Deciphering the regulatory logic of enhancer elements that control tissue-specific gene expression has been a long-standing goal in the fields of gene regulation and synthetic biology. Although specific DNA motifs such as transcription-factor binding sites are known, their required arrangement (such as spacing, orientation or combination for spatiotemporal control) has been elusive. Taskiran et al. and de Almeida et al. have now published computational strategies in Nature for understanding and designing such regulatory sequences, while proving their functionality in vivo.
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Despang, A. Designer enhancers for cell-type-specific gene regulation.
Nat Biotechnol 42, 31 (2024). https://doi.org/10.1038/s41587-023-02112-z
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Published: 17 January 2024
Issue Date: January 2024
DOI: https://doi.org/10.1038/s41587-023-02112-z
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