* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Thursday, October 2, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Major airline to offer new in-flight entertainment options for passengers – PennLive.com

    Major airline to offer new in-flight entertainment options for passengers – PennLive.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    The Police Made Chart History With This 1979 Hit Nearly 50 Years Ago – Yahoo

    How The Police Changed Music Forever with Their Iconic 1979 Hit Nearly 50 Years Ago

    Good Deed Entertainment Acquires Worldwide Rights To Liza Mandelup’s Documentary ‘Caterpillar’ – Deadline

    Good Deed Entertainment Lands Global Rights to Liza Mandelup’s Captivating Documentary ‘Caterpillar

    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

    Jussie Smollett Claims He Was ‘Disrespected’ on the ‘Special Forces’ Season Premiere – Yahoo

    Jussie Smollett Opens Up About Feeling ‘Disrespected’ During the ‘Special Forces’ Season Premiere

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    A Tech Expo Shows What China Can Make, but Not Who’ll Buy It All – The New York Times

    Inside China’s Tech Expo: Cutting-Edge Innovations Face Uncertain Demand

    Steampunk Metal Oval Technology Sense Sunglasses Personality Handmade Chain Multicolor Sunglasses UV400 – The San Joaquin Valley Sun

    Steampunk Metal Oval Sunglasses with Handmade Multicolor Chain – Bold UV400 Protection and Unique Style

    STELLA Automotive AI Appoints Fred Seidelman as Chief Technology Officer – Yahoo Finance

    STELLA Automotive AI Appoints Fred Seidelman as New Chief Technology Officer

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Four Strategic Signals Technology Leaders Are Tuning In To – SPONSOR CONTENT FROM ARM – Harvard Business Review

    Four Essential Strategic Signals Every Technology Leader Should Watch

    Virginia Tech hosts annual New Music + Technology Festival this week – Cardinal News

    Virginia Tech Kicks Off Exciting Annual New Music and Technology Festival This Week

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Major airline to offer new in-flight entertainment options for passengers – PennLive.com

    Major airline to offer new in-flight entertainment options for passengers – PennLive.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    Penn State-Themed Restaurant and Entertainment Spot Happy Valley Live Set to Open in State College – StateCollege.com

    The Police Made Chart History With This 1979 Hit Nearly 50 Years Ago – Yahoo

    How The Police Changed Music Forever with Their Iconic 1979 Hit Nearly 50 Years Ago

    Good Deed Entertainment Acquires Worldwide Rights To Liza Mandelup’s Documentary ‘Caterpillar’ – Deadline

    Good Deed Entertainment Lands Global Rights to Liza Mandelup’s Captivating Documentary ‘Caterpillar

    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

    Danielle Fishel Explains Why Being on “DWTS” Makes Her Feel ‘Like It’s 1994 Again’ Filming “Boy Meets World” (Exclusive) – Yahoo

    Jussie Smollett Claims He Was ‘Disrespected’ on the ‘Special Forces’ Season Premiere – Yahoo

    Jussie Smollett Opens Up About Feeling ‘Disrespected’ During the ‘Special Forces’ Season Premiere

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    A Tech Expo Shows What China Can Make, but Not Who’ll Buy It All – The New York Times

    Inside China’s Tech Expo: Cutting-Edge Innovations Face Uncertain Demand

    Steampunk Metal Oval Technology Sense Sunglasses Personality Handmade Chain Multicolor Sunglasses UV400 – The San Joaquin Valley Sun

    Steampunk Metal Oval Sunglasses with Handmade Multicolor Chain – Bold UV400 Protection and Unique Style

    STELLA Automotive AI Appoints Fred Seidelman as Chief Technology Officer – Yahoo Finance

    STELLA Automotive AI Appoints Fred Seidelman as New Chief Technology Officer

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Saving Energy and Money with Smart Technology – Terms of Service with Clare Duffy – Podcast on CNN Podcasts – CNN

    Four Strategic Signals Technology Leaders Are Tuning In To – SPONSOR CONTENT FROM ARM – Harvard Business Review

    Four Essential Strategic Signals Every Technology Leader Should Watch

    Virginia Tech hosts annual New Music + Technology Festival this week – Cardinal News

    Virginia Tech Kicks Off Exciting Annual New Music and Technology Festival This Week

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Team delivers breakthrough ‘nanobody’ technology

October 12, 2023
in Health
Team delivers breakthrough ‘nanobody’ technology
Share on FacebookShare on Twitter

thrombosis

Credit: Pixabay/CC0 Public Domain

Researchers led by Professor Steve Watson and Dr. Eleyna Martin from the Institute of Cardiovascular Sciences at the University of Birmingham have delivered a breakthrough for thrombosis researchers, by producing the first binding molecules (ligands) of defined composition to make platelets clump together in a predictable way.

The research team developed antibody fragments called nanobodies and crosslinked these to make ligands to four platelet receptors (GPVI, CLEC-2, FcɣRIIA and PEAR1).

The nanobodies can be used to develop validated clinical assays for testing patients with platelet disorders such as bleeding or thrombosis, and as research tools to study platelet activation.

Professor Watson said, “Nanobodies have the same properties as antibodies but have several inherent advantages for platelet researchers. They are smaller, which makes them more suitable for cross-linking, and this size, coupled with their stability and high affinity for platelet receptors, makes them ideal reagents for receptor imaging.”

Scientists already know that when these four receptors cluster on the platelet surface, signaling molecules are generated that trigger platelet activation and clotting.

However, they currently have a limited understanding of the relationship between cluster size, signal generation and how this relates to platelet activation.

Further research in this area is hampered due to limitations of the currently used ligands. Some have undefined valency (binding power), while others, such as the snake venom toxin rhodocytin, show significant batch variation, or uncertain specificity for the receptors.

The Birmingham researchers developed nanobodies with one, two, three and four binding sites, and tested the ability of these to generate signaling molecules and stimulate platelet activation. Their work is published in the Journal of Thrombosis and Haemostasis.

The versatility of nanobodies in biological research has already been illustrated in two earlier papers from the Birmingham Platelet Group.

In these studies, Professor Steve Watson and Dr. Natalie Poulter used novel nanobodies the team had raised to bind to the GPVI receptor. Present on platelet membranes, this receptor is an attractive target for drug therapies as it plays a critical role in thrombosis (clot formation) but only has minor involvement in haemostasis (which stops bleeding from a blood vessel).

In the first study, the researchers used a nanobody called Nb28, which they labeled with a fluorescent dye, enabling, for the first time, the visualization of GPVI receptors clustering on platelets in flowing blood. In the same study, they showed that a nanobody called Nb2, which has high binding affinity for GPVI, can potently inhibit platelet activation, block thrombus formation—making it potentially suitable for development into an anti-thrombotic agent.

In the second study, the same researchers demonstrated that there is a relationship between cluster formation and thrombus size, and that cluster size is related to thrombus formation, with the formation of GPVI ‘macroclusters’ supporting the formation of significantly bigger aggregates of platelets.

Professor Watson added, “We are entering an exciting period in thrombosis research. Reagents based on nanobodies will increase our understanding of platelet activation in the laboratory. Although nanobodies have a short half-life in vivo, this could be counteracted by linkage to larger inert molecules and yield novel therapeutics for blood and thrombotic disorders.”

More information:
Eleyna M. Martin et al, Trivalent nanobody-based ligands mediate powerful activation of GPVI, CLEC-2 and PEAR1 in human platelets whereas FcγRIIA requires a tetravalent ligand, Journal of Thrombosis and Haemostasis (2023). DOI: 10.1016/j.jtha.2023.09.026

Citation:
Team delivers breakthrough ‘nanobody’ technology (2023, October 12)
retrieved 12 October 2023
from https://medicalxpress.com/news/2023-10-team-breakthrough-nanobody-technology.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2023-10-team-breakthrough-nanobody-technology.html

Tags: Breakthroughdelivershealth
Previous Post

Restoring nerve-muscle connections boosts strength of aging mice, study finds

Next Post

A better ‘map’ of the lights you see when you close your eyes can improve ‘bionic eye’ outcomes

Oak Ridge Reservation Set for $42M Ecological Restoration, Balancing – Hoodline

Oak Ridge Reservation to Undergo $42M Ecological Restoration and Balancing Effort

October 2, 2025
Mayor green lights Science Center development; residents call it ‘giant win’ for St. Pete – WFLA

Mayor green lights Science Center development; residents call it ‘giant win’ for St. Pete – WFLA

October 2, 2025
A ‘Great Wave’ is rippling through our galaxy, pushing thousands of stars out of place – Live Science

A ‘Great Wave’ is rippling through our galaxy, pushing thousands of stars out of place – Live Science

October 2, 2025
These are the best breweries in New Jersey, according to recent online ranking – Yahoo

These are the best breweries in New Jersey, according to recent online ranking – Yahoo

October 2, 2025
A Tech Expo Shows What China Can Make, but Not Who’ll Buy It All – The New York Times

Inside China’s Tech Expo: Cutting-Edge Innovations Face Uncertain Demand

October 2, 2025
E-Sports Week in Review – gobrits.com

This Week’s Most Exciting Moments in E-Sports

October 2, 2025
FIFA World Cup 2026 tickets go on sale today. Here’s how you can get them – LiveNOW from FOX

Score Your Spot: How to Get FIFA World Cup 2026 Tickets Now!

October 2, 2025
Factories struggle in September as soft demand in China and US take toll – Reuters

Factories struggle in September as soft demand in China and US take toll – Reuters

October 2, 2025
Major airline to offer new in-flight entertainment options for passengers – PennLive.com

Major airline to offer new in-flight entertainment options for passengers – PennLive.com

October 2, 2025
FACT: Democrats Shut Down Government Over Free Healthcare for Illegals – The White House (.gov)

Democrats Push Government Shutdown Over Free Healthcare for Undocumented Immigrants

October 2, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (847)
  • Economy (867)
  • Entertainment (21,741)
  • General (17,364)
  • Health (9,910)
  • Lifestyle (881)
  • News (22,149)
  • People (870)
  • Politics (878)
  • Science (16,078)
  • Sports (21,368)
  • Technology (15,851)
  • World (850)

Recent News

Oak Ridge Reservation Set for $42M Ecological Restoration, Balancing – Hoodline

Oak Ridge Reservation to Undergo $42M Ecological Restoration and Balancing Effort

October 2, 2025
Mayor green lights Science Center development; residents call it ‘giant win’ for St. Pete – WFLA

Mayor green lights Science Center development; residents call it ‘giant win’ for St. Pete – WFLA

October 2, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version