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Published: 30 April 2024
Drug design
Nature Biotechnology
(2024)Cite this article
A strategy for creating drugs that can be quickly neutralized is demonstrated for anticoagulants.
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Fig. 1: Schematic representation of DNA and PNA derivatives and their pharmaceutical applications.
References
Dockerill, M. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02209-z (2024).
Article
Google Scholar
Hirsh, J., Anand, S. S., Halperin, J. L. & Fuster, V. Circulation 103, 2994–3018 (2001).
Article
CAS
PubMed
Google Scholar
Brenner, S. & Lerner, R. A. Proc. Natl Acad. Sci. USA 89, 5381–5383 (1992).
Article
CAS
PubMed
PubMed Central
Google Scholar
Melkko, S., Scheuermann, J., Dumelin, C. E. & Neri, D. Nat. Biotechnol. 22, 568–574 (2004).
Article
CAS
PubMed
Google Scholar
Mannocci, L. et al. Proc. Natl Acad. Sci. USA 105, 17670–17675 (2008).
Article
CAS
PubMed
PubMed Central
Google Scholar
Gartner, Z. J. et al. Science 305, 1601–1605 (2004).
Article
CAS
PubMed
PubMed Central
Google Scholar
Clark, M. A. et al. Nat. Chem. Biol. 5, 647–654 (2009).
Article
CAS
PubMed
Google Scholar
Barluenga, S. & Winssinger, N. Acc. Chem. Res. 48, 1319–1331 (2015).
Article
CAS
PubMed
Google Scholar
Download references
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Authors and Affiliations
Philogen SpA, Siena, Italy
Dario Neri
ETH Zürich, Zurich, Switzerland
Dario Neri
Corresponding author
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Competing interests
D.N. is co-founder, CEO and shareholder of Philogen, a biotech company that works (among other things) in the field of DNA-encoded chemical libraries.
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Neri, D. Designing drugs with reversible activity.
Nat Biotechnol (2024). https://doi.org/10.1038/s41587-024-02242-y
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Published: 30 April 2024
DOI: https://doi.org/10.1038/s41587-024-02242-y
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