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    Israel’s Entertainment Industry Is Being Targeted by the Left in Hollywood and the Right at Home – The Wall Street Journal

    Inside the Fierce Clash Shaping Israel’s Entertainment Industry: Hollywood vs. Local Voices

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    Israel’s Entertainment Industry Is Being Targeted by the Left in Hollywood and the Right at Home – The Wall Street Journal

    Inside the Fierce Clash Shaping Israel’s Entertainment Industry: Hollywood vs. Local Voices

    Offset Is Ready To Finalize Divorce With Cardi B for a Major Reason – Yahoo

    Offset Poised to Finalize Divorce from Cardi B for a Major Reason

    Beyond the Stage: 8 Performing Arts Centers Driving Entertainment and Education – Livability.com

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    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

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    Charlie Hunnam Reveals the Dark Challenges of Playing a Serial Killer in Monster: The Ed Gein Story

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    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

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    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

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    Trump’s Narrow Window to Spread the Truth About Harris

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Home Health

Treatment with enzyme inhibitor can help combat antimicrobial resistance

June 18, 2023
in Health
Treatment with enzyme inhibitor can help combat antimicrobial resistance
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bacteria
Credit: Pixabay/CC0 Public Domain

New research by investigators in Ghent, Belgium shows that intravenous treatment with MK-3402, a metallo-beta-lactamase inhibitor, can be an effective strategy in fighting antimicrobial resistance. The findings are presented at ASM Microbe 2023, the annual meeting of the American Society for Microbiology.

Antimicrobial resistance is a major threat to public health. Some bacteria are resistant to treatment because they produce the enzyme metallo-beta-lactamase, which make a certain class of antibacterial drugs called beta-lactams ineffective. MK-3402 is designed to block metallo-beta-lactamase enzymes, so that if it is administered as treatment with an antibacterial drug (and another type of blocking drug against other types of beta-lactamase enzymes made by bacteria), the antibacterial drug will still be able to work against bacteria that are otherwise resistant.

Two studies were done with MK-3402 and a placebo, with different dosages and number of doses given between the studies. Neither the participants nor the study staff knew which participants were receiving the study drug or placebo. Safety was monitored by checking results of blood tests, electrocardiograms, blood pressure, heart rate, temperature, breathing rate and participant-reported side effects.

The blood levels of MK-3402 measured in these studies suggest that dosing three times per day should provide adequate MK-3402 blood levels to block bacterial metallo-beta-lactamase. However, larger studies are required to evaluate the safety and efficacy of MK-3402 in combination with other antibacterial agents.

Citation:
Treatment with enzyme inhibitor can help combat antimicrobial resistance (2023, June 18)
retrieved 18 June 2023
from https://medicalxpress.com/news/2023-06-treatment-enzyme-inhibitor-combat-antimicrobial.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

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