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Published: 17 May 2024
Genomics
Nature Biotechnology
(2024)Cite this article
Two CRISPR tools for combinatorial genetic perturbations reveal gene regulatory networks.
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Fig. 1: Two novel CRISPR tools to map genomic regulatory sequences.
References
Pacalin, N. M. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02213-3 (2024).
Article
Google Scholar
Hsiung, C. C.-S. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02224-0 (2024).
Article
Google Scholar
Henikoff, S. & Ahmad, K. Protein Sci.31, e4458 (2022).
Article
CAS
PubMed
PubMed Central
Google Scholar
Melnikov, A. et al. Nat. Biotechnol.30, 271–277 (2012).
Article
CAS
PubMed
PubMed Central
Google Scholar
Arnold, C. D. et al. Science339, 1074–1077 (2013).
Article
CAS
PubMed
Google Scholar
Fulco, C. P. et al. Nat. Genet.51, 1664–1669 (2019).
Article
CAS
PubMed
PubMed Central
Google Scholar
Najm, F. J. et al. Nat. Biotechnol.36, 179–189 (2018).
Article
CAS
PubMed
Google Scholar
Boettcher, M. et al. Nat. Biotechnol.36, 170–178 (2018).
Article
CAS
PubMed
PubMed Central
Google Scholar
Gasperini, M. et al. Cell176, 377–390.e19 (2019).
Article
CAS
PubMed
PubMed Central
Google Scholar
Download references
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Authors and Affiliations
Department of Microbiology and Immunology & UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA, USA
Stefan Oberlin & Michael T. McManus
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The authors declare no competing interests.
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Cite this article
Oberlin, S., McManus, M.T. Decoding gene regulation with CRISPR perturbations.
Nat Biotechnol (2024). https://doi.org/10.1038/s41587-024-02222-2
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Published: 17 May 2024
DOI: https://doi.org/10.1038/s41587-024-02222-2
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