* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Tuesday, September 30, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Good Deed Entertainment Acquires Worldwide Rights To Liza Mandelup’s Documentary ‘Caterpillar’ – Deadline

    Good Deed Entertainment Lands Global Rights to Liza Mandelup’s Captivating Documentary ‘Caterpillar

    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

    Jussie Smollett Claims He Was ‘Disrespected’ on the ‘Special Forces’ Season Premiere – Yahoo

    Jussie Smollett Opens Up About Feeling ‘Disrespected’ During the ‘Special Forces’ Season Premiere

    TicketSmarter Fall Entertainment Guide – Eastern Illinois University Athletics

    TicketSmarter Fall Entertainment Guide – Eastern Illinois University Athletics

    Cardi B Adds More Dates to Little Miss Drama Tour: ‘Y’all Making Me Work’ – Yahoo

    Cardi B Extends Little Miss Drama Tour: “Y’all Making Me Work

    ‘Today’: Sheinelle Jones Thanks Katie Couric for Support After Husband’s Death – CBS 19 News

    Sheinelle Jones Expresses Heartfelt Thanks to Katie Couric for Support After Husband’s Passing

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Four Strategic Signals Technology Leaders Are Tuning In To – SPONSOR CONTENT FROM ARM – Harvard Business Review

    Four Essential Strategic Signals Every Technology Leader Should Watch

    Virginia Tech hosts annual New Music + Technology Festival this week – Cardinal News

    Virginia Tech Kicks Off Exciting Annual New Music and Technology Festival This Week

    Why I gave the world wide web away for free | Tim Berners-Lee – The Guardian

    Why I Decided to Make the World Wide Web Free for Everyone | Tim Berners-Lee

    From shale to steam: Fossil fuel technology boosts clean geothermal energy – Washington Examiner

    From Shale to Steam: How Fossil Fuel Technology is Powering a Clean Geothermal Energy Revolution

    How Sustainable Technology is Shaping a Greener Future – Technology Magazine

    How Sustainable Technology is Driving the Revolution Toward a Greener Future

    Aurora police hope to add facial recognition technology to crime-fighting tools – CBS News

    Aurora Police Aim to Boost Crime-Fighting with New Facial Recognition Technology

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Good Deed Entertainment Acquires Worldwide Rights To Liza Mandelup’s Documentary ‘Caterpillar’ – Deadline

    Good Deed Entertainment Lands Global Rights to Liza Mandelup’s Captivating Documentary ‘Caterpillar

    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

    Jussie Smollett Claims He Was ‘Disrespected’ on the ‘Special Forces’ Season Premiere – Yahoo

    Jussie Smollett Opens Up About Feeling ‘Disrespected’ During the ‘Special Forces’ Season Premiere

    TicketSmarter Fall Entertainment Guide – Eastern Illinois University Athletics

    TicketSmarter Fall Entertainment Guide – Eastern Illinois University Athletics

    Cardi B Adds More Dates to Little Miss Drama Tour: ‘Y’all Making Me Work’ – Yahoo

    Cardi B Extends Little Miss Drama Tour: “Y’all Making Me Work

    ‘Today’: Sheinelle Jones Thanks Katie Couric for Support After Husband’s Death – CBS 19 News

    Sheinelle Jones Expresses Heartfelt Thanks to Katie Couric for Support After Husband’s Passing

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Four Strategic Signals Technology Leaders Are Tuning In To – SPONSOR CONTENT FROM ARM – Harvard Business Review

    Four Essential Strategic Signals Every Technology Leader Should Watch

    Virginia Tech hosts annual New Music + Technology Festival this week – Cardinal News

    Virginia Tech Kicks Off Exciting Annual New Music and Technology Festival This Week

    Why I gave the world wide web away for free | Tim Berners-Lee – The Guardian

    Why I Decided to Make the World Wide Web Free for Everyone | Tim Berners-Lee

    From shale to steam: Fossil fuel technology boosts clean geothermal energy – Washington Examiner

    From Shale to Steam: How Fossil Fuel Technology is Powering a Clean Geothermal Energy Revolution

    How Sustainable Technology is Shaping a Greener Future – Technology Magazine

    How Sustainable Technology is Driving the Revolution Toward a Greener Future

    Aurora police hope to add facial recognition technology to crime-fighting tools – CBS News

    Aurora Police Aim to Boost Crime-Fighting with New Facial Recognition Technology

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Study suggests two copies of APOE4 gene behind up to 20% of Alzheimer’s cases

May 12, 2024
in Health
Study suggests two copies of APOE4 gene behind up to 20% of Alzheimer’s cases
Share on FacebookShare on Twitter

Study suggests two copies of APOE4 gene behind up to 20% of Alzheimer's cases

Penetrance and predictive value of APOE4 homozygosity in AD. a, Distribution of ADNC scores by age of death. b, Frequency of positive amyloid and tau biomarkers across 5-year age intervals. c, Overview of the mean and 95% confidence interval ages at which symptoms, MCI and dementia manifest. d, The 95% prediction intervals for various genetically determined forms of AD. Credit: Nature Medicine (2024). DOI: 10.1038/s41591-024-02931-w

A team of neurologists affiliated with multiple institutions in Spain and the U.S. has found evidence that suggests up to 20% of all cases of Alzheimer’s disease (AD) may be attributable to double copies of the APOE4 gene.

For their paper published in the journal Nature Medicine, the group studied data from the brains of thousands of deceased AD patients and biomarkers in an additional 10,000 living patients.

Qin Xu, Zherui Liang and Yadong Huan, with the Gladstone Institute of Neurological Disease, has published a News & Views piece in the same journal issue outlining the work done by the team on this new effort.

AD is a specific type of dementia that involves mental deterioration due to gradual degeneration of the brain. Prior research has found that there are two main kinds of AD; genetic forms and late onset forms. Prior research has also shown that homozygous APOE4 genes (having two copies) is one of the risk factors for the genetic kind of the disease.

In this new study, the research team has found evidence suggesting that AD due to homozygous APOE4 genes should be classified as a third general type of the disease, rather than as a risk factor.

The work by the team involved analyzing pathological data obtained from 3,300 AD patients and data for an additional 10,000 living AD patients collected from multiple medical facilities. They found that 800 of the people included in the study had homozygous APOE4 genes. They also found that virtually all of them had high levels of amyloid levels in their brain fluid by the age of 65—a finding, they suggest, that indicates the disease was fully penetrant in those patients.

They also found that the age at which symptoms became apparent was consistent among those with homozygous APOE4 genes. And, biomarkers for those with the genes evolved into predictable patterns that were very similar across patients.

Their findings suggest that between 15% and 20% of AD cases may likely be attributable to patients having homozygous APOE4 genes. Taken together, the research team says the evidence indicates that AD cases involving homozygous APOE4 genes should be considered a unique type of AD, and not just a risk factor.

More information:
Juan Fortea et al, APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease, Nature Medicine (2024). DOI: 10.1038/s41591-024-02931-w

Qin Xu et al, APOE4 homozygosity is a new genetic form of Alzheimer’s disease, Nature Medicine (2024). DOI: 10.1038/s41591-024-02923-w

© 2024 Science X Network

Citation:
Study suggests two copies of APOE4 gene behind up to 20% of Alzheimer’s cases (2024, May 12)
retrieved 12 May 2024
from https://medicalxpress.com/news/2024-05-apoe4-gene-alzheimer-cases.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2024-05-apoe4-gene-alzheimer-cases.html

Tags: healthstudySuggests
Previous Post

Researchers show genetic variant common among Black Americans contributes to large cardiovascular disease burden

Next Post

A Mother’s Love: The Challenges of Parenting a Child With Eczema

Common juniper, the oldest nonclonal woody species across the tundra biome and the European continent – ESA Journals

Unveiling the Common Juniper: The Ancient Woody Survivor Spanning Tundra and Europe

September 30, 2025
What Forensic Science Is and How to Become a Forensic Scientist | Education | U.S. News – U.S. News & World Report

Unlocking the Secrets of Forensic Science: Your Guide to Becoming a Forensic Scientist

September 30, 2025
BLM celebrates International Archaeology Day at the Campbell Creek Science Center – Bureau of Land Management (.gov)

BLM Celebrates International Archaeology Day with Exciting Events at Campbell Creek Science Center

September 30, 2025
Sagittarius Daily Horoscope Today (Nov 22- Dec 21), September 30, 2025: Lifestyle will get refined! – India Today

Sagittarius Daily Horoscope Today (Nov 22- Dec 21), September 30, 2025: Lifestyle will get refined! – India Today

September 30, 2025
Four Strategic Signals Technology Leaders Are Tuning In To – SPONSOR CONTENT FROM ARM – Harvard Business Review

Four Essential Strategic Signals Every Technology Leader Should Watch

September 30, 2025

Latest sportsbook receives Missouri license through partnership with Royals – KCTV

September 30, 2025
World-Building With Daisies – 032C

Bringing Color to Life: The Art of Building Vibrant Worlds with Daisies

September 29, 2025
Milei Vowed to Fix Argentina’s Economy. Then Came a New Crisis. – The New York Times

Milei Vowed to Fix Argentina’s Economy. Then Came a New Crisis. – The New York Times

September 29, 2025
Good Deed Entertainment Acquires Worldwide Rights To Liza Mandelup’s Documentary ‘Caterpillar’ – Deadline

Good Deed Entertainment Lands Global Rights to Liza Mandelup’s Captivating Documentary ‘Caterpillar

September 29, 2025
Report finds increased nitrates as fertilizer application poses costs to public health and farmers – Wisconsin Examiner

Rising Nitrate Levels from Fertilizer Use Threaten Public Health and Farmers’ Livelihoods

September 29, 2025

Categories

Archives

September 2025
M T W T F S S
1234567
891011121314
15161718192021
22232425262728
2930  
« Aug    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (843)
  • Economy (864)
  • Entertainment (21,738)
  • General (17,320)
  • Health (9,907)
  • Lifestyle (877)
  • News (22,149)
  • People (866)
  • Politics (874)
  • Science (16,074)
  • Sports (21,364)
  • Technology (15,847)
  • World (846)

Recent News

Common juniper, the oldest nonclonal woody species across the tundra biome and the European continent – ESA Journals

Unveiling the Common Juniper: The Ancient Woody Survivor Spanning Tundra and Europe

September 30, 2025
What Forensic Science Is and How to Become a Forensic Scientist | Education | U.S. News – U.S. News & World Report

Unlocking the Secrets of Forensic Science: Your Guide to Becoming a Forensic Scientist

September 30, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version