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Evolutionary gambit to defeat drug resistance in cancer

July 5, 2024
in Science
Evolutionary gambit to defeat drug resistance in cancer
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Published: 04 July 2024

Cancer

Nature Biotechnology

(2024)Cite this article

A therapeutic strategy harnesses evolutionary dynamics to overcome tumor resistance to targeted therapies.

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Fig. 1: The dual gene drive strategy.

References

Leighow, S. M. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02271-7 (2024).

França, G. S. et al. Preprint at bioRxiv https://doi.org/10.1101/2022.06.21.496830 (2022).

Vander Velde, R. et al. Nat. Commun. 11, 2393 (2020).

Article 

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Duarte, S., Carle, G., Faneca, H., de Lima, M. C. & Pierrefite-Carle, V. Cancer Lett. 324, 160–170 (2012).

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Maley, C. C., Reid, B. J. & Forrest, S. Cancer Epidemiol. Biomarkers Prev. 13, 1375–1384 (2004).

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Gatenby, R. A. & Brown, J. S. Nat. Rev. Clin. Oncol. 17, 675–686 (2020).

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Author information

Authors and Affiliations

Department of Metabolism and Physiology, Moffitt Cancer Center, Tampa, FL, USA

Andriy Marusyk

Corresponding author

Correspondence to
Andriy Marusyk.

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Competing interests

The author declares no competing interests.

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Cite this article

Marusyk, A. Evolutionary gambit to defeat drug resistance in cancer.
Nat Biotechnol (2024). https://doi.org/10.1038/s41587-024-02284-2

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Published: 04 July 2024

DOI: https://doi.org/10.1038/s41587-024-02284-2

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