* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Sunday, August 17, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Iconic ‘M*A*S*H’ Actor, 86, Has Fans Swooning Over Resurfaced Images: ‘My Crush Since ’75’ – yahoo.com

    Iconic ‘M*A*S*H’ Actor, 86, Has Fans Swooning Over Resurfaced Images: ‘My Crush Since ’75’ – yahoo.com

    ‘The Rainmaker’ Premiere: Milo Callaghan Breaks Down Rudy Baylor’s ‘Misguided Valor’ – The Laconia Daily Sun

    Inside ‘The Rainmaker’ Premiere: Milo Callaghan Uncovers the Real Story Behind Rudy Baylor’s Misguided Valor

    Suicide Squad Member Gets New Origin in Absolute Flash – yahoo.com

    Suicide Squad Member Unveiled with Exciting New Origin in Absolute Flash

    I’ll miss the chaos of ‘And Just like That…’ (and Che Diaz too) – yahoo.com

    Why I’ll Truly Miss the Wild Ride of ‘And Just Like That…’ (and Che Diaz!)

    Webtoon Entertainment Stages Recovery With Disney’s Stamp of Approval – The Wall Street Journal

    Webtoon Entertainment Soars to New Heights with Disney’s Stamp of Approval

    Georgia Tech Launches Arts, Entertainment, and Creative Technologies Degree – Georgia Tech News Center

    Georgia Tech Unveils Exciting New Degree in Arts, Entertainment, and Creative Technologies

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    AI’s backyard: A map of the 21st-century gold rush – EL PAÍS English

    The AI Frontier: Exploring the Thrilling Gold Rush of the 21st Century

    Youxin Technology Ltd Faces Nasdaq Deficiency Notices Over Listing Compliance Issues

    Vermont famers say new technology is changing the state’s agriculture industry – News Channel 3-12

    Vermont Farmers Embrace New Technology Transforming the State’s Agriculture Industry

    Verb Technology Reports Revenue Growth Amidst Strategic Expansions – TipRanks

    Verb Technology Soars with Impressive Revenue Growth Driven by Strategic Expansions

    Midwest Technology Summit held in Fargo – WDAY Radio

    Midwest Technology Summit held in Fargo – WDAY Radio

    K1 Semiconductor Joins Chicago Quantum Exchange To Advance Wafer Technology. – Quantum Zeitgeist

    K1 Semiconductor Partners with Chicago Quantum Exchange to Revolutionize Wafer Technology

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Iconic ‘M*A*S*H’ Actor, 86, Has Fans Swooning Over Resurfaced Images: ‘My Crush Since ’75’ – yahoo.com

    Iconic ‘M*A*S*H’ Actor, 86, Has Fans Swooning Over Resurfaced Images: ‘My Crush Since ’75’ – yahoo.com

    ‘The Rainmaker’ Premiere: Milo Callaghan Breaks Down Rudy Baylor’s ‘Misguided Valor’ – The Laconia Daily Sun

    Inside ‘The Rainmaker’ Premiere: Milo Callaghan Uncovers the Real Story Behind Rudy Baylor’s Misguided Valor

    Suicide Squad Member Gets New Origin in Absolute Flash – yahoo.com

    Suicide Squad Member Unveiled with Exciting New Origin in Absolute Flash

    I’ll miss the chaos of ‘And Just like That…’ (and Che Diaz too) – yahoo.com

    Why I’ll Truly Miss the Wild Ride of ‘And Just Like That…’ (and Che Diaz!)

    Webtoon Entertainment Stages Recovery With Disney’s Stamp of Approval – The Wall Street Journal

    Webtoon Entertainment Soars to New Heights with Disney’s Stamp of Approval

    Georgia Tech Launches Arts, Entertainment, and Creative Technologies Degree – Georgia Tech News Center

    Georgia Tech Unveils Exciting New Degree in Arts, Entertainment, and Creative Technologies

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    AI’s backyard: A map of the 21st-century gold rush – EL PAÍS English

    The AI Frontier: Exploring the Thrilling Gold Rush of the 21st Century

    Youxin Technology Ltd Faces Nasdaq Deficiency Notices Over Listing Compliance Issues

    Vermont famers say new technology is changing the state’s agriculture industry – News Channel 3-12

    Vermont Farmers Embrace New Technology Transforming the State’s Agriculture Industry

    Verb Technology Reports Revenue Growth Amidst Strategic Expansions – TipRanks

    Verb Technology Soars with Impressive Revenue Growth Driven by Strategic Expansions

    Midwest Technology Summit held in Fargo – WDAY Radio

    Midwest Technology Summit held in Fargo – WDAY Radio

    K1 Semiconductor Joins Chicago Quantum Exchange To Advance Wafer Technology. – Quantum Zeitgeist

    K1 Semiconductor Partners with Chicago Quantum Exchange to Revolutionize Wafer Technology

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

What to Know About Treatment-Resistant Depression

March 8, 2024
in Health
What to Know About Treatment-Resistant Depression
Share on FacebookShare on Twitter

Standard treatments ease depression for a lot of people, but they don’t work for everyone. At least 30% of those who try two or more antidepressants continue to have serious symptoms. That’s called treatment-resistant depression.

If it happens to you, keep in mind that there are still ways to manage your depression. Talk to your doctor about all of your treatment choices.

“The most important point is not to give up,” says John Krystal, MD, chair of the Department of Psychiatry at Yale School of Medicine and a pioneer in research on ketamine and depression. “There are so many of these options – current and emerging – that can really make a difference in a person’s life.”

What Is Treatment-Resistant Depression?

Experts don’t agree on one definition. But in general, it’s a form of depression that doesn’t improve after you try two antidepressants from different classes of drugs. “If you have to go to a third medication, that’s the standard threshold,” Krystal says.

For example, he says your doctor might diagnose you with treatment-resistant depression after you’re first treated with a selective serotonin reuptake inhibitor (SSRI), such as fluoxetine, and you don’t respond. And next, you’re treated with a serotonin-norepinephrine reuptake inhibitor (SNRI), such as venlafaxine or duloxetine, and you don’t respond to that either.

“Medication acts as a kind of filter,” Krystal says. “If you respond to it, then by definition, you don’t have treatment-resistant depression.”

How to Get a Diagnosis

Before you get a diagnosis of treatment-resistant depression, Krystal says you’ll need to go through two rounds of antidepressant treatments. That typically means giving each antidepressant 6 to 8 weeks to work. And if the dose of your first antidepressants doesn’t help, your doctor might raise the amount of the drug you take before you switch to a different medicine.

Crystal Clark, MD, an associate professor of psychiatry and behavioral sciences at Northwestern University Feinberg School of Medicine, says it’s important to maximize the dose of each antidepressant.

“Sometimes we’ll see that people have tried several [antidepressants] that haven’t worked, but they’ve only tried half of the potential dose. That may not necessarily be a failed trial.”

Your doctor might also look for hidden causes that could explain why your drug treatments aren’t working. There are a “cluster of different reasons” why people don’t respond to antidepressants, Krystal says, including things such as:

You don’t take your medicine every day.Your body doesn’t absorb the drug.You have another health condition, like an underactive thyroid.

Outside issues can also play a role. “Some people don’t respond [to antidepressants] because so much is going on in their life, and they experience such stress and turmoil that the resolution of their depression is masked or prevented,” Krystal says. 

What Causes Treatment-Resistant Depression?

There are some theories about genetic and brain differences, Clark says, but there isn’t a biomarker or other mechanism that can identify people who’ll have treatment-resistant depression. “There’s no definitive answer on that question.” 

Krystal says there are “many different pockets of people” who don’t respond to antidepressants. Researchers are trying to figure out the biology behind why that is. This might lead to more personalized treatment down the road. “That strategy is called precision medicine,” he says.

Experts are specifically looking into how this targeted approach might help certain groups, such as those who have treatment-resistant depression and lots of inflammation. Krystal says this includes people with conditions such as arthritis, asthma, heart disease, inflammatory bowel disease, and are overweight or have obesity.

In general, your odds of depression go up when you have ongoing inflammation. And Krystal says there’s some evidence that the amount of inflammation you have can predict whether you’ll respond to antidepressants. He says there’s promising evidence that immunosuppressant medication, which blocks signals from pro-inflammatory cytokines, might help ease symptoms for certain people with treatment-resistant depression.

Symptoms

There isn’t a specific set of symptoms that makes treatment-resistant depression different from other forms of depression. Experts agree it’d be a lot easier if that were the case. But Krystal says your antidepressant definitely isn’t working if you wake up every morning and think, “I don’t know how I’m going to get through the day.”

Krystal says that if you have no joy, pleasure, or excitement in your life, “that’s a good time to start talking to a therapist, counselor, or doctor about what’s going on.”

Here are some other questions to gauge whether your antidepressant is helping:

To what degree are you back to your old self?Are you sleeping too much or too little?Do certain parts of your life not feel right?Is your appetite back to normal?

How to Manage Treatment-Resistant Depression

Antidepressants alone may not work very well. Seek help from a doctor who’ll give you more choices. “I encourage people to make sure they’re working with a psychiatrist who feels comfortable going through the gamut,” Clark says. “Not just with oral therapies, but someone who has knowledge of some of the more advanced and novel treatments.”

Treatment options for treatment-resistant depression include:

Adjunctive medication. Your doctor can add other drugs to go with your antidepressant. Everyone is different, but common choices may include antipsychotics, mood stabilizers, anti-anxiety medications, thyroid hormone, or other drugs. Your doctor may also suggest pharmacogenetic testing to check for specific genes that show how well you process certain antidepressants.

Talk therapy. There’s evidence that psychotherapy can ease depression in some people who don’t respond well to antidepressant drugs. “Yet, often, when we’re talking about treatment-resistant depression, and thinking about interventions, we’re not always including cognitive behavior therapy, family therapy, or supervised work therapy,” Krystal says. These therapies may help:

Cognitive behavioral therapy: Focuses on thoughts, emotions, and behaviors that affect your mood. CBT can help make you aware of your negative thoughts and work on changing to a more positive mindset.Dialectical behavioral therapy: Helps you grow problem-solving and acceptance skills. This is especially helpful for people who harm themselves or have repeated suicidal thoughts.Behavioral activation: Slowly lowers avoidance and isolation and helps people take part in things they once enjoyed or activities that make them feel betterGroup therapy: Involves other people who have depression working together with a therapistFamily or marital therapy: Works on lowering stress in your relationships with family members or your spouse or partner. In many cases, this can help with your depression.

Ketamine. Your doctor may suggest this drug to give you rapid relief from treatment-resistant depression. You’ll take it in low doses through an IV. The FDA has approved a nasal spray form called esketamine (Spravato). Doctors typically recommend that you take an oral antidepressant along with esketamine or ketamine.

Brain stimulation. Your doctor might want you to go this route if nothing else works or your symptoms are really serious. These procedures include: 

Repetitive transcranial magnetic stimulation (rTMS): Magnetic fields are used to stimulate nerve cells in the area of your brain that involves mood and depression. Electroconvulsive therapy (ECT): A small dose of electricity is passed through your brain while you’re asleep. That causes a short seizure, which can change the brain’s chemistry to help ease symptoms of severe depression. Some side effects might happen, including confusion or memory loss, but they usually don’t last a long time.Vagus nerve stimulation (VNS): A device is implanted in your chest with a wire that goes to the vagus nerve in your neck. Electrical impulses go from that nerve to the area of your brain that controls moods. That may improve your depression. This procedure is usually tried only if ECT and rTMS don’t work.

Tell your doctor if you don’t feel 100% better. The goal for your treatment should be the same as other health conditions, Krystal says, such as cancer, heart attacks, or broken bones. “In other words, we don’t go to an orthopedic surgeon and tell them, ‘I broke my leg, but I want it to be 60% better.’ We tell the orthopedic surgeon, ‘I want my leg fixed.’ “

Photo Credit: amana images/Getty Images

SOURCES:

John Krystal, MD, Robert L. McNeil Jr. professor of translational research and professor of psychiatry and of neuroscience; chair, Department of Psychiatry, Yale School of Medicine; chief of psychiatry, Yale New Haven Hospital.

Crystal T. Clark, MD, associate professor of psychiatry and behavioral sciences and obstetrics and gynecology, Northwestern University Feinberg School of Medicine.

Neuropsychiatric Disease and Treatment: “Management of Treatment-Resistant Depression: Challenges and Strategies.”

Frontiers in Immunology: “The role of Inflammation in Depression and Fatigue.”

Handbook of Experimental Pharmacology: “Role of Inflammation in Depression and Treatment Implications.”

Psychological Medicine: “Effectiveness of psychotherapy for treatment-resistant depression: a meta-analysis and meta-regression.

Mayo Clinic: “Treatment-resistant depression.”

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : WebMD – https://www.webmd.com/depression/features/treatment-resistant-depression?src=RSS_PUBLIC

Tags: AbouthealthTreatment-Resistant
Previous Post

Medication Strategies for Treatment-Resistant Depression

Next Post

What Are Vaginal Gummies? Debunking the Latest Health Craze

Global Ecology – Carnegie Science

August 17, 2025
Citizen science for the people, by the people – Jamaica Gleaner

How Citizen Science is Empowering Communities and Sparking a People-Driven Movement

August 17, 2025
Science Cheats: A Reading List on Unscrupulous Scientists – Longreads

Deceptive Discoveries: Unveiling Science’s Most Unscrupulous Minds

August 17, 2025
A yogi in recovery, 500 drawings of toast: 7 Lifestyle highlights – South China Morning Post

From Healing to Art: One Yogi’s Inspiring Journey Through 500 Toast Drawings and Beyond

August 17, 2025
AI’s backyard: A map of the 21st-century gold rush – EL PAÍS English

The AI Frontier: Exploring the Thrilling Gold Rush of the 21st Century

August 17, 2025
Lakers play clean, slide by Hawley – nujournal.com

Lakers Dominate with a Flawless Win Over Hawley

August 17, 2025
Little League World Series pleads for fans to not bet on games involving children – Yahoo Sports

Little League World Series Urges Fans to Avoid Betting on Youth Games

August 16, 2025
What 630,000 paintings say about the world economy – The Economist

What 630,000 Paintings Uncover About the Hidden Patterns of the Global Economy

August 16, 2025
Iconic ‘M*A*S*H’ Actor, 86, Has Fans Swooning Over Resurfaced Images: ‘My Crush Since ’75’ – yahoo.com

Iconic ‘M*A*S*H’ Actor, 86, Has Fans Swooning Over Resurfaced Images: ‘My Crush Since ’75’ – yahoo.com

August 16, 2025
Amid growing ‘scandal’ of elder homelessness, health care groups aim to help – NPR

Amid growing ‘scandal’ of elder homelessness, health care groups aim to help – NPR

August 16, 2025

Categories

Archives

August 2025
MTWTFSS
 123
45678910
11121314151617
18192021222324
25262728293031
« Jul    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (775)
  • Economy (797)
  • Entertainment (21,674)
  • General (16,511)
  • Health (9,835)
  • Lifestyle (808)
  • News (22,149)
  • People (799)
  • Politics (804)
  • Science (16,010)
  • Sports (21,295)
  • Technology (15,777)
  • World (779)

Recent News

Global Ecology – Carnegie Science

August 17, 2025
Citizen science for the people, by the people – Jamaica Gleaner

How Citizen Science is Empowering Communities and Sparking a People-Driven Movement

August 17, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version