* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Monday, October 6, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Charlie Hunnam Reflects on Playing a Serial Killer in Monster: The Ed Gein Story – Yahoo

    Charlie Hunnam Reveals the Dark Challenges of Playing a Serial Killer in Monster: The Ed Gein Story

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    Why Taylor Swift Name-Dropped Elizabeth Taylor in Her New Album – Yahoo

    Here’s Why Taylor Swift Dropped Elizabeth Taylor’s Name in Her New Album

    Al Roker Gives Olivia Dean an Unexpected ‘New Job’ on the ‘Today’ Show – Yahoo

    Al Roker Shocks Olivia Dean with an Exciting New Role on the ‘Today’ Show

    Books about the arts and some haunts for a Denton October – Denton Record-Chronicle

    Uncover Artistic Treasures and Spooky Adventures to Experience in Denton This October

    Taylor Swift Releases New Album The Life of a Showgirl : Listen and Read the Full Credits – Yahoo

    Taylor Swift Releases New Album The Life of a Showgirl : Listen and Read the Full Credits – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Forget Cowbells. Cows Wear High-Tech Collars Now. – The New York Times

    Ditch the Cowbells: Discover the High-Tech Collars Transforming Cattle Care

    What the Recent Price Surge Means for Figure Technology Solutions After SEC Settlement – Yahoo Finance

    What the Recent Price Surge Reveals About Figure Technology Solutions Following SEC Settlement

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    A Tech Expo Shows What China Can Make, but Not Who’ll Buy It All – The New York Times

    Inside China’s Tech Expo: Cutting-Edge Innovations Face Uncertain Demand

    Steampunk Metal Oval Technology Sense Sunglasses Personality Handmade Chain Multicolor Sunglasses UV400 – The San Joaquin Valley Sun

    Steampunk Metal Oval Sunglasses with Handmade Multicolor Chain – Bold UV400 Protection and Unique Style

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Charlie Hunnam Reflects on Playing a Serial Killer in Monster: The Ed Gein Story – Yahoo

    Charlie Hunnam Reveals the Dark Challenges of Playing a Serial Killer in Monster: The Ed Gein Story

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    “Reba” cast, then and now: See the stars 24 years later (and who’s reunited for another show) – Yahoo

    Why Taylor Swift Name-Dropped Elizabeth Taylor in Her New Album – Yahoo

    Here’s Why Taylor Swift Dropped Elizabeth Taylor’s Name in Her New Album

    Al Roker Gives Olivia Dean an Unexpected ‘New Job’ on the ‘Today’ Show – Yahoo

    Al Roker Shocks Olivia Dean with an Exciting New Role on the ‘Today’ Show

    Books about the arts and some haunts for a Denton October – Denton Record-Chronicle

    Uncover Artistic Treasures and Spooky Adventures to Experience in Denton This October

    Taylor Swift Releases New Album The Life of a Showgirl : Listen and Read the Full Credits – Yahoo

    Taylor Swift Releases New Album The Life of a Showgirl : Listen and Read the Full Credits – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Forget Cowbells. Cows Wear High-Tech Collars Now. – The New York Times

    Ditch the Cowbells: Discover the High-Tech Collars Transforming Cattle Care

    What the Recent Price Surge Means for Figure Technology Solutions After SEC Settlement – Yahoo Finance

    What the Recent Price Surge Reveals About Figure Technology Solutions Following SEC Settlement

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    MAC Brings iPad Technology to Football Sidelines Across All 13 Member Schools – Sports Video Group

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    Technology Is Becoming More Important Than Humans In CX – No Jitter

    A Tech Expo Shows What China Can Make, but Not Who’ll Buy It All – The New York Times

    Inside China’s Tech Expo: Cutting-Edge Innovations Face Uncertain Demand

    Steampunk Metal Oval Technology Sense Sunglasses Personality Handmade Chain Multicolor Sunglasses UV400 – The San Joaquin Valley Sun

    Steampunk Metal Oval Sunglasses with Handmade Multicolor Chain – Bold UV400 Protection and Unique Style

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

How Many Microbes Does It Take to Make You Sick?

September 28, 2023
in Science
How Many Microbes Does It Take to Make You Sick?
Share on FacebookShare on Twitter

For a pathogen to make us sick, it must overcome a lot. First it has to enter the body, bypassing natural barriers such as skin, mucus, cilia and stomach acid. Then it needs to reproduce; some bacteria and parasites can do this virtually anywhere in the body, while viruses and some other pathogens can only do so from within a cell. And all the while, it must parry attacks from the body’s immune system.

So while we are constantly inundated by microbes, the number of microbes that enter our bodies is usually too low to get past our defenses. (A tiny enough dose may even serve to remind our immune system of a pathogen’s existence, boosting our antibody response to keep us protected against it.)

When enough pathogens do manage to breach our defenses and start to replicate, we get sick. Often this is just a numbers game. The more invaders you’re fighting off, the more likely you are to feel ill.

How many microbes need to enter the body before we start to feel sick?

This varies by pathogen and is known as a microbe’s “infectious dose.” Usually it takes quite a few, but some microbes require an incredibly small number of organisms to start an infection. Take norovirus for example, the stomach bug notorious for spreading whenever people are in close contact and touch the same surfaces, such as on cruise ships. Its infectious dose can be as small as 18 individual viruses, making it incredibly easy to transmit. It is also very hardy even outside the body, so an infected person who’s oozing the virus may leave a large amount of it behind — enough to easily infect others, even several days later.

What about the concept of “viral load”? Is that related?

They’re similar ideas, but while infectious dose refers to how many organisms will lead to an infection, viral load is an active measurement of infection: the number of organisms that are replicating within the host. The terminology was first introduced to the general public as part of our understanding of HIV/AIDS, and it increased in use after the start of the Covid pandemic.

How do researchers figure out a microbe’s infectious dose?

That’s still an inexact science. The gold-standard study, called a human challenge study, involves purposely giving people a dose of the pathogen. Unfortunately, this approach is ethically difficult since it (obviously) carries a risk of serious illness and potential long-term complications.

So instead, researchers expose guinea pigs, rats, mice or ferrets, depending on the pathogen. But it can be difficult to directly extrapolate animal dosage to the human equivalent.

Additionally, the route of infection matters. Something that gets right into your bloodstream will likely require far fewer microbes to take hold than one that comes in through your mouth or lungs, for example, since the bloodstream allows the pathogen to bypass many host defenses. This is why, for example, the risk of HIV infection is much higher when it comes from a blood transfusion or needle stick versus a sexual route.

A third way of trying to figure out infectious dose is to use observational studies, where researchers deduce the number from seeing how long it takes for an exposed person (especially in families or other close-contact settings) to become sick. As you might suspect, this is often messy and inexact compared to the previous two methods.

Why are the infectious doses of some pathogens higher or lower than those of others?

We aren’t sure. It could be due to how an invader operates. Researchers have suggested that pathogens requiring direct contact with host cells tended to be more effective, so their infectious doses were fairly low. But if bacteria attack host cells indirectly (such as by secreting proteins that go on to harm host cells), then a larger dose of bacteria is necessary to infect the host, since the host-modifying secretions could be diluted by time and space. This idea was supported in a 2012 study that looked at viruses, fungi and parasites as well. But we still need additional confirmation for a wider variety of microbes.

What do we know about the infectious dose for the virus that causes Covid?

We’ve learned a lot in the nearly four years since it first appeared, but much of it comes from animal models of infection and human observational studies. Most animal models require a high dose of the virus — 10,000 to 1 million “plaque-forming units” (PFUs), where each unit is enough to infect a cell in tissue culture and kill it. Observational studies in humans, however, suggest that the infectious dose may be around 100 to 400 PFU on average, though again this method offers only a very rough guideline.

These studies suggest that one reason the virus is so easily transmissible is because it has a relatively low infectious dose, similar to other respiratory viruses such as RSV and “common cold” coronaviruses (and lower than the infectious dose of most strains of influenza virus).

And when we compare the infectious dose to the amount of virus exhaled by an infected individual, it’s not surprising that the virus spreads so quickly. A recent preprint shows that infected patients can exhale up to 800 viral RNA copies per minute for about eight days after their symptoms began. Even though we can’t directly translate RNA copies into the amount of live virus particles, if even half of those RNA copies are from a currently infectious virus, it’s theoretically possible to get a dose large enough to start an infection in just a minute of close contact.

Do vaccines raise the infectious dose?

When someone encounters a pathogen for the second time (whether because of a prior illness or vaccination), several host defenses spring into action. Antibodies generated from vaccination or prior infection will bind to the invading microbe. These will interfere with its ability to attach to a host cell, or single out the microbe for ingestion by cells called neutrophils. And if a virus does manage to invade a host cell, it will be targeted for destruction by memory T cells.

Due to this rapid response, fewer of the invading microbes survive compared to a naïve individual encountering the pathogen for the first time, which effectively raises infectious dose.

How can this knowledge help us avoid illnesses?

Exposure is a function of pathogen concentration and contact time, so if you can reduce either of those, you can better avoid infectious diseases.

This is why, from the start of the Covid pandemic, experts have recommended a “Swiss cheese” model of layered protection, with social distancing from other individuals playing a key role. The farther you are from an infectious person, the fewer of their viral particles you will be exposed to. Adding a mask, especially a high-quality respirator such as an N95 with a snug fit, will further reduce the number of viruses you could inhale. Ventilation also dilutes the number of viral particles in the air, hence why being outside or using an air filter indoors lessens your risk of infection.

Vaccination is another way to decrease your risk of Covid infection. Though the vaccines are imperfect, vaccination still reduces your risk of becoming infected in the first place, by increasing the infectious dose necessary to initiate an infection. It also reduces the chances of developing serious illness if you are infected. Several studies also suggest that vaccinated people are less likely to shed as many virus particles and that vaccination reduces viral load.

Masking, increased ventilation and distancing reduces the number of microbes you’re exposed to. Vaccination increases the infectious dose. These are the pillars of protection against infection from pretty much every pathogen. Transmission dynamics are complex, but the interventions we can take to protect ourselves are comparatively simple.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Quanta Magazine – https://www.quantamagazine.org/how-many-microbes-does-it-take-to-make-you-sick-20230927/

Tags: microbesscience
Previous Post

More than 70% of farmers have already seen large impacts of climate change on their farm, new global research across 8 countries reveals

Next Post

In the Milky Way’s Stars, a History of Violence

Air quality speed run – Washington State Department of Ecology (.gov)

Battling Pollution: Washington State’s Urgent Fight for Cleaner Air

October 6, 2025
Equity in science is a beautiful lie — and I’m done pretending – Nature

Equity in science is a beautiful lie — and I’m done pretending – Nature

October 6, 2025
Explore a bird database with 11,500 species – Popular Science

Explore an Incredible Bird Database Showcasing 11,500 Stunning Species

October 6, 2025
South Shore broker funded ‘extravagant lifestyle’ with $11.6 million taken from clients and colleagues, prosecutors say – Boston.com

South Shore broker funded ‘extravagant lifestyle’ with $11.6 million taken from clients and colleagues, prosecutors say – Boston.com

October 6, 2025
QRG Capital Management Inc. Purchases 9,519 Shares of Marvell Technology, Inc. $MRVL – MarketBeat

QRG Capital Management Takes Bold Step by Acquiring 9,519 Shares of Marvell Technology

October 6, 2025
Jaxson Dart, Cam Skattebo fumble away a Giant opportunity vs. Saints – Yahoo Sports

Jaxson Dart, Cam Skattebo fumble away a Giant opportunity vs. Saints – Yahoo Sports

October 6, 2025
‘The World Report’ of The Church of Jesus Christ of Latter-day Saints – KSL TV 5

Inside The World Report: Exploring the Impact of The Church of Jesus Christ of Latter-day Saints

October 6, 2025
Thai Airways Launches New Premium Economy on Flights From Most Visited City in the World – Aviation A2Z

Thai Airways Launches New Premium Economy on Flights From Most Visited City in the World – Aviation A2Z

October 6, 2025
Charlie Hunnam Reflects on Playing a Serial Killer in Monster: The Ed Gein Story – Yahoo

Charlie Hunnam Reveals the Dark Challenges of Playing a Serial Killer in Monster: The Ed Gein Story

October 6, 2025
Pre-rolls, education and industry optimism: Takeaways from Ohio Cannabis Health & Business Summit 2025 – Cleveland.com

Pre-rolls, Education, and Industry Optimism: Top Insights from the Ohio Cannabis Health & Business Summit 2025

October 6, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (854)
  • Economy (874)
  • Entertainment (21,748)
  • General (17,441)
  • Health (9,916)
  • Lifestyle (887)
  • News (22,149)
  • People (876)
  • Politics (885)
  • Science (16,085)
  • Sports (21,375)
  • Technology (15,855)
  • World (857)

Recent News

Air quality speed run – Washington State Department of Ecology (.gov)

Battling Pollution: Washington State’s Urgent Fight for Cleaner Air

October 6, 2025
Equity in science is a beautiful lie — and I’m done pretending – Nature

Equity in science is a beautiful lie — and I’m done pretending – Nature

October 6, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version