* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Tuesday, October 7, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Charlie Hunnam Reflects on Playing a Serial Killer in Monster: The Ed Gein Story – Yahoo

    Charlie Hunnam Reveals the Dark Challenges of Playing a Serial Killer in Monster: The Ed Gein Story

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    Why Taylor Swift Name-Dropped Elizabeth Taylor in Her New Album – Yahoo

    Here’s Why Taylor Swift Dropped Elizabeth Taylor’s Name in Her New Album

    Al Roker Gives Olivia Dean an Unexpected ‘New Job’ on the ‘Today’ Show – Yahoo

    Al Roker Shocks Olivia Dean with an Exciting New Role on the ‘Today’ Show

    Books about the arts and some haunts for a Denton October – Denton Record-Chronicle

    Uncover Artistic Treasures and Spooky Adventures to Experience in Denton This October

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Is Light-Speed Analog Computing the Future of Technology? – BIOENGINEER.ORG

    Could Light-Speed Analog Computing Transform the Future of Technology?

    ARM Institute opens technology project call to speed submarine manufacturing – The Robot Report

    ARM Institute Unveils Cutting-Edge Technology Project to Revolutionize Submarine Manufacturing

    Forget Cowbells. Cows Wear High-Tech Collars Now. – The New York Times

    Ditch the Cowbells: Discover the High-Tech Collars Transforming Cattle Care

    What the Recent Price Surge Means for Figure Technology Solutions After SEC Settlement – Yahoo Finance

    What the Recent Price Surge Reveals About Figure Technology Solutions Following SEC Settlement

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Row K Entertainment Emerges as Major New Hollywood Buyer With Splashy TIFF Shopping Spree – TheWrap

    Charlie Hunnam Reflects on Playing a Serial Killer in Monster: The Ed Gein Story – Yahoo

    Charlie Hunnam Reveals the Dark Challenges of Playing a Serial Killer in Monster: The Ed Gein Story

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    Why Taylor Swift Name-Dropped Elizabeth Taylor in Her New Album – Yahoo

    Here’s Why Taylor Swift Dropped Elizabeth Taylor’s Name in Her New Album

    Al Roker Gives Olivia Dean an Unexpected ‘New Job’ on the ‘Today’ Show – Yahoo

    Al Roker Shocks Olivia Dean with an Exciting New Role on the ‘Today’ Show

    Books about the arts and some haunts for a Denton October – Denton Record-Chronicle

    Uncover Artistic Treasures and Spooky Adventures to Experience in Denton This October

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Is Light-Speed Analog Computing the Future of Technology? – BIOENGINEER.ORG

    Could Light-Speed Analog Computing Transform the Future of Technology?

    ARM Institute opens technology project call to speed submarine manufacturing – The Robot Report

    ARM Institute Unveils Cutting-Edge Technology Project to Revolutionize Submarine Manufacturing

    Forget Cowbells. Cows Wear High-Tech Collars Now. – The New York Times

    Ditch the Cowbells: Discover the High-Tech Collars Transforming Cattle Care

    What the Recent Price Surge Means for Figure Technology Solutions After SEC Settlement – Yahoo Finance

    What the Recent Price Surge Reveals About Figure Technology Solutions Following SEC Settlement

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

Compressed Perturb-seq enables highly efficient genetic screens

October 24, 2023
in Science
Compressed Perturb-seq enables highly efficient genetic screens
Share on FacebookShare on Twitter

Using an experimental and computational framework inspired by compressed sensing, we greatly reduced the number of measurements needed to run Perturb-seq. Our compressed Perturb-seq strategy relies on collecting measurements comprising random linear combinations of genetic perturbations, followed by deconvolving the perturbation effects on the transcriptome using sparsity-exploiting algorithms.

Access options

Access Nature and 54 other Nature Portfolio journals

Get Nature+, our best-value online-access subscription

24,99 € / 30 days

cancel any time

Subscribe to this journal

Receive 12 print issues and online access

209,00 € per year

only 17,42 € per issue

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Log in

Learn about institutional subscriptions

Read our FAQs

Contact customer support

Fig. 1: Compressed Perturb-seq.

References

Dixit, A. et al. Perturb-seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens. Cell 167, 1853–1866 (2016). This was one of the initial papers that developed Perturb-seq.

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Replogle, J. M. et al. Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq. Cell 185, 2559–2575 (2022). This paper represents the largest Perturb-seq screen conducted to date.

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Candes, E. J. & Wakin, M. B. An introduction to compressive sampling. IEEE Signal Process. Mag. 25, 21–30 (2008). This review article presents an overview of compressed sensing.

Article 

Google Scholar 

Cleary, B. & Regev, A. The necessity and power of random, under-sampled experiments in biology. Preprint at https://doi.org/10.48550/arXiv.2012.12961 (2020). This review article presents a general framework for efficient data collection using random experiments.

Sharan, V. et al. Compressed factorization: fast and accurate low-rank factorization of compressively-sensed data. Proc. 36th Int. Conf. Machine Learning 5690–5700 (2019). This paper provides the theoretical basis for the computational method introduced in our paper.

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Yao, D. et al. Scalable genetic screening for regulatory circuits using compressed Perturb-seq. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01964-9 (2023).

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Compressed Perturb-seq enables highly efficient genetic screens.
Nat Biotechnol (2023). https://doi.org/10.1038/s41587-023-02003-3

Download citation

Published: 23 October 2023

DOI: https://doi.org/10.1038/s41587-023-02003-3

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Nature.com – https://www.nature.com/articles/s41587-023-02003-3

Tags: CompressedPerturb-seqscience
Previous Post

AI for drug discovery is booming, but who owns the patents?

Next Post

Hypoimmune cells resist rejection in monkeys

Pets of the Day: Sweep the clouds away with Zoe, Telly and Elmo – Yahoo

Meet Zoe, Telly, and Elmo: Your Daily Dose of Sunshine and Smiles

October 7, 2025
Is Light-Speed Analog Computing the Future of Technology? – BIOENGINEER.ORG

Could Light-Speed Analog Computing Transform the Future of Technology?

October 7, 2025
Frustrations grow around Bill Belichick and North Carolina after team’s porous start to the 2025 season – Yahoo Sports

Frustrations grow around Bill Belichick and North Carolina after team’s porous start to the 2025 season – Yahoo Sports

October 7, 2025
Jason Anderson Signs for Suzuki for 2026 SMX World Championship – Monster Energy AMA Supercross

Jason Anderson Signs for Suzuki for 2026 SMX World Championship – Monster Energy AMA Supercross

October 7, 2025
Downtown St. Paul’s economy showing new life after state employees mandated to return to office – 5 EYEWITNESS NEWS

Downtown St. Paul Thrives Again as State Employees Return to the Office

October 7, 2025
No, Anthony Boyle Didn’t Use a Prosthetic in His House of Guinness Bath Scene – Yahoo

Anthony Boyle Opens Up About the Shocking Truth Behind His House of Gucci Bath Scene

October 7, 2025
Ozzy Osbourne documentary reveals agonizing health struggles of his final years – USA Today

Inside Ozzy Osbourne’s Heartbreaking Battle with Health in His Final Years

October 7, 2025
Latino leaders explore the role community organizing can play in national politics – OSV News

Latino Leaders Unite to Amplify Community Power and Drive National Change

October 7, 2025
Ecology blazing the trail for more clean energy projects – Washington State Department of Ecology (.gov)

How Ecology is Powering the Shift to a Greener Energy Future

October 7, 2025
Penn State Brandywine Earth sciences professor earns two national awards – Penn State University

Penn State Brandywine Earth sciences professor earns two national awards – Penn State University

October 7, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (855)
  • Economy (876)
  • Entertainment (21,749)
  • General (17,460)
  • Health (9,918)
  • Lifestyle (889)
  • News (22,149)
  • People (877)
  • Politics (887)
  • Science (16,086)
  • Sports (21,377)
  • Technology (15,857)
  • World (859)

Recent News

Pets of the Day: Sweep the clouds away with Zoe, Telly and Elmo – Yahoo

Meet Zoe, Telly, and Elmo: Your Daily Dose of Sunshine and Smiles

October 7, 2025
Is Light-Speed Analog Computing the Future of Technology? – BIOENGINEER.ORG

Could Light-Speed Analog Computing Transform the Future of Technology?

October 7, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version