* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Tuesday, July 8, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Longhua District and Max-Matching Entertainments, supported by RWS Global forge strategic partnership to develop international IP-themed entertainment complex – Amusement Today

    Longhua District and Max-Matching Entertainments, supported by RWS Global forge strategic partnership to develop international IP-themed entertainment complex – Amusement Today

    Government whip to withdraw Entertainment Complex Bill on July 9 – Nation Thailand

    Government whip to withdraw Entertainment Complex Bill on July 9 – Nation Thailand

    Magicians and Battlebots light up Las Vegas entertainment scene – KSNV

    Magicians and Battlebots Take Las Vegas Entertainment by Storm

    Max-Matching Entertainments & Longhua District form partnership for new entertainment complex – Blooloop

    Max-Matching Entertainments and Longhua District Unite to Launch Thrilling New Entertainment Complex

    Kennedy Publishing, MGA Entertainment Launch Yummiland Magazine – License Global

    Kennedy Publishing, MGA Entertainment Launch Yummiland Magazine – License Global

    MAY HER SOUL REST IN PEACE 🙏 Veteran entertainment columnist and talent manager Lolit Solis has passed away. She was 78 years old. https://tinyurl.com/6kumarkx | LatestChika.com – Facebook

    Beloved Entertainment Icon Lolit Solis Passes Away at 78 – A Life Remembered with Love and Respect 🙏

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    AI and the Trust Revolution: How Technology Is Transforming Human Connections – Foreign Affairs

    AI and the Trust Revolution: How Technology Is Transforming Human Connections – Foreign Affairs

    Technology And Construction Names Join Top Stock Lists: Check Out Additions To IBD 50, Big Cap 20 And More – Investor’s Business Daily

    Technology and Construction Leaders Surge Into Top Stock Rankings: See the Latest Additions to IBD 50, Big Cap 20, and More

    Column: Teach kupuna new technology skills – Honolulu Star-Advertiser

    Empowering Kupuna: Unlocking New Technology Skills for a Connected Future

    EIFO invests $5 million in D3, the Ukraine-focused defence technology venture fund – sUAS News

    EIFO Pledges $5 Million to Supercharge Ukraine-Focused Defense Technology Fund

    New Technology for Water Efficiency and Working with Mexico on Screwworm – AG INFORMATION NETWORK OF THE WEST

    Revolutionary Water Efficiency Technology and Cross-Border Collaboration to Defeat Screwworm

    Environmental cognitive distance, R&D capability distance, and supply chain green technology innovation – Nature

    Bridging Gaps: How Environmental and R&D Differences Drive Green Technology Innovation in Supply Chains

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Longhua District and Max-Matching Entertainments, supported by RWS Global forge strategic partnership to develop international IP-themed entertainment complex – Amusement Today

    Longhua District and Max-Matching Entertainments, supported by RWS Global forge strategic partnership to develop international IP-themed entertainment complex – Amusement Today

    Government whip to withdraw Entertainment Complex Bill on July 9 – Nation Thailand

    Government whip to withdraw Entertainment Complex Bill on July 9 – Nation Thailand

    Magicians and Battlebots light up Las Vegas entertainment scene – KSNV

    Magicians and Battlebots Take Las Vegas Entertainment by Storm

    Max-Matching Entertainments & Longhua District form partnership for new entertainment complex – Blooloop

    Max-Matching Entertainments and Longhua District Unite to Launch Thrilling New Entertainment Complex

    Kennedy Publishing, MGA Entertainment Launch Yummiland Magazine – License Global

    Kennedy Publishing, MGA Entertainment Launch Yummiland Magazine – License Global

    MAY HER SOUL REST IN PEACE 🙏 Veteran entertainment columnist and talent manager Lolit Solis has passed away. She was 78 years old. https://tinyurl.com/6kumarkx | LatestChika.com – Facebook

    Beloved Entertainment Icon Lolit Solis Passes Away at 78 – A Life Remembered with Love and Respect 🙏

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    AI and the Trust Revolution: How Technology Is Transforming Human Connections – Foreign Affairs

    AI and the Trust Revolution: How Technology Is Transforming Human Connections – Foreign Affairs

    Technology And Construction Names Join Top Stock Lists: Check Out Additions To IBD 50, Big Cap 20 And More – Investor’s Business Daily

    Technology and Construction Leaders Surge Into Top Stock Rankings: See the Latest Additions to IBD 50, Big Cap 20, and More

    Column: Teach kupuna new technology skills – Honolulu Star-Advertiser

    Empowering Kupuna: Unlocking New Technology Skills for a Connected Future

    EIFO invests $5 million in D3, the Ukraine-focused defence technology venture fund – sUAS News

    EIFO Pledges $5 Million to Supercharge Ukraine-Focused Defense Technology Fund

    New Technology for Water Efficiency and Working with Mexico on Screwworm – AG INFORMATION NETWORK OF THE WEST

    Revolutionary Water Efficiency Technology and Cross-Border Collaboration to Defeat Screwworm

    Environmental cognitive distance, R&D capability distance, and supply chain green technology innovation – Nature

    Bridging Gaps: How Environmental and R&D Differences Drive Green Technology Innovation in Supply Chains

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Venetoclax Combo Safe, Effective in AML Patients Age 80 and Up, Real-World Data Show

May 10, 2024
in Health
Venetoclax Combo Safe, Effective in AML Patients Age 80 and Up, Real-World Data Show
Share on FacebookShare on Twitter

Venetoclax (Venclexta) combined with a hypomethylating agent (HMA) — the standard of care for older patients with acute myeloid leukemia (AML) — appeared to be safe and effective in patients in their 80s and 90s, a retrospective analysis showed.

Median overall survival (OS) was 8.1 months among a total of 154 patients with a median age of 82 years (range 80-92), and was 13.2 months among the 87 patients who achieved a response, reported Justin Watts, MD, of the Sylvester Comprehensive Cancer Center at the University of Miami, and colleagues in Blood Neoplasia.

With a median follow-up of 7.7 months, 23% of patients remained in remission, with 20% still on treatment.

“There is certainly a subset of these patients who can be treated,” Watts told MedPage Today. “The response rates themselves — even in a high-risk population, and especially in newly diagnosed AML or de novo AML patients — did just as well as younger patients did in VIALE-A. They still respond to treatment.”

“The question is how long they will respond to treatment, and what is their survival,” he continued. “And about one-quarter of patients had prolonged survival, and those patients in whom there was a response could have quite long survival.”

The FDA approved the combination of venetoclax with azacitidine, decitabine, or low-dose cytarabine in 2020 for the treatment of newly diagnosed AML in adults ages 75 and older or those unfit to receive intensive chemotherapy. Approval was based on results from the VIALE-A trial, in which median OS increased from 9.6 months with azacitidine plus placebo to 14.7 months with the addition of venetoclax. Patients had a median age of 76 years, and about 60% were 75 or older.

In explaining the rationale behind the current study, Watts and colleagues noted that while the use of HMAs led to improved outcomes, venetoclax combined with HMAs provide even more of an opportunity for these older patients to increase survival — “if they can tolerate it.”

While better tolerated than intensive chemotherapy, venetoclax plus HMAs can cause significant myelosuppression, as well as infectious and other non-infectious complications.

“The extent to which this may limit its use in a population of extreme advanced age (>80 years) is not known,” the authors wrote, adding that their study is the first to assess the tolerability and efficacy of the combination in an exclusively octogenarian and nonagenarian population.

Watts and colleagues analyzed electronic medical records for 154 patients with AML treated with venetoclax plus HMAs for the first time from March 2015 to April 2022 across six medical institutions in the U.S. and Italy.

Of the patients included in the study, 77% were newly diagnosed, 10% had relapsed or refractory AML, and disease status was unknown in the remaining 14%. More than half (53%) of patients had European LeukemiaNet 2017 adverse risk AML, 33% had intermediate risk, 8% had favorable risk, and 6% were unknown.

Among newly diagnosed patients, 56% had newly diagnosed AML without prior myelodysplastic syndrome (MDS) or other myeloid neoplasm, and 44% had newly diagnosed AML with a history of prior MDS or other myeloid neoplasm.

In terms of how to dose these patients, “it does seem a lower dose is OK, even if they receive less venetoclax,” Watts said. “You can give them less therapy, because the therapy is very effective, even when we give it in shorter durations.”

Two-thirds of patients started treatment with the standard dose and treatment schedule, with 72% subsequently modifying their venetoclax dose or schedule after cycle 1.

Across the cohort, patients were administered a final median venetoclax dose of 400 mg for 21 days, repeated every 35 days, and those patients who demonstrated a treatment response received a final median venetoclax dose of 200 mg for 21 days in 35-day cycles.

A shorter final venetoclax duration (≤14 days vs>14 days) was associated with improved OS.

The median follow-up of 7.7 months was a limitation of the study, the authors acknowledged. However, they also pointed out that the median follow-up was 18.6 months for those still alive at data cutoff, “which underscores the notable response durability in a subset of patients.”

In the entire patient population, the complete remission with incomplete count recovery (CRc) rate was 57%, and the complete response (CR) rate was 41%. In patients who had a response assessment, the CRc rate was 63% and the CR rate was 46%.

For patients with newly diagnosed AML without prior MDS, 73% achieved CR or CRc.

Favorable risk AML, as well as NPM1 and FLT3 mutations were associated with improved response rates, while patients with relapsed/refractory AML, prior MDS, prior HMA use, TP53 mutations, and complex karyotype had lower response rates.

“And the safety, even in this older patient group who are going to be more frail and have more comorbidity, was quite similar to VIALE-A in terms of 30- and 60-day mortality rates (8.5% and 17%, respectively),” Watts pointed out. “So, it is tolerable in most of these patients.”

Treatment-emergent grade 3-4 anemia occurred in 50% of patients, thrombocytopenia in 48%, neutropenia in 53%, and neutropenic fever in 46%. Mortality was attributed to progression/relapse in 60% of cases.

Watts and colleagues said further research is needed to define subsets of patients more likely to durably respond (such as those with NPM1, IDH1/2, and RUNX1 mutations) versus those who might benefit from less venetoclax exposure (those with TP53 mutations and prior MDS), in order to better determine how intensively to treat octogenarians and nonagenarians with venetoclax and HMAs.

author['full_name']

Mike Bassett is a staff writer focusing on oncology and hematology. He is based in Massachusetts.

Disclosures

Watts reported advisory board/consulting roles with Servier, Rigel, Bristol Myers Squibb, Aptose Biosciences, Daiichi Sankyo, and Attivare Therapeutics, and research support from Takeda, Rigel, and Immune System Key.

Several co-authors also reported relationships with industry.

Primary Source

Blood Neoplasia

Source Reference: Madarang E, et al “Venetoclax and hypomethylating agents in octo- and nonagenarians with acute myeloid leukemia” Blood Neoplasia 2024; DOI: 10.1016/j.bneo.2024.100016.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/hematologyoncology/leukemia/110059

Tags: CombohealthVenetoclax
Previous Post

RFK Jr. Explains Why His Voice Sounds Hoarse

Next Post

Brain Worms Like RFK Jr.’s: Here’s What to Know

AI and the Trust Revolution: How Technology Is Transforming Human Connections – Foreign Affairs

AI and the Trust Revolution: How Technology Is Transforming Human Connections – Foreign Affairs

July 8, 2025
Brewers chase All-Star Yoshinobu Yamamoto with 5 runs in 1st inning, hand Dodgers their 4th straight loss – Yahoo Sports

Brewers chase All-Star Yoshinobu Yamamoto with 5 runs in 1st inning, hand Dodgers their 4th straight loss – Yahoo Sports

July 8, 2025
An episodic burst of massive genomic rearrangements and the origin of non-marine annelids – Nature

Explosive Genomic Shifts Ignite the Evolutionary Rise of Land-Dwelling Annelids

July 8, 2025
Earth is going to spin much faster over the next few months — so fast that several days are going to get shorter – Live Science

Earth is going to spin much faster over the next few months — so fast that several days are going to get shorter – Live Science

July 8, 2025
Putnam Museum and Science Center Ribbon-Cutting July 12 – River Cities’ Reader

Putnam Museum and Science Center Ribbon-Cutting July 12 – River Cities’ Reader

July 8, 2025
New Miiro Lifestyle Hotel Brand Expands Further In Europe – Forbes

New Miiro Lifestyle Hotel Brand Expands Further In Europe – Forbes

July 8, 2025
Dino Might!: ‘Jurassic World Rebirth’ Bows To $318.3M Global In Biggest Studio Opening Year-To-Date WW; ‘F1’ Nears $300M’ & ‘Dragon’ Tops $500M – International Box Office – Deadline

Dino Might!: ‘Jurassic World Rebirth’ Bows To $318.3M Global In Biggest Studio Opening Year-To-Date WW; ‘F1’ Nears $300M’ & ‘Dragon’ Tops $500M – International Box Office – Deadline

July 8, 2025
As a Nation’s Economy Slows, Some Say It’s No Time for a Free Lunch – The New York Times

As a Nation’s Economy Slows, Some Say It’s No Time for a Free Lunch – The New York Times

July 8, 2025
Longhua District and Max-Matching Entertainments, supported by RWS Global forge strategic partnership to develop international IP-themed entertainment complex – Amusement Today

Longhua District and Max-Matching Entertainments, supported by RWS Global forge strategic partnership to develop international IP-themed entertainment complex – Amusement Today

July 8, 2025
The 63 Best Amazon Prime Day Health & Fitness Deals, Up to 85% Off – health.com

The 63 Best Amazon Prime Day Health & Fitness Deals, Up to 85% Off – health.com

July 8, 2025

Categories

Archives

July 2025
MTWTFSS
 123456
78910111213
14151617181920
21222324252627
28293031 
« Jun    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (710)
  • Economy (735)
  • Entertainment (21,623)
  • General (15,773)
  • Health (9,773)
  • Lifestyle (740)
  • News (22,149)
  • People (735)
  • Politics (744)
  • Science (15,952)
  • Sports (21,234)
  • Technology (15,719)
  • World (716)

Recent News

AI and the Trust Revolution: How Technology Is Transforming Human Connections – Foreign Affairs

AI and the Trust Revolution: How Technology Is Transforming Human Connections – Foreign Affairs

July 8, 2025
Brewers chase All-Star Yoshinobu Yamamoto with 5 runs in 1st inning, hand Dodgers their 4th straight loss – Yahoo Sports

Brewers chase All-Star Yoshinobu Yamamoto with 5 runs in 1st inning, hand Dodgers their 4th straight loss – Yahoo Sports

July 8, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version