* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Friday, October 10, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    The Best “Friends” Halloween Episodes That Blend Spooky And Silly In The Perfect Way – Yahoo

    The Best “Friends” Halloween Episodes That Blend Spooky And Silly In The Perfect Way – Yahoo

    MSG Entertainment Takes Radio City Music Hall Into the Future With Introduction of Sphere Immersive Sound – Business Wire

    MSG Entertainment Transforms Radio City Music Hall with Cutting-Edge Sphere Immersive Sound Experience

    Israel’s Entertainment Industry Is Being Targeted by the Left in Hollywood and the Right at Home – The Wall Street Journal

    Inside the Fierce Clash Shaping Israel’s Entertainment Industry: Hollywood vs. Local Voices

    Offset Is Ready To Finalize Divorce With Cardi B for a Major Reason – Yahoo

    Offset Poised to Finalize Divorce from Cardi B for a Major Reason

    Beyond the Stage: 8 Performing Arts Centers Driving Entertainment and Education – Livability.com

    Beyond the Stage: 8 Performing Arts Centers Transforming Entertainment and Education

    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    4J schools trying out new electronic hall pass technology – Lookout Eugene-Springfield

    4J Schools Unveils Cutting-Edge Electronic Hall Pass System to Transform Student Experience

    China outlines more controls on exports of rare earths and technology – fox40.com

    China Unveils Tougher Restrictions on Rare Earth and Technology Exports

    Wisconsin Dairy Leads the Way with Cutting-Edge Technology Systems

    ENERCON and Biome collaborate for wind turbine noise reduction technology – Yahoo Finance

    ENERCON and Biome Join Forces to Revolutionize Wind Turbine Noise Reduction

    US and investors gambling on unproven nuclear technology, warn experts – Financial Times

    US and investors gambling on unproven nuclear technology, warn experts – Financial Times

    Is Light-Speed Analog Computing the Future of Technology? – BIOENGINEER.ORG

    Could Light-Speed Analog Computing Transform the Future of Technology?

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    The Best “Friends” Halloween Episodes That Blend Spooky And Silly In The Perfect Way – Yahoo

    The Best “Friends” Halloween Episodes That Blend Spooky And Silly In The Perfect Way – Yahoo

    MSG Entertainment Takes Radio City Music Hall Into the Future With Introduction of Sphere Immersive Sound – Business Wire

    MSG Entertainment Transforms Radio City Music Hall with Cutting-Edge Sphere Immersive Sound Experience

    Israel’s Entertainment Industry Is Being Targeted by the Left in Hollywood and the Right at Home – The Wall Street Journal

    Inside the Fierce Clash Shaping Israel’s Entertainment Industry: Hollywood vs. Local Voices

    Offset Is Ready To Finalize Divorce With Cardi B for a Major Reason – Yahoo

    Offset Poised to Finalize Divorce from Cardi B for a Major Reason

    Beyond the Stage: 8 Performing Arts Centers Driving Entertainment and Education – Livability.com

    Beyond the Stage: 8 Performing Arts Centers Transforming Entertainment and Education

    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    4J schools trying out new electronic hall pass technology – Lookout Eugene-Springfield

    4J Schools Unveils Cutting-Edge Electronic Hall Pass System to Transform Student Experience

    China outlines more controls on exports of rare earths and technology – fox40.com

    China Unveils Tougher Restrictions on Rare Earth and Technology Exports

    Wisconsin Dairy Leads the Way with Cutting-Edge Technology Systems

    ENERCON and Biome collaborate for wind turbine noise reduction technology – Yahoo Finance

    ENERCON and Biome Join Forces to Revolutionize Wind Turbine Noise Reduction

    US and investors gambling on unproven nuclear technology, warn experts – Financial Times

    US and investors gambling on unproven nuclear technology, warn experts – Financial Times

    Is Light-Speed Analog Computing the Future of Technology? – BIOENGINEER.ORG

    Could Light-Speed Analog Computing Transform the Future of Technology?

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Subclasses of Steatotic Liver Disease Can Help Determine Prognosis

January 18, 2024
in Health
Subclasses of Steatotic Liver Disease Can Help Determine Prognosis
Share on FacebookShare on Twitter

The new nomenclature for classifying steatotic liver disease (SLD) can help clinicians determine distinct prognoses, with the integration of alcohol intake as an aid in risk stratification, according to an analysis of a prospective cohort study from Denmark.

At a single center among 446 patients with a history of excessive alcohol intake, those with SLD had a significantly higher risk of hepatic decompensation and overall mortality than those without SLD, independent of age, sex, and liver stiffness, reported Mary E. Rinella, MD, of the Pritzker School of Medicine at the University of Chicago, and colleagues.

Notably, the risk of hepatic decompensation increased in a stepwise manner from metabolic dysfunction-associated steatotic liver disease (MASLD; HR 4.73, 95% CI 1.03-21.6), through metabolic dysfunction and alcohol-related steatotic liver disease (MetALD; HR 7.69, 95% CI 1.66-35.6), to alcohol-related liver disease (ALD; HR 10.2, 95% CI 2.24-46.4), they noted in the Lancet Gastroenterology & Hepatology.

The same was true for overall mortality, increasing from MASLD (HR 2.30, 95% CI 1.08-4.90), through MetALD (HR 2.94, 95% CI 1.31-6.58), to ALD (HR 3.57, 95% CI 1.64-7.80).

“Importantly, we found that the subclasses had different prognoses, underlining the significance of considering steatotic liver disease … as a spectrum rather than distinct conditions (NAFLD [nonalcoholic fatty liver disease] or ALD),” the authors wrote, adding that the criteria for SLD are easy to apply in clinical studies.

“Further specification on how historical alcohol intake should be incorporated into the nomenclature is needed, because this subclassification has important implications for clinical studies and management,” they concluded. “Criteria for moving between subclasses also need to be defined.”

In an accompanying comment, Fredrik Åberg, MD, PhD, of the University of Helsinki in Finland, noted that the study “provides critical insights into the interplay between dysmetabolism and past and present alcohol consumption in steatotic liver disease.”

“This subclassification acknowledges the frequent coexistence and synergism of metabolic risk and alcohol use, viewing them more as a spectrum than mutually exclusive conditions,” he wrote. “Given its consensus-based origin, the steatotic liver disease subclassification requires validation for clinical relevance and applicability.”

Åberg also pointed out that the thresholds for alcohol consumption within the subclasses of SLD are still arbitrary, and patients with SLD should be counseled that abstinence from alcohol is the “best bet for a brighter forecast.”

For this analysis, Rinella and team enrolled 446 patients (median age 56, 75% men) from Odense University Hospital with a history of current or previous excessive alcohol use (>24 g/day for women and>36 g/day for men) of at least a year’s duration who had no hepatic decompensation from April 2013 to September 2018. They were classified as having MASLD, MetALD, or ALD based on metabolic comorbidity and self-reported average alcohol intake in the 3 months leading up to inclusion and were followed until Sept. 15, 2022.

Of these patients, 13% had cirrhosis, and 98% had at least one cardiometabolic risk factor, such as a body mass index of 25 or higher, type 2 diabetes, blood pressure of 130/85 mm Hg or higher, plasma triglycerides of 150 mg/dL or higher, or plasma high-density lipoprotein cholesterol of 40 mg/dL or less for women or 50 mg/dL or less for men, or treatment for any of these conditions.

Of the cohort, 72% met SLD criteria, and 28% did not, meaning they had no evident liver steatosis and no significant fibrosis (≥F2). Of the patients with SLD, only 2% were identified as having ALD due to the absence of cardiometabolic risk factors. The other 98% of patients had at least one cardiometabolic risk factor. Of these patients, 49% had MASLD, 24% had MetALD, and 27% had ALD.

During a median follow-up of 70 months, 15% of patients decompensated and 22% died, with 48 dying after liver decompensation and one due to cholangiocarcinoma.

The risk of all-cause mortality was lower in groups who self-reported abstinence when they enrolled in the study: less than 1 year of alcohol abstinence (HR 0.64, 95% CI 0.30-1.36), 1 to 5 years (HR 0.97, 95% CI 0.33-2.82), and more than 5 years (HR 0.37, 95% CI 0.08-1.74), though the authors noted the wide confidence intervals with these estimates.

Rinella and team acknowledged that the classification of many patients as having MASLD, despite documented excessive alcohol intake during the follow-up period, “probably does not accurately represent the prognosis of so-called pure MASLD without a history of excessive alcohol intake,” which was a limitation to the study.

Disclosures

This study was funded by the EU Horizon 2020 Research and Innovation Program.

Rinella reported scientific consulting for Boehringer Ingelheim, Intercept Pharmaceuticals, Madrigal, NGM Biopharmaceuticals, Novo Nordisk, GlaxoSmithKline, Sonic Incytes, HistoIndex, Takeda, and CytoDyn, and has received support for travel to symposia from GlaxoSmithKline and Novo Nordisk.

Co-authors also reported multiple relationships with industry.

Åberg reported no competing interests.

Primary Source

The Lancet Gastroenterology & Hepatology

Source Reference: Israelsen M, et al “Validation of the new nomenclature of steatotic liver disease in patients with a history of excessive alcohol intake: an analysis of data from a prospective cohort study” Lancet Gastroenterol Hepatol 2024; DOI: 10.1016/S2468-1253(23)00443-0.

Secondary Source

The Lancet Gastroenterology & Hepatology

Source Reference: Åberg F “The role of past and present alcohol use in steatotic liver disease” Lancet Gastroenterol Hepatol 2024; DOI: 10.1016/S2468-1253(23)00450-8.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/gastroenterology/generalhepatology/108305

Tags: healthSteatoticSubclasses
Previous Post

Study Slams Community Rheum Docs for Sloppy RA Management

Next Post

Docs’ Ketamine Scheme Accusation; Texas Doc Wins Snake Case; Maternal Death Suit

Mbappe credits Madrid lifestyle for helping him reset mentally and physically – Reuters

Mbappe credits Madrid lifestyle for helping him reset mentally and physically – Reuters

October 10, 2025
4J schools trying out new electronic hall pass technology – Lookout Eugene-Springfield

4J Schools Unveils Cutting-Edge Electronic Hall Pass System to Transform Student Experience

October 10, 2025
Six Pack of college football picks, predictions: Alabama vs. Missouri, Oregon vs. Indiana in spotlight – CBS Sports

Six Can’t-Miss College Football Showdowns: Alabama vs. Missouri and Oregon vs. Indiana Steal the Spotlight

October 10, 2025

High Five: The rest of the world’s top upcoming qualifiers – The New York Times

October 10, 2025
Donald Trump’s fortress economy is starting to hurt America – The Economist

How Donald Trump’s Fortress Economy Is Starting to Hurt America

October 10, 2025
The Best “Friends” Halloween Episodes That Blend Spooky And Silly In The Perfect Way – Yahoo

The Best “Friends” Halloween Episodes That Blend Spooky And Silly In The Perfect Way – Yahoo

October 10, 2025
Board of Health Meeting – City of Somerville (.gov)

Inside the Latest Somerville Board of Health Meeting: Key Updates and Decisions

October 10, 2025
The Politics Hour: Why a candidate’s text messages are shaking up Virginia’s elections – WAMU

How a Candidate’s Text Messages Are Shaking Up Virginia’s Elections

October 10, 2025
Climate Change Poses ‘Ecological Trap’ for Species Struggling to Adapt – Bioengineer.org

Climate Change Creates a Dangerous Ecological Trap for Struggling Species

October 10, 2025
Science and the heart: Remembering Jane Goodall – American Animal Hospital Association – AAHA

Unlocking the Heart’s Secrets: Celebrating Jane Goodall’s Enduring Legacy

October 10, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (860)
  • Economy (881)
  • Entertainment (21,754)
  • General (17,514)
  • Health (9,923)
  • Lifestyle (894)
  • News (22,149)
  • People (881)
  • Politics (891)
  • Science (16,091)
  • Sports (21,382)
  • Technology (15,862)
  • World (864)

Recent News

Mbappe credits Madrid lifestyle for helping him reset mentally and physically – Reuters

Mbappe credits Madrid lifestyle for helping him reset mentally and physically – Reuters

October 10, 2025
4J schools trying out new electronic hall pass technology – Lookout Eugene-Springfield

4J Schools Unveils Cutting-Edge Electronic Hall Pass System to Transform Student Experience

October 10, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version