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    Neil Young Plays Rare Full-Band ‘Ambulance Blues’ With The Chrome Hearts – Yahoo

    Neil Young Stuns Fans with Rare Full-Band Performance of ‘Ambulance Blues’ Alongside The Chrome Hearts

    BTS Announce Their Big Return and Yes, They Already Have Some Major Plans in the Works – Yahoo

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    George Lopez is coming to Spokane – KXLY.com

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    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

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    Inspira Technologies Secures Landmark $22.5M Deal: Major Revenue Breakthrough After FDA Clearance – Stock Titan

    Inspira Technologies Secures Landmark $22.5M Deal: Major Revenue Breakthrough After FDA Clearance – Stock Titan

    Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

    Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

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    Neil Young Plays Rare Full-Band ‘Ambulance Blues’ With The Chrome Hearts – Yahoo

    Neil Young Stuns Fans with Rare Full-Band Performance of ‘Ambulance Blues’ Alongside The Chrome Hearts

    BTS Announce Their Big Return and Yes, They Already Have Some Major Plans in the Works – Yahoo

    BTS Announce Their Big Return and Yes, They Already Have Some Major Plans in the Works – Yahoo

    Nantucket Dance Festival opens July 8 – The Inquirer and Mirror

    Nantucket Dance Festival Launches with Thrilling Performances Beginning July 8

    A Secret Society, Ritualistic Killings, and a Century-Old Curse Netflix and YRF Entertainment’s ‘Mandala Murders’ Premieres July 25 – About Netflix

    A Secret Society, Ritualistic Killings, and a Century-Old Curse: Dive into the Chilling World of ‘Mandala Murders’ Premiering July 25

    Susquehanna Raises Penn Entertainment Inc. (PENN) Price Target. – Yahoo Finance

    Susquehanna Raises Price Target for Penn Entertainment Inc. (PENN)

    George Lopez is coming to Spokane – KXLY.com

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    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

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    PAP Boss to Niger Delta Youths, Stay Away from the Protest

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    Court Restricts Protests In Lagos To Freedom, Peace Park

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    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

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    Inspira Technologies Secures Landmark $22.5M Deal: Major Revenue Breakthrough After FDA Clearance – Stock Titan

    Inspira Technologies Secures Landmark $22.5M Deal: Major Revenue Breakthrough After FDA Clearance – Stock Titan

    Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

    Meiwu Technology Company Limited and Shenzhen Zhinuo – GlobeNewswire

    Owls inspire new revolutionary noise reduction technology – KTEN

    Owls inspire new revolutionary noise reduction technology – KTEN

    New center coming to Mizzou will focus on energy research and technology – Columbia Missourian

    Mizzou Launches Innovative New Center Dedicated to Energy Research and Technology

    Mirrors in space and underwater curtains: can technology buy us enough time to save the Arctic ice caps? – The Guardian

    Can Technology Like Space Mirrors and Underwater Curtains Buy Us Time to Save the Arctic Ice Caps?

    Naples restaurant owner prepares for hurricane season with new flood technology – Fox4Now.com

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Home Health

Who Might Benefit From CAR T-Cell Therapy?

March 17, 2024
in Health
Who Might Benefit From CAR T-Cell Therapy?
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Chimeric antigen receptor (CAR) T-cell therapy is a new way to treat cancer. It’s a living drug made from T cells, white cells that are an important part of your immune system. After specialists change the T cells in a lab, the cells are put back into your body to find and kill cancer cells.

This kind of therapy may work when other treatments haven’t. It’s not right for everyone. But the number of cancers T-cell therapy treats has grown over the last few years.

Before recommending this treatment, your doctor will consider:

What type of cancer you haveWhich treatments you’ve already hadYour overall health

Who Might Get CAR T-Cell Therapy?

The FDA has approved five CAR T-cell therapies:

Axicabtagene ciloleucel (Yescarta)Brexucabtagene autoleucel (Tecartus)Idecabtagene vicleucel (Abecma)Lisocabtagene maraleucel (Breyanzi)Tisagenlecleucel (Kymriah)

CAR T-cell therapies are approved to treat these types of cancer:

B-cell precursor acute lymphoblastic leukemia (ALL) in children and young adults up to age 25Diffuse large B-cell lymphoma (DLBCL)Primary mediastinal large B-cell lymphomaLarge B-cell lymphoma transformed from follicular lymphomaHigh grade B-cell lymphomaAggressive B-cell lymphoma not otherwise specified (NOS)Follicular lymphomaMantle cell lymphomaMultiple myeloma

Is CAR T-Cell Therapy Right for Me?

CAR T-cell therapy is for people who’ve tried two or more treatments, but their cancer hasn’t improved or has come back.

“Most of these patients have few, if any, effective treatment options available,” says David Porter, MD, the Jodi Fisher Horowitz Professor in Leukemia Care Excellence at the Hospital of the University of Pennsylvania.

Studies are showing that there’s a benefit to starting CAR T-cell therapy even before you’ve tried two other treatments.

“I think we will be seeing more and more earlier application of these cells,” says Porter, who is director of cell therapy and transplantation at the hospital.

CAR T-Cell Therapy for Other Cancers

This treatment is still very new. Doctors have to learn more about it before they can use it earlier in the disease or to treat more types of cancer. They learn about CAR T-cell therapy by testing it in clinical trials. In these studies, researchers use new drugs or treatments with small groups of people to see how well they work.

Studies are looking to see whether it might be right for other blood cancers. Other studies are trying to find out if CAR T-cell therapy might work against solid tumors such as:

Lung cancerOvarian cancerBreast cancerProstate cancerLiver and kidney cancerStomach cancerPancreatic cancerColon cancer

“These are still at the very early stages, but a few CAR-T products look promising,” says Sattva Neelapu, MD, professor in the Department of Lymphoma and Myeloma at The University of Texas M.D. Anderson Cancer Center in Houston.

He says it’s harder to treat solid tumors than blood cancers. That’s because the substance that T cells target is also found in some normal tissues. The altered T cells might kill healthy tissue by mistake and cause side effects.

When CAR T-Cell Therapy Might Not Be the Right Choice

There aren’t any guidelines to keep you from getting this type of therapy if it’s approved for your age group and your type of cancer. But because it can cause serious side effects, it may not be a good choice for people with other health problems like heart disease or chronic kidney disease.

“We have to evaluate those types of patients on a case-by-case basis to see which ones might qualify,” Neelapu says. Your doctor will do tests to make sure you’re healthy enough for this treatment.

CAR T-cell therapy also isn’t best for people with a fast-growing cancer. “Patients with rapidly growing disease don’t seem to do as well and have more side effects,” Porter says. With a fast cancer, you can’t afford to wait 3 to 4 weeks for the lab to prepare your T cells.

How You Can Try This Treatment

“CAR T-cell therapy doesn’t work for everybody. But when it does work, it can work dramatically,” Porter says.

Some people who received CAR T-cells in studies have been in remission for more than 10 years. Despite this success, he says not everyone who could benefit from this treatment gets it.

Taking part in a clinical study of CAR T-cell therapy could give you or your child the chance to try this treatment before it’s approved for your cancer. But you have to find the right study.

“There are lots of resources for people who might be interested in looking into clinical trials,” Porter says. One of the best ones, he says, is the U.S. National Library of Medicine’s clinicaltrials.gov website.

Porter also suggests that you ask your health care team to connect you with a clinical trial of CAR T-cell therapy in your area. Or check with an advocacy organization like the Leukemia & Lymphoma Society.

If there’s a clinical trial for your type of cancer, you still need to qualify for it. The study’s doctors will make sure you’re healthy enough to benefit from the therapy.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : WebMD – https://www.webmd.com/cancer/features/who-benefits-car-t-cell-therapy?src=RSS_PUBLIC

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