* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Wednesday, June 4, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    California Mid-State Fair announces entertainment lineups for Frontier and Mission stages – KSBY News

    Exciting Entertainment Lineup Unveiled for California Mid-State Fair’s Frontier and Mission Stages!

    Spotify & OpenAI: Will Gen AI ‘Hollow Out’ Entertainment? – Technology Magazine

    Will Generative AI Transform the Future of Entertainment

    Author Richard Russo Will Speak At Sandwich Town Hall – CapeNews.net

    Join Us for an Inspiring Evening with Author Richard Russo at Sandwich Town Hall!

    Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

    Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

    Salem’s Harborwalk Garden Cultivates Community with Entertainment, Food, and Events – 105.7 WROR

    Discover the Vibrant Community Spirit at Salem’s Harborwalk Garden: A Hub for Entertainment, Food, and Fun!

    Entertainment-Focused Narrative and Culture Change Practice – New America

    Transforming Culture Through Engaging Entertainment Narratives

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    When fiction becomes fact: 3 pieces of modern technology inspired by Star Trek – Redshirts Always Die

    From Screen to Reality: 3 Modern Technologies Inspired by Star Trek

    The Isfahan Center for Nuclear Technology – UCF, ZPP, and IRR10 – Alma Research and Education Center

    Exploring the Isfahan Center for Nuclear Technology: Innovations and Insights from UCF, ZPP, and IRR10

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Finland Set to Lead EU Quantum Technology Defense Project – IoT World Today

    Finland Set to Lead EU Quantum Technology Defense Project – IoT World Today

    AI for lawyers: Win back your time using technology – nationaljurist.com

    Reclaim Your Time: How AI is Transforming the Legal Profession

    Prosecutors accuse men of exporting U.S. military technology to China – Milwaukee Journal Sentinel

    Men Charged with Illegally Exporting U.S. Military Technology to China

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    California Mid-State Fair announces entertainment lineups for Frontier and Mission stages – KSBY News

    Exciting Entertainment Lineup Unveiled for California Mid-State Fair’s Frontier and Mission Stages!

    Spotify & OpenAI: Will Gen AI ‘Hollow Out’ Entertainment? – Technology Magazine

    Will Generative AI Transform the Future of Entertainment

    Author Richard Russo Will Speak At Sandwich Town Hall – CapeNews.net

    Join Us for an Inspiring Evening with Author Richard Russo at Sandwich Town Hall!

    Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

    Entertainment Partners Acquires CASHét, Digital Payments Vendor for Productions – Variety

    Salem’s Harborwalk Garden Cultivates Community with Entertainment, Food, and Events – 105.7 WROR

    Discover the Vibrant Community Spirit at Salem’s Harborwalk Garden: A Hub for Entertainment, Food, and Fun!

    Entertainment-Focused Narrative and Culture Change Practice – New America

    Transforming Culture Through Engaging Entertainment Narratives

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    When fiction becomes fact: 3 pieces of modern technology inspired by Star Trek – Redshirts Always Die

    From Screen to Reality: 3 Modern Technologies Inspired by Star Trek

    The Isfahan Center for Nuclear Technology – UCF, ZPP, and IRR10 – Alma Research and Education Center

    Exploring the Isfahan Center for Nuclear Technology: Innovations and Insights from UCF, ZPP, and IRR10

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Inside the tedious effort to tally AI’s energy appetite – MIT Technology Review

    Finland Set to Lead EU Quantum Technology Defense Project – IoT World Today

    Finland Set to Lead EU Quantum Technology Defense Project – IoT World Today

    AI for lawyers: Win back your time using technology – nationaljurist.com

    Reclaim Your Time: How AI is Transforming the Legal Profession

    Prosecutors accuse men of exporting U.S. military technology to China – Milwaukee Journal Sentinel

    Men Charged with Illegally Exporting U.S. Military Technology to China

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

How ‘Idle’ Egg Cells Defend Their DNA From Damage

May 14, 2024
in Science
How ‘Idle’ Egg Cells Defend Their DNA From Damage
Share on FacebookShare on Twitter

Having lots of mitochondria is normally risky for cells because their chemical activity generates toxic byproducts known as free radicals. But when Böke peered inside dormant human and frog oocytes, they weren’t overloaded with free radicals at all. As she reported in a Nature paper published in 2022, the oocytes’ mitochondria were doing something surprising: They were skipping the step in their energy-generating process that produces these dangerous molecules. This meant that they produced less energy overall; Böke speculated that they direct all the energy they do produce for growth. No other cell had been observed to do this.

“Oocytes are crazy,” said David Pépin, associate director of the pediatric surgical research labs at Massachusetts General Hospital. “They have more mitochondria than any other cell, and those mitochondria are weird.”

The perils for long-lived cells go beyond free radicals. Scientists have seen how energy production and growth generate many proteins, including clumps of misfolded and damaged ones. To clear this harmful detritus, neurons, which like oocytes are long-lasting cells that don’t divide, rely on biochemical pathways that refold and degrade bungled proteins. When this machinery fails, protein aggregates can devastate entire neural networks, snuffing out communication and leading to neurodegenerative diseases like Alzheimer’s, Parkinson’s, Huntington’s and ALS.

After Böke published her 2022 research on free radicals, she wondered how oocytes tamp down problematic proteins. She dug through thousands of papers but couldn’t find any studies characterizing how oocytes cope. So, she looked to mouse oocytes to find the answer.

Because oocytes expand so massively and produce proteins so intensively during their growth period, Böke expected to see high protein activity in the two major pathways responsible for clearing aggregates. Instead, she saw less activity in immature oocytes than in mature egg cells.

“It doesn’t make much sense,” she said. “Why would you put your degradative activity down if you’re going to grow and make lots of things?”

It was because the oocytes weren’t degrading the damaging proteins — they were storing them to destroy later.

When Böke and her team infused oocytes with a dye that illuminates protein aggregates, she saw the proteins clustered in large compartments. Probing further, she used electron microscopy to reveal these distinct storage units as super-organelles, which she named ELVAs, or endolysosomal vesicular assemblies. These pouchlike objects are composed of lysosomes — the cell’s waste-disposal organelles — and other protein-degrading machinery.

In young oocytes, they are situated throughout the cytoplasm. Later, as oocytes mature, ELVAs fuse together, relocate and ramp up their degradative machinery. By the time an oocyte is fully mature, harmful protein aggregates are undetectable, and the ELVAs vanish, revealing a clean cytoplasm.

It’s possible that other long-lived, nondividing cells have similar machinery that uses this catch-and-release strategy for disposing of cellular waste. For example, researchers have found that some long-lived stem cells also have ELVA-like components, which capture and store aggregates until the cells are ready to divide. Neurons, too, can develop triage centers, called aggresomes, for organizing misfolded proteins. However, neurons destroy their cellular detritus throughout their life spans, while oocytes store them and then wipe them out all at once. Böke speculated that the oocytes’ method is more energy-efficient: Since their mitochondria produce less energy overall, they need all of it for necessary growth to reach reproductive maturity.

Böke’s findings offer new details and a fresh perspective on the biology of oocytes. They also suggest new approaches to fertility research. Clinical research has shown that older people are less likely to get pregnant than younger ones. The standard explanation is that their eggs may be “too old” for pregnancy. But what if an old egg is simply one that has accumulated too many misfolded proteins?

Böke’s lab is currently collaborating with fertility clinics to look at protein aggregates in human oocytes. She suspects that elements related to oocyte growth and quality control, such as mitochondria and protein aggregation, may account for some unexplained infertility cases. “A broken system gives errors in many different ways,” she said. The key to identifying those errors, and addressing them, will likely come from research, like Böke’s, that seeks to understand fundamentally how oocytes work.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Quanta Magazine – https://www.quantamagazine.org/how-idle-egg-cells-defend-their-dna-from-damage-20240513/

Tags: Cells‎Idlescience
Previous Post

Asia shares hit 15-month high as traders wait for CPI

Next Post

Where to Find Lightsabers in Lego Fortnite

Ecological crisis in Brazil’s Pantanal fuels human-jaguar conflict – Mongabay

Rising Tensions: How Brazil’s Pantanal Ecological Crisis is Igniting Human-Jaguar Conflicts

June 4, 2025
Why you’re catching the ‘ick’ so easily, according to science – Fast Company

Unpacking the ‘Ick’: The Science Behind Why We Fall Out of Attraction So Easily

June 4, 2025
Science Perspectives to Inform the ICJ Advisory Opinion on Climate Change – SDG Knowledge Hub

Science Perspectives to Inform the ICJ Advisory Opinion on Climate Change – SDG Knowledge Hub

June 4, 2025
My company transferred me from Chicago to London. Here’s how my lifestyle and the work culture compare. – Business Insider

My company transferred me from Chicago to London. Here’s how my lifestyle and the work culture compare. – Business Insider

June 4, 2025
Nvidia reclaims crown as world’s most valuable company as $1 trillion rally continues – Yahoo Finance

Nvidia reclaims crown as world’s most valuable company as $1 trillion rally continues – Yahoo Finance

June 4, 2025
Americans Are Worried About These 3 Aspects of the Economy — Should They Be? – MSN

Are Americans Right to Worry? Unpacking 3 Key Economic Concerns

June 4, 2025
California Mid-State Fair announces entertainment lineups for Frontier and Mission stages – KSBY News

Exciting Entertainment Lineup Unveiled for California Mid-State Fair’s Frontier and Mission Stages!

June 4, 2025
Altera Digital Health Collaborates With MCAG Amid $2.8B Blue Cross Blue Shield Provider Settlement – Business Wire

Altera Digital Health Teams Up with MCAG Following Major $2.8B Blue Cross Blue Shield Settlement

June 4, 2025
Appeals court upholds New York’s Reproductive Health Act – Spectrum News

Victory for Women’s Rights: Appeals Court Affirms New York’s Reproductive Health Act

June 4, 2025
When fiction becomes fact: 3 pieces of modern technology inspired by Star Trek – Redshirts Always Die

From Screen to Reality: 3 Modern Technologies Inspired by Star Trek

June 4, 2025

Categories

Archives

June 2025
MTWTFSS
 1
2345678
9101112131415
16171819202122
23242526272829
30 
« May    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (666)
  • Economy (680)
  • Entertainment (21,586)
  • General (15,261)
  • Health (9,722)
  • Lifestyle (683)
  • News (22,149)
  • People (681)
  • Politics (689)
  • Science (15,900)
  • Sports (21,184)
  • Technology (15,666)
  • World (667)

Recent News

Ecological crisis in Brazil’s Pantanal fuels human-jaguar conflict – Mongabay

Rising Tensions: How Brazil’s Pantanal Ecological Crisis is Igniting Human-Jaguar Conflicts

June 4, 2025
Why you’re catching the ‘ick’ so easily, according to science – Fast Company

Unpacking the ‘Ick’: The Science Behind Why We Fall Out of Attraction So Easily

June 4, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version