* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Monday, July 28, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Top 5 entertainment news: Sandeep Reddy Vanga regrets trimming Animal’s runtime by 7-8 minutes, Akshay Ku – Times of India

    Top 5 Entertainment Highlights: Sandeep Reddy Vanga Reveals Why He Trimmed Animal’s Runtime by 7-8 Minutes, Plus Akshay Ku Updates

    Cote de Pablo reveals how Michael Weatherly used his soap opera roots to put her at ease in “NCIS” love scene – yahoo.com

    Cote de Pablo Reveals How Michael Weatherly’s Soap Opera Background Made Their “NCIS” Love Scene Easier

    City of Pelham announces entertainment district plans for former Oak Mountain Amphitheatre site – WVTM

    Pelham Unveils Exciting New Entertainment District Plans for Former Oak Mountain Amphitheatre Site

    Black Box Players presents ‘The Three Musketeers’ – CBS 19 News

    Experience the Adventure: Black Box Players Bring ‘The Three Musketeers’ to Life!

    AP Entertainment SummaryBrief at 1:51 p.m. EDT – Channel 3000

    Entertainment Highlights: Key Updates You Can’t Miss

    ‘Devil Wears Prada 2’ casts Anne Hathaway’s love interest replacing Adrian Grenier’s Nate – Entertainment Weekly

    Devil Wears Prada 2′ Casts New Love Interest for Anne Hathaway, Replacing Adrian Grenier’s Nate

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    AI’s race in the dark with China – Axios

    The High-Stakes AI Race: Innovation and Competition in the Shadows

    Eagle Unveils Revolutionary X-Ray Technology at Pack Expo

    Validea’s Top Information Technology Stocks Based On Peter Lynch – 7/25/2025 – Nasdaq

    Validea’s Top Information Technology Stocks Based On Peter Lynch – 7/25/2025 – Nasdaq

    WhoFi: New surveillance technology can track people by how they disrupt Wi-Fi signals – Tech Xplore

    WhoFi: New surveillance technology can track people by how they disrupt Wi-Fi signals – Tech Xplore

    Google Cloud Announced as a Key Technology Partner for Odoo Connect 2025 in San Francisco – GlobeNewswire

    Google Cloud Announced as a Key Technology Partner for Odoo Connect 2025 in San Francisco – GlobeNewswire

    Behind the Screens: The Impact of Technology on Real Estate – TRREB

    Behind the Screens: How Technology is Transforming the Future of Real Estate

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Top 5 entertainment news: Sandeep Reddy Vanga regrets trimming Animal’s runtime by 7-8 minutes, Akshay Ku – Times of India

    Top 5 Entertainment Highlights: Sandeep Reddy Vanga Reveals Why He Trimmed Animal’s Runtime by 7-8 Minutes, Plus Akshay Ku Updates

    Cote de Pablo reveals how Michael Weatherly used his soap opera roots to put her at ease in “NCIS” love scene – yahoo.com

    Cote de Pablo Reveals How Michael Weatherly’s Soap Opera Background Made Their “NCIS” Love Scene Easier

    City of Pelham announces entertainment district plans for former Oak Mountain Amphitheatre site – WVTM

    Pelham Unveils Exciting New Entertainment District Plans for Former Oak Mountain Amphitheatre Site

    Black Box Players presents ‘The Three Musketeers’ – CBS 19 News

    Experience the Adventure: Black Box Players Bring ‘The Three Musketeers’ to Life!

    AP Entertainment SummaryBrief at 1:51 p.m. EDT – Channel 3000

    Entertainment Highlights: Key Updates You Can’t Miss

    ‘Devil Wears Prada 2’ casts Anne Hathaway’s love interest replacing Adrian Grenier’s Nate – Entertainment Weekly

    Devil Wears Prada 2′ Casts New Love Interest for Anne Hathaway, Replacing Adrian Grenier’s Nate

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    AI’s race in the dark with China – Axios

    The High-Stakes AI Race: Innovation and Competition in the Shadows

    Eagle Unveils Revolutionary X-Ray Technology at Pack Expo

    Validea’s Top Information Technology Stocks Based On Peter Lynch – 7/25/2025 – Nasdaq

    Validea’s Top Information Technology Stocks Based On Peter Lynch – 7/25/2025 – Nasdaq

    WhoFi: New surveillance technology can track people by how they disrupt Wi-Fi signals – Tech Xplore

    WhoFi: New surveillance technology can track people by how they disrupt Wi-Fi signals – Tech Xplore

    Google Cloud Announced as a Key Technology Partner for Odoo Connect 2025 in San Francisco – GlobeNewswire

    Google Cloud Announced as a Key Technology Partner for Odoo Connect 2025 in San Francisco – GlobeNewswire

    Behind the Screens: The Impact of Technology on Real Estate – TRREB

    Behind the Screens: How Technology is Transforming the Future of Real Estate

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Subcutaneous infusion of levodopa-carbidopa beneficial for Parkinson’s disease

April 14, 2024
in Health
Subcutaneous infusion of levodopa-carbidopa beneficial for Parkinson’s disease
Share on FacebookShare on Twitter

Subcutaneous infusion of levodopa-carbidopa beneficial for parkinson disease

Subcutaneous infusion of ND0612 (a levodopa-carbidopa solution) increases on time without troublesome dyskinesia among patients with Parkinson disease, according to a study published online March 15 in The Lancet Neurology.

Alberto J. Espay, M.D., from the University of Cincinnati, and colleagues examined the safety and efficacy of a continuous 24-hour/day subcutaneous infusion of ND0612 compared with oral immediate-release levodopa-carbidopa for the treatment of motor fluctuations in Parkinson’s disease. Participants underwent an open-label run-in phase and were then randomly assigned (1:1) to 12 weeks of treatment with their optimized regimen of subcutaneous ND0612 or oral levodopa-carbidopa, with matching oral or subcutaneous placebo given as required to maintain blinding. A total of 381 participants were enrolled; 259 were randomly assigned to receive subcutaneous ND0612 (128; 49 percent) or oral levodopa-carbidopa (131; 51 percent).

The researchers found that compared with oral levodopa-carbidopa, treatment with subcutaneous ND0612 provided an additional 1.72 hours of on time without troublesome dyskinesia (change from baseline, −0.48 and −2.20 hours, respectively). In the first four of nine prespecified hierarchical outcomes of daily off time (−1.40 hours), Movement Disorders Society-Unified Parkinson’s Disease Rating Scale part II scores (−3.05), Patients Global Impression of Change (odds ratio, 5.31), and Clinical Global Impression of Improvement (odds ratio, 7.23), significant treatment differences favoring subcutaneous ND0612 were seen. After the fourth secondary end point, hierarchical testing ended.

“ND0612 infusion could offer an efficacious and safe individualized infusion approach to managing motor fluctuations in people with Parkinson’s disease before considering surgery-associated interventions,” the authors write.

Several authors disclosed ties to biopharmaceutical companies, including NeuroDerm, which is developing ND0612 and funded the study.

More information:
Alberto J Espay et al, Safety and efficacy of continuous subcutaneous levodopa–carbidopa infusion (ND0612) for Parkinson’s disease with motor fluctuations (BouNDless): a phase 3, randomised, double-blind, double-dummy, multicentre trial, The Lancet Neurology (2024). DOI: 10.1016/S1474-4422(24)00052-8

Francisco Cardoso et al, Fluctuations in Parkinson’s disease: progress and challenges, The Lancet Neurology (2024). DOI: 10.1016/S1474-4422(24)00116-9

Copyright © 2024 HealthDay. All rights reserved.

Citation:
Subcutaneous infusion of levodopa-carbidopa beneficial for Parkinson’s disease (2024, April 13)
retrieved 14 April 2024
from https://medicalxpress.com/news/2024-04-subcutaneous-infusion-levodopa-carbidopa-beneficial.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2024-04-subcutaneous-infusion-levodopa-carbidopa-beneficial.html

Tags: healthInfusionSubcutaneous
Previous Post

ACC: Ticagrelor monotherapy cuts bleeding risk in acute coronary syndrome

Next Post

Important health information missing in online food delivery menus

US military kills ISIS leader in Syria – CNN

US Military Strikes Down ISIS Leader in Syria, Dealing a Crushing Blow to Terror Network

July 28, 2025
AI’s race in the dark with China – Axios

The High-Stakes AI Race: Innovation and Competition in the Shadows

July 27, 2025
LeBron James’ future with Lakers beyond 2025-26 certain to generate speculation leading up to training camp – Yahoo Sports

LeBron James’ Lakers Future Beyond 2025-26 Sparks Intense Speculation Ahead of Training Camp

July 27, 2025
Energy landscapes direct the movement preferences of elephants – besjournals

Energy landscapes direct the movement preferences of elephants – besjournals

July 27, 2025
At United Nations Summer Program, Computer Science Student Examines AI Ethics – Georgetown University

At United Nations Summer Program, Computer Science Student Examines AI Ethics – Georgetown University

July 27, 2025
Return of wolves to Yellowstone has led to a surge in aspen trees unseen for 80 years – Live Science

Wolves’ Return to Yellowstone Sparks Unprecedented Aspen Tree Boom After 80 Years

July 27, 2025
‘Bluey’ Is Growing Up: BBC Plots All-Ages Expansion For The Franchise As A Full-Fledged Lifestyle Brand – Cartoon Brew

‘Bluey’ Is Growing Up: BBC Plots All-Ages Expansion For The Franchise As A Full-Fledged Lifestyle Brand – Cartoon Brew

July 27, 2025
Katie Ledecky, Summer McIntosh and a race for the ages at World Swimming Championships – NBC Sports

Katie Ledecky and Summer McIntosh Ignite an Epic Showdown at the World Swimming Championships

July 27, 2025
5 ways Trump has shaped the economy in 6 months – The Hill

5 Game-Changing Ways Trump Transformed the Economy in Just 6 Months

July 27, 2025
Flutter Entertainment Announces Pricing Of $1.272 Bln Of Additional Senior Secured Notes Due 2031 – Nasdaq

Flutter Entertainment Raises $1.27 Billion in Major Senior Secured Notes Offering Due 2031

July 27, 2025

Categories

Archives

July 2025
MTWTFSS
 123456
78910111213
14151617181920
21222324252627
28293031 
« Jun    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (741)
  • Economy (765)
  • Entertainment (21,645)
  • General (16,137)
  • Health (9,804)
  • Lifestyle (773)
  • News (22,149)
  • People (767)
  • Politics (775)
  • Science (15,980)
  • Sports (21,263)
  • Technology (15,747)
  • World (748)

Recent News

US military kills ISIS leader in Syria – CNN

US Military Strikes Down ISIS Leader in Syria, Dealing a Crushing Blow to Terror Network

July 28, 2025
AI’s race in the dark with China – Axios

The High-Stakes AI Race: Innovation and Competition in the Shadows

July 27, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version