* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Wednesday, May 21, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Jason Momoa Is Done With Peace in Apple’s ‘Chief of War’ Teaser – Yahoo

    Jason Momoa Embraces Chaos in Gripping Teaser for Apple’s ‘Chief of War’

    AI Entertainment Studio Promise Inks Deal With Google, Raises Investment from Michael Ovitz’s Crossbeam – The Hollywood Reporter

    AI Entertainment Studio Promise Secures Major Deal with Google and Attracts Investment from Michael Ovitz’s Crossbeam!

    Jennifer Lawrence and Robert Pattinson Did This “Humiliating” Thing to Prep for Sex Scenes – Yahoo

    Jennifer Lawrence and Robert Pattinson’s Hilarious Preparation for Steamy Sex Scenes!

    Meet the Cast of FX’s New Comedy ‘Adults’ – WFXG

    Meet the Cast of FX’s New Comedy ‘Adults’ – WFXG

    First Celebrities Playing in the 2025 American Century Championship Announced – El Paso Inc.

    Exciting Lineup Revealed: First Celebrities Set to Compete in the 2025 American Century Championship!

    Palm Beach Council approves Breakers plans for new Family Entertainment Center – Palm Beach Daily News

    Palm Beach Council Greenlights Exciting New Family Entertainment Center at The Breakers!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Novotech Honored with Triple Win in 2025 Pharmaceutical Technology Excellence Awards – Morningstar

    Novotech Celebrates Triple Triumph at the 2025 Pharmaceutical Technology Excellence Awards!

    Experts Issue Warning on New TSA Technology – Men’s Journal

    Experts Sound Alarm Over New TSA Technology: What You Need to Know

    Cellino’s iPSC Manufacturing Technology Receives FDA Advanced Manufacturing Technology (AMT) Designation – Business Wire

    Cellino’s Groundbreaking iPSC Manufacturing Technology Earns FDA’s Advanced Manufacturing Designation!

    New technology adapting the study of Anatomy | Why’s Guy’s – WCIA.com

    Revolutionizing Anatomy: How Cutting-Edge Technology is Transforming the Study of the Human Body

    We Think GigaCloud Technology’s (NASDAQ:GCT) Solid Earnings Are Understated – Yahoo Finance

    Unlocking Potential: Why GigaCloud Technology’s Impressive Earnings Deserve More Recognition

    JPMorgan Chase plans to spend $18B in technology in 2025 (JPM:NYSE) – Seeking Alpha

    JPMorgan Chase Unveils Ambitious $18 Billion Tech Investment Plan for 2025!

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Jason Momoa Is Done With Peace in Apple’s ‘Chief of War’ Teaser – Yahoo

    Jason Momoa Embraces Chaos in Gripping Teaser for Apple’s ‘Chief of War’

    AI Entertainment Studio Promise Inks Deal With Google, Raises Investment from Michael Ovitz’s Crossbeam – The Hollywood Reporter

    AI Entertainment Studio Promise Secures Major Deal with Google and Attracts Investment from Michael Ovitz’s Crossbeam!

    Jennifer Lawrence and Robert Pattinson Did This “Humiliating” Thing to Prep for Sex Scenes – Yahoo

    Jennifer Lawrence and Robert Pattinson’s Hilarious Preparation for Steamy Sex Scenes!

    Meet the Cast of FX’s New Comedy ‘Adults’ – WFXG

    Meet the Cast of FX’s New Comedy ‘Adults’ – WFXG

    First Celebrities Playing in the 2025 American Century Championship Announced – El Paso Inc.

    Exciting Lineup Revealed: First Celebrities Set to Compete in the 2025 American Century Championship!

    Palm Beach Council approves Breakers plans for new Family Entertainment Center – Palm Beach Daily News

    Palm Beach Council Greenlights Exciting New Family Entertainment Center at The Breakers!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Novotech Honored with Triple Win in 2025 Pharmaceutical Technology Excellence Awards – Morningstar

    Novotech Celebrates Triple Triumph at the 2025 Pharmaceutical Technology Excellence Awards!

    Experts Issue Warning on New TSA Technology – Men’s Journal

    Experts Sound Alarm Over New TSA Technology: What You Need to Know

    Cellino’s iPSC Manufacturing Technology Receives FDA Advanced Manufacturing Technology (AMT) Designation – Business Wire

    Cellino’s Groundbreaking iPSC Manufacturing Technology Earns FDA’s Advanced Manufacturing Designation!

    New technology adapting the study of Anatomy | Why’s Guy’s – WCIA.com

    Revolutionizing Anatomy: How Cutting-Edge Technology is Transforming the Study of the Human Body

    We Think GigaCloud Technology’s (NASDAQ:GCT) Solid Earnings Are Understated – Yahoo Finance

    Unlocking Potential: Why GigaCloud Technology’s Impressive Earnings Deserve More Recognition

    JPMorgan Chase plans to spend $18B in technology in 2025 (JPM:NYSE) – Seeking Alpha

    JPMorgan Chase Unveils Ambitious $18 Billion Tech Investment Plan for 2025!

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

Common Cold Virus Linked to Life-Threatening Blood Clotting Disorder

September 19, 2023
in Science
Common Cold Virus Linked to Life-Threatening Blood Clotting Disorder
Share on FacebookShare on Twitter

Sick Boy Cold

Researchers have linked adenovirus to a rare blood clotting disorder, expanding knowledge on causes of severe thrombocytopenia and prompting further studies on its treatment and prevalence.

Platelets, or thrombocytes, are specialized cellular fragments that form blood clots when we get scrapes and traumatic injuries. Conditions such as viral infections, autoimmune diseases, and others can lead to a decline in platelet count in the body, a condition known as thrombocytopenia.

Through an extensive clinical and research partnership, Dr. Stephan Moll and Dr. Jacquelyn Baskin-Miller, both from the UNC School of Medicine, have identified a connection between adenovirus infections and a rare blood clotting disorder. This discovery marks the first time the widespread respiratory virus, known to cause mild symptoms resembling the common cold and flu, has been implicated in blood clotting and severe thrombocytopenia.

“This adenovirus-associated disorder is now one of four recognized anti-PF4 disorders,” said Moll, professor of medicine in the Department of Medicine’s Division of Hematology. “We hope that our findings will lead to earlier diagnosis, appropriate and optimized treatment, and better outcomes in patients who develop this life-threatening disorder.”

Stephan Moll

Stephan Moll, MD. Credit: UNC Blood Research Center

Their new observation, which was published in the New England Journal of Medicine, sheds new light on the virus and its role in causing an anti-platelet factor 4 disorder. Additionally, the discovery opens a whole new door for research, as many questions remain as to how and why this condition occurs – and who is most likely to develop the disorder.

HIT, VITT, and “Spontaneous HIT”

Antibodies are large Y-shaped proteins that can stick to the surface of bacteria and other “foreign” substances, flagging them for destruction by the immune system or neutralizing the threat directly.

In anti-PF4 disorders, the person’s immune system makes antibodies against platelet factor-4 (PF4), a protein that is released by platelets. When an antibody forms against PF4 and binds to it, this can trigger the activation and rapid removal of platelets in the bloodstream, leading to blood clotting and low platelets, respectively.

Sometimes, the formation of anti-PF4 antibodies is triggered by a patient’s exposure to heparin, called heparin-induced thrombocytopenia (HIT), and sometimes it occurs as an autoimmune condition without heparin exposure, which is referred to as “spontaneous HIT.”

In the last three years, thrombocytopenia has been shown to rarely occur after injection with COVID-19 vaccines that are made with inactivated pieces of an adenoviral vector. These vaccines are different than the ones made in the United States, such as those by Moderna and Pfizer. The condition is referred to as vaccine-induced immune thrombotic thrombocytopenia (VITT).

The Road to Discovery

The road to the discovery started when a 5-year-old boy who had been diagnosed as an outpatient with adenovirus infection had to be admitted to the hospital with an aggressive blood clot forming in his brain (called cerebral sinus vein thrombosis) and severe thrombocytopenia. Doctors determined that he hadn’t been exposed to heparin or the adeno-vector COVID-19 vaccination, the classical triggers for HIT and VITT.

“The intensive care unit physicians, the neuro-intensivist, and the hematology group were working around the clock to determine the next steps in the care for this young boy,” said Baskin-Miller. “He wasn’t responding to therapy and was progressing quickly. We had questioned whether it could have been linked to his adenovirus considering the vaccine data, but there was nothing in the literature at that time to suggest it.”

The collaborative clinical effort to help the patient expanded: Baskin-Miller reached out to Moll, who is an expert in thrombosis and has various connections throughout the field. To Moll, it looked like the pediatric patient could have “spontaneous HIT”. They then tested for the HIT platelet-activating antibody, which came back positive.

Collaboration is Key

Moll reached out to, Theodore E. Warkentin, MD, a professor of pathology and molecular medicine at McMaster University in Hamilton, Ontario, who has been researching anti-PF4 disorders for three decades, to hear if he was aware of an association between adenoviral infection and spontaneous HIT. Warkentin, who is one of the premier international anti-PF-4 disorders researchers, wasn’t aware of the condition.

Around the same time, Moll received a phone call from Alison L. Raybould, MD, a hematologist-oncologist in Richmond, Virginia, and a previous trainee from UNC. She was seeing a patient who had multiple blood clots, a stroke and heart attack, arm and leg deep-vein thromboses (DVT), and severe thrombocytopenia.

The patient had not been exposed to heparin or vaccines. However, this patient’s severe illness had also started with viral symptoms of cough and fever, and she had tested positive for adenoviral infection. Testing for an anti-PF4 antibody also turned out to be positive.

To help clarify the diagnoses of the two patients, Warkentin immediately offered to further test the patients’ blood and samples were directly to his laboratory in the Hamilton General Hospital for further study. They confirmed that the antibodies were targeting platelet factor 4, much like the HIT antibodies.

Surprisingly, the antibody resembled that of the VITT and bound to PF4 in the same region as VITT antibodies do. They concluded that both the patients had “spontaneous HIT” or a VITT-like disorder, associated with an adenovirus infection.

More Questions

Following such a groundbreaking conclusion, Moll and colleagues are now left with many questions about the prevalence of the new anti-PF4 disorder, whether the condition can be caused by other viruses, and why this condition doesn’t occur with every infection with adenovirus.

They also wonder what preventative or treatment measures can be made to help patients who develop the new, potentially deadly anti-PF4 disorder.

“How common is the disorder?” asked Moll. “What degree of thrombocytopenia raises the threshold to test for anti-PF4 antibodies? And then finally, how do we best treat these patients to optimize the chance that they will survive such a potentially deadly disease?”

Reference: “Adenovirus-Associated Thrombocytopenia, Thrombosis, and VITT-like Antibodies” by Theodore E. Warkentin, Jacquelyn Baskin-Miller, Alison L. Raybould, Jo-Ann I. Sheppard, Mercy Daka, Ishac Nazy and Stephan Moll, 10 August 2023, New England Journal of Medicine.
DOI: 10.1056/NEJMc2307721

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : SciTechDaily – https://scitechdaily.com/common-cold-virus-linked-to-life-threatening-blood-clotting-disorder/

Tags: CommonscienceVirus
Previous Post

An Unexpected New Way To Recycle – Scientists Transform Plastic Waste Into Soap

Next Post

5 Defensive Changes Broncos Must Consider to Avert Disaster

New BS in Ecology, Evolution and Environmental Biology degree program prepares students for diverse careers – Oakland University

Unlock Your Future: Explore the New BS in Ecology, Evolution, and Environmental Biology Degree!

May 21, 2025
Los Alamos Faith And Science Forum 2025 Summer Series – Los Alamos Daily Post

Explore the Intersection of Faith and Science: Join the 2025 Summer Series in Los Alamos!

May 21, 2025
🧪 Science with Sarah: Cloud in a jar ☁️ – KSAT

Create Your Own Cloud in a Jar: A Fun Science Experiment with Sarah!

May 21, 2025
Simple lifestyle changes to avoid prostate cancer – Times of India

Simple lifestyle changes to avoid prostate cancer – Times of India

May 21, 2025
Ask the Developer Vol. 18: Mario Kart World — Part 4 – Nintendo

Revving Up the Fun: Dive into Mario Kart World – Part 4!

May 21, 2025
Trump Is Slowly but Surely Killing U.S. Economy, Experts Warn – The New Republic

Experts Warn: Trump’s Policies Are Gradually Undermining the U.S. Economy

May 21, 2025
Jason Momoa Is Done With Peace in Apple’s ‘Chief of War’ Teaser – Yahoo

Jason Momoa Embraces Chaos in Gripping Teaser for Apple’s ‘Chief of War’

May 21, 2025
Attendance improves in rural NYS schools with on-site health clinics – Cornell Chronicle

Boosting Attendance: How On-Site Health Clinics are Transforming Rural NYS Schools

May 21, 2025
Justice Department ends police reform agreements and halts investigations into major departments – CNN

Justice Department Shifts Gears: Police Reform Agreements and Major Investigations Come to a Halt

May 21, 2025
Novotech Honored with Triple Win in 2025 Pharmaceutical Technology Excellence Awards – Morningstar

Novotech Celebrates Triple Triumph at the 2025 Pharmaceutical Technology Excellence Awards!

May 21, 2025

Categories

Archives

May 2025
MTWTFSS
 1234
567891011
12131415161718
19202122232425
262728293031 
« Apr    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (627)
  • Economy (640)
  • Entertainment (21,554)
  • General (15,224)
  • Health (9,682)
  • Lifestyle (645)
  • News (22,149)
  • People (643)
  • Politics (648)
  • Science (15,864)
  • Sports (21,150)
  • Technology (15,630)
  • World (630)

Recent News

New BS in Ecology, Evolution and Environmental Biology degree program prepares students for diverse careers – Oakland University

Unlock Your Future: Explore the New BS in Ecology, Evolution, and Environmental Biology Degree!

May 21, 2025
Los Alamos Faith And Science Forum 2025 Summer Series – Los Alamos Daily Post

Explore the Intersection of Faith and Science: Join the 2025 Summer Series in Los Alamos!

May 21, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version