* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Saturday, August 16, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    ‘The Rainmaker’ Premiere: Milo Callaghan Breaks Down Rudy Baylor’s ‘Misguided Valor’ – The Laconia Daily Sun

    Inside ‘The Rainmaker’ Premiere: Milo Callaghan Uncovers the Real Story Behind Rudy Baylor’s Misguided Valor

    Suicide Squad Member Gets New Origin in Absolute Flash – yahoo.com

    Suicide Squad Member Unveiled with Exciting New Origin in Absolute Flash

    I’ll miss the chaos of ‘And Just like That…’ (and Che Diaz too) – yahoo.com

    Why I’ll Truly Miss the Wild Ride of ‘And Just Like That…’ (and Che Diaz!)

    Webtoon Entertainment Stages Recovery With Disney’s Stamp of Approval – The Wall Street Journal

    Webtoon Entertainment Soars to New Heights with Disney’s Stamp of Approval

    Georgia Tech Launches Arts, Entertainment, and Creative Technologies Degree – Georgia Tech News Center

    Georgia Tech Unveils Exciting New Degree in Arts, Entertainment, and Creative Technologies

    John Davison departs from IGN Entertainment – GamesIndustry.biz

    John Davison Steps Down from IGN Entertainment Leadership

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Vermont famers say new technology is changing the state’s agriculture industry – News Channel 3-12

    Vermont Farmers Embrace New Technology Transforming the State’s Agriculture Industry

    Verb Technology Reports Revenue Growth Amidst Strategic Expansions – TipRanks

    Verb Technology Soars with Impressive Revenue Growth Driven by Strategic Expansions

    Midwest Technology Summit held in Fargo – WDAY Radio

    Midwest Technology Summit held in Fargo – WDAY Radio

    K1 Semiconductor Joins Chicago Quantum Exchange To Advance Wafer Technology. – Quantum Zeitgeist

    K1 Semiconductor Partners with Chicago Quantum Exchange to Revolutionize Wafer Technology

    Indirect tax transformation: Navigating change, embracing technology – Thomson Reuters tax and accounting

    Revolutionizing Indirect Tax: Embracing Technology to Navigate Change

    California’s wildfire moonshot: How new technology will defeat advancing flames – Los Angeles Times

    California’s Wildfire Revolution: How Cutting-Edge Technology Is Poised to Stop Raging Flames

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    ‘The Rainmaker’ Premiere: Milo Callaghan Breaks Down Rudy Baylor’s ‘Misguided Valor’ – The Laconia Daily Sun

    Inside ‘The Rainmaker’ Premiere: Milo Callaghan Uncovers the Real Story Behind Rudy Baylor’s Misguided Valor

    Suicide Squad Member Gets New Origin in Absolute Flash – yahoo.com

    Suicide Squad Member Unveiled with Exciting New Origin in Absolute Flash

    I’ll miss the chaos of ‘And Just like That…’ (and Che Diaz too) – yahoo.com

    Why I’ll Truly Miss the Wild Ride of ‘And Just Like That…’ (and Che Diaz!)

    Webtoon Entertainment Stages Recovery With Disney’s Stamp of Approval – The Wall Street Journal

    Webtoon Entertainment Soars to New Heights with Disney’s Stamp of Approval

    Georgia Tech Launches Arts, Entertainment, and Creative Technologies Degree – Georgia Tech News Center

    Georgia Tech Unveils Exciting New Degree in Arts, Entertainment, and Creative Technologies

    John Davison departs from IGN Entertainment – GamesIndustry.biz

    John Davison Steps Down from IGN Entertainment Leadership

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Vermont famers say new technology is changing the state’s agriculture industry – News Channel 3-12

    Vermont Farmers Embrace New Technology Transforming the State’s Agriculture Industry

    Verb Technology Reports Revenue Growth Amidst Strategic Expansions – TipRanks

    Verb Technology Soars with Impressive Revenue Growth Driven by Strategic Expansions

    Midwest Technology Summit held in Fargo – WDAY Radio

    Midwest Technology Summit held in Fargo – WDAY Radio

    K1 Semiconductor Joins Chicago Quantum Exchange To Advance Wafer Technology. – Quantum Zeitgeist

    K1 Semiconductor Partners with Chicago Quantum Exchange to Revolutionize Wafer Technology

    Indirect tax transformation: Navigating change, embracing technology – Thomson Reuters tax and accounting

    Revolutionizing Indirect Tax: Embracing Technology to Navigate Change

    California’s wildfire moonshot: How new technology will defeat advancing flames – Los Angeles Times

    California’s Wildfire Revolution: How Cutting-Edge Technology Is Poised to Stop Raging Flames

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Sweet taste receptor affects how glucose is handled metabolically by humans

May 18, 2024
in Health
Sweet taste receptor affects how glucose is handled metabolically by humans
Share on FacebookShare on Twitter

sugar

Credit: Unsplash/CC0 Public Domain

The rich research portfolio of the Monell Chemical Senses Center on sweet taste goes way back: Monell scientists were one of four teams in 2001 that found and described the mammalian sweet taste receptor—TAS1R2-TAS1R3. Twenty years later in 2021, a pair of papers published in Mammalian Genome by Monell researchers covered the genetics of sugar-loving mice.

The sweet taste receptor, expressed in taste bud cells, conveys sweetness from the mouth when it is activated. Earlier this month, a study in PLOS One, led by another Monell researcher, delved into how the sweet-taste receptor might be the first stop in a metabolic surveillance system for sugar. The receptor is also expressed in certain intestinal cells, where it may facilitate glucose absorption and assimilation, as part of this system.

The team found that stimulation and inhibition of TAS1R2-TAS1R3 demonstrates that it helps regulate glucose metabolism in humans and may have implications for managing such metabolic disorders as diabetes. Glucose is the primary type of sugar found in human blood, making it a key source of energy for cells.

“Our objective was to determine whether TAS1R2-TAS1R3 influences glucose metabolism in two directions,” said Monell Member Paul Breslin, Ph.D., Professor of Nutritional Sciences, Rutgers University, and senior author on the paper.

They showed that a TAS1R2-TAS1R3 agonist (sucralose, a zero-calorie sweetener) or a TAS1R2-TAS1R3 antagonist (lactisole, a sodium salt that inhibits sweet taste) mixed with a glucose meal acutely altered human glucose tolerance in different ways. Here, an agonist binds to a receptor and stimulates a cell and an antagonist binds to a receptor and prevents stimulation.

“The novelty of our findings is that the receptor we studied in this experiment impacts blood glucose and insulin during a glucose meal differently, depending on whether it is stimulated or inhibited,” said Breslin. This work provides further evidence that taste receptors help regulate metabolism and nutrient handling.

Plasma insulin levels were measured in study participants given an oral glucose tolerance test (OGTT), which follows blood sugar levels before and after a person drinks a liquid meal containing glucose. Participants’ ratings of perceived sucralose sweetness correlated with early increases in plasma glucose, as well as increases in plasma insulin levels when sucralose was added to the OGTT. The added sucralose tended to accelerate the release of insulin to the glucose load. On the other hand, participants’ sensitivity to lactisole-driven inhibition of sweetness was correlated with decreased plasma glucose levels. Lactisole also tended to slow insulin release.

“When glucose stimulates taste receptors before being absorbed into the body, signals are sent via the mouth and intestine to regulatory organs such as the pancreas. Perhaps, we could devise ways of using TAS1R2-TAS1R3 to help the body handle glucose better by anticipating when glucose will appear in the blood,” said Breslin. When the body senses glucose, it speeds up the absorption to deliver glucose to tissues that may need it and possibly also to prevent glucose from moving too far along the intestine, which may not be good for maintaining a healthy gut microbiome.

“This system is elegant in its simplicity,” said Breslin. The same taste receptor is all over the body—the mouth, gastrointestinal tract, pancreas, liver, and fat cells, with the last three being major metabolic regulatory tissues, all part of the body’s 24/7 metabolic watch.

Is there a relationship between a person’s health status and the activity of their TAS1R2-TAS1R3 receptors? Study authors say likely, suggesting that the degree of receptor activation exerts acute influences on plasma glucose and insulin levels and their timing of onset, which is important for metabolic health.

The team maintains that, in general, the current dietary habits of excessive consumption of food and beverages high in sucrose, high fructose corn syrup, and high-potency sweeteners could hyperstimulate TAS1R2-TAS1R3, contributing to the improper regulation of glucose in the blood. This could lead to a diagnosis of metabolic syndrome, a cluster of risk factors including elevated plasma glucose and insulin insensitivity (along with obesity, hypertension, and elevated plasma fats) that increases the risk of heart disease, stroke, and diabetes. The authors say that future studies should examine the effects of TAS1R2-TAS1R3 stimulation and inhibition in people who are at risk for metabolic syndrome to determine the therapeutic potential of manipulating TAS1R2-TAS1R3 for better metabolic control instead of worse.

“Studies like these—using Monell’s technical capability and deep expertise in the chemical senses—show that the sweet taste receptor TAS1R2-TAS1R3 helps to regulate glucose differently, depending on the sweetness of the food or beverage,” said Breslin. The team’s hope is to apply what they learned to make what we eat and drink healthier.

“A small metabolic change for the positive can add a lot more to the life and health of humans when compounded over decades and millions of people,” said Breslin.

Along with Breslin, co-authors are Emily C. Hanselman and Matthew C. Kochem, Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ.

More information:
Matthew C. Kochem et al, Activation and inhibition of the sweet taste receptor TAS1R2-TAS1R3 differentially affect glucose tolerance in humans, PLOS ONE (2024). DOI: 10.1371/journal.pone.0298239

Citation:
Sweet taste receptor affects how glucose is handled metabolically by humans (2024, May 18)
retrieved 18 May 2024
from https://medicalxpress.com/news/2024-05-sweet-receptor-affects-glucose-metabolically.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2024-05-sweet-receptor-affects-glucose-metabolically.html

Tags: healthSweettaste
Previous Post

Fruit fly wing research offers window into birth defects

Next Post

Life Support Withdrawn Too Soon in Severe TBI?

Box, run, crash: China’s humanoid robot games show advances and limitations – The Guardian

Box, Run, Crash: Inside China’s Humanoid Robot Games Revealing Stunning Progress and Surprising Challenges

August 16, 2025
Customers look set to bear the tariff cost burden – Axios

Rising Tariff Costs: How They Impact Your Wallet and What You Can Do

August 16, 2025
‘The Rainmaker’ Premiere: Milo Callaghan Breaks Down Rudy Baylor’s ‘Misguided Valor’ – The Laconia Daily Sun

Inside ‘The Rainmaker’ Premiere: Milo Callaghan Uncovers the Real Story Behind Rudy Baylor’s Misguided Valor

August 16, 2025
NC state employee and teacher reps say health insurance increases will hurt worker retention – NC Newsline

Rising Health Insurance Costs Jeopardize Retention of State Employees and Teachers

August 16, 2025
DC police to share information with federal immigration officers – CNN

DC Police to Collaborate with Federal Immigration Officers in New Information Sharing Initiative

August 16, 2025
China’s Ecological Civilization Shaping a Sustainable Future – 中国科技网

China’s Ecological Civilization Shaping a Sustainable Future – 中国科技网

August 16, 2025
NVIDIA, National Science Foundation Support Ai2 Development of Open AI Models to Drive US Scientific Leadership – NVIDIA Blog

NVIDIA, National Science Foundation Support Ai2 Development of Open AI Models to Drive US Scientific Leadership – NVIDIA Blog

August 16, 2025
Boise State plans to build new science research building to help with capacity needs – KTVB

Boise State Unveils Plans for New Science Research Building to Boost Capacity

August 16, 2025
Why Some Physicians Still Lead With Lifestyle-First Obesity Care Despite the GLP-1 Revolution – Medscape

Why Many Physicians Still Champion Lifestyle-First Strategies in Obesity Care Despite the GLP-1 Revolution

August 16, 2025
Vermont famers say new technology is changing the state’s agriculture industry – News Channel 3-12

Vermont Farmers Embrace New Technology Transforming the State’s Agriculture Industry

August 16, 2025

Categories

Archives

August 2025
MTWTFSS
 123
45678910
11121314151617
18192021222324
25262728293031
« Jul    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (773)
  • Economy (796)
  • Entertainment (21,673)
  • General (16,494)
  • Health (9,834)
  • Lifestyle (806)
  • News (22,149)
  • People (797)
  • Politics (803)
  • Science (16,008)
  • Sports (21,293)
  • Technology (15,775)
  • World (778)

Recent News

Box, run, crash: China’s humanoid robot games show advances and limitations – The Guardian

Box, Run, Crash: Inside China’s Humanoid Robot Games Revealing Stunning Progress and Surprising Challenges

August 16, 2025
Customers look set to bear the tariff cost burden – Axios

Rising Tariff Costs: How They Impact Your Wallet and What You Can Do

August 16, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version