* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Thursday, May 8, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Blackstone River Theatre presents music from Scotland with Cantrip – The Valley Breeze

    Experience the Enchanting Sounds of Scotland: Cantrip Takes the Stage at Blackstone River Theatre!

    The viral wireless audio dongle for in-flight entertainment just got a big upgrade – and I love it – ZDNET

    Game-Changer for In-Flight Entertainment: The Upgraded Wireless Audio Dongle You’ll Love!

    Tahoe City Downtown Association opens 4th of July Entertainment Grant Program – Sierra Sun

    Celebrate Independence Day: Tahoe City Launches Exciting 4th of July Entertainment Grant Program!

    WEBTOON Entertainment Revolutionizes Webcomic Discovery with Innovative New Personalization Features and Product Updates – Business Wire

    Unlocking a New Era of Webcomic Discovery: WEBTOON’s Exciting Personalization Features and Updates!

    What does Gen Z consider entertainment? – The Drum

    Unlocking Gen Z’s Entertainment Preferences: What Captivates the Next Generation

    MSQ Sport + Entertainment appoints Steph Lund as North America CEO – Campaign US

    Steph Lund Takes the Helm as CEO of MSQ Sport + Entertainment in North America!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Trump administration set to overhaul Biden’s AI chip export regulations – TechHQ

    Trump administration set to overhaul Biden’s AI chip export regulations – TechHQ

    Technology is the key to empathy in insurance – InsuranceNewsNet

    Unlocking Empathy: How Technology is Transforming the Insurance Experience

    Technology – Inflexion

    Revolutionizing the Future: The Impact of Cutting-Edge Technology

    Outdated technology and stress-related absences contribute to Newark Airport chaos – Travel Weekly

    How Outdated Technology and Stress Are Fueling Chaos at Newark Airport

    Tech & AI LIVE London: Q&A with IBM’s Nabeel Nawaz – Technology Magazine

    Tech & AI LIVE London: Q&A with IBM’s Nabeel Nawaz – Technology Magazine

    Radar Technology Offers Contactless Vital Sign Monitoring for Rural Healthcare – AZoSensors

    Revolutionizing Rural Healthcare: How Radar Technology Enables Contactless Vital Sign Monitoring

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Blackstone River Theatre presents music from Scotland with Cantrip – The Valley Breeze

    Experience the Enchanting Sounds of Scotland: Cantrip Takes the Stage at Blackstone River Theatre!

    The viral wireless audio dongle for in-flight entertainment just got a big upgrade – and I love it – ZDNET

    Game-Changer for In-Flight Entertainment: The Upgraded Wireless Audio Dongle You’ll Love!

    Tahoe City Downtown Association opens 4th of July Entertainment Grant Program – Sierra Sun

    Celebrate Independence Day: Tahoe City Launches Exciting 4th of July Entertainment Grant Program!

    WEBTOON Entertainment Revolutionizes Webcomic Discovery with Innovative New Personalization Features and Product Updates – Business Wire

    Unlocking a New Era of Webcomic Discovery: WEBTOON’s Exciting Personalization Features and Updates!

    What does Gen Z consider entertainment? – The Drum

    Unlocking Gen Z’s Entertainment Preferences: What Captivates the Next Generation

    MSQ Sport + Entertainment appoints Steph Lund as North America CEO – Campaign US

    Steph Lund Takes the Helm as CEO of MSQ Sport + Entertainment in North America!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Trump administration set to overhaul Biden’s AI chip export regulations – TechHQ

    Trump administration set to overhaul Biden’s AI chip export regulations – TechHQ

    Technology is the key to empathy in insurance – InsuranceNewsNet

    Unlocking Empathy: How Technology is Transforming the Insurance Experience

    Technology – Inflexion

    Revolutionizing the Future: The Impact of Cutting-Edge Technology

    Outdated technology and stress-related absences contribute to Newark Airport chaos – Travel Weekly

    How Outdated Technology and Stress Are Fueling Chaos at Newark Airport

    Tech & AI LIVE London: Q&A with IBM’s Nabeel Nawaz – Technology Magazine

    Tech & AI LIVE London: Q&A with IBM’s Nabeel Nawaz – Technology Magazine

    Radar Technology Offers Contactless Vital Sign Monitoring for Rural Healthcare – AZoSensors

    Revolutionizing Rural Healthcare: How Radar Technology Enables Contactless Vital Sign Monitoring

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

Calcium Uptake: New Discovery Could Slow Aging and Prevent Age-Related Diseases

August 3, 2023
in Science
Calcium Uptake: New Discovery Could Slow Aging and Prevent Age-Related Diseases
Share on FacebookShare on Twitter

Anti-Aging Rejuvenation Concept

A team from the University of Virginia School of Medicine has discovered that improper calcium signaling in the mitochondria of certain immune cells contributes to chronic inflammation that accelerates aging. They propose that enhancing calcium uptake in these cells could help to slow down age-related diseases. The findings are published in the scientific journal Nature Aging.

University of Virginia School of Medicine researchers have discovered a key driver of chronic inflammation that accelerates aging. That finding could let us slow the clock to live longer, healthier lives, and may allow us to prevent age-related conditions such as deadly heart disease and devastating brain disorders that rob us of our faculties.

So what drives this harmful inflammation? The answer is improper calcium signaling in the mitochondria of certain immune cells. Mitochondria are the power generators in all cells, and they rely heavily on calcium signaling.

Implications of the Findings

The team at UVA Health, under the leadership of Bimal N. Desai, PhD, found that the mitochondria in macrophages, a type of immune cell, lose their ability to absorb and utilize calcium as they age. They demonstrated that this issue leads to the chronic inflammation accountable for many health problems associated with old age.

Bimal Desai

The University of Virginia School of Medicine’s Bimal N. Desai, PhD, and colleagues have found a key trigger for “inflammaging” — inflammation that drives aging. Credit: Dan Addison, University of Virginia

The researchers propose that enhancing calcium uptake by these mitochondrial macrophages could deter this harmful inflammation and its severe consequences. Given that macrophages are present in all our body organs, including the brain, directing targeted drugs towards such “tissue-resident macrophages” may enable us to slow age-related neurodegenerative diseases.

“I think we have made a key conceptual breakthrough in understanding the molecular underpinnings of age-associated inflammation,” said Desai, of UVA’s Department of Pharmacology and UVA’s Carter Immunology Center. “This discovery illuminates new therapeutic strategies to interdict the inflammatory cascades that lie at the heart of many cardiometabolic and neurodegenerative diseases.”

The Inflammation of Aging – ‘Inflammaging’

Macrophages are white blood cells that play critical roles in our immune systems and, in turn, our good health. They swallow up dead or dying cells, allowing our bodies to remove cellular debris, and patrol for pathogens and other foreign invaders. In this latter role, they act as important sentries for our immune systems, calling for help from other immune cells as needed.

Scientists have known that macrophages’ effectiveness diminishes with age, but the reasons for this were previously unclear. Desai’s recent discovery provides some answers.

A Keystone Mechanism in Aging

Desai and his team say their research has identified a “keystone” mechanism responsible for age-related changes in the macrophages. These changes, the scientists believe, make the macrophages prone to chronic, low-grade inflammation at the best of times. And when the immune cells are confronted by an invader or tissue damage, they can become hyperactive. This drives what is known as “inflammaging” – chronic inflammation that drives aging.

Further, the UVA Health scientists suspect that the mechanism they have discovered will hold true not just for macrophages but for many other related immune cells generated in the bone marrow. That means we may be able to stimulate the proper functioning of those cells as well, potentially giving our immune systems a big boost in old age, when we become more susceptible to disease.

The Way Forward

Fixing “inflammaging” won’t be as simple as taking a calcium supplement. The problem isn’t a shortage of calcium so much as the macrophages’ inability to use it properly. But Desai’s new discovery has pinpointed the precise molecular machinery involved in this process, so we should be able to discover ways to stimulate this machinery in aging cells.

“This highly interdisciplinary research effort, at the interface of computational biology, immunology, cell biology, and biophysics, wouldn’t have been possible without the determination of Phil Seegren, the graduate student who spearheaded this ambitious project,” Desai said. “Now, moving forward, we need an equally ambitious effort to figure out the wiring that controls this mitochondrial process in different types of macrophages and then manipulate that wiring in creative ways for biomedical impact.”  

Aging Findings Published

The researchers have published their findings in the scientific journal Nature Aging. The article is open access, meaning it is free to read.

Reference: “Reduced mitochondrial calcium uptake in macrophages is a major driver of inflammaging” by Philip V. Seegren, Logan R. Harper, Taylor K. Downs, Xiao-Yu Zhao, Shivapriya B. Viswanathan, Marta E. Stremska, Rachel J. Olson, Joel Kennedy, Sarah E. Ewald, Pankaj Kumar and Bimal N. Desai, 5 June 2023, Nature Aging.
DOI: 10.1038/s43587-023-00436-8

The research team consisted of Seegren, Logan R. Harper, Taylor K. Downs, Xiao-Yu Zhao, Shivapriya B. Viswanathan, Marta E. Stremska, Rachel J. Olson, Joel Kennedy, Sarah E. Ewald, Pankaj Kumar, and Desai. The scientists reported that they have no financial interests in the work.

The research was supported by the National Institutes of Health, grants AI155808, GM108989, GM138381, P30 CA044579 and T32 GM007055-46, and by the Owens Family Foundation.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : SciTechDaily – https://scitechdaily.com/calcium-uptake-new-discovery-could-slow-aging-and-prevent-age-related-diseases/

Tags: CalciumscienceUptake
Previous Post

Windpark Fryslân: The World’s Largest Freshwater Wind Farm

Next Post

Surprising Finding: Scientists Discover New, Unexpected Mechanism of Cancer Cell Spread

Winner–loser plant trait replacements in human-modified tropical forests – Nature

May 8, 2025
WTMS Science & Social Studies wins State Championship at Academic Super Bowl Competition – Valpo.Life

WTMS Science & Social Studies Team Clinches State Championship at Academic Super Bowl!

May 8, 2025
Europe turns its back on the wolf and on science – WWF EU

Europe’s Struggle: Balancing Conservation and Controversy Over Wolves

May 8, 2025
Creative and Thoughtful Gifts for Mom – WCPO 9 Cincinnati

Heartfelt and Unique Gift Ideas to Delight Mom

May 8, 2025
Geophysicists pinpoint location of Yellowstone magma reservoir – Physics World

Geophysicists Uncover the Hidden Secrets of Yellowstone’s Magma Reservoir!

May 8, 2025
Economy: China Extends A Hand To The U.S…. But At What Cost? – Cointribune

China Reaches Out to the U.S.: What Are the Hidden Costs

May 8, 2025
Blackstone River Theatre presents music from Scotland with Cantrip – The Valley Breeze

Experience the Enchanting Sounds of Scotland: Cantrip Takes the Stage at Blackstone River Theatre!

May 8, 2025
Sonde Health and Saaya Health Forge Strategic Partnership to Improve Workforce Performance and Wellness for Blue-Collar Enterprises – Business Wire

Transforming Blue-Collar Workplaces: Sonde Health and Saaya Health Join Forces to Boost Performance and Wellness

May 8, 2025
Friedrich Merz calls for US to ‘stay out’ of German politics – The Guardian

Friedrich Merz Urges the US to Keep Its Distance from German Politics

May 8, 2025
Update On How Centers Of Platform Gravity Are Shaping The Cybersecurity Technology Market – Seeking Alpha

How Centers of Platform Gravity Are Transforming the Cybersecurity Technology Landscape

May 8, 2025

Categories

Archives

May 2025
MTWTFSS
 1234
567891011
12131415161718
19202122232425
262728293031 
« Apr    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (592)
  • Economy (603)
  • Entertainment (21,516)
  • General (15,209)
  • Health (9,646)
  • Lifestyle (608)
  • News (22,149)
  • People (606)
  • Politics (610)
  • Science (15,825)
  • Sports (21,113)
  • Technology (15,593)
  • World (593)

Recent News

Winner–loser plant trait replacements in human-modified tropical forests – Nature

May 8, 2025
WTMS Science & Social Studies wins State Championship at Academic Super Bowl Competition – Valpo.Life

WTMS Science & Social Studies Team Clinches State Championship at Academic Super Bowl!

May 8, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version