* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Tuesday, September 23, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

    Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

    Why Hilaria Baldwin Has Found the ‘DWTS’ Process ‘Embarrassing’ At Times – WFXG

    Hilaria Baldwin Opens Up About the Embarrassing Moments on Her ‘DWTS’ Journey

    Harvest Fest 2025 – yadkinripple.com

    Celebrate the Bounty: Harvest Fest 2025 is Coming!

    Fox News Entertainment Newsletter: Kate Middleton stuns during Trump state visit, Brett James dead at 57 – Fox News

    Kate Middleton Stuns During Trump State Visit; Remembering Brett James at 57

    Lara Beitz to headline Oshkosh show with top comedians at Time Community Theater Sept. 27 – Yahoo

    Lara Beitz to Headline Star-Studded Oshkosh Comedy Night on September 27

    Shakespeare (with a twist) in Grand Junction – Yahoo

    Experience Shakespeare Like Never Before in Grand Junction

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Agentic AI and the future of work: navigating technological promise and the risk of increased automation – Equal Times

    Agentic AI and the Future of Work: Embracing Innovation While Navigating Automation Challenges

    Technology alliance introduces system for stable recycling quality – RECYCLING magazine

    Innovative Technology Alliance Unveils Breakthrough System for Consistent Recycling Quality

    Pepper Pike council considers upgrading technology for streaming meetings, remote meeting participation – Cleveland.com

    Pepper Pike Council Explores Upgrading Technology for Enhanced Streaming and Remote Participation

    How Michelin Uses Technology to Rethink Tire Manufacturing: Interview – Motor1.com

    How Michelin’s Tech-Driven Revolution Is Transforming Tire Manufacturing

    Analysts Offer Insights on Technology Companies: Avnet (AVT), Nvidia (NVDA) and Atlassian (TEAM) – The Globe and Mail

    Experts Share Key Insights on Avnet, Nvidia, and Atlassian’s Future Prospects

    Top Technology Executives Recognized at the 2025 Carolina CIO ORBIE Awards – Yahoo Finance

    Celebrating Excellence: Top Technology Executives Honored at the 2025 Carolina CIO ORBIE Awards

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

    Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

    Why Hilaria Baldwin Has Found the ‘DWTS’ Process ‘Embarrassing’ At Times – WFXG

    Hilaria Baldwin Opens Up About the Embarrassing Moments on Her ‘DWTS’ Journey

    Harvest Fest 2025 – yadkinripple.com

    Celebrate the Bounty: Harvest Fest 2025 is Coming!

    Fox News Entertainment Newsletter: Kate Middleton stuns during Trump state visit, Brett James dead at 57 – Fox News

    Kate Middleton Stuns During Trump State Visit; Remembering Brett James at 57

    Lara Beitz to headline Oshkosh show with top comedians at Time Community Theater Sept. 27 – Yahoo

    Lara Beitz to Headline Star-Studded Oshkosh Comedy Night on September 27

    Shakespeare (with a twist) in Grand Junction – Yahoo

    Experience Shakespeare Like Never Before in Grand Junction

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Agentic AI and the future of work: navigating technological promise and the risk of increased automation – Equal Times

    Agentic AI and the Future of Work: Embracing Innovation While Navigating Automation Challenges

    Technology alliance introduces system for stable recycling quality – RECYCLING magazine

    Innovative Technology Alliance Unveils Breakthrough System for Consistent Recycling Quality

    Pepper Pike council considers upgrading technology for streaming meetings, remote meeting participation – Cleveland.com

    Pepper Pike Council Explores Upgrading Technology for Enhanced Streaming and Remote Participation

    How Michelin Uses Technology to Rethink Tire Manufacturing: Interview – Motor1.com

    How Michelin’s Tech-Driven Revolution Is Transforming Tire Manufacturing

    Analysts Offer Insights on Technology Companies: Avnet (AVT), Nvidia (NVDA) and Atlassian (TEAM) – The Globe and Mail

    Experts Share Key Insights on Avnet, Nvidia, and Atlassian’s Future Prospects

    Top Technology Executives Recognized at the 2025 Carolina CIO ORBIE Awards – Yahoo Finance

    Celebrating Excellence: Top Technology Executives Honored at the 2025 Carolina CIO ORBIE Awards

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Subcutaneous Alzheimer’s Drug May Be on the Horizon

October 28, 2023
in Health
Subcutaneous Alzheimer’s Drug May Be on the Horizon
Share on FacebookShare on Twitter

A subcutaneous version of the newly approved Alzheimer’s drug lecanemab (Leqembi) may be on the horizon.

Weekly subcutaneous lecanemab 100 mg/mL injection appeared to be as effective at amyloid plaque removal as biweekly IV administration, a preliminary analysis suggested.

Reduction of amyloid from baseline to 6 months in newly treated patients was -40.3 centiloids with subcutaneous lecanemab compared with -35.4 centiloids with IV administration, said Eisai vice president Michael Irizarry, MD, MPH, during a symposium at the 2023 Clinical Trials on Alzheimer’s Disease conference in Boston. This translated to a 14% relative reduction for the subcutaneous version.

The incidence of amyloid-related imaging abnormalities with edema (ARIA-E) or with cerebral hemorrhage, cerebral microhemorrhage, and hemosiderin deposition (ARIA-H) did not appear to be better with subcutaneous lecanemab.

The subcutaneous substudy was part of an open-label extension (OLE) of the phase III CLARITY AD trial and included 72 people with early Alzheimer’s who received lecanemab for the first time as the subcutaneous formulation, and 322 people who converted from IV lecanemab in CLARITY AD to subcutaneous administration in the OLE.

The phase III CLARITY AD trial — the basis for the FDA’s full approval decision — showed IV lecanemab led to less decline on cognitive and functional measures. The study met its primary and all key secondary endpoints.

The goal of the subcutaneous substudy was to assess pharmacokinetics, measured as area under the curve (AUC), and pharmacodynamics, measured as amyloid clearance. The mean age of lecanemab-naive patients treated subcutaneously was 73, and 51% were women. About 49% carried one APOE4 allele, and 8% carried two.

The weekly subcutaneous administration AUC was 11% higher than the biweekly IV formulation, with confidence intervals within bioequivalent levels, Irizarry said.

Subcutaneous administration led to 8.1% of patients overall having local injection site reactions (15.3% in lecanemab-naive patients). Most were mild and moderate in severity consisting of redness, irritation, or swelling. No skin rash or other hypersensitivities emerged.

In the CLARITY-AD trial of IV lecanemab, the incidence of ARIA-E was 12.6%; ARIA-H occurred in 17.3%, and isolated ARIA-H without ARIA-E occurred in 8.9%. In patients newly treated with subcutaneous lecanemab in the substudy, ARIA-E incidence was 16.7%, 22.2% for ARIA-H, and 8.3% for isolated ARIA-H. There were no intracerebral hemorrhages with subcutaneous lecanemab.

“The incidence, timing, radiographic severity, and clinical severity of ARIA was generally similar for subcutaneous relative to IV, taking into account the variability and also the greater exposure for the subcutaneous formulation,” Irizarry said.

“In general, ARIA-E tended to occur early in treatment, was generally asymptomatic, and was mild to moderate radiographically,” he added.

In the phase II and III lecanemab studies, maximum exposure was the strongest predictor of ARIA-E incidence with IV administration, he pointed out. In the subcutaneous substudy, steady-state exposure appeared to be a better predictor of ARIA-E rates.

“The subcutaneous formulation has comparable pharmacokinetics and amyloid clearance to IV, providing another convenient dosing option for lecanemab,” Irizarry noted. Drugmaker Eisai said it plans to submit an application for its lecanemab subcutaneous formulation to the FDA in the first quarter of 2024.

Judy George covers neurology and neuroscience news for MedPage Today, writing about brain aging, Alzheimer’s, dementia, MS, rare diseases, epilepsy, autism, headache, stroke, Parkinson’s, ALS, concussion, CTE, sleep, pain, and more. Follow

Disclosures

This research was supported by Eisai.

Irizarry is an employee of Eisai.

Primary Source

Clinical Trials on Alzheimer’s Disease

Source Reference: Irizarry M “Preliminary update on lecanemab safety in CLARITY AD open-label extension, including subcutaneous formulation” CTAD 2023.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/neurology/alzheimersdisease/107057

Tags: Alzheimer’shealthSubcutaneous
Previous Post

EP Study During TAVR Offers Better Prediction of Late Conduction Disturbances

Next Post

COVID Upended Bronchiolitis Admission Patterns in Kids

U.S. and Israel against the world as Palestine dominates UN week – Axios

U.S. and Israel against the world as Palestine dominates UN week – Axios

September 23, 2025
Global economic outlook weakens as policy uncertainty weighs on demand – OECD

Global economic outlook weakens as policy uncertainty weighs on demand – OECD

September 23, 2025
Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

September 23, 2025
AI Tool Predicts Health Problems in Patients 20 Years Before They Emerge – eWeek

AI Tool Detects Health Issues Two Decades Before Symptoms Appear

September 23, 2025
Germany’s €80B Rearmament Plan Sidelines US Weapons – politicstoday.org

Germany’s €80B Rearmament Plan Sidelines US Weapons – politicstoday.org

September 23, 2025
FOCUS | SCIO holds press conference on promoting high-quality development through high-level ecological & environmental protection – Xinhua

FOCUS | SCIO holds press conference on promoting high-quality development through high-level ecological & environmental protection – Xinhua

September 23, 2025
Researcher on Tylenol-Autism Connection: Not the Best Science – Managed Healthcare Executive

Researcher Questions the Science Behind Tylenol-Autism Link

September 23, 2025
Da Vinci’s Genetic Secrets May Soon Be Revealed by Ambitious DNA Project – ScienceAlert

Unlocking Da Vinci’s Genetic Mysteries: The Ambitious DNA Project Set to Reveal All

September 23, 2025
Eco-Chic Home & Lifestyle Design Market Is Booming Worldwide | Major Giants The Joinery, Emeco, Greenington – openPR.com

Eco-Chic Home & Lifestyle Design Market Is Booming Worldwide | Major Giants The Joinery, Emeco, Greenington – openPR.com

September 23, 2025
Agentic AI and the future of work: navigating technological promise and the risk of increased automation – Equal Times

Agentic AI and the Future of Work: Embracing Innovation While Navigating Automation Challenges

September 23, 2025

Categories

Archives

September 2025
MTWTFSS
1234567
891011121314
15161718192021
22232425262728
2930 
« Aug    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (832)
  • Economy (853)
  • Entertainment (21,731)
  • General (17,194)
  • Health (9,896)
  • Lifestyle (865)
  • News (22,149)
  • People (855)
  • Politics (863)
  • Science (16,063)
  • Sports (21,352)
  • Technology (15,835)
  • World (837)

Recent News

U.S. and Israel against the world as Palestine dominates UN week – Axios

U.S. and Israel against the world as Palestine dominates UN week – Axios

September 23, 2025
Global economic outlook weakens as policy uncertainty weighs on demand – OECD

Global economic outlook weakens as policy uncertainty weighs on demand – OECD

September 23, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version