* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Tuesday, October 28, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Free Live Entertainment – Fremont Street Experience

    Enjoy Free Live Entertainment on Fremont Street Tonight!

    What to Know About ‘Good Morning America’s 50th Anniversary Episode – Wyoming News Now

    Celebrate the Milestone: Everything You Need to Know About Good Morning America’s 50th Anniversary Episode

    Dylan Efron suffers brutal nose injury in ‘DWTS’ rehearsals – Yahoo

    Dylan Efron Endures Painful Nose Injury During ‘DWTS’ Rehearsals

    Person shot, injured in parking lot of adult entertainment club in Gresham – KPTV

    Person Shot and Injured in Gresham Adult Entertainment Club Parking Lot

    Meet Belynda From ‘Married at First Sight’ Season 19: Age, Job, Instagram and More – Yahoo

    Meet Belynda from ‘Married at First Sight’ Season 19: Age, Career, Instagram & More Revealed!

    General Hospital’s Rena Sofer Exits as Lois — But the Door Isn’t Closed – Yahoo

    General Hospital’s Rena Sofer Exits as Lois — But the Door Isn’t Closed – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    CPE Technology Berhad (KLSE:CPETECH) Has Affirmed Its Dividend Of MYR0.015 – Yahoo Finance

    CPE Technology Berhad (KLSE:CPETECH) Has Affirmed Its Dividend Of MYR0.015 – Yahoo Finance

    Researchers Discover New Bacterium That Turns Food Waste Into Energy – Technology Networks

    Scientists Unveil Breakthrough Bacterium That Transforms Food Waste Into Clean Energy

    Jim Cramer on GSI Technology: “That Thing is a Rocket Ship” – Yahoo Finance

    Jim Cramer Labels GSI Technology a “Rocket Ship” Poised for Takeoff

    The Anti-Tech Backlash Is Going to Grow Stronger – Jacobin

    The Anti-Tech Backlash Is Gaining Unstoppable Momentum

    Comments to EU Regarding the Draft Revised Technology Transfer Block Exemption Regulation and Technology Transfer Guidelines – Information Technology and Innovation Foundation

    Have Your Say: Share Your Thoughts on the Draft Revised Technology Transfer Block Exemption Regulation and Guidelines

    Ghost Tapping is exploiting tap-to-pay technology in order to steal your money; what your need to know – ABC7 New York

    Ghost Tapping: How Thieves Are Using Tap-to-Pay Technology to Steal Your Money and What You Need to Know

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Free Live Entertainment – Fremont Street Experience

    Enjoy Free Live Entertainment on Fremont Street Tonight!

    What to Know About ‘Good Morning America’s 50th Anniversary Episode – Wyoming News Now

    Celebrate the Milestone: Everything You Need to Know About Good Morning America’s 50th Anniversary Episode

    Dylan Efron suffers brutal nose injury in ‘DWTS’ rehearsals – Yahoo

    Dylan Efron Endures Painful Nose Injury During ‘DWTS’ Rehearsals

    Person shot, injured in parking lot of adult entertainment club in Gresham – KPTV

    Person Shot and Injured in Gresham Adult Entertainment Club Parking Lot

    Meet Belynda From ‘Married at First Sight’ Season 19: Age, Job, Instagram and More – Yahoo

    Meet Belynda from ‘Married at First Sight’ Season 19: Age, Career, Instagram & More Revealed!

    General Hospital’s Rena Sofer Exits as Lois — But the Door Isn’t Closed – Yahoo

    General Hospital’s Rena Sofer Exits as Lois — But the Door Isn’t Closed – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    CPE Technology Berhad (KLSE:CPETECH) Has Affirmed Its Dividend Of MYR0.015 – Yahoo Finance

    CPE Technology Berhad (KLSE:CPETECH) Has Affirmed Its Dividend Of MYR0.015 – Yahoo Finance

    Researchers Discover New Bacterium That Turns Food Waste Into Energy – Technology Networks

    Scientists Unveil Breakthrough Bacterium That Transforms Food Waste Into Clean Energy

    Jim Cramer on GSI Technology: “That Thing is a Rocket Ship” – Yahoo Finance

    Jim Cramer Labels GSI Technology a “Rocket Ship” Poised for Takeoff

    The Anti-Tech Backlash Is Going to Grow Stronger – Jacobin

    The Anti-Tech Backlash Is Gaining Unstoppable Momentum

    Comments to EU Regarding the Draft Revised Technology Transfer Block Exemption Regulation and Technology Transfer Guidelines – Information Technology and Innovation Foundation

    Have Your Say: Share Your Thoughts on the Draft Revised Technology Transfer Block Exemption Regulation and Guidelines

    Ghost Tapping is exploiting tap-to-pay technology in order to steal your money; what your need to know – ABC7 New York

    Ghost Tapping: How Thieves Are Using Tap-to-Pay Technology to Steal Your Money and What You Need to Know

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Shifting focus: Investigators describe changes to pancreatic β cells at onset of type 1 diabetes

February 26, 2024
in Health
Shifting focus: Investigators describe changes to pancreatic β cells at onset of type 1 diabetes
Share on FacebookShare on Twitter

Shifting focus: Investigators describe changes to pancreatic β cells at onset of type 1 diabetes

In vivo AAV8-mediated overexpression of Mettl3 in NOD mouse β-cells delays T1D progression. Credit: Nature Cell Biology (2024). DOI: 10.1038/s41556-024-01368-0

About eight million people live with type 1 diabetes (T1D) worldwide, a chronic autoimmune condition in which the body attacks and destroys its own insulin-producing β-cells (pronounced “beta”) in the pancreas, leading to a lack of insulin and inability to regulate blood sugar. It’s not known why the body suddenly perceives its own β-cells as the enemy; some lines of evidence suggest environmental factors such as viral infections may trigger the onset of T1D, others suggest genetics may also play some role.

Groundbreaking research by investigators at Joslin Diabetes Center sheds new light on the specific changes β-cells go through at the onset of T1D. Their findings—published in Nature Cell Biology—offer new avenues for targeted interventions for the chronic autoimmune condition.

“In the field of type 1 diabetes, research has largely focused on understanding the immune component, but our study argues that the β-cell is a significant player,” said Rohit N. Kulkarni, M.D., Ph.D., Margaret A. Congleton Chair and Co-Head of the Section on Islet & Regenerative Biology at Joslin Diabetes Center.

“Our findings suggest that the β-cell could be initiating key events which then promote the autoimmune mechanism to go awry. It’s a paradigm shifting approach.”

In a series of experiments with β-cells taken from a mouse model of T1D, as well as from humans with established T1D, Kulkarni and colleagues teased out the complex cascade of biochemical steps called a signaling pathway that controls the innate immune response at the onset of T1D.

The team identified one pathway that influences the immune characteristics of β-cells, acting like control switches that identify them as friend or foe to the body. These control switches can be imagined as tiny tags.

One specific tag the investigators focused on—called N6-methyladenosine (m6A)—plays a vital role in the response of β-cells during T1D onset. By adjusting these control switches, the researchers were able to influence the levels of a crucial protein along this pathway, leading to a notable delay in the progression of the disease in a mouse model of T1D.

Dario F. De Jesus MSc, Ph.D., lead author of the study and Research Associate in the Kulkarni Lab, identified the key enzyme METTL3 as crucial for regulating β-cell antiviral defenses.

In the late stages of T1D, when METTL3 levels were low, it hinted that higher METTL3 levels shield β-cells from dysfunction. By enhancing METTL3 production in the mouse model, the team successfully delayed progression of disease.

“This discovery suggests that interventions to boost METTL3 levels is a potential strategy to protect β-cells and slow down progression of type 1 diabetes,” said De Jesus, who is also an Instructor in Medicine at Harvard Medical School.

Taken together, these several lines of evidence paint a clearer picture of the immune events surrounding the still mysterious onset of T1D, including a novel mechanism that could be harnessed for β-cell protection. They also demonstrated that the enzyme METTL3 has the potential to promote β-cell survival and function during disease progression.

“It is notable that this pathway has commercially available compounds that have been used in the context of other diseases,” said Kulkarni, who is also a professor of medicine at Harvard Medical School.

“While it’s a different target, it’s an approach which has been shown to work. Among our next steps, we will focus on identifying specific molecules and pathways that can be harnessed to enhance protection of the β-cell.”

More information:
Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes, Nature Cell Biology (2024). DOI: 10.1038/s41556-024-01368-0 www.nature.com/articles/s41556-024-01368-0

Citation:
Shifting focus: Investigators describe changes to pancreatic β cells at onset of type 1 diabetes (2024, February 26)
retrieved 26 February 2024
from https://medicalxpress.com/news/2024-02-shifting-focus-pancreatic-cells-onset.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2024-02-shifting-focus-pancreatic-cells-onset.html

Tags: Focushealthshifting
Previous Post

First-in-humans discovery reveals brain chemicals at work influencing social behavior

Next Post

For Many, Stigma of Hearing Loss Brings Trouble; Here’s What May Help

Shohei Ohtani Hits 2 Homers, Ties 119-Year-Old Record In Dodgers’ World Series Game 3 Win – FOX Sports

Shohei Ohtani Hits 2 Homers, Ties 119-Year-Old Record In Dodgers’ World Series Game 3 Win – FOX Sports

October 28, 2025
Trump’s ‘golden age’ economic message undercut by his desire for much lower interest rates – which typically signal a weak jobs market – The Conversation

Trump’s ‘Golden Age’ Economy Questioned as Calls for Lower Interest Rates Reveal Job Market Weakness

October 28, 2025
Free Live Entertainment – Fremont Street Experience

Enjoy Free Live Entertainment on Fremont Street Tonight!

October 28, 2025

SGMC Health Launches Lung Nodule Clinic to Advance Early Detection and Treatment of Lung Cancer – SGMC Health

October 28, 2025
Former presidential photographer Pete Souza on his favorite memories of the East Wing after its demolition – CNN

Former presidential photographer Pete Souza on his favorite memories of the East Wing after its demolition – CNN

October 28, 2025

Once tadpoles lose lungs, they never get them back – Cornell Chronicle

October 28, 2025
Texas A&M Department of Poultry Science hires Williams – WATTPoultry.com

Texas A&M’s Poultry Science Department Welcomes Expert Williams to the Team

October 28, 2025

Raffaele Colombo Highlights the Thriving Community and Cutting-Edge Science at the Incredible AACR-NCI-EORTC Meeting

October 28, 2025
The Donut Chain Known For Making Some Of The Most Unique Flavors In The Game – Yahoo

Discover the Donut Chain Revolutionizing Flavor with Its Uniquely Delicious Creations

October 28, 2025
CPE Technology Berhad (KLSE:CPETECH) Has Affirmed Its Dividend Of MYR0.015 – Yahoo Finance

CPE Technology Berhad (KLSE:CPETECH) Has Affirmed Its Dividend Of MYR0.015 – Yahoo Finance

October 28, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (889)
  • Economy (912)
  • Entertainment (21,783)
  • General (17,850)
  • Health (9,953)
  • Lifestyle (924)
  • News (22,149)
  • People (912)
  • Politics (922)
  • Science (16,122)
  • Sports (21,411)
  • Technology (15,891)
  • World (895)

Recent News

Shohei Ohtani Hits 2 Homers, Ties 119-Year-Old Record In Dodgers’ World Series Game 3 Win – FOX Sports

Shohei Ohtani Hits 2 Homers, Ties 119-Year-Old Record In Dodgers’ World Series Game 3 Win – FOX Sports

October 28, 2025
Trump’s ‘golden age’ economic message undercut by his desire for much lower interest rates – which typically signal a weak jobs market – The Conversation

Trump’s ‘Golden Age’ Economy Questioned as Calls for Lower Interest Rates Reveal Job Market Weakness

October 28, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version