Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules | Science

Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules | Science

Tubulin, one of the most abundant cytoskeletal building blocks, has numerous isotypes in metazoans encoded by different conserved genes. Whether these distinct isotypes form cell type– and context-specific microtubule structures is poorly understood. …
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