* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Saturday, May 31, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Rachel Guttman Launches Entertainment Law Firm Gutt Law, PLLC [Exclusive] – MusicRow.com

    Rachel Guttman Unveils Exciting New Entertainment Law Firm: Gutt Law, PLLC!

    HYBE Cashes In: Offloads Final Stake in K-Pop Rival SM Entertainment for $177 Million!

    Allied Gaming & Entertainment Receives Expected Nasdaq Notice Regarding Delayed Quarterly Report – Business Wire

    Allied Gaming & Entertainment Faces Nasdaq Notice Over Delayed Quarterly Report

    Weekly Entertainment Report May 29-June 1: Where to find lively arts, music, and shows – Manchester Ink Link

    Weekly Entertainment Report May 29-June 1: Where to find lively arts, music, and shows – Manchester Ink Link

    Aziz Ansari made Keanu Reeves Indian food so he wouldn’t feel ‘freaked out’ directing him in Good Fortune (exclusive) – Entertainment Weekly

    Aziz Ansari Whips Up Indian Cuisine for Keanu Reeves to Ease Directing Jitters in Good Fortune

    Cassie Ventura welcomes third child – crossroadstoday.com

    Cassie Ventura Joyfully Welcomes Her Third Child!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Stop the Machines: The Rise of Anti-Technology Extremism – International Centre for Counter-Terrorism – ICCT

    Unplugged: The Surge of Anti-Technology Extremism

    Finland to head EU’s quantum defense technology project – Latest news from Azerbaijan

    Finland Takes the Lead in Pioneering EU’s Quantum Defense Technology Initiative!

    i3D Robotics Unveils Breakthrough Glass Defect Detection Technology – USGlass Magazine

    Revolutionary Glass Defect Detection Technology Unveiled by i3D Robotics!

    4Liberty Announces Collaboration with Itron to Drive Innovation in Utility Technology Adoption and Optimization – FinancialContent

    4Liberty Partners with Itron to Revolutionize Utility Technology and Boost Innovation

    Q1 2025 Quantum Technology Investment: What’s Driving the Surge in Quantum Investment? – The Quantum Insider

    Unleashing the Future: Exploring the Surge in Quantum Technology Investments for Q1 2025

    MIT Team Releases Tempting Report on Electric Aircraft Technology – AVweb

    MIT Team Releases Tempting Report on Electric Aircraft Technology – AVweb

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Rachel Guttman Launches Entertainment Law Firm Gutt Law, PLLC [Exclusive] – MusicRow.com

    Rachel Guttman Unveils Exciting New Entertainment Law Firm: Gutt Law, PLLC!

    HYBE Cashes In: Offloads Final Stake in K-Pop Rival SM Entertainment for $177 Million!

    Allied Gaming & Entertainment Receives Expected Nasdaq Notice Regarding Delayed Quarterly Report – Business Wire

    Allied Gaming & Entertainment Faces Nasdaq Notice Over Delayed Quarterly Report

    Weekly Entertainment Report May 29-June 1: Where to find lively arts, music, and shows – Manchester Ink Link

    Weekly Entertainment Report May 29-June 1: Where to find lively arts, music, and shows – Manchester Ink Link

    Aziz Ansari made Keanu Reeves Indian food so he wouldn’t feel ‘freaked out’ directing him in Good Fortune (exclusive) – Entertainment Weekly

    Aziz Ansari Whips Up Indian Cuisine for Keanu Reeves to Ease Directing Jitters in Good Fortune

    Cassie Ventura welcomes third child – crossroadstoday.com

    Cassie Ventura Joyfully Welcomes Her Third Child!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Stop the Machines: The Rise of Anti-Technology Extremism – International Centre for Counter-Terrorism – ICCT

    Unplugged: The Surge of Anti-Technology Extremism

    Finland to head EU’s quantum defense technology project – Latest news from Azerbaijan

    Finland Takes the Lead in Pioneering EU’s Quantum Defense Technology Initiative!

    i3D Robotics Unveils Breakthrough Glass Defect Detection Technology – USGlass Magazine

    Revolutionary Glass Defect Detection Technology Unveiled by i3D Robotics!

    4Liberty Announces Collaboration with Itron to Drive Innovation in Utility Technology Adoption and Optimization – FinancialContent

    4Liberty Partners with Itron to Revolutionize Utility Technology and Boost Innovation

    Q1 2025 Quantum Technology Investment: What’s Driving the Surge in Quantum Investment? – The Quantum Insider

    Unleashing the Future: Exploring the Surge in Quantum Technology Investments for Q1 2025

    MIT Team Releases Tempting Report on Electric Aircraft Technology – AVweb

    MIT Team Releases Tempting Report on Electric Aircraft Technology – AVweb

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Why do some men not produce sperm? Scientists uncover one underlying reason for male infertility

October 20, 2023
in Health
Why do some men not produce sperm? Scientists uncover one underlying reason for male infertility
Share on FacebookShare on Twitter

Why do some men not produce sperm?

Microscopy images showing normal seminiferous tubules in control testes with mature sperm (black arrow: left) but smaller empty seminiferous tubules in testes harboring a synaptonemal complex protein point mutation (black asterisk: right). Credit: Stowers Institute for Medical Research

Millions of couples worldwide experience infertility with half of the cases originating in men. For 10% of infertile males, little or no sperm are produced. Now, new research from the Stowers Institute for Medical Research, in collaboration with the Wellcome Center for Cell Biology at the University of Edinburgh, is shedding light on what may be going wrong in the process of sperm formation, leading to potential theories on possible treatments.

“A significant cause of infertility in males is that they just cannot make sperm,” said Stowers Investigator Scott Hawley, Ph.D. “If you know exactly what is wrong, there are technologies emerging right now that might give you a way to fix it.”

The study published on October 20, 2023, in Science Advances from the Hawley Lab and Wellcome Center Investigator Owen Davies, Ph.D., may help explain why some men do not make enough sperm to fertilize an egg.

In most sexually-reproducing species, including humans, a critical protein structure resembling a lattice-like bridge needs to be built properly to produce sperm and egg cells. The team led by former Postdoctoral Research Associate Katherine Billmyre, Ph.D., discovered that in mice, changing a single and very specific point in this bridge caused it to collapse, leading to infertility and thus providing insight into human infertility in males due to similar problems with meiosis.

Stowers scientists collaborate to uncover one underlying reason for male infertility. The study published on October 20, 2023, in Science Advances from the Hawley Lab and Wellcome Centre Investigator Owen Davies, Ph.D., may help explain why some men do not make enough sperm to fertilize an egg. Credit: Stowers Institute for Medical Research

Meiosis, the cell division process giving rise to sperm and eggs, involves several steps, one of which is the formation of a large protein structure called the synaptonemal complex. Like a bridge, the complex holds chromosome pairs in place enabling necessary genetic exchanges to occur that are essential for the chromosomes to then correctly separate into sperm and eggs.

“A significant contributor to infertility is defects in meiosis,” said Billmyre. “To understand how chromosomes separate into reproductive cells correctly, we are really interested in what happens right before that when the synaptonemal complex forms between them.”

Previous studies have examined many proteins comprising the synaptonemal complex, how they interact with each other, and have identified various mutations linked to male infertility. The protein the researchers investigated in this study forms the lattices of the proverbial bridge, which has a section found in humans, mice, and most other vertebrates suggesting it is critical for assembly. Modeling different mutations in a potentially crucial region in the human protein enabled the team to predict which of these might disrupt protein function.

Why do some men not produce sperm?

Model of the synaptonemal complex in control and mutant mice. The protein the team investigated (SYCP1) forms normally, and all additional necessary proteins are recruited. In the mutant, SYCP1 localizes to the chromosome axes but does not successfully form the bridge-like structure (head-to-head interactions), and the additional proteins that help keep the bridge intact are either missing or not properly organized. Credit: Stowers Institute for Medical Research

The authors used a precise gene editing technique to make mutations in one key synaptonemal complex protein in mice, which allowed the researchers, for the first time, to test the function of key regions of the protein in live animals. Just a single mutation, predicted from the modeling experiments, was verified as the culprit of infertility in mice.

“We’re talking about pinpoint surgery here,” said Hawley. “We focused on a tiny little region of one protein in this gigantic structure that we were pretty sure could be a significant cause of infertility.”

Why do some men not produce sperm?

Representative testes from nine-week-old control mice (left) and mice with a point mutation in one synaptonemal complex protein (right). Credit: Stowers Institute for Medical Research

Mice have long been used as models for human diseases. From the modeling experiments using human protein sequences, along with the high conservation of this protein structure across species, the precise molecule that caused infertility in mice likely functions the same way in humans.

“What is really exciting to me is that our research can help us understand this really basic process that is necessary for life,” said Billmyre.

For Hawley, this research is a true representation of the versatility of the Institute. Hawley’s lab typically conducts research in fruit flies, yet the protein discovered in this study was not present in fruit flies and demanded a different research organism to continue. Because of the resources and Technology Centers at the Institute, it was possible to quickly pivot and test the new infertility hypothesis in mice.

Additional authors include Emily A. Kesler, Dai Tsuchiya, Ph.D., Timothy J. Corbin, Kyle Weaver, Andrea Moran, Zulin Yu, Ph.D., Lane Adams, Kym Delventhal, Michael Durnin, Ph.D., and Owen Richard Davies, Ph.D.

More information:
Katherine Billmyre et al, SYCP1 head-to-head assembly is required for chromosome synapsis in mouse meiosis, Science Advances (2023). DOI: 10.1126/sciadv.adi1562. www.science.org/doi/10.1126/sciadv.adi1562

Citation:
Why do some men not produce sperm? Scientists uncover one underlying reason for male infertility (2023, October 20)
retrieved 20 October 2023
from https://medicalxpress.com/news/2023-10-men-sperm-scientists-uncover-underlying.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2023-10-men-sperm-scientists-uncover-underlying.html

Tags: healthProduceSperm
Previous Post

Pembrolizumab in First-Line Boosts PFS in HER2-Positive Stomach Cancer

Next Post

High risk for psychiatric disorders seen before dementia diagnosis

Revolutionary Approach to Assessing the Ecological Impact of Offshore Activities

May 31, 2025
OpenAI’s ‘smartest’ AI model was explicitly told to shut down — and it refused – Live Science

OpenAI’s ‘Smartest’ AI Model Defies Shutdown Command!

May 31, 2025
Alarmed by Trump Cuts, Scientists Are Talking Science. For 100 Hours. – The New York Times

Scientists Unite for 100 Hours of Dialogue in Response to Trump’s Budget Cuts

May 31, 2025
The big ‘Cheese’: Apple TV+ series delivers a surrealist family comedy – Albuquerque Journal

The big ‘Cheese’: Apple TV+ series delivers a surrealist family comedy – Albuquerque Journal

May 31, 2025
International Research Team Builds World’s Most Efficient Organic Solar Cell – SciTechDaily

Revolutionary Breakthrough: Scientists Create the Most Efficient Organic Solar Cell Yet!

May 31, 2025
JPMorgan’s Dimon discusses dangers from ‘tectonic shifts’ in geopolitics, the global economy (JPM:NYSE) – Seeking Alpha

Dimon Warns of Geopolitical ‘Tectonic Shifts’ Impacting the Global Economy

May 31, 2025
Khruangbin takes Boise on a hypnotic journey – Idaho Press

Khruangbin Transports Boise into a Mesmerizing Musical Odyssey

May 31, 2025
VSee Health, Inc. Receives Nasdaq Notice on Delayed Form 10-Q Filing – Business Wire

VSee Health Faces Nasdaq Notice Over Delayed 10-Q Filing: What It Means for the Future

May 31, 2025
A 30 Year Dungeons and Dragons Game Gets Upended By Politics – StoryCorps

How Politics Turned a 30-Year Dungeons and Dragons Campaign Upside Down

May 31, 2025
Stop the Machines: The Rise of Anti-Technology Extremism – International Centre for Counter-Terrorism – ICCT

Unplugged: The Surge of Anti-Technology Extremism

May 31, 2025

Categories

Archives

May 2025
MTWTFSS
 1234
567891011
12131415161718
19202122232425
262728293031 
« Apr    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (653)
  • Economy (667)
  • Entertainment (21,573)
  • General (15,251)
  • Health (9,709)
  • Lifestyle (669)
  • News (22,149)
  • People (669)
  • Politics (675)
  • Science (15,889)
  • Sports (21,171)
  • Technology (15,654)
  • World (655)

Recent News

Revolutionary Approach to Assessing the Ecological Impact of Offshore Activities

May 31, 2025
OpenAI’s ‘smartest’ AI model was explicitly told to shut down — and it refused – Live Science

OpenAI’s ‘Smartest’ AI Model Defies Shutdown Command!

May 31, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version