* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Wednesday, May 14, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Reznor, Ross Celebrate Film/TV Score Favs With Future Ruins Fest – Yahoo

    Reznor, Ross Celebrate Film/TV Score Favs With Future Ruins Fest – Yahoo

    ‘Lilo & Stitch’ director unpacks key animation-to-live-action changes (exclusive) – ew.com

    Behind the Scenes: Key Changes in the Animation-to-Live-Action Transformation of ‘Lilo & Stitch

    HG Vora Files Definitive Proxy Materials and Sends Letter to PENN Entertainment, Inc. Shareholders – Business Wire

    HG Vora Takes Action: A Bold Move to Engage PENN Entertainment Shareholders

    Downtown Frederick Partnership announces Alive@Five season lineup – The Frederick News-Post

    Get Ready for Fun: Downtown Frederick’s Exciting Alive@Five Season Lineup Revealed!

    ‘American Idol’ Top 3 revealed as 2 contestants eliminated: Who advanced to the Season 23 finale? – Yahoo

    ‘American Idol’ Top 3 revealed as 2 contestants eliminated: Who advanced to the Season 23 finale? – Yahoo

    60,000 Fans Caused a Small Earthquake Because of One Famous Rock Song – Yahoo

    How 60,000 Fans Rocked the Ground with One Iconic Song!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology

    Revolutionary Technology Unlocks Hydrogen from Seawater!

    Administration issues RFI on health technology – American Hospital Association

    Unlocking Innovation: Administration Seeks Insights on Health Technology

    Bridger Photonics Appoints Ryan Sullivan as Chief Technology Officer to Accelerate New Era of Data Insights – Business Wire

    Bridger Photonics Welcomes Ryan Sullivan as CTO to Propel Data Insights into a New Era!

    Michigan Public Policy Survey suggests uncertainty among local officials on AI police surveillance technology – The Michigan Daily

    Local Officials Grapple with Uncertainty Over AI Surveillance Technology in Policing

    Trump Media & Technology Group: When Politics Gets A Ticker Symbol (NASDAQ:DJT) – Seeking Alpha

    Trump Media & Technology Group: When Politics Gets A Ticker Symbol (NASDAQ:DJT) – Seeking Alpha

    GenTech offers coding, AI lessons for elementary students – KTAR.com

    GenTech offers coding, AI lessons for elementary students – KTAR.com

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Reznor, Ross Celebrate Film/TV Score Favs With Future Ruins Fest – Yahoo

    Reznor, Ross Celebrate Film/TV Score Favs With Future Ruins Fest – Yahoo

    ‘Lilo & Stitch’ director unpacks key animation-to-live-action changes (exclusive) – ew.com

    Behind the Scenes: Key Changes in the Animation-to-Live-Action Transformation of ‘Lilo & Stitch

    HG Vora Files Definitive Proxy Materials and Sends Letter to PENN Entertainment, Inc. Shareholders – Business Wire

    HG Vora Takes Action: A Bold Move to Engage PENN Entertainment Shareholders

    Downtown Frederick Partnership announces Alive@Five season lineup – The Frederick News-Post

    Get Ready for Fun: Downtown Frederick’s Exciting Alive@Five Season Lineup Revealed!

    ‘American Idol’ Top 3 revealed as 2 contestants eliminated: Who advanced to the Season 23 finale? – Yahoo

    ‘American Idol’ Top 3 revealed as 2 contestants eliminated: Who advanced to the Season 23 finale? – Yahoo

    60,000 Fans Caused a Small Earthquake Because of One Famous Rock Song – Yahoo

    How 60,000 Fans Rocked the Ground with One Iconic Song!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology

    Revolutionary Technology Unlocks Hydrogen from Seawater!

    Administration issues RFI on health technology – American Hospital Association

    Unlocking Innovation: Administration Seeks Insights on Health Technology

    Bridger Photonics Appoints Ryan Sullivan as Chief Technology Officer to Accelerate New Era of Data Insights – Business Wire

    Bridger Photonics Welcomes Ryan Sullivan as CTO to Propel Data Insights into a New Era!

    Michigan Public Policy Survey suggests uncertainty among local officials on AI police surveillance technology – The Michigan Daily

    Local Officials Grapple with Uncertainty Over AI Surveillance Technology in Policing

    Trump Media & Technology Group: When Politics Gets A Ticker Symbol (NASDAQ:DJT) – Seeking Alpha

    Trump Media & Technology Group: When Politics Gets A Ticker Symbol (NASDAQ:DJT) – Seeking Alpha

    GenTech offers coding, AI lessons for elementary students – KTAR.com

    GenTech offers coding, AI lessons for elementary students – KTAR.com

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

Bone Stem Cell Discovery: The Hidden Cause of Premature Skull Fusion

October 31, 2023
in Science
Bone Stem Cell Discovery: The Hidden Cause of Premature Skull Fusion
Share on FacebookShare on Twitter

Newly Discovered Bone Stem Cell Causes Premature Skull Fusion

A previously unknown stem cell, DDR2+, is linked to craniosynostosis, a condition causing infants’ skulls to fuse prematurely, according to Weill Cornell Medicine research. This discovery may lead to new treatments. This conceptual rendering shows how a new stem cell in the joints between the flat bones of the skull drives skull growth and fusion. Credit: Greenblatt lab, AI image generated using Midjourney

Researchers at Weill Cornell Medicine have found that the premature fusion of the skull in infants, known as craniosynostosis, is caused by an increase in a previously unidentified stem cell, the DDR2+ stem cell. This discovery offers potential for treatments beyond surgery.

Craniosynostosis, the premature fusion of the top of the skull in infants, is caused by an abnormal excess of a previously unknown type of bone-forming stem cell, according to a preclinical study led by researchers at Weill Cornell Medicine.

Craniosynostosis arises from one of several possible gene mutations, and occurs in about one in 2,500 babies. By constricting brain growth, it can lead to abnormal brain development if not corrected surgically. In complex cases, multiple surgeries are needed.

Research Findings

In the study, which was recently published in the journal Nature, the researchers examined in detail what happens in the skull of mice with one of the most common mutations found in human craniosynostosis. They found that the mutation drives premature skull fusion by inducing the abnormal proliferation of a type of bone-making stem cell—the DDR2+ stem cell—that had never been described before.

New Stem Cell Driving Disorders of Premature Skull Fusion

A new stem cell driving disorders of premature skull fusion was transplanted (red), showing that it makes the cartilage seen at sites of skull fusion (green). Credit: Greenblatt lab

“We can now start to think about treating craniosynostosis not just with surgery but also by blocking this abnormal stem cell activity,” said study co-senior author Dr. Matt Greenblatt, an associate professor of pathology and laboratory medicine at Weill Cornell Medicine and a pathologist at NewYork-Presbyterian/Weill Cornell Medical Center.

The other co-senior author of the study was Dr. Shawon Debnath, a research associate in the Greenblatt laboratory.

In a study published in Nature in 2018, Drs. Debnath and Greenblatt and their colleagues described the discovery of a type of bone-forming stem cell they called the CTSK+ stem cell. Because this type of cell is present in the top of the skull, or “calvarium,” in mice, they suspected that it has a role in causing craniosynostosis.

Unforeseen Results and Future Implications

In the new study, they investigated that possibility by engineering mice in which CTSK+ stem cells lack one of the genes whose loss of function causes craniosynostosis. They expected that the gene deletion somehow would induce these calvarial stem cells to go into bone-making overdrive. This new bone would fuse the flexible, fibrous material called sutures in the skull that normally allow it to expand in infants.

“We were surprised to find that, instead of the mutation in CTSK+ stem cells leading to these stem cells being activated to fuse the bony plates in the skull as we expected, mutations in the CTSK+ stem cells instead led to the depletion of these stem cells at the sutures—and the greater the depletion, the more complete the fusion of the sutures,” Dr. Debnath said.

The unexpected finding led the team to hypothesize that another type of bone-forming stem cell was driving the abnormal suture fusion. After further experiments, and a detailed analysis of the cells present at fusing sutures, they identified the culprit: the DDR2+ stem cell, whose daughter cells make bone using a different process than that utilized by CTSK+ cells.

The team found that CTSK+ stem cells normally suppress the production of the DDR2+ stem cells. However, the craniosynostosis gene mutation causes the CTSK+ stem cells to die off, allowing the DDR2+ cells to proliferate abnormally.

To investigate these stem cells in human tissue, the team formed a collaboration with craniosynostosis surgeon Dr. Caitlin Hoffman, neurogeneticist Dr. Elizabeth Ross, and neuropathologist Dr. David Pisapia, all at Weill Cornell Medicine and NewYork-Presbyterian/Weill Cornell Medical Center; and craniosynostosis surgeon Dr. Thomas Imahiyerobo of Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian/Columbia University Irving Medical Center.

The researchers found the human versions of DDR2+ stem cells and CTSK+ stem cells in calvarial samples from craniosynostosis surgeries—underscoring the likely clinical relevance of their findings in mice.

The findings suggest that inappropriate DDR2+ stem cell proliferation in the calvarium, in infants with craniosynostosis-linked gene mutations, could be treated by suppressing this stem cell population, through mimicking the methods that CTSK+ stem cells normally use to prevent expansion of DDR2+stem cells. The researchers found that the CTSK+ stem cells achieve this suppression by secreting a growth factor protein called IGF-1, and possibly other regulatory proteins.

“We observed that we could partly prevent calvarial fusion by injecting IGF-1 over the calvarium,” said study first author Dr. Seoyeon Bok, a postdoctoral researcher in the Greenblatt laboratory.

“I can imagine DDR2+ stem cell-suppressing drug treatments being used along with surgical management, essentially to limit the number of surgeries needed or enhance outcomes,” Dr. Greenblatt said.

In addition to treatment-oriented research, he and his colleagues now are looking for other bone-forming stem cell populations in the skull.

“This work has uncovered much more complexity in the skull than we ever imagined, and we suspect the complexity doesn’t end with these two stem cell types,” Dr. Greenblatt said.

Reference: “A multi-stem cell basis for craniosynostosis and calvarial mineralization” by Seoyeon Bok, Alisha R. Yallowitz, Jun Sun, Jason McCormick, Michelle Cung, Lingling Hu, Sarfaraz Lalani, Zan Li, Branden R. Sosa, Tomas Baumgartner, Paul Byrne, Tuo Zhang, Kyle W. Morse, Fatma F. Mohamed, Chunxi Ge, Renny T. Franceschi, Randy T. Cowling, Barry H. Greenberg, David J. Pisapia, Thomas A. Imahiyerobo, Shenela Lakhani, M. Elizabeth Ross, Caitlin E. Hoffman, Shawon Debnath and Matthew B. Greenblatt, 20 September 2023, Nature.
DOI: 10.1038/s41586-023-06526-2

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : SciTechDaily – https://scitechdaily.com/bone-stem-cell-discovery-the-hidden-cause-of-premature-skull-fusion/

Tags: DiscoveryHiddenscience
Previous Post

Cardiovascular Deaths Due to Extreme Heat Expected To Skyrocket

Next Post

Permafrost Apocalypse: 93% Could Vanish by 2100, Warns Global Study

Reznor, Ross Celebrate Film/TV Score Favs With Future Ruins Fest – Yahoo

Reznor, Ross Celebrate Film/TV Score Favs With Future Ruins Fest – Yahoo

May 14, 2025
How Tennessee is working to put more mental health professionals in rural schools – WPLN News

Bridging the Gap: Tennessee’s Initiative to Boost Mental Health Support in Rural Schools

May 14, 2025
The State of Politics: Meet the Legislature’s Fiscal Big Shots – Urban Milwaukee

The State of Politics: Meet the Legislature’s Fiscal Big Shots – Urban Milwaukee

May 14, 2025

Revolutionary Technology Unlocks Hydrogen from Seawater!

May 14, 2025
Best Minnesota Sports Betting Sites: BetOnline Picked as the Top MN Sportsbook – GlobeNewswire

Best Minnesota Sports Betting Sites: BetOnline Picked as the Top MN Sportsbook – GlobeNewswire

May 14, 2025
The data-driven path to clean water – Department of Ecology – State of Washington (.gov)

Unlocking Clean Water: A Data-Driven Journey to a Sustainable Future

May 14, 2025
Modern-day alchemy! Scientists turn lead into gold at the Large Hadron Collider – Space

Transforming Lead into Gold: The Modern Alchemy Unveiled at the Large Hadron Collider!

May 14, 2025
This Is Who’s Causing Global Warming, According to Science – VICE

Unveiling the Real Culprits Behind Global Warming: What Science Reveals

May 14, 2025
Is Basting Your Steak in Butter Actually Worth It? – Yahoo

Is Butter-Basting Your Steak a Game Changer for Flavor

May 14, 2025
‘Captain America: Brave New World’ OTT debut: When and where to watch it at home – The Economic Times

‘Captain America: Brave New World’ OTT debut: When and where to watch it at home – The Economic Times

May 14, 2025

Categories

Archives

May 2025
MTWTFSS
 1234
567891011
12131415161718
19202122232425
262728293031 
« Apr    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (608)
  • Economy (619)
  • Entertainment (21,533)
  • General (15,216)
  • Health (9,662)
  • Lifestyle (624)
  • News (22,149)
  • People (622)
  • Politics (627)
  • Science (15,842)
  • Sports (21,130)
  • Technology (15,611)
  • World (610)

Recent News

Reznor, Ross Celebrate Film/TV Score Favs With Future Ruins Fest – Yahoo

Reznor, Ross Celebrate Film/TV Score Favs With Future Ruins Fest – Yahoo

May 14, 2025
How Tennessee is working to put more mental health professionals in rural schools – WPLN News

Bridging the Gap: Tennessee’s Initiative to Boost Mental Health Support in Rural Schools

May 14, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version