* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Wednesday, June 25, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Netflix unveils Dallas immersive venue for fans of hit shows like ‘Squid Game,’ ‘Stranger Things’ – Houston Chronicle

    Step Inside Netflix’s New Dallas Immersive Experience Featuring Hits Like ‘Squid Game’ and ‘Stranger Things

    ‘Puttin’ on the Ritz’: Civic Players bring ‘Young Frankenstein’ to life – Yahoo

    Civic Players Deliver a Hilarious and Unforgettable Performance of ‘Young Frankenstein

    ‘Wheel of Fortune’: Amputee Wins $60,000 After Breaking Incredible ‘Curse’ – Hastings Tribune

    Wheel of Fortune’ Amputee Breaks Incredible ‘Curse’ to Win $60,000!

    North Star Sports & Entertainment Network: Coming soon – KTTC News

    North Star Sports & Entertainment Network: Coming soon – KTTC News

    Safety concerns in Deep Ellum create apprehension as the entertainment district gains visitors – CBS News

    Safety Concerns Surge Amid Deep Ellum’s Booming Popularity and Growing Crowds

    Elisabeth Moss’ ‘Handmaid’s Tale’ Emmy chances, by the numbers – Yahoo

    Elisabeth Moss’ ‘Handmaid’s Tale’ Emmy chances, by the numbers – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Defense technology giant Northrop Grumman to host interviews in Iuka to fill technician roles – supertalk.fm

    Defense technology giant Northrop Grumman to host interviews in Iuka to fill technician roles – supertalk.fm

    China’s Military Introduces Mosquito-Sized Drones: A Game-Changing Surveillance Technology – Indian Defence Review

    China Unveils Mosquito-Sized Drones: Revolutionizing Surveillance Technology

    Marvell Technology Stock Rallies After AI Event Sparks Investor Optimism – Yahoo Finance

    Marvell Technology Stock Rallies After AI Event Sparks Investor Optimism – Yahoo Finance

    Promising Technology Stocks To Follow Today – June 22nd – MarketBeat

    Top Technology Stocks to Watch Today – June 22nd

    Technology Convergence Report 2025 – The World Economic Forum

    Technology Convergence Report 2025 – The World Economic Forum

    How AI can help make cities work better for residents – MIT Technology Review

    How AI can help make cities work better for residents – MIT Technology Review

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Netflix unveils Dallas immersive venue for fans of hit shows like ‘Squid Game,’ ‘Stranger Things’ – Houston Chronicle

    Step Inside Netflix’s New Dallas Immersive Experience Featuring Hits Like ‘Squid Game’ and ‘Stranger Things

    ‘Puttin’ on the Ritz’: Civic Players bring ‘Young Frankenstein’ to life – Yahoo

    Civic Players Deliver a Hilarious and Unforgettable Performance of ‘Young Frankenstein

    ‘Wheel of Fortune’: Amputee Wins $60,000 After Breaking Incredible ‘Curse’ – Hastings Tribune

    Wheel of Fortune’ Amputee Breaks Incredible ‘Curse’ to Win $60,000!

    North Star Sports & Entertainment Network: Coming soon – KTTC News

    North Star Sports & Entertainment Network: Coming soon – KTTC News

    Safety concerns in Deep Ellum create apprehension as the entertainment district gains visitors – CBS News

    Safety Concerns Surge Amid Deep Ellum’s Booming Popularity and Growing Crowds

    Elisabeth Moss’ ‘Handmaid’s Tale’ Emmy chances, by the numbers – Yahoo

    Elisabeth Moss’ ‘Handmaid’s Tale’ Emmy chances, by the numbers – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Defense technology giant Northrop Grumman to host interviews in Iuka to fill technician roles – supertalk.fm

    Defense technology giant Northrop Grumman to host interviews in Iuka to fill technician roles – supertalk.fm

    China’s Military Introduces Mosquito-Sized Drones: A Game-Changing Surveillance Technology – Indian Defence Review

    China Unveils Mosquito-Sized Drones: Revolutionizing Surveillance Technology

    Marvell Technology Stock Rallies After AI Event Sparks Investor Optimism – Yahoo Finance

    Marvell Technology Stock Rallies After AI Event Sparks Investor Optimism – Yahoo Finance

    Promising Technology Stocks To Follow Today – June 22nd – MarketBeat

    Top Technology Stocks to Watch Today – June 22nd

    Technology Convergence Report 2025 – The World Economic Forum

    Technology Convergence Report 2025 – The World Economic Forum

    How AI can help make cities work better for residents – MIT Technology Review

    How AI can help make cities work better for residents – MIT Technology Review

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

Decoding Metastasis: Unveiling the Secrets Behind Cancer’s Stealthy Spread

February 2, 2024
in Science
Decoding Metastasis: Unveiling the Secrets Behind Cancer’s Stealthy Spread
Share on FacebookShare on Twitter

Cancer Metastasis Concept

Scientists have identified that the spread of cancer and the formation of deadly metastases are influenced by DNA methylation patterns and the role of endothelial cells, offering new insights into cancer treatment and patient prognosis. Credit: SciTechDaily.com

Research highlights the critical role of endothelial cells and DNA methylation in cancer metastasis, pointing to new strategies for diagnosis and therapy.

Scientists from the German Cancer Research Center (DKFZ) and Heidelberg University investigated in mice how spreading tumor cells behave at the site of metastasis: Some tumor cells immediately start to form metastases. Others leave the blood vessel and may then enter a long period of dormancy. What determines which path the cancer cells take is their epigenetic status. This was also confirmed in experiments with human tumor cells. The results of the study could pave the way for novel diagnostic and therapeutic applications.

The Danger of Metastases in Cancer

What makes cancer so dangerous? Cancer cells that leave the primary tumor to reach distant sites of the body where they may grow into daughter tumors, called metastases. While most primary tumors can be effectively treated, metastases are the real danger. Oncologists estimate that more than 90 percent of all cancer deaths in solid tumors are due to metastases.

Understanding and Preventing Cancer Spread

Researchers have been working for decades to understand and prevent the spread of tumor cells. However, the mechanisms that enable a cancer cell to survive in a distant organ and ultimately grow into a metastasis are still largely unknown.

To spread throughout the body, cancer cells travel through blood and lymphatic system. Scientists at the DKFZ and at Heidelberg University have now developed a method to observe the behavior of migrating cancer cells in mice immediately upon arrival in the metastatic organ — in this case, the lung.

The team led by the two first authors Moritz Jakab and Ki Hong Lee discovered that some tumor cells, once they have arrived in the metastatic organ, leave the blood vessel and enter a resting state. Other cancer cells start to divide directly within the blood vessel and grow into metastases.

This delicate fate decision of the metastasizing tumor cells is controlled by the endothelial cells that line the inside of all blood vessels. They release factors from the Wnt signaling pathway that promote the exit of tumor cells from the blood vessel and thereby initiate latency. When the researchers switched off the Wnt factors, latency no longer occurred.

Distinguishing Between Latent and Active Metastatic Cells

“At this point, we asked ourselves the question: Why do some cancer cells immediately form a metastasis, while others fall into a kind of sleep?” says Moritz Jakab. The dormant and metastasizing cancer cells did not differ genetically, nor in many other molecular aspects. But the researchers were able to detect a subtle difference: The methylation of the DNA differed between the two cell types. Tumor cells, whose DNA was less methylated, responded sensitively to the Wnt factors, which resulted in extravasation from the blood vessel and subsequent latency. On the other hand, the more methylated cancer cells did not respond to the Wnt factors, remained in the blood vessel, and immediately started metastatic growth.

To test this hypothesis, the team examined the DNA methylation status of various tumor cell lines. Indeed, they found that this directly correlated with their metastatic potential.

“These results are surprising and could have far-reaching consequences for tumor diagnosis and therapy. The results of the study could, for example, help to use certain methylation patterns as biomarkers to predict for patients how high the load of dormant cancer cells is and, thus, how likely the patient is to relapse after successful treatment of the primary tumor,” says senior author Hellmut Augustin. “But first we need to study whether natural human tumors behave in the same way as the employed cell lines or experimental tumors.”

Reference: “Lung endothelium exploits suscepible tumour cell states to instruct metastatic latency” by Moritz Jakab, Ki Hong Lee, Alexey Uvarovkii, Svetlana Ovchinnikova, Shubharda L Kulkarni; Sevinc Jakab, Till Rostalski, Carleen Spegg, Simon Anders and Hellmut Augustin, 2 February 2024, Nature Cancer.
DOI: 10.1038/s43018-023-00716-7

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : SciTechDaily – https://scitechdaily.com/decoding-metastasis-unveiling-the-secrets-behind-cancers-stealthy-spread/

Tags: DecodingMetastasisscience
Previous Post

Bad News: A Cure for Malaria Is Likely Farther Away Than Scientists Thought

Next Post

Unraveling the Psychology Behind Climate Change Skeptics

Defense technology giant Northrop Grumman to host interviews in Iuka to fill technician roles – supertalk.fm

Defense technology giant Northrop Grumman to host interviews in Iuka to fill technician roles – supertalk.fm

June 25, 2025
Celtics reportedly trade Kristaps Porzingis to Hawks – FOX Sports

Celtics Make Bold Move, Trading Kristaps Porzingis to Hawks

June 25, 2025
April 7 – Ecology, Safeway, and Washington State University Partner to Feed Cougs Well – Washington State Department of Ecology (.gov)

April 7 – Ecology, Safeway, and Washington State University Partner to Feed Cougs Well – Washington State Department of Ecology (.gov)

June 24, 2025
Iranian missile strikes Israel’s ‘crown jewel of science’ – AP News

Iranian Missile Strikes Rock Israel’s ‘Crown Jewel of Science’ in Dramatic Assault

June 24, 2025
Drone footage reveals orcas using tools in a stunning first – CNN

Incredible Drone Footage Reveals Orcas Using Tools in the Wild for the First Time

June 24, 2025
Lifestyle Brand Life Time Takes 52K SF at PBC’s 10 Bryant Park – Commercial Observer

Lifestyle Brand Life Time Expands with New 52K SF Space at 10 Bryant Park

June 24, 2025
How to Watch Benfica vs Bayern München: Live Stream FIFA Club World Cup, TV Channel – Newsweek

How to Watch Benfica vs Bayern München Live: FIFA Club World Cup Streaming and TV Guide

June 24, 2025
Trump Policies Slam Brakes on NYC Economy – THE CITY – NYC News

How Trump’s Policies Put the Brakes on NYC’s Economic Growth

June 24, 2025
Main Line Health combines culinary creativity with healthy eating – 6abc Philadelphia

Main Line Health combines culinary creativity with healthy eating – 6abc Philadelphia

June 24, 2025
Sen. Murkowski on new memoir ‘Far From Home’ and adapting to Trump era politics – PBS

Sen. Murkowski on new memoir ‘Far From Home’ and adapting to Trump era politics – PBS

June 24, 2025

Categories

Archives

June 2025
MTWTFSS
 1
2345678
9101112131415
16171819202122
23242526272829
30 
« May    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (698)
  • Economy (715)
  • Entertainment (21,611)
  • General (15,546)
  • Health (9,754)
  • Lifestyle (720)
  • News (22,149)
  • People (717)
  • Politics (722)
  • Science (15,933)
  • Sports (21,212)
  • Technology (15,701)
  • World (695)

Recent News

Defense technology giant Northrop Grumman to host interviews in Iuka to fill technician roles – supertalk.fm

Defense technology giant Northrop Grumman to host interviews in Iuka to fill technician roles – supertalk.fm

June 25, 2025
Celtics reportedly trade Kristaps Porzingis to Hawks – FOX Sports

Celtics Make Bold Move, Trading Kristaps Porzingis to Hawks

June 25, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version