* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Sunday, August 3, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Sens. Blackburn, Warnock introduce CREATE Act to provide tax relief to music creators – Yahoo Home

    Sens. Blackburn and Warnock Launch CREATE Act to Deliver Tax Relief for Music Creators

    That’s (Political) Entertainment: When Theatre Meets Politics

    Future Script: How Generative AI Is Changing Collective Bargaining in the Entertainment Industry – Jackson Lewis

    Future Script: How Generative AI Is Transforming Collective Bargaining in Entertainment

    The SBA’s live-entertainment bailout was supposed to end two years ago. We still don’t know how $1.5 billion was spent. – Yahoo Home

    $1.5 Billion Live-Entertainment Bailout: Two Years Later, Where Did the Money Go?

    Wall Street Bets: Caesars, Golden Entertainment, Churchill Downs, GLPI, Boyd – CDC Gaming

    Top Wall Street Bets: Caesars, Golden Entertainment, Churchill Downs, GLPI, and Boyd Take Center Stage

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Livonia police use grappler technology to stop drunk driver – ClickOnDetroit | WDIV Local 4

    Livonia Police Deploy Grappler Technology to Safely Stop Drunk Driver

    Emory orthopaedic surgeons use robotic technology to transform knee replacement surgery – Emory News Center

    How Robotic Technology is Revolutionizing Knee Replacement Surgery

    Cognizant Technology Solutions Corp (CTSH) Q2 2025 Earnings Call Highlights: Strong Revenue … – Yahoo.co

    Cognizant Q2 2025 Earnings: Impressive Revenue Growth and Key Takeaways

    Revving Up The U.S. Technology Engine – Forbes

    Revving Up The U.S. Technology Engine – Forbes

    More than just a hockey player – Rochester Institute of Technology Athletics

    Beyond the Ice: The Inspiring Journey of a Remarkable Athlete from Rochester Institute of Technology

    Smart Logistics in Warehousing – From Legacy Protocols to Green IoT – How Technology Is Reshaping the Sustainable Supply Chain – Logistics Viewpoints –

    Smart Logistics in Warehousing – From Legacy Protocols to Green IoT – How Technology Is Reshaping the Sustainable Supply Chain – Logistics Viewpoints –

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Sens. Blackburn, Warnock introduce CREATE Act to provide tax relief to music creators – Yahoo Home

    Sens. Blackburn and Warnock Launch CREATE Act to Deliver Tax Relief for Music Creators

    That’s (Political) Entertainment: When Theatre Meets Politics

    Future Script: How Generative AI Is Changing Collective Bargaining in the Entertainment Industry – Jackson Lewis

    Future Script: How Generative AI Is Transforming Collective Bargaining in Entertainment

    The SBA’s live-entertainment bailout was supposed to end two years ago. We still don’t know how $1.5 billion was spent. – Yahoo Home

    $1.5 Billion Live-Entertainment Bailout: Two Years Later, Where Did the Money Go?

    Wall Street Bets: Caesars, Golden Entertainment, Churchill Downs, GLPI, Boyd – CDC Gaming

    Top Wall Street Bets: Caesars, Golden Entertainment, Churchill Downs, GLPI, and Boyd Take Center Stage

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Livonia police use grappler technology to stop drunk driver – ClickOnDetroit | WDIV Local 4

    Livonia Police Deploy Grappler Technology to Safely Stop Drunk Driver

    Emory orthopaedic surgeons use robotic technology to transform knee replacement surgery – Emory News Center

    How Robotic Technology is Revolutionizing Knee Replacement Surgery

    Cognizant Technology Solutions Corp (CTSH) Q2 2025 Earnings Call Highlights: Strong Revenue … – Yahoo.co

    Cognizant Q2 2025 Earnings: Impressive Revenue Growth and Key Takeaways

    Revving Up The U.S. Technology Engine – Forbes

    Revving Up The U.S. Technology Engine – Forbes

    More than just a hockey player – Rochester Institute of Technology Athletics

    Beyond the Ice: The Inspiring Journey of a Remarkable Athlete from Rochester Institute of Technology

    Smart Logistics in Warehousing – From Legacy Protocols to Green IoT – How Technology Is Reshaping the Sustainable Supply Chain – Logistics Viewpoints –

    Smart Logistics in Warehousing – From Legacy Protocols to Green IoT – How Technology Is Reshaping the Sustainable Supply Chain – Logistics Viewpoints –

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

Huntington’s Disease Breakthrough: Scientists Tame Deadly Biological Trigger

January 23, 2024
in Science
Huntington’s Disease Breakthrough: Scientists Tame Deadly Biological Trigger
Share on FacebookShare on Twitter

Glowing Brain Disease

Researchers at UC Riverside have advanced the treatment of Huntington’s disease by identifying the role of RNA methylation in its progression, offering potential for developing effective therapies for this and other neurodegenerative diseases. Credit: SciTechDaily.com

New treatments offer hope for other nervous system disorders, including ALS.

Huntington’s disease, characterized by involuntary movements and dementia, is currently incurable and ultimately fatal. However, scientists at UC Riverside have made a groundbreaking discovery. They have successfully slowed the progression of this disease in flies and worms, which marks a significant step toward developing treatments for humans.

Key to understanding these advancements is the way that genetic information in cells is converted from DNA into RNA, and then into proteins. DNA is composed of chemicals called nucleotides: adenine (A), thymine (T), guanine (G), and cytosine (C). The order of these nucleotides determines what biological instructions are contained in a strand of DNA.

On occasion, some DNA nucleotides repeat themselves, expanding the DNA strand. In Huntington’s disease, this expansion occurs with three nucleotides, cytosine-adenine-guanine, or CAG. Expansion into an extraordinary number of repeated CAG sequences of DNA is associated with earlier onset and increased severity of Huntington’s disease symptoms. Similar observations were made for a number of other neurodegenerative diseases.

When these DNA repeats are translated into RNA, there is an insidious side effect. The cell chemically modifies the extra RNA buildup. Wang and his collaborators learned that the modified RNA plays a crucial role in neurodegeneration.

Research Findings and Implications

“We are first to discover that a type of chemical modification, called methylation, occurs more frequently with extra repeats in RNA. Then we see abnormal distribution and buildup of a particular protein in cells,” said Yinsheng Wang, distinguished UCR professor of chemistry. “In other words, methylation converts an important cellular protein into waste.”

These findings parallel observations made for the same protein in brain tissues of Huntington’s disease, ALS, and frontotemporal dementia patients. Longer RNA repeats mean a higher modification rate, which generates more protein waste and exacerbates disease.

“Even healthy people have up to 34 CAG repeats on a particular gene, the HTT gene,” Wang said. “However, due to environmental or genetic causes, there might be as many as 100 CAG repeats in the cells of people with Huntington’s disease.”

Long, repetitive RNA sequences can turn into an excess of protein in cells, creating “cellular trash,” which has toxic effects.

A new Nature journal article details how RNA methylation on CAG repeats is implicated in the complex mechanism underlying Huntington’s disease. The article also explains how the researchers greatly reduced the progression of disease in worms and fruit flies and extended the lifespan of flies by introducing a protein into cells that removes methylation.

Potential for Therapy and Broader Impact

At present there is no way to cure or even slow the progression of Huntington’s disease. Healthcare providers typically offer medications to help with some symptoms. While this breakthrough is not a cure, it represents the possibility of an effective therapy where none currently exists.

The research team, which includes professors Weifeng Gu at UCR, X. William Yang at UCLA, and Nancy M. Bonini at the University of Pennsylvania, is now searching for small molecules that can inhibit methylation and form the basis of a Huntington’s therapy.

Because RNA repeats are present in similar diseases, like ALS and certain types of spinocerebellar ataxia, the door is open to treatments for these other fatal, degenerative diseases.

“We don’t think the mechanisms we studied are the only ones that contribute to Huntington’s,” Wang said. “However, we have shown that by targeting them we can reduce the disease in model organisms, which could lead to longer, better lives for those who suffer from this and potentially other diseases as well.”

Reference: “m1A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration” by Yuxiang Sun, Hui Dai, Xiaoxia Dai, Jiekai Yin, Yuxiang Cui, Xiaochuan Liu, Gwendolyn Gonzalez, Jun Yuan, Feng Tang, Nan Wang, Alexandra E. Perlegos, Nancy M. Bonini, X. William Yang, Weifeng Gu and Yinsheng Wang, 8 November 2023, Nature.
DOI: 10.1038/s41586-023-06701-5

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : SciTechDaily – https://scitechdaily.com/huntingtons-disease-breakthrough-scientists-tame-deadly-biological-trigger/

Tags: DiseaseHuntington’sscience
Previous Post

The Megalodon Makeover: How Science Just Flipped the Script on the Ancient Shark

Next Post

Microgravity Masters: Expedition 70 and Ax-3 Crews Working Together on Space Station

Endemism shapes viral ecology and evolution in globally distributed hydrothermal vent ecosystems – Nature

Endemism shapes viral ecology and evolution in globally distributed hydrothermal vent ecosystems – Nature

August 2, 2025
Scientists Finally Reveal the Hidden Trigger Behind Lightning Strikes

Scientists Finally Reveal the Hidden Trigger Behind Lightning Strikes

August 2, 2025
Young minds explore science at NDSU summer research program – InForum

Young Minds Ignite Curiosity at NDSU Summer Science Research Program

August 2, 2025
PlayStation Preparing to Release More Games on Xbox – Report – PlayStation LifeStyle

PlayStation Gears Up to Launch Exciting New Games on Xbox

August 2, 2025
Lexington County hits a home run hosting the Diamond Youth Baseball World Series – WLTX

Lexington County Hits a Home Run Hosting the Diamond Youth Baseball World Series

August 2, 2025
Some rural Texans see THC as a lifeline for their health and economy – The Texas Tribune

How THC Is Revolutionizing Health and Sparking Economic Growth in Rural Texas

August 2, 2025
Fox Corporation Acquires One-Third Interest in Penske Entertainment – INDYCAR.com

Fox Corporation Makes Bold Move with Major Investment in Penske Entertainment, Powering INDYCAR’s Future

August 2, 2025
Minnesotans face health impacts as wildfire smoke lingers – kare11.com

Minnesotans face health impacts as wildfire smoke lingers – kare11.com

August 2, 2025
Trump announces sweeping new levies for scores of countries – as it happened – The Guardian

Trump announces sweeping new levies for scores of countries – as it happened – The Guardian

August 2, 2025
Livonia police use grappler technology to stop drunk driver – ClickOnDetroit | WDIV Local 4

Livonia Police Deploy Grappler Technology to Safely Stop Drunk Driver

August 2, 2025

Categories

Archives

August 2025
MTWTFSS
 123
45678910
11121314151617
18192021222324
25262728293031
« Jul    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (751)
  • Economy (776)
  • Entertainment (21,653)
  • General (16,252)
  • Health (9,813)
  • Lifestyle (784)
  • News (22,149)
  • People (776)
  • Politics (785)
  • Science (15,989)
  • Sports (21,271)
  • Technology (15,753)
  • World (758)

Recent News

Endemism shapes viral ecology and evolution in globally distributed hydrothermal vent ecosystems – Nature

Endemism shapes viral ecology and evolution in globally distributed hydrothermal vent ecosystems – Nature

August 2, 2025
Scientists Finally Reveal the Hidden Trigger Behind Lightning Strikes

Scientists Finally Reveal the Hidden Trigger Behind Lightning Strikes

August 2, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version