* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Tuesday, October 28, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    What to Know About ‘Good Morning America’s 50th Anniversary Episode – Wyoming News Now

    Celebrate the Milestone: Everything You Need to Know About Good Morning America’s 50th Anniversary Episode

    Dylan Efron suffers brutal nose injury in ‘DWTS’ rehearsals – Yahoo

    Dylan Efron Endures Painful Nose Injury During ‘DWTS’ Rehearsals

    Person shot, injured in parking lot of adult entertainment club in Gresham – KPTV

    Person Shot and Injured in Gresham Adult Entertainment Club Parking Lot

    Meet Belynda From ‘Married at First Sight’ Season 19: Age, Job, Instagram and More – Yahoo

    Meet Belynda from ‘Married at First Sight’ Season 19: Age, Career, Instagram & More Revealed!

    General Hospital’s Rena Sofer Exits as Lois — But the Door Isn’t Closed – Yahoo

    General Hospital’s Rena Sofer Exits as Lois — But the Door Isn’t Closed – Yahoo

    CNN Launches New Show – What to Know About Host Elex Michaelson – Central Oregon Daily

    Get to Know Elex Michaelson: The Dynamic New Host Taking CNN by Storm

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    CPE Technology Berhad (KLSE:CPETECH) Has Affirmed Its Dividend Of MYR0.015 – Yahoo Finance

    CPE Technology Berhad (KLSE:CPETECH) Has Affirmed Its Dividend Of MYR0.015 – Yahoo Finance

    Researchers Discover New Bacterium That Turns Food Waste Into Energy – Technology Networks

    Scientists Unveil Breakthrough Bacterium That Transforms Food Waste Into Clean Energy

    Jim Cramer on GSI Technology: “That Thing is a Rocket Ship” – Yahoo Finance

    Jim Cramer Labels GSI Technology a “Rocket Ship” Poised for Takeoff

    The Anti-Tech Backlash Is Going to Grow Stronger – Jacobin

    The Anti-Tech Backlash Is Gaining Unstoppable Momentum

    Comments to EU Regarding the Draft Revised Technology Transfer Block Exemption Regulation and Technology Transfer Guidelines – Information Technology and Innovation Foundation

    Have Your Say: Share Your Thoughts on the Draft Revised Technology Transfer Block Exemption Regulation and Guidelines

    Ghost Tapping is exploiting tap-to-pay technology in order to steal your money; what your need to know – ABC7 New York

    Ghost Tapping: How Thieves Are Using Tap-to-Pay Technology to Steal Your Money and What You Need to Know

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    What to Know About ‘Good Morning America’s 50th Anniversary Episode – Wyoming News Now

    Celebrate the Milestone: Everything You Need to Know About Good Morning America’s 50th Anniversary Episode

    Dylan Efron suffers brutal nose injury in ‘DWTS’ rehearsals – Yahoo

    Dylan Efron Endures Painful Nose Injury During ‘DWTS’ Rehearsals

    Person shot, injured in parking lot of adult entertainment club in Gresham – KPTV

    Person Shot and Injured in Gresham Adult Entertainment Club Parking Lot

    Meet Belynda From ‘Married at First Sight’ Season 19: Age, Job, Instagram and More – Yahoo

    Meet Belynda from ‘Married at First Sight’ Season 19: Age, Career, Instagram & More Revealed!

    General Hospital’s Rena Sofer Exits as Lois — But the Door Isn’t Closed – Yahoo

    General Hospital’s Rena Sofer Exits as Lois — But the Door Isn’t Closed – Yahoo

    CNN Launches New Show – What to Know About Host Elex Michaelson – Central Oregon Daily

    Get to Know Elex Michaelson: The Dynamic New Host Taking CNN by Storm

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    CPE Technology Berhad (KLSE:CPETECH) Has Affirmed Its Dividend Of MYR0.015 – Yahoo Finance

    CPE Technology Berhad (KLSE:CPETECH) Has Affirmed Its Dividend Of MYR0.015 – Yahoo Finance

    Researchers Discover New Bacterium That Turns Food Waste Into Energy – Technology Networks

    Scientists Unveil Breakthrough Bacterium That Transforms Food Waste Into Clean Energy

    Jim Cramer on GSI Technology: “That Thing is a Rocket Ship” – Yahoo Finance

    Jim Cramer Labels GSI Technology a “Rocket Ship” Poised for Takeoff

    The Anti-Tech Backlash Is Going to Grow Stronger – Jacobin

    The Anti-Tech Backlash Is Gaining Unstoppable Momentum

    Comments to EU Regarding the Draft Revised Technology Transfer Block Exemption Regulation and Technology Transfer Guidelines – Information Technology and Innovation Foundation

    Have Your Say: Share Your Thoughts on the Draft Revised Technology Transfer Block Exemption Regulation and Guidelines

    Ghost Tapping is exploiting tap-to-pay technology in order to steal your money; what your need to know – ABC7 New York

    Ghost Tapping: How Thieves Are Using Tap-to-Pay Technology to Steal Your Money and What You Need to Know

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Tool Predicts PsA Progression From Psoriasis, No Fancy Biomarkers Needed

August 9, 2023
in Health
Tool Predicts PsA Progression From Psoriasis, No Fancy Biomarkers Needed
Share on FacebookShare on Twitter

A risk-prediction algorithm was modestly accurate for identifying patients with psoriasis who are likely to progress to psoriatic arthritis (PsA), researchers reported.

Based on patients’ demographics and clinical presentations routinely assessed during office visits, the model was about 72% effective in predicting 1-year risk of progression, and 75% effective (using slightly different input data) for 5-year risk, according to Lihi Eder, MD, PhD, of Women’s College Hospital in Toronto, and colleagues.

These findings were based on the model’s performance with 635 psoriasis patients, of whom 51 actually developed PsA within 1 year of input data collection; 71 did so within 5 years, the researchers reported in Arthritis & Rheumatology.

An area under the receiver operating characteristic curve (AUC) of 0.723 was obtained for 1-year prediction, using the following inputs:

AgeMale sexFamily history of psoriasisBack stiffnessNail pittingJoint stiffnessUse of biologic medicationsPatient global healthPain severity

For 5-year risk, the model’s AUC was 0.749 and achieved this accuracy with fewer inputs: presence or absence of morning stiffness, pain, and psoriatic nail lesions; scores for psoriasis severity and fatigue; and use of phototherapy or systemic non-biologic drugs.

Eder and colleagues dubbed the model PRESTO, for Psoriatic Arthritis Risk Estimation Tool, and have made it publicly available on the internet as a risk calculator. To take a hypothetical example, PRESTO estimated that a patient with a 10-year history of psoriasis, using an oral corticosteroid, morning stiffness, some mild pain, and moderate fatigue, but with no nail lesions, has a 5-year risk for PsA development of 9%.

Something like 30% of psoriasis patients eventually develop PsA, earlier studies have found. However, it hasn’t been obvious how to tell which patients are most likely to show this type of worsening. A recent “points to consider” document from a European Alliance of Associations for Rheumatology (EULAR) committee recommended that clinicians watch for certain signs, such as persistent pain and joint imaging abnormalities. But the EULAR panel didn’t try to quantify the extra risk associated with such signs and symptoms.

Other groups have attempted to find biomarkers that could underpin a risk prediction tool. Last year, for example, researchers from the University of Rochester in New York reported developing a model based on serum levels of leukotriene B4 and glycoursodeoxycholic acid sulfate that yielded an impressive AUC of 0.94. However, no validation in an independent patient sample was conducted, and it could also be sensitive to different assays for these biomarkers.

PRESTO, while perhaps less accurate, has the advantage of using routinely collected data, as well as plausibility insofar as most of the input variables were already considered, as in the EULAR document, to be risk factors for psoriasis-to-PsA progression.

To develop the model, Eder and colleagues examined 29 different variables under multivariate logistic regression and other statistical tools to find the best fit. “A priori, we considered an AUC of greater than 70% acceptable,” the group noted.

In addition to PRESTO’s potential for informing management of individual patients, the researchers argued that it could also be useful for enrolling patients in PsA prevention trials. Just such a study is now underway, they observed, and others are likely.

Limitations to PRESTO included the relatively small patient cohort that was its basis — this “prevented inclusion of previously reported risk factors that were present in only a few patients but may have a strong effect size,” Eder and colleagues acknowledged. Also, like the serum biomarker-based model, it was not validated in an independent patient group.

author['full_name']

John Gever was Managing Editor from 2014 to 2021; he is now a regular contributor.

Disclosures

The study was funded by the Physician Services Inc. Foundation.

Eder reported relationships with AbbVie, UCB, Pfizer, Janssen, Novartis, Eli Lilly, Sandoz, and Fresenius Kabi. Co-authors reported relationships with numerous pharmaceutical companies.

Primary Source

Arthritis & Rheumatology

Source Reference: Eder L, et al “Derivation of a multivariable psoriatic arthritis risk estimation tool (PRESTO): a step towards prevention” Arthritis Rheumatol 2023; DOI: 10.1002/art.42661.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/rheumatology/arthritis/105810

Tags: healthPredictsProgression
Previous Post

Minor Arcana Cards: Unveiling Their Role in Tarot Readings

Next Post

Women get far more migraines than men—a neurologist explains why, and what brings relief

Once tadpoles lose lungs, they never get them back – Cornell Chronicle

October 28, 2025
Texas A&M Department of Poultry Science hires Williams – WATTPoultry.com

Texas A&M’s Poultry Science Department Welcomes Expert Williams to the Team

October 28, 2025

Raffaele Colombo Highlights the Thriving Community and Cutting-Edge Science at the Incredible AACR-NCI-EORTC Meeting

October 28, 2025
The Donut Chain Known For Making Some Of The Most Unique Flavors In The Game – Yahoo

Discover the Donut Chain Revolutionizing Flavor with Its Uniquely Delicious Creations

October 28, 2025
CPE Technology Berhad (KLSE:CPETECH) Has Affirmed Its Dividend Of MYR0.015 – Yahoo Finance

CPE Technology Berhad (KLSE:CPETECH) Has Affirmed Its Dividend Of MYR0.015 – Yahoo Finance

October 28, 2025
Clippers fans chant “F-B-I” at Blazers players while shooting free throws during Sunday’s game – Yahoo Sports

Clippers Fans Erupt with “F-B-I” Chants at Blazers Players During Sunday’s Intense Showdown

October 28, 2025
Enter the world of the Pirates of Emerson… if you dare! – NBC4 Los Angeles

Enter the world of the Pirates of Emerson… if you dare! – NBC4 Los Angeles

October 27, 2025
Seneca Nation drives nearly $2B impact on Western New York economy – ReadWrite

Seneca Nation Ignites Nearly $2 Billion Economic Surge in Western New York

October 27, 2025
What to Know About ‘Good Morning America’s 50th Anniversary Episode – Wyoming News Now

Celebrate the Milestone: Everything You Need to Know About Good Morning America’s 50th Anniversary Episode

October 27, 2025
Shingles vaccine connected to ‘exciting’ health benefits in large study – Fox News

Shingles vaccine connected to ‘exciting’ health benefits in large study – Fox News

October 27, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (889)
  • Economy (911)
  • Entertainment (21,782)
  • General (17,845)
  • Health (9,952)
  • Lifestyle (924)
  • News (22,149)
  • People (912)
  • Politics (921)
  • Science (16,122)
  • Sports (21,411)
  • Technology (15,891)
  • World (894)

Recent News

Once tadpoles lose lungs, they never get them back – Cornell Chronicle

October 28, 2025
Texas A&M Department of Poultry Science hires Williams – WATTPoultry.com

Texas A&M’s Poultry Science Department Welcomes Expert Williams to the Team

October 28, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version