TOPLINE:
Transcranial direct current stimulation (tDCS) delivered twice daily over 6 weeks can improve cognitive function in patients with Alzheimer’s disease (AD), highlighting the potential of tDCS as a therapeutic intervention, new research shows.
METHODOLOGY:
The study enrolled 124 patients with mild to moderate AD, with 63 randomly allocated to receive active tDCS and 61 to receive sham tDCS.Active or sham tDCS was applied twice daily for 20 minutes to the dorsolateral prefrontal cortex for 5 consecutive days per week for 6 weeks.Cognitive function was assessed at baseline, week 2, and week 6 using the Alzheimer’s Disease Assessment Scale-Cognitive (ADAS-Cog) and Mini-Mental State Examination (MMSE). Cortical plasticity was represented by motor-evoked potential (MEP) measured with electromyography.
TAKEAWAY:
Compared with sham tDCS, active tDCS led to significant improvements at 6 weeks in ADAS-Cog memory-related cognitive functions, especially in the memory domains of word recall, recall of test instructions, and word recognition (all P
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