* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Monday, July 28, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Micro wrestling coming to NE Ohio – Cleveland.com

    Get Ready, NE Ohio: Micro Wrestling Is Making Its Exciting Debut!

    League City seeking proposals for 53-acre entertainment district on sportsplex land – galvnews.com

    League City Invites Proposals to Transform 53-Acre Sportsplex into Vibrant Entertainment District

    Top 5 entertainment news: Sandeep Reddy Vanga regrets trimming Animal’s runtime by 7-8 minutes, Akshay Ku – Times of India

    Top 5 Entertainment Highlights: Sandeep Reddy Vanga Reveals Why He Trimmed Animal’s Runtime by 7-8 Minutes, Plus Akshay Ku Updates

    Cote de Pablo reveals how Michael Weatherly used his soap opera roots to put her at ease in “NCIS” love scene – yahoo.com

    Cote de Pablo Reveals How Michael Weatherly’s Soap Opera Background Made Their “NCIS” Love Scene Easier

    City of Pelham announces entertainment district plans for former Oak Mountain Amphitheatre site – WVTM

    Pelham Unveils Exciting New Entertainment District Plans for Former Oak Mountain Amphitheatre Site

    Black Box Players presents ‘The Three Musketeers’ – CBS 19 News

    Experience the Adventure: Black Box Players Bring ‘The Three Musketeers’ to Life!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    AI’s race in the dark with China – Axios

    The High-Stakes AI Race: Innovation and Competition in the Shadows

    Eagle Unveils Revolutionary X-Ray Technology at Pack Expo

    Validea’s Top Information Technology Stocks Based On Peter Lynch – 7/25/2025 – Nasdaq

    Validea’s Top Information Technology Stocks Based On Peter Lynch – 7/25/2025 – Nasdaq

    WhoFi: New surveillance technology can track people by how they disrupt Wi-Fi signals – Tech Xplore

    WhoFi: New surveillance technology can track people by how they disrupt Wi-Fi signals – Tech Xplore

    Google Cloud Announced as a Key Technology Partner for Odoo Connect 2025 in San Francisco – GlobeNewswire

    Google Cloud Announced as a Key Technology Partner for Odoo Connect 2025 in San Francisco – GlobeNewswire

    Behind the Screens: The Impact of Technology on Real Estate – TRREB

    Behind the Screens: How Technology is Transforming the Future of Real Estate

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Micro wrestling coming to NE Ohio – Cleveland.com

    Get Ready, NE Ohio: Micro Wrestling Is Making Its Exciting Debut!

    League City seeking proposals for 53-acre entertainment district on sportsplex land – galvnews.com

    League City Invites Proposals to Transform 53-Acre Sportsplex into Vibrant Entertainment District

    Top 5 entertainment news: Sandeep Reddy Vanga regrets trimming Animal’s runtime by 7-8 minutes, Akshay Ku – Times of India

    Top 5 Entertainment Highlights: Sandeep Reddy Vanga Reveals Why He Trimmed Animal’s Runtime by 7-8 Minutes, Plus Akshay Ku Updates

    Cote de Pablo reveals how Michael Weatherly used his soap opera roots to put her at ease in “NCIS” love scene – yahoo.com

    Cote de Pablo Reveals How Michael Weatherly’s Soap Opera Background Made Their “NCIS” Love Scene Easier

    City of Pelham announces entertainment district plans for former Oak Mountain Amphitheatre site – WVTM

    Pelham Unveils Exciting New Entertainment District Plans for Former Oak Mountain Amphitheatre Site

    Black Box Players presents ‘The Three Musketeers’ – CBS 19 News

    Experience the Adventure: Black Box Players Bring ‘The Three Musketeers’ to Life!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    AI’s race in the dark with China – Axios

    The High-Stakes AI Race: Innovation and Competition in the Shadows

    Eagle Unveils Revolutionary X-Ray Technology at Pack Expo

    Validea’s Top Information Technology Stocks Based On Peter Lynch – 7/25/2025 – Nasdaq

    Validea’s Top Information Technology Stocks Based On Peter Lynch – 7/25/2025 – Nasdaq

    WhoFi: New surveillance technology can track people by how they disrupt Wi-Fi signals – Tech Xplore

    WhoFi: New surveillance technology can track people by how they disrupt Wi-Fi signals – Tech Xplore

    Google Cloud Announced as a Key Technology Partner for Odoo Connect 2025 in San Francisco – GlobeNewswire

    Google Cloud Announced as a Key Technology Partner for Odoo Connect 2025 in San Francisco – GlobeNewswire

    Behind the Screens: The Impact of Technology on Real Estate – TRREB

    Behind the Screens: How Technology is Transforming the Future of Real Estate

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Venetoclax Combo Safe, Effective in AML Patients Age 80 and Up, Real-World Data Show

May 10, 2024
in Health
Venetoclax Combo Safe, Effective in AML Patients Age 80 and Up, Real-World Data Show
Share on FacebookShare on Twitter

Venetoclax (Venclexta) combined with a hypomethylating agent (HMA) — the standard of care for older patients with acute myeloid leukemia (AML) — appeared to be safe and effective in patients in their 80s and 90s, a retrospective analysis showed.

Median overall survival (OS) was 8.1 months among a total of 154 patients with a median age of 82 years (range 80-92), and was 13.2 months among the 87 patients who achieved a response, reported Justin Watts, MD, of the Sylvester Comprehensive Cancer Center at the University of Miami, and colleagues in Blood Neoplasia.

With a median follow-up of 7.7 months, 23% of patients remained in remission, with 20% still on treatment.

“There is certainly a subset of these patients who can be treated,” Watts told MedPage Today. “The response rates themselves — even in a high-risk population, and especially in newly diagnosed AML or de novo AML patients — did just as well as younger patients did in VIALE-A. They still respond to treatment.”

“The question is how long they will respond to treatment, and what is their survival,” he continued. “And about one-quarter of patients had prolonged survival, and those patients in whom there was a response could have quite long survival.”

The FDA approved the combination of venetoclax with azacitidine, decitabine, or low-dose cytarabine in 2020 for the treatment of newly diagnosed AML in adults ages 75 and older or those unfit to receive intensive chemotherapy. Approval was based on results from the VIALE-A trial, in which median OS increased from 9.6 months with azacitidine plus placebo to 14.7 months with the addition of venetoclax. Patients had a median age of 76 years, and about 60% were 75 or older.

In explaining the rationale behind the current study, Watts and colleagues noted that while the use of HMAs led to improved outcomes, venetoclax combined with HMAs provide even more of an opportunity for these older patients to increase survival — “if they can tolerate it.”

While better tolerated than intensive chemotherapy, venetoclax plus HMAs can cause significant myelosuppression, as well as infectious and other non-infectious complications.

“The extent to which this may limit its use in a population of extreme advanced age (>80 years) is not known,” the authors wrote, adding that their study is the first to assess the tolerability and efficacy of the combination in an exclusively octogenarian and nonagenarian population.

Watts and colleagues analyzed electronic medical records for 154 patients with AML treated with venetoclax plus HMAs for the first time from March 2015 to April 2022 across six medical institutions in the U.S. and Italy.

Of the patients included in the study, 77% were newly diagnosed, 10% had relapsed or refractory AML, and disease status was unknown in the remaining 14%. More than half (53%) of patients had European LeukemiaNet 2017 adverse risk AML, 33% had intermediate risk, 8% had favorable risk, and 6% were unknown.

Among newly diagnosed patients, 56% had newly diagnosed AML without prior myelodysplastic syndrome (MDS) or other myeloid neoplasm, and 44% had newly diagnosed AML with a history of prior MDS or other myeloid neoplasm.

In terms of how to dose these patients, “it does seem a lower dose is OK, even if they receive less venetoclax,” Watts said. “You can give them less therapy, because the therapy is very effective, even when we give it in shorter durations.”

Two-thirds of patients started treatment with the standard dose and treatment schedule, with 72% subsequently modifying their venetoclax dose or schedule after cycle 1.

Across the cohort, patients were administered a final median venetoclax dose of 400 mg for 21 days, repeated every 35 days, and those patients who demonstrated a treatment response received a final median venetoclax dose of 200 mg for 21 days in 35-day cycles.

A shorter final venetoclax duration (≤14 days vs>14 days) was associated with improved OS.

The median follow-up of 7.7 months was a limitation of the study, the authors acknowledged. However, they also pointed out that the median follow-up was 18.6 months for those still alive at data cutoff, “which underscores the notable response durability in a subset of patients.”

In the entire patient population, the complete remission with incomplete count recovery (CRc) rate was 57%, and the complete response (CR) rate was 41%. In patients who had a response assessment, the CRc rate was 63% and the CR rate was 46%.

For patients with newly diagnosed AML without prior MDS, 73% achieved CR or CRc.

Favorable risk AML, as well as NPM1 and FLT3 mutations were associated with improved response rates, while patients with relapsed/refractory AML, prior MDS, prior HMA use, TP53 mutations, and complex karyotype had lower response rates.

“And the safety, even in this older patient group who are going to be more frail and have more comorbidity, was quite similar to VIALE-A in terms of 30- and 60-day mortality rates (8.5% and 17%, respectively),” Watts pointed out. “So, it is tolerable in most of these patients.”

Treatment-emergent grade 3-4 anemia occurred in 50% of patients, thrombocytopenia in 48%, neutropenia in 53%, and neutropenic fever in 46%. Mortality was attributed to progression/relapse in 60% of cases.

Watts and colleagues said further research is needed to define subsets of patients more likely to durably respond (such as those with NPM1, IDH1/2, and RUNX1 mutations) versus those who might benefit from less venetoclax exposure (those with TP53 mutations and prior MDS), in order to better determine how intensively to treat octogenarians and nonagenarians with venetoclax and HMAs.

author['full_name']

Mike Bassett is a staff writer focusing on oncology and hematology. He is based in Massachusetts.

Disclosures

Watts reported advisory board/consulting roles with Servier, Rigel, Bristol Myers Squibb, Aptose Biosciences, Daiichi Sankyo, and Attivare Therapeutics, and research support from Takeda, Rigel, and Immune System Key.

Several co-authors also reported relationships with industry.

Primary Source

Blood Neoplasia

Source Reference: Madarang E, et al “Venetoclax and hypomethylating agents in octo- and nonagenarians with acute myeloid leukemia” Blood Neoplasia 2024; DOI: 10.1016/j.bneo.2024.100016.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/hematologyoncology/leukemia/110059

Tags: CombohealthVenetoclax
Previous Post

RFK Jr. Explains Why His Voice Sounds Hoarse

Next Post

Brain Worms Like RFK Jr.’s: Here’s What to Know

Max Eisenbud Named Head of Client Representation for WME Sports – Variety

Max Eisenbud Named Head of Client Representation for WME Sports – Variety

July 28, 2025
Pine Park Becomes a Cold-Weather Ecology Lab – Dartmouth

Pine Park Becomes a Cold-Weather Ecology Lab – Dartmouth

July 28, 2025
National Science Foundation staff decry Trump’s ‘politically motivated’ cuts – The Guardian

National Science Foundation Staff Rally Against Politically Motivated Budget Cuts Under Trump

July 28, 2025
Test Yourself on Science Fiction That Became Reality – The New York Times

Can You Believe These Science Fiction Ideas Are Now Reality?

July 28, 2025
At 35, wobbling on a bike, I met the child I never got to be – VegOut

At 35, Wobbling on a Bike, I Rediscovered the Child I Never Got to Be

July 28, 2025
In a stressful human world, ‘mermaiding’ gains popularity in D.C. area – The Washington Post

Escape Stress with the Magical World of Mermaiding: A Growing Trend in the D.C. Area

July 28, 2025

Iran’s Economy in Crisis: Soaring Inflation and Collapsing Investments Shake the Nation

July 28, 2025
Micro wrestling coming to NE Ohio – Cleveland.com

Get Ready, NE Ohio: Micro Wrestling Is Making Its Exciting Debut!

July 28, 2025
Pacific Mind Health Releases 5-Minute Mental Health Check-In Toolkit – Yahoo Finance

Boost Your Wellbeing with the New 5-Minute Mental Health Check-In Toolkit

July 28, 2025
‘Adapt … or we’re in danger of becoming extinct’: See Rep. Torres’ warning for Democrats – CNN

Adapt or Face Extinction: Rep. Torres Delivers Stark Warning to Democrats

July 28, 2025

Categories

Archives

July 2025
MTWTFSS
 123456
78910111213
14151617181920
21222324252627
28293031 
« Jun    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (743)
  • Economy (767)
  • Entertainment (21,647)
  • General (16,156)
  • Health (9,804)
  • Lifestyle (775)
  • News (22,149)
  • People (769)
  • Politics (776)
  • Science (15,981)
  • Sports (21,265)
  • Technology (15,747)
  • World (750)

Recent News

Max Eisenbud Named Head of Client Representation for WME Sports – Variety

Max Eisenbud Named Head of Client Representation for WME Sports – Variety

July 28, 2025
Pine Park Becomes a Cold-Weather Ecology Lab – Dartmouth

Pine Park Becomes a Cold-Weather Ecology Lab – Dartmouth

July 28, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version