populations,” said Koenen. “Our next steps will focus on addressing that inequity through partnerships with African scientists to make sure research in PTSD genetics benefits everyone equally.”

More information:
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder, Nature Genetics (2024). DOI: 10.1038/s41588-024-01707-9

Citation:
Scientists uncover 95 regions of the genome linked to PTSD (2024, April 18)
retrieved 18 April 2024
from https://medicalxpress.com/news/2024-04-scientists-uncover-regions-genome-linked.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2024-04-scientists-uncover-regions-genome-linked.html

Tags: healthScientistsuncover
Previous Post

UK, EU face significant medicine shortages: Study

Next Post

AI tool predicts responses to cancer therapy using information from each cell of the tumor

Thresholds of functional trait diversity driven by land use intensification – Nature

Thresholds of functional trait diversity driven by land use intensification – Nature

June 7, 2025
Discovery Camps launch at the Museum of Science and History this summer – 104.5 WOKV

Exciting Discovery Camps Unveiled at the Museum of Science and History This Summer!

June 7, 2025

University of Texas Track Star Unleashes Imagination with New Science-Fiction Novel!

June 7, 2025
From Paris to Global: Yseult — Euromaxx – DW

Yseult: A Journey from Paris to Global Stardom

June 7, 2025
Norway vs. Italy: Livestream World Cup 2026 Qualifier Soccer From Anywhere – CNET

Norway vs. Italy: Livestream World Cup 2026 Qualifier Soccer From Anywhere – CNET

June 7, 2025
Dollar stores are seeing higher-income shoppers rush in the door. It’s a warning sign for the US economy. – Yahoo Finance

Why Higher-Income Shoppers Are Flocking to Dollar Stores: A Red Flag for the US Economy

June 7, 2025
Brass Lion Entertainment unveils co-op action RPG Wu-Tang: Rise of the Deceiver – VentureBeat

Unleash Your Inner Warrior: Discover the Co-Op Action RPG Wu-Tang: Rise of the Deceiver!

June 7, 2025
Popular Upper West Side restaurant Jacob’s Pickles shut down by NYC health department – ABC7 New York

Beloved Upper West Side Eatery Jacob’s Pickles Closes Its Doors After Health Department Intervention

June 7, 2025
Trump preparing large-scale cancellation of federal funding for California, sources say – CNN

Trump preparing large-scale cancellation of federal funding for California, sources say – CNN

June 7, 2025
ECS Professor Pankaj K. Jha Receives NSF Grant to Develop Quantum Technology – Syracuse University News

Unlocking the Future: ECS Professor Pankaj K. Jha Secures NSF Grant for Groundbreaking Quantum Technology Development

June 7, 2025

Categories

Archives

June 2025
MTWTFSS
 1
2345678
9101112131415
16171819202122
23242526272829
30 
« May    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (674)
  • Economy (688)
  • Entertainment (21,594)
  • General (15,268)
  • Health (9,729)
  • Lifestyle (691)
  • News (22,149)
  • People (688)
  • Politics (695)
  • Science (15,906)
  • Sports (21,191)
  • Technology (15,673)
  • World (673)

Recent News

Thresholds of functional trait diversity driven by land use intensification – Nature

Thresholds of functional trait diversity driven by land use intensification – Nature

June 7, 2025
Discovery Camps launch at the Museum of Science and History this summer – 104.5 WOKV

Exciting Discovery Camps Unveiled at the Museum of Science and History This Summer!

June 7, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version