* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Sunday, July 6, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Magicians and Battlebots light up Las Vegas entertainment scene – KSNV

    Magicians and Battlebots Take Las Vegas Entertainment by Storm

    Max-Matching Entertainments & Longhua District form partnership for new entertainment complex – Blooloop

    Max-Matching Entertainments and Longhua District Unite to Launch Thrilling New Entertainment Complex

    Kennedy Publishing, MGA Entertainment Launch Yummiland Magazine – License Global

    Kennedy Publishing, MGA Entertainment Launch Yummiland Magazine – License Global

    MAY HER SOUL REST IN PEACE 🙏 Veteran entertainment columnist and talent manager Lolit Solis has passed away. She was 78 years old. https://tinyurl.com/6kumarkx | LatestChika.com – Facebook

    Beloved Entertainment Icon Lolit Solis Passes Away at 78 – A Life Remembered with Love and Respect 🙏

    Neil Young Plays Rare Full-Band ‘Ambulance Blues’ With The Chrome Hearts – Yahoo

    Neil Young Stuns Fans with Rare Full-Band Performance of ‘Ambulance Blues’ Alongside The Chrome Hearts

    BTS Announce Their Big Return and Yes, They Already Have Some Major Plans in the Works – Yahoo

    BTS Announce Their Big Return and Yes, They Already Have Some Major Plans in the Works – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Column: Teach kupuna new technology skills – Honolulu Star-Advertiser

    Empowering Kupuna: Unlocking New Technology Skills for a Connected Future

    EIFO invests $5 million in D3, the Ukraine-focused defence technology venture fund – sUAS News

    EIFO Pledges $5 Million to Supercharge Ukraine-Focused Defense Technology Fund

    New Technology for Water Efficiency and Working with Mexico on Screwworm – AG INFORMATION NETWORK OF THE WEST

    Revolutionary Water Efficiency Technology and Cross-Border Collaboration to Defeat Screwworm

    Environmental cognitive distance, R&D capability distance, and supply chain green technology innovation – Nature

    Bridging Gaps: How Environmental and R&D Differences Drive Green Technology Innovation in Supply Chains

    LG Innotek CEO Moon Hyuksoo: “Our Next-gen Substrate Technology Will Change the Industry Paradigm” – TechPowerUp

    LG Innotek CEO Moon Hyuksoo: “Our Next-Gen Substrate Technology Will Revolutionize the Industry” Revolutionizing the Future: LG Innotek’s CEO Unveils Game-Changing Next-Gen Substrate Technology

    Inspira Technologies Secures Landmark $22.5M Deal: Major Revenue Breakthrough After FDA Clearance – Stock Titan

    Inspira Technologies Secures Landmark $22.5M Deal: Major Revenue Breakthrough After FDA Clearance – Stock Titan

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Magicians and Battlebots light up Las Vegas entertainment scene – KSNV

    Magicians and Battlebots Take Las Vegas Entertainment by Storm

    Max-Matching Entertainments & Longhua District form partnership for new entertainment complex – Blooloop

    Max-Matching Entertainments and Longhua District Unite to Launch Thrilling New Entertainment Complex

    Kennedy Publishing, MGA Entertainment Launch Yummiland Magazine – License Global

    Kennedy Publishing, MGA Entertainment Launch Yummiland Magazine – License Global

    MAY HER SOUL REST IN PEACE 🙏 Veteran entertainment columnist and talent manager Lolit Solis has passed away. She was 78 years old. https://tinyurl.com/6kumarkx | LatestChika.com – Facebook

    Beloved Entertainment Icon Lolit Solis Passes Away at 78 – A Life Remembered with Love and Respect 🙏

    Neil Young Plays Rare Full-Band ‘Ambulance Blues’ With The Chrome Hearts – Yahoo

    Neil Young Stuns Fans with Rare Full-Band Performance of ‘Ambulance Blues’ Alongside The Chrome Hearts

    BTS Announce Their Big Return and Yes, They Already Have Some Major Plans in the Works – Yahoo

    BTS Announce Their Big Return and Yes, They Already Have Some Major Plans in the Works – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Column: Teach kupuna new technology skills – Honolulu Star-Advertiser

    Empowering Kupuna: Unlocking New Technology Skills for a Connected Future

    EIFO invests $5 million in D3, the Ukraine-focused defence technology venture fund – sUAS News

    EIFO Pledges $5 Million to Supercharge Ukraine-Focused Defense Technology Fund

    New Technology for Water Efficiency and Working with Mexico on Screwworm – AG INFORMATION NETWORK OF THE WEST

    Revolutionary Water Efficiency Technology and Cross-Border Collaboration to Defeat Screwworm

    Environmental cognitive distance, R&D capability distance, and supply chain green technology innovation – Nature

    Bridging Gaps: How Environmental and R&D Differences Drive Green Technology Innovation in Supply Chains

    LG Innotek CEO Moon Hyuksoo: “Our Next-gen Substrate Technology Will Change the Industry Paradigm” – TechPowerUp

    LG Innotek CEO Moon Hyuksoo: “Our Next-Gen Substrate Technology Will Revolutionize the Industry” Revolutionizing the Future: LG Innotek’s CEO Unveils Game-Changing Next-Gen Substrate Technology

    Inspira Technologies Secures Landmark $22.5M Deal: Major Revenue Breakthrough After FDA Clearance – Stock Titan

    Inspira Technologies Secures Landmark $22.5M Deal: Major Revenue Breakthrough After FDA Clearance – Stock Titan

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

Exosome formulation developed to deliver antibodies for choroidal neovascularization therapy

September 17, 2023
in Science
Exosome formulation developed to deliver antibodies for choroidal neovascularization therapy
Share on FacebookShare on Twitter

Regulatory T-cell exosome-based formulation to deliver VEGF antibodies for synergistic therapy in CNV mouse model

image: Regulatory T-cell exosome-based formulation to deliver VEGF antibodies for synergistic therapy in CNV mouse model
view more 

Credit: TIAN Ying and ZHANG Fan

Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences, Beijing Chaoyang Hospital and the University of Queensland have developed a new formulation based on regulatory T-cell exosomes (rEXS) to deliver vascular endothelial growth factor (VEGF) antibodies for choroidal neovascularization therapy.

The study was published in Nature Biomedical Engineering on July 26.

Ocular neovascularization is often associated with age-related macular degeneration, diabetic retinopathy and other ocular diseases, which can cause severe vision loss.

The present treatment for ocular neovascular disease in clinic is intravitreal injection of VEGF antibodies (aV) to block the activity of VEGF and suppress pathogenic angiogenesis. However, this therapy alone faces problems of fast metabolism with the aqueous humor, poor accumulation in lesions and limited efficacy. A considerable proportion of patients still show incomplete response to above aV treatment.

In this study, the researchers collected aqueous humor samples from a large cohort of patients and quantified VEGF and other proinflammatory cytokines. “We observed a strong association between inflammation and high VEGF expression in aqueous humor samples,” said Prof. TAO Yong from Beijing Chaoyang Hospital. Thus, they proposed a synergistic therapeutic approach that combines anti-VEGF and anti-inflammatory therapies.

Following this approach, exosomes isolated from regulatory T-cells were utilized to conjugate aV using a peptide linker (cL), which was subject to cleavage by matrix metalloproteinases (MMPs) in inflammatory lesions. “This design concept could achieve efficient spatiotemporal delivery for combination therapy. After intravitreal injection, rEXS-cL-aV exploited the ability of rEXS to localize in neovascularization lesions and, upon MMP-mediated cleavage, released rEXS and aV to suppress inflammation and VEGF activity, respectively,” said Prof. WEI Wei from IPE.

The potent therapeutic efficacies were confirmed in both murine and nonhuman primate models of choroidal neovascularization. “This study is still at the preclinical stage. Given that rEXS can be produced from the patients’ own cells and aV has been approved for clinical use, our rEXS-cL-aV has the potential for translation to clinic,” said Prof. YU Di from the University of Queensland.

A peer reviewer from Nature Biomedical Engineering said, “The technology is novel and the treatment efficacy is impressive.” The reviewer also emphasized that “collectively, the work provides a substantial technological and potentially therapeutic advance for the treatment of neovascular disease.”

###

Journal

Nature Biomedical Engineering

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : EurekAlert – https://www.eurekalert.org/pub_releases/2021-07/caos-efd072321.php

Tags: ExosomeFormulationscience
Previous Post

Islet transplantation boosts long-term survival in kidney transplant recipients with type 1 diabetes

Next Post

Turn Your Shower Into a Spa with These Zero Waste Eucalyptus Discs

Column: Teach kupuna new technology skills – Honolulu Star-Advertiser

Empowering Kupuna: Unlocking New Technology Skills for a Connected Future

July 6, 2025
Ben Shelton’s sister booed by Wimbledon crowd when job revealed – Yahoo Sports

Wimbledon Crowd Booes Ben Shelton’s Sister Following Shocking Job Reveal

July 6, 2025
New book digs into Indigenous cuisine through archaeology, culture, ecology – Gander Newsroom

Unveiling Indigenous Cuisine: Exploring the Rich Tapestry of Archaeology, Culture, and Ecology

July 6, 2025
BANG! James Webb telescope catches stray galaxies in the Bullet Cluster: Space photo of the week – Live Science

BANG! James Webb Telescope Unveils Breathtaking Image of Stray Galaxies in the Bullet Cluster

July 6, 2025
How Do You Teach Computer Science in the A.I. Era? – The New York Times

Unlocking Success: Mastering Computer Science Education in the Age of A.I

July 6, 2025
If you want to be younger looking in 60 days, start practicing these 8 daily habits – VegOut

If you want to be younger looking in 60 days, start practicing these 8 daily habits – VegOut

July 6, 2025
Real Madrid vs Borussia Dortmund 3-2: FIFA Club World Cup – as it happened – Al Jazeera

Real Madrid vs Borussia Dortmund 3-2: FIFA Club World Cup – as it happened – Al Jazeera

July 6, 2025

Israel’s economy can’t survive a long war with Iran – and Trump knows it – Middle East Eye

July 6, 2025
The long-term health risks as extreme heat becomes a new normal – PBS

Uncovering the Silent, Long-Term Health Risks of Life in Extreme Heat

July 6, 2025
Trump Says He Will Start Talks With China on TikTok Deal – The New York Times

Trump Says He Will Start Talks With China on TikTok Deal – The New York Times

July 6, 2025

Categories

Archives

July 2025
MTWTFSS
 123456
78910111213
14151617181920
21222324252627
28293031 
« Jun    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (707)
  • Economy (732)
  • Entertainment (21,621)
  • General (15,741)
  • Health (9,770)
  • Lifestyle (737)
  • News (22,149)
  • People (733)
  • Politics (741)
  • Science (15,949)
  • Sports (21,232)
  • Technology (15,717)
  • World (713)

Recent News

Column: Teach kupuna new technology skills – Honolulu Star-Advertiser

Empowering Kupuna: Unlocking New Technology Skills for a Connected Future

July 6, 2025
Ben Shelton’s sister booed by Wimbledon crowd when job revealed – Yahoo Sports

Wimbledon Crowd Booes Ben Shelton’s Sister Following Shocking Job Reveal

July 6, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version