Thousands of cellular mRNAs contain the methyl modification m6A, which plays critical roles in mRNA processing and gene expression. We developed GEMS, a genetically encoded m6A sensor that provides a simple readout for m6A methylation in living cells and offers a platform for achieving m6A-coupled effector protein expression.
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Fig. 1: Schematic of the GEMS system for sensing cellular m6A.
References
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This is a summary of: Marayati, B. F., Thompson, M. G., Holley, C. L., Horner, S. M. & Meyer, K. D. Programmable protein expression using a genetically encoded m6A sensor. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01978-3 (2024).
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GEMS enables mRNA m6A methylation sensing in living cells and m6A-coupled protein delivery.
Nat Biotechnol (2024). https://doi.org/10.1038/s41587-023-01997-0
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Published: 02 January 2024
DOI: https://doi.org/10.1038/s41587-023-01997-0
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