* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Friday, May 9, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Georgia Entertainment CEO says large-scale production is slowing down – Decaturish

    Georgia Entertainment CEO Warns of Slowdown in Large-Scale Productions

    Zugalu Entertainment Welcomes Crimson Herring Studios to Its Family!

    Fall 2025 TV Schedule: Your Guide to the Complete Lineup – Wyoming News Now

    Get Ready for Fall 2025: Your Ultimate Guide to the Exciting TV Lineup!

    Blackstone River Theatre presents music from Scotland with Cantrip – The Valley Breeze

    Experience the Enchanting Sounds of Scotland: Cantrip Takes the Stage at Blackstone River Theatre!

    The viral wireless audio dongle for in-flight entertainment just got a big upgrade – and I love it – ZDNET

    Game-Changer for In-Flight Entertainment: The Upgraded Wireless Audio Dongle You’ll Love!

    Tahoe City Downtown Association opens 4th of July Entertainment Grant Program – Sierra Sun

    Celebrate Independence Day: Tahoe City Launches Exciting 4th of July Entertainment Grant Program!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Technology Innovation to Take Center Stage at The 2025 National Restaurant Association Show – Restaurant Technology News

    Get Ready for a Tech Revolution: The 2025 National Restaurant Association Show Unveils Cutting-Edge Innovations!

    Newmont signs deal to use Chrysos Corporation technology – Capital Brief

    Newmont Partners with Chrysos Corporation to Revolutionize Mining Technology

    Air Force Invests in Whisper’s Ultraquiet Propulsion Technology – FLYING Magazine

    Air Force Invests in Whisper’s Ultraquiet Propulsion Technology – FLYING Magazine

    Trump administration set to overhaul Biden’s AI chip export regulations – TechHQ

    Trump administration set to overhaul Biden’s AI chip export regulations – TechHQ

    Technology is the key to empathy in insurance – InsuranceNewsNet

    Unlocking Empathy: How Technology is Transforming the Insurance Experience

    Technology – Inflexion

    Revolutionizing the Future: The Impact of Cutting-Edge Technology

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Georgia Entertainment CEO says large-scale production is slowing down – Decaturish

    Georgia Entertainment CEO Warns of Slowdown in Large-Scale Productions

    Zugalu Entertainment Welcomes Crimson Herring Studios to Its Family!

    Fall 2025 TV Schedule: Your Guide to the Complete Lineup – Wyoming News Now

    Get Ready for Fall 2025: Your Ultimate Guide to the Exciting TV Lineup!

    Blackstone River Theatre presents music from Scotland with Cantrip – The Valley Breeze

    Experience the Enchanting Sounds of Scotland: Cantrip Takes the Stage at Blackstone River Theatre!

    The viral wireless audio dongle for in-flight entertainment just got a big upgrade – and I love it – ZDNET

    Game-Changer for In-Flight Entertainment: The Upgraded Wireless Audio Dongle You’ll Love!

    Tahoe City Downtown Association opens 4th of July Entertainment Grant Program – Sierra Sun

    Celebrate Independence Day: Tahoe City Launches Exciting 4th of July Entertainment Grant Program!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Technology Innovation to Take Center Stage at The 2025 National Restaurant Association Show – Restaurant Technology News

    Get Ready for a Tech Revolution: The 2025 National Restaurant Association Show Unveils Cutting-Edge Innovations!

    Newmont signs deal to use Chrysos Corporation technology – Capital Brief

    Newmont Partners with Chrysos Corporation to Revolutionize Mining Technology

    Air Force Invests in Whisper’s Ultraquiet Propulsion Technology – FLYING Magazine

    Air Force Invests in Whisper’s Ultraquiet Propulsion Technology – FLYING Magazine

    Trump administration set to overhaul Biden’s AI chip export regulations – TechHQ

    Trump administration set to overhaul Biden’s AI chip export regulations – TechHQ

    Technology is the key to empathy in insurance – InsuranceNewsNet

    Unlocking Empathy: How Technology is Transforming the Insurance Experience

    Technology – Inflexion

    Revolutionizing the Future: The Impact of Cutting-Edge Technology

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

How E. coli get the power to cause urinary tract infections

May 6, 2024
in Science
How E. coli get the power to cause urinary tract infections
Share on FacebookShare on Twitter

Through a quirk of anatomy, women are especially prone to urinary tract infections, with almost half dealing with one at some point in their lives.

Scientists have been trying to figure out for decades how bacteria gain a foothold in otherwise healthy people, examining everything from how the microbes move inside and stick to the inside of the bladder to how they deploy their toxins to produce uncomfortable and often painful symptoms.

Research published in PNAS examines how the bacteria Escherichia coli, or E. coli — responsible for most UTIs — is able to use host nutrients to reproduce at an extraordinarily rapid pace during infection despite the near sterile environment of fresh urine.

Investigators working in the lab of Harry Mobley, Ph.D., at the University of Michigan Medical School began by looking at mutant strains that weren’t as good at replicating in mouse models to identify bacterial genes that may be important for establishing infection.

Doing so, they identified a group of genes controlling transport systems as critical.

“When bacteria need something to grow, say an amino acid, they can get it in two ways,” explained Mobley, who is the Frederick G. Novy Distinguishes Professor of Microbiology and Immunology.

“They can make it itself, or they can steal it from their host using what we call a transport system.”

Their previous gene expression screen revealed that nearly 25% of bacterial genes were dedicated to replication tactics including transport systems for specific amino acids, which E. coli use to bring in thousands of molecules per second, said Mobley.

First author Allyson Shea, Ph.D., a former member of Mobley’s lab and now assistant professor of Microbiology and Immunology at the University of South Alabama, cross referenced a library of transport proteins from E. coli against other species of UTI pathogens to see which were important for infection. She discovered that a type of transporter called ABC (for ATP-binding cassette) transporters appeared to be critical.

Then using organ agar made from the mouse urinary tract, she confirmed that ABC transporters were essential for infection. Many bacteria strains lacking these nutrient import systems were defective for growth on bladder and kidney organ agar.

“It appears bacteria make an investment into these energy expensive ATP transport systems in order to have a higher affinity for the energy sources they are interested in,” said Shea.

“These systems are very, very good at getting nutrients inside the cell.”

The findings, Mobley notes, open avenues for the development of new therapeutics — which is especially important in an era of increasing antibiotic resistance.

“If you inhibit these transport systems, maybe you can inhibit the rapid growth of these bacteria,” he said.

Doing so won’t be easy, notes Shea, as bacteria have evolved multiple backups systems for this important class of transporters.

“What’s nice about this ATP-binding family is they all have an ATP binding subunit which gives the transport system the energy it needs to get nutrients across the cell membrane.”

This subunit could potentially be a target to make the entire family of transporters dysfunctional.

While this wouldn’t necessarily replace antibiotics, she says, it could slow down growth so that antibiotics and the host immune system could do a better job at stopping the bugs.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Science Daily – https://www.sciencedaily.com/releases/2024/05/240503135316.htm

Tags: PowerscienceUrinary
Previous Post

Ditch the Heavy Cream and Make This Dairy-Free Vodka Sauce

Next Post

Tweaking isotopes sheds light on promising approach to engineer semiconductors

Cash Flows: Industry, Ecology, and the Future of the Great Lakes Blue Economy – Michigan Public

Cash Flows: Industry, Ecology, and the Future of the Great Lakes Blue Economy – Michigan Public

May 9, 2025
Under Trump, job prospects look ‘bleak’ for Mass. grads in environmental science – WBUR

Massachusetts Environmental Science Graduates Face Gloomy Job Prospects Under Trump Administration

May 9, 2025
A Leaked Memo Reveals Details About Trump’s War on Science at the NIH – Mother Jones

Inside the Leaked Memo: Uncovering Trump’s Battle Against Science at the NIH

May 9, 2025
Hyatt Lifestyle Group opens inaugural property in Florida – Hotel Dive

Hyatt Lifestyle Group Unveils Its First Florida Gem!

May 9, 2025
2025 IIHF World Championships Begin for Danault, Chromiak, Slukynsky – LA Kings Insider

Exciting Kickoff: Danault, Chromiak, and Slukynsky Take Center Stage at the 2025 IIHF World Championships!

May 9, 2025
US Farm Economy Is Starting to See First Hits From Trump Tariffs – Bloomberg.com

US Farm Economy Faces Initial Impact from Trump Tariffs

May 9, 2025
Georgia Entertainment CEO says large-scale production is slowing down – Decaturish

Georgia Entertainment CEO Warns of Slowdown in Large-Scale Productions

May 9, 2025
Georgia first responders unite for mental health conference to combat trauma – FOX 5 Atlanta

Georgia First Responders Join Forces for Groundbreaking Mental Health Conference to Tackle Trauma

May 9, 2025
Upcoming changes at CIA shine a spotlight on the spy agency’s director John Ratcliffe – CNN

Transformative Shifts at the CIA: Spotlight on Director John Ratcliffe

May 9, 2025
Technology Innovation to Take Center Stage at The 2025 National Restaurant Association Show – Restaurant Technology News

Get Ready for a Tech Revolution: The 2025 National Restaurant Association Show Unveils Cutting-Edge Innovations!

May 9, 2025

Categories

Archives

May 2025
MTWTFSS
 1234
567891011
12131415161718
19202122232425
262728293031 
« Apr    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (595)
  • Economy (606)
  • Entertainment (21,519)
  • General (15,210)
  • Health (9,648)
  • Lifestyle (611)
  • News (22,149)
  • People (609)
  • Politics (613)
  • Science (15,828)
  • Sports (21,116)
  • Technology (15,596)
  • World (596)

Recent News

Cash Flows: Industry, Ecology, and the Future of the Great Lakes Blue Economy – Michigan Public

Cash Flows: Industry, Ecology, and the Future of the Great Lakes Blue Economy – Michigan Public

May 9, 2025
Under Trump, job prospects look ‘bleak’ for Mass. grads in environmental science – WBUR

Massachusetts Environmental Science Graduates Face Gloomy Job Prospects Under Trump Administration

May 9, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version