* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Friday, August 29, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    South Park Is In Trouble And Needs To Change Course, Fast – yahoo.com

    South Park Faces Major Challenges and Must Adapt Fast to Survive

    ‘Netflix House’ entertainment complexes are coming. Here’s when they open – Los Angeles Times

    Exciting News: Netflix’s House Entertainment Complexes Are Opening Soon!

    ‘Big Brother’s’ Rylie Jeffries Finally Speaks Out on Katherine Woodman Controversy – El Paso Inc.

    Big Brother’s Rylie Jeffries Finally Speaks Out on Katherine Woodman Controversy

    ‘SNL’ Parts Ways With Emil Wakim Amid Rumored Season 51 Cast Shakeup – yahoo.com

    SNL Shakes Up Season 51 Cast with Emil Wakim’s Surprising Exit

    Do you have a favorable or an unfavorable opinion of Taylor Swift? – YouGov

    Do You Love Taylor Swift or Not? Share Your Thoughts!

    Upload Season 4 Review – yahoo.com

    Upload Season 4 Review: A Thrilling New Chapter Unveiled

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    13 Top Technology Trends (2025) – Exploding Topics

    13 Game-Changing Technology Trends to Watch in 2025

    Japan’s legacy LCD and chip technology find new home in India – Nikkei Asia

    How Japan’s Breakthrough LCD and Chip Technologies Are Driving Innovation in India

    ITSWC 2025: Thursday sessions guide – Traffic Technology Today

    Your Ultimate Guide to Thursday Sessions at ITSWC 2025

    MC Machinery Technology Summit Showcases Manufacturing Innovations – Modern Machine Shop

    MC Machinery Technology Summit Unveils Cutting-Edge Manufacturing Innovations

    US-ROK Technology Cooperation Faces Rising Tensions – The National Interest

    Rising Tensions Put US-South Korea Technology Partnership to the Test

    The Role of AI and Technology in Shaping the Future of Interactive Entertainment – Technology Org

    How AI and Technology Are Transforming the Future of Interactive Entertainment

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    South Park Is In Trouble And Needs To Change Course, Fast – yahoo.com

    South Park Faces Major Challenges and Must Adapt Fast to Survive

    ‘Netflix House’ entertainment complexes are coming. Here’s when they open – Los Angeles Times

    Exciting News: Netflix’s House Entertainment Complexes Are Opening Soon!

    ‘Big Brother’s’ Rylie Jeffries Finally Speaks Out on Katherine Woodman Controversy – El Paso Inc.

    Big Brother’s Rylie Jeffries Finally Speaks Out on Katherine Woodman Controversy

    ‘SNL’ Parts Ways With Emil Wakim Amid Rumored Season 51 Cast Shakeup – yahoo.com

    SNL Shakes Up Season 51 Cast with Emil Wakim’s Surprising Exit

    Do you have a favorable or an unfavorable opinion of Taylor Swift? – YouGov

    Do You Love Taylor Swift or Not? Share Your Thoughts!

    Upload Season 4 Review – yahoo.com

    Upload Season 4 Review: A Thrilling New Chapter Unveiled

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    13 Top Technology Trends (2025) – Exploding Topics

    13 Game-Changing Technology Trends to Watch in 2025

    Japan’s legacy LCD and chip technology find new home in India – Nikkei Asia

    How Japan’s Breakthrough LCD and Chip Technologies Are Driving Innovation in India

    ITSWC 2025: Thursday sessions guide – Traffic Technology Today

    Your Ultimate Guide to Thursday Sessions at ITSWC 2025

    MC Machinery Technology Summit Showcases Manufacturing Innovations – Modern Machine Shop

    MC Machinery Technology Summit Unveils Cutting-Edge Manufacturing Innovations

    US-ROK Technology Cooperation Faces Rising Tensions – The National Interest

    Rising Tensions Put US-South Korea Technology Partnership to the Test

    The Role of AI and Technology in Shaping the Future of Interactive Entertainment – Technology Org

    How AI and Technology Are Transforming the Future of Interactive Entertainment

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

Blocking inflammatory protein boosts mouse longevity

July 20, 2024
in Science
Blocking inflammatory protein boosts mouse longevity
Share on FacebookShare on Twitter

Scientists have found that turning off a protein called IL-11 can increase the healthy lifespan of mice by nearly 25%. Researchers in the UK and Singapore discovered that blocking a critical inflammatory protein in mice can extend their lifespan, reduce age-related diseases, and make older mice less frail.

The team from the MRC LMS, Imperial College London, and Duke-NUS Medical School in Singapore studied mice without the IL-11 gene and found their lifespan increased by over 20%. They also treated older mice, about 55 years old, with an anti-IL-11 antibody, which blocked IL-11 effects, further proving the benefits.

The results published in Nature were dramatic. Mice given the anti-IL-11 drug from 75 weeks old until death had their median lifespan extended by 22.4% in males and 25% in females. The treated mice lived an average of 155 weeks compared to 120 weeks for untreated mice.

While these findings are in mice, they suggest the drugs could have a similar effect in elderly humans. Professor Stuart Cook from MRC LMS, Imperial College London, and Duke-NUS Medical School in Singapore said the treatment reduced deaths from cancer and diseases caused by fibrosis, chronic inflammation, and poor metabolism, with few side effects.

“The treated mice had fewer cancers and showed fewer signs of aging and frailty, with reduced muscle wasting and improved muscle strength,” he added.

Previously proposed life-extending drugs and treatments either had terrible side effects, didn’t work for both sexes, or extended life but not a healthy life. This doesn’t seem to be the case for IL-11.

While these findings are only in mice, the drugs could have a similar effect in elderly humans. Anti-IL-11 treatments are currently in human clinical trials for other conditions, offering exciting opportunities to study their impact on aging humans in the future.

The researchers have been studying IL-11 for many years. In 2018, they were the first to show that IL-11 is a pro-fibrotic and pro-inflammatory protein, overturning previous beliefs that it was anti-fibrotic and anti-inflammatory.

Assistant Professor Anissa Widjaja from Duke-NUS Medical School, Singapore, shared that the project began in 2017 when they noticed IL-11 levels increased with age in tissue samples.

These rising IL-11 levels contribute to adverse effects in the body, such as inflammation and preventing organs from healing. While the work was done in mice, they hope the findings will be relevant to humans, as similar effects have been seen in studies of human cells and tissues.

“This research helps us better understand aging and shows a potential therapy in mice that could extend healthy aging by reducing frailty and aging signs,” she said.

Previously, scientists suggested IL-11 might be an ‘evolutionary hangover’ in humans. It is important for limb regeneration in some animals but largely unnecessary in humans.

In humans, more IL-11 is produced after about age 55, leading to chronic inflammation, organ fibrosis, metabolism disorders, muscle wasting, frailty, and cardiac fibrosis, all signs of aging.

When multiple such conditions occur together, it is called multimorbidity, which includes lung disease, cardiovascular disease, diabetes, and vision and hearing decline.

Professor Cook said that IL-11 gene activity increases in all tissues in mice with age, causing multimorbidity and loss of function in the whole body, including eyesight, hearing, muscle strength, hair, heart, and kidneys.

Multimorbidity and frailty are significant global healthcare challenges. Currently, no treatment exists for multimorbidity other than treating each underlying cause separately.

Scientists caution that these results are in mice, and the safety and effectiveness of anti-IL-11 treatments in humans need further testing in clinical trials before use.

Journal reference:

Widjaja, A.A., Lim, WW., Viswanathan, S. et al. Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature. DOI: 10.1038/s41586-024-07701-9.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Tech Explorist – https://www.techexplorist.com/blocking-inflammatory-protein-boosts-mouse-longevity/86292/#utm_source=rss&utm_medium=rss&utm_campaign=blocking-inflammatory-protein-boosts-mouse-longevity

Tags: blockingInflammatoryscience
Previous Post

New ambient-energy-driven membrane to remove CO2 from the air

Next Post

Fish alter reproduction due to predators

Hottest engine in the world reveals weirdness of microscopic physics – New Scientist

The World’s Hottest Engine Unveils the Strange Secrets of Microscopic Physics

August 29, 2025
Secretary Greg Reed: ‘If we’re going to grow the economy, we must be able to grow the workforce’ – Yellowhammer News

Secretary Greg Reed: Expanding the Economy Starts with Growing the Workforce

August 29, 2025
South Park Is In Trouble And Needs To Change Course, Fast – yahoo.com

South Park Faces Major Challenges and Must Adapt Fast to Survive

August 29, 2025
RFK Jr. praises Texas for implementing his health vision – The Texas Tribune

RFK Jr. Applauds Texas for Leading the Way in His Bold Health Vision

August 29, 2025
Former special counsel Jack Smith responds to federal investigation against him about his prosecution of Donald Trump – CNN

Former Special Counsel Jack Smith Breaks Silence on Federal Investigation Into His Trump Prosecution

August 29, 2025
Lake Tanganyika cichlids partition habitat by time – Nature

How Lake Tanganyika Cichlids Share Their Habitat by Time to Thrive

August 29, 2025
Ancient Life “Wakes Up” After 100 Million Years Under the Seafloor – IFLScience

Ancient Life Resurfaces After 100 Million Years Hidden Beneath the Seafloor

August 29, 2025
Golden Apple: Seward science teacher helps students soar – KOLN | Nebraska Local News, Weather, Sports | Lincoln, NE

Golden Apple Award: Seward Science Teacher Inspires Students to Soar

August 29, 2025
Maverick Lifestyle Inc.’s Beta Climbs After Market Volatility getLinesFromResByArray error: size == 0 – thegnnews.com

Maverick Lifestyle Inc.’s Beta Climbs After Market Volatility getLinesFromResByArray error: size == 0 – thegnnews.com

August 29, 2025
13 Top Technology Trends (2025) – Exploding Topics

13 Game-Changing Technology Trends to Watch in 2025

August 29, 2025

Categories

Archives

August 2025
MTWTFSS
 123
45678910
11121314151617
18192021222324
25262728293031
« Jul    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (796)
  • Economy (816)
  • Entertainment (21,695)
  • General (16,744)
  • Health (9,857)
  • Lifestyle (829)
  • News (22,149)
  • People (816)
  • Politics (823)
  • Science (16,025)
  • Sports (21,314)
  • Technology (15,796)
  • World (798)

Recent News

Hottest engine in the world reveals weirdness of microscopic physics – New Scientist

The World’s Hottest Engine Unveils the Strange Secrets of Microscopic Physics

August 29, 2025
Secretary Greg Reed: ‘If we’re going to grow the economy, we must be able to grow the workforce’ – Yellowhammer News

Secretary Greg Reed: Expanding the Economy Starts with Growing the Workforce

August 29, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version